To improve the bioavailability of hawthorn leaves flavonoids（HLF）, bioadhesive powders（BP） were prepared by an emulsion-solvent evaporation technique. Bioadhesive polymers such as sodium alginate（SA）,carboxyl ch...
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To improve the bioavailability of hawthorn leaves flavonoids（HLF）, bioadhesive powders（BP） were prepared by an emulsion-solvent evaporation technique. Bioadhesive polymers such as sodium alginate（SA）,carboxyl chitosan（CPCTS） and carbopol 974p（CP） were used in the bioadhesive powders *** formulations of HLF bioadhesive powders were respectively given to six healthy beagle *** from statistical analysis showed that there were significant differences between the HLF-BP and the commercially available HLF pills in pharmacokinetic parameters（AUC0-∞,Cmax and Tmax）.The rate and extent of absorption of HLF-BP was found to be significantly faster and larger than HLF pills,as shown by a higher Cmax, a shorter Tmax and a larger *** to HLF *** bioavailability of HLF in beagle dogs was improved by using bioadhesion.
Protein spherulite,a new form of protein aggregation,was prepared for sustained-release of recombinant human interferonα-2b(rhIFN).rhIFN spherulites exhibit good sustained release potential in *** inhibition assay wa...
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Protein spherulite,a new form of protein aggregation,was prepared for sustained-release of recombinant human interferonα-2b(rhIFN).rhIFN spherulites exhibit good sustained release potential in *** inhibition assay was conducted and shown that the spherulitic rhIFN well kept their structural and functional *** vivo studies showed that rhIFN spherulites provided a significantly prolonged PK profile as compared with the soluble rhIFN formulation.
Purpose In this study,a novel class of stabilizer—cationic polymers—was introduced into the family of *** Influence of three cationic polymers, chitosan(CS),N-trimethyl chitosan(TMC),and polyethyleneimine(PEI) on th...
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Purpose In this study,a novel class of stabilizer—cationic polymers—was introduced into the family of *** Influence of three cationic polymers, chitosan(CS),N-trimethyl chitosan(TMC),and polyethyleneimine(PEI) on the properties of the itraconazole nanocrystals was *** Polymer molecular weight and charge density can significantly influence the magnitude of the particle *** The cationic polymers are effective stabilizers in reducing the particle size of poorly soluble drug nanocrystals with improved physical stability.
The study is aimed at solving a significant challenge of extending the half-life of therapeutic proteins using crystalline biopharmaceuticals and without redesigning the *** human interferonα-2b(rhIFN) was crystalliz...
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The study is aimed at solving a significant challenge of extending the half-life of therapeutic proteins using crystalline biopharmaceuticals and without redesigning the *** human interferonα-2b(rhIFN) was crystallized by chelating with zinc in the presence of *** resulted rhIFN crystal formulations containing protamine exhibited good sustained-release potential both in vitro and in *** well kept their structural and functional integrity in these *** approach described here offers an exciting possibility of being broadly applicable to other therapeutic proteins.
pH-Responsive systems are promising for their applicability in wide areas including drug delivery and gene transfection *** routes and fabrication strategies leading to new-generation,dynamically tunable materials are...
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pH-Responsive systems are promising for their applicability in wide areas including drug delivery and gene transfection *** routes and fabrication strategies leading to new-generation,dynamically tunable materials are often inspired by biological systems due to their specificity and ability to respond to *** formation and cleavage of metal ion-ligand coordination bonds are sensitive to external pH variations because both metal ions and protons are Lewis acids and compete to combine with the ligand,which is a Lewis base. This mechanism is intrinsic to natural systems,*** transferrin recycle in cells,iron ions are transferred from the extracellular environment into the cytoplasm by the formation and breakage of coordination bonds in response to a pH ***,it is possible to use a biomimetic coordination bonding process to construct an advanced synthetic
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