Application of contrast agents（or microbubbles） in diagnostic and therapeutic ultrasound has grown rapidly during the past two ***（with the exception of the U.S.） microbubbles are used in a broad range of applicat...
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Application of contrast agents（or microbubbles） in diagnostic and therapeutic ultrasound has grown rapidly during the past two ***（with the exception of the U.S.） microbubbles are used in a broad range of applications including cancer detection and on-demand *** to their shell-stabilized gas-core structure their behavior in the ultrasound field permits superb detection at near picomolar concentrations,besides their shell facilitates robust functionalization with various targeting *** are also susceptible to on-demand disruption with higher power ultrasound,making them ideal for drug ***,because the agents range in diameter from 1～10 μm,they are confined to the *** limits their applications in targeted molecular imaging and drug delivery,especially in the cancer *** these applications,particles which are highly echogenic and sufficiently small in size（with a nanoparticle-sized footprint）would enable the detection of targets to reside beyond the vasculature and could revolutionize the ultrasound imaging *** facilitate ultrasound imaging beyond the vasculature,we have formulated a series of nanoparticle-based ultrasound contrast agents（nanobubbles） which possess many of the same benefits as microbubbles but are much more stable and offer additional cargo space for drug loading and enable simple functionalization all with a footprint approaching 100 *** nanobubbles consist of a perfluoropropane（C F） gas core stabilized with lipids and the surfactant,*** stabilization with anacrylamide-based crosslinking mesh provides a scaffold for drug loading/The nanobubbles,functionalized with a superbly selective,high affinity-ligand or antibody,are able to penetrate into the tumor from the vasculature,making them ideal for molecular imaging *** are currently utilizing targeted nanobubbles for early detection of ovarian cancer and for ultrasound-guided biopsy of prostate cance
Objective To explore the diagnostic value of shear wave quality（SWQ） for two-dimensional shear wave elastography（2 D-SWE） in the diagnosis of breast lesions with different *** This prospective study was approved b...
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Objective To explore the diagnostic value of shear wave quality（SWQ） for two-dimensional shear wave elastography（2 D-SWE） in the diagnosis of breast lesions with different *** This prospective study was approved by the institution review board and informed consent was obtained from all the *** August 2014 to January 2015,243 patients with 260 pathologically proven breast lesions were included into this *** patients underwent conventional ultrasound（US） and 2 D-SWE *** to the size,all breast lesions were divided into three groups（group one:≤10 mm,group two:10 ～ 20 mm,group three:≥20 mm） and then make an *** evaluation of SWQ for 2 D-SWE was as follow:if the SWQ images of breast lesions were in the whole green,the SWQs were regarded as *** the contrary,if the images had yellow or/and red component,the SWQs were regarded as *** evaluation of SWQ were performed by two independent observers with difference experience of breast ultrasound diagnosis（one with 2-year experience and the other with 7-year experience）.Lastly,in the three groups with different sizes,the comparisons of poor SWQ rates between benign and malignant breast lesions were performed（P＜ 0.05）,*** the Observer consistency was *** In this study,63（95.4%） breast lesions were confirmed by postoperative pathology and 8（4.6%） breast lesions were proven by ***,192（73.8%） breast lesions were confirmed as benign and 68（26.2%） ones were confirmed as *** all the breast lesions,the poor SWQ rate is 25.4%（66/260） with 38（19.8%） in the benign breast lesions and 28（41.2%） in malignant *** the benign breast lesions,the rates of poor SWQ were 6.3%（4/63）,21.4%（21/98） and41.9%（13/31）for the group one,the group two and the group three,*** the malignant breast lesions,the rates of poor SWQ were 10.0%（1/10）,34.5%（10/29） and 58.6%（l7/29） for the group one,the group two and the group thr
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