背景:脆性骨折是骨质疏松(osteoporosis,OP)最严重的并发症,何时应对OP患者进行干预性治疗是临床工作者遇到的最为棘手的问题。骨密度(bone mineral density,BMD)在一定程度上是骨折风险的预测因子,但BMD只能反映50%0%骨强度的变化...
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背景:脆性骨折是骨质疏松(osteoporosis,OP)最严重的并发症,何时应对OP患者进行干预性治疗是临床工作者遇到的最为棘手的问题。骨密度(bone mineral density,BMD)在一定程度上是骨折风险的预测因子,但BMD只能反映50%0%骨强度的变化,仅根据BMD测量值来评价骨折风险将遗漏一半以上可能发生OP性骨折的患者。骨髓脂肪组织与松质骨的某些特征具有密切关联性,因此,研究OP性椎体骨折骨髓脂肪含量变化具有重要意义。目的:探讨MRS骨髓脂肪含量预测骨质疏松性椎体骨折的价值。方法 13例椎体骨折及19例无椎体骨折女性患者(年龄59.2±4.9岁,体重指数23.0±3.3kg·m-2)行DXA检查测定椎体骨密度(BMD)及MRS扫描计测L3椎体骨髓脂肪分数(FF),FF值对OP及OP性椎体骨折的诊断价值和临界值采用受试者工作特征曲线(ROC)来判断。结果:FF与BMD存在负相关性,r=-0.527,P=0.002。FF判断DXA诊断的骨质疏松ROC曲线下面积为0.762,95%CI(0.594~0.930),敏感性0.786,特异性0.611。FF判断椎体骨折的ROC曲线下面积为0.819,95%CI(0.689~0.949),敏感性0.846,特异性0.645。结论:骨髓脂肪含量对预测OP性椎体骨折有潜在价值,为研究OP性骨折风险评估提供了一种新的思路。
Purpose:To compare a free-breath acquisition(FB)with one-breath-hold(BH)using 3D inversion recovery gradient echo MR pulse sequence for imaging of myocardial delayed *** and Methods:3D enhanced images were acquired us...
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Purpose:To compare a free-breath acquisition(FB)with one-breath-hold(BH)using 3D inversion recovery gradient echo MR pulse sequence for imaging of myocardial delayed *** and Methods:3D enhanced images were acquired using FB and BH techniques in the 20 patients with myocardial *** FB acquisition used navigator *** quality of myocardial imaging was assessed as"1=poor、2=fair、3=good、4=excellent".infarct SNR(SNRinf)and infarct-viable myocardium CNR(CNRinf-myo)of the two groups were calculated,as well as infarct *** the findings with SPSS12.0 ***:Findings for total myocardial contrast enhanced area agreed well between the two *** image quality score、SNRinf、CNRinf-myo was 1.9±0.5、2.6±0.7,126.8±5.3、253.2±10.8,84.1±7.2、130.5±6.7,*** there were significant difference between the ***:An FB navigator echo acquisition can be effectived used in the myocardial delayed hyperenhancement *** quality and spatial resolution are superior to that of BH imaging.
Purpose To evaluate the clinic application value of 4D computed tomography(CT)performed with a prototype 128-slice CT scanner in acute infarction caused by cerebral artery severe stenosis or *** Thirty-four patients w...
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Purpose To evaluate the clinic application value of 4D computed tomography(CT)performed with a prototype 128-slice CT scanner in acute infarction caused by cerebral artery severe stenosis or *** Thirty-four patients with intracranial artery severe stenosis were scanned by 128-slice CT *** volume CT perfusion(CTP)parameter maps of cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT),and time to peak(TTP)ware *** cerebral CTA images were *** CTP was showed abnormal in Thirty-four *** decreased than contralateral side in the region of ischemic penumbra around the cerebral infarct(P>0.05).There were significant differences of CBV between affected side and contralateral side(P<0.05).TTP and MTT of affected side were significantly prolonged compared to contralateral side(P<0.05).The agreement between CTA and DSA was greater in the detection of cerebral artery severe stenosis or occlusion(kappa=0.888,P=0.039<0.05).Conclusion Comprehensive information of intracranial artery severe stenosis and hemodynamic changes in acute infarction could be achieved with the 4D-CTA protocol by 128-slice CT *** has great value for clinical application.
目的建立稳定可靠的大鼠C6脑神经胶质瘤模型,并运用1.5 T MRI观察脑胶质瘤瘤体生长的变化规律,为进一步进行脑胶质瘤的在体实验研究提供基础。方法 C6胶质瘤细胞培养后,采用立体定向仪种植C6胶质瘤细胞,建立C6脑胶质瘤大鼠模型50只,分为...
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目的建立稳定可靠的大鼠C6脑神经胶质瘤模型,并运用1.5 T MRI观察脑胶质瘤瘤体生长的变化规律,为进一步进行脑胶质瘤的在体实验研究提供基础。方法 C6胶质瘤细胞培养后,采用立体定向仪种植C6胶质瘤细胞,建立C6脑胶质瘤大鼠模型50只,分为4组,分别于第7天(n=10),第14天(n=10),第21天(n=10)处死,最后1组自然死亡(n=20)用于生存分析。用1.5 T MRI作扫描成像动态观察接种后第1、2、3周末后肿瘤的MRI瘤体生长变化,并在第1、2、3周末处死各组大鼠将大体病理结果同MRI瘤体积进行比较。结果本研究应用立体定向尾状核接种C6胶质瘤细胞,所有接种大鼠均有胶质瘤生长(100%),免疫组化GFAP染色阳性,肿瘤生长速度于第二周开始明显加快;3周后大鼠开始出现死亡。1.5 T MRI能够较好的显示大鼠大脑正常组织及结构、瘤体和瘤周水肿区。MRI测量瘤体和大体病理结果相近。结论采用立体定向法向大鼠尾状核接种C6神经胶质瘤细胞成功率达100%;1.5 T MRI能够较好的反映大鼠脑胶质瘤生长的变化,为脑胶质瘤的在体实验研究提供基础。于第二周末至第三周末之间行相关医学干预是合适时机。
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