Systemic oxidative stress is defined as an imbalance between the generation of reactive oxygen species(ROS) and the body's endogenous antioxidant ***(?O) is regarded as the parent ROS,readily generating hydrog...
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Systemic oxidative stress is defined as an imbalance between the generation of reactive oxygen species(ROS) and the body's endogenous antioxidant ***(?O) is regarded as the parent ROS,readily generating hydrogen peroxide(HO),peroxynitrite (? ONOO),and hydroxyl(? OH).HO and ? ONOO are formed even under normal physiological *** the last decade,oxidative stress has been implicated as playing a causal role in the development of cardiac dysfunction and remodelling in a range
AIM:Agonist -evoked[Ca]:oscillations are irregular and *** aim of this study is to address how irregular [Ca]:oscillations dynamically regulate agonist - stimulated transcription and gene ***:NF - kB/STAT3 - GFP nucle...
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AIM:Agonist -evoked[Ca]:oscillations are irregular and *** aim of this study is to address how irregular [Ca]:oscillations dynamically regulate agonist - stimulated transcription and gene ***:NF - kB/STAT3 - GFP nuclear translocation and[Ca]:oscillations were simultaneously monitored in each single cell.[Ca],oscillation models mimicking
It is currently clarified that Ca ions play a key role not only in cardiac E - C coupling in contractile regulation,but also in regulation of SA node pace - making activity,genetic regulation and other important proce...
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It is currently clarified that Ca ions play a key role not only in cardiac E - C coupling in contractile regulation,but also in regulation of SA node pace - making activity,genetic regulation and other important processes,including intracellular signal transduction, mitochondrial function and cell *** regulation is achieved by two mechanisms,the regulation of Ca transients and/or
In contrast to the traditional belief of an "inside - out" progression of vascular dysfunction,recent evidence suggests an "outside -in" hypothesis,proposing that inflammation can originate from th...
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In contrast to the traditional belief of an "inside - out" progression of vascular dysfunction,recent evidence suggests an "outside -in" hypothesis,proposing that inflammation can originate from the adventitia and develop towards the intima,resulting in vascular wall *** remodeling such as neointima formation is signified by the acquisition of migratory and proliferative ability of
AIM:To address the role of the mitochondrial Src tyrosine kinase and mitochondrial oxidative stress in the cardioprotective action of ***:Isolated rat hearts and cardiac HL - 1 cells were subjected to ischemia and ***...
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AIM:To address the role of the mitochondrial Src tyrosine kinase and mitochondrial oxidative stress in the cardioprotective action of ***:Isolated rat hearts and cardiac HL - 1 cells were subjected to ischemia and *** infarct size,LDH release,Src phosphorylation,and mitochondrial protein carbonylation were ***:Morphine given prior to
AIM:Our previous studies demonstrated that an anti - apoptotic protein,HS - 1 - associated protein X - 1(HAX - 1),regulated cardiac contractility through interaction with phospholamban and sarcoplasmic reticulum(SR) c...
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AIM:Our previous studies demonstrated that an anti - apoptotic protein,HS - 1 - associated protein X - 1(HAX - 1),regulated cardiac contractility through interaction with phospholamban and sarcoplasmic reticulum(SR) calcium ATPase,the two important proteins in SR calcium ***,the levels of HAX -1 were found to be reduced in cardiac I/R injury induced by myocar-
作者:
LI Zi-jianInstitute of Vascular Medicine
Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of Health and Key Laboratory of Molecular CardiologyMinistry of Education
AIM:Clathrin - depended receptor internalization is a complex,yet delicate process,which is tightly regulated by an intricate complex protein *** far,there are still much unknown about how the multiple components of c...
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AIM:Clathrin - depended receptor internalization is a complex,yet delicate process,which is tightly regulated by an intricate complex protein *** far,there are still much unknown about how the multiple components of clathrin - coated structures are spatially and temporally organized and *** this work,we studied the regulatory role of HIP - 55,an endocytic adaptor pro-
AIM:The receptor of advanced glycation endproducts(RAGE) is a pattern - recognition receptor that binds diverse classes of ligands, and it has been identified as a central player in perpetuating the innate immune *** ...
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AIM:The receptor of advanced glycation endproducts(RAGE) is a pattern - recognition receptor that binds diverse classes of ligands, and it has been identified as a central player in perpetuating the innate immune *** clarify the effects of anti - RAGE antibody on immune function and mortality in a rat model of severe thermal ***:The present study was performed in
High-density lipoprotein(HDL) plays a key role in protecting against *** cardiovascular disease,HDL can be nitrated and chlorinated by myeloperoxidase(MPO).In the current study,we discovered that MPO oxidized HDL is d...
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High-density lipoprotein(HDL) plays a key role in protecting against *** cardiovascular disease,HDL can be nitrated and chlorinated by myeloperoxidase(MPO).In the current study,we discovered that MPO oxidized HDL is dysfunctional in promoting endothelial repair compared to normal *** assay,wound - healing and Transwell migration experiments showed that
AIM:Establishment of an inflammatory milieu and disruption of the vascular tone are two featured events taking place in stressed vascular endothelium and contributing to the pathogenesis of chronic hypoxia - induced p...
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AIM:Establishment of an inflammatory milieu and disruption of the vascular tone are two featured events taking place in stressed vascular endothelium and contributing to the pathogenesis of chronic hypoxia - induced pulmonary hypertension(HPH).The molecular switch that dictates the transcriptional events in response to hypoxia in endothelial cells leading up to HPH is not fully *** goal was to determine the involvement of the transcriptional modulator megakaryocytic leukemia 1(MKL1) in the pathogenesis of HPH
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