AIM:CD73 is an ectoenzyme overexpressed in breast cancer cells,catalyzing the dephosphorylation of adenosine monophosphates into *** aim of this research is to explore the relation between CD73 and epidermal growth fa...
详细信息
AIM:CD73 is an ectoenzyme overexpressed in breast cancer cells,catalyzing the dephosphorylation of adenosine monophosphates into *** aim of this research is to explore the relation between CD73 and epidermal growth factor receptor(EGFR) and potential mechanisms of them,and to examine the clinical significance and potential prognostic value of CD73 in human breast cancer. METHODS:Firstly,CD73 and EGFR expression was investigated by immunohistochemistry on tissue microarrays and breast cancer
AIM:Microenvironment plays an important regulatory role in the process of *** is one of major components of the extracellular ***:To illustrate the role of lumican in angiogenesis,abdominal aortas and capillaries of l...
详细信息
AIM:Microenvironment plays an important regulatory role in the process of *** is one of major components of the extracellular ***:To illustrate the role of lumican in angiogenesis,abdominal aortas and capillaries of livers,lungs and kidneys were ***:Lumican transgenic mice were found to have capillary dysplasia with markedly
AIM:MicroRNAs comprise a broad class of small non-coding RNA that control expression of complementary target messenger *** microRNAs are highly expressed in the diseased *** microRNAs have been found to be critical mo...
详细信息
AIM:MicroRNAs comprise a broad class of small non-coding RNA that control expression of complementary target messenger *** microRNAs are highly expressed in the diseased *** microRNAs have been found to be critical modulators of vascular pathologies,such as atherosclerosis,arterial remodeling,neointimal hyperplasia and signal transduction ***-cod-
To analysis the function of cardiomyocytes requires isolation and culture of functionally and morphologically intact *** isolation of cardiomyocytes from adult rat hearts is performed with Langendorff perfusion *** Pe...
详细信息
To analysis the function of cardiomyocytes requires isolation and culture of functionally and morphologically intact *** isolation of cardiomyocytes from adult rat hearts is performed with Langendorff perfusion *** Percoll,iodixanol and BSA density gradient centrifugation separated and purified the myocytes from *** rod-shaped and calcium-tolerant cardiomyo-
To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gra...
详细信息
To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gradients 19%to 27% (W/V) iodixanol,30%iodixanol containing HMF or LMF and layer beneath the gradient,and centrifugation at 70000×g for 1.5~
AIM:KCNE2 is a promiscuous auxiliary subunit of voltage - gated K channels in the *** study investigated the possible role of KCNE2 in regulating L - type Ca current(I) in rdiac myocytes and HEK 293 cells expressing C...
详细信息
AIM:KCNE2 is a promiscuous auxiliary subunit of voltage - gated K channels in the *** study investigated the possible role of KCNE2 in regulating L - type Ca current(I) in rdiac myocytes and HEK 293 cells expressing Caα and Caβ/δ. METHODS:Cultured adult rat ventricular myocytes(ARVMs) were infected with recombinant adenovirus vectors carrying KCNE2
AIM:Endoplasmic reticulum stress(ERS) may contribute to the pathogenesis of myocardial reperfusion *** purpose of this study was to investigate the detailed time course of ERS induction and to test if resveratrol prev...
详细信息
AIM:Endoplasmic reticulum stress(ERS) may contribute to the pathogenesis of myocardial reperfusion *** purpose of this study was to investigate the detailed time course of ERS induction and to test if resveratrol prevents reperfusion injury through inhibition of ERS upon ***:Isolated rat hearts were perfused on a Langendorff apparatus and subjected to 30 min of
AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for ...
详细信息
AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for this effect are largely elusive and *** study aimed at addressing the controversial mechanisms for and the functional importance of the interaction of HS
AIM:It has been found that TLRs/IL - 1R signaling pathway were activitied due to the metabolism disorders especially high FFA in diabetic cardiomyopathy(DCM),and further study suggested TLRs/IL - 1R signaling molecula...
详细信息
AIM:It has been found that TLRs/IL - 1R signaling pathway were activitied due to the metabolism disorders especially high FFA in diabetic cardiomyopathy(DCM),and further study suggested TLRs/IL - 1R signaling molecular may involved in the ROS production in *** 1,a new defined E3 ligase,interacted with TLRs/IL - IR signaling molecules and mediated signaling *** study was designed to explore the effects of Pellino 1 and its E3 ligase activity in ***:Echocardio-
AIM:Apolipoprotein CⅢ(ApoCⅢ) is characteristic of subjects with hypertriglyceridemia(HTG) which has been established as an independent risk factor for *** studies on the role jn atherogenesis of ApoCⅢfocused mainly...
详细信息
AIM:Apolipoprotein CⅢ(ApoCⅢ) is characteristic of subjects with hypertriglyceridemia(HTG) which has been established as an independent risk factor for *** studies on the role jn atherogenesis of ApoCⅢfocused mainly on cellular levels using various cell types involved in atherogenesis and direct in vivo evidence is *** therefore generated ApoCⅢtransgenic mice
暂无评论