AIM:AngiotensinⅡ(AngⅡ) -induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study,we determined whether renin - angiotensin system(RAS) activation in the hypot...
详细信息
AIM:AngiotensinⅡ(AngⅡ) -induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study,we determined whether renin - angiotensin system(RAS) activation in the hypothalamic paraventricular nucleus (PVN) contributes to the AngⅡ- induced hypertensive response via interaction with neurotransmitters in the ***:Rats
AIM:Apolipoprotein CⅢ(ApoCⅢ) is characteristic of subjects with hypertriglyceridemia(HTG) which has been established as an independent risk factor for *** studies on the role jn atherogenesis of ApoCⅢfocused mainly...
详细信息
AIM:Apolipoprotein CⅢ(ApoCⅢ) is characteristic of subjects with hypertriglyceridemia(HTG) which has been established as an independent risk factor for *** studies on the role jn atherogenesis of ApoCⅢfocused mainly on cellular levels using various cell types involved in atherogenesis and direct in vivo evidence is *** therefore generated ApoCⅢtransgenic mice
AIM:Progressive oxidative damage is an early event involved in pathological process of Alzheimer's disease(AD).MicroRNAs (miRNAs) are a class of endogenous small(about 22 nucleotides),non -coding RNAs,which play a...
详细信息
AIM:Progressive oxidative damage is an early event involved in pathological process of Alzheimer's disease(AD).MicroRNAs (miRNAs) are a class of endogenous small(about 22 nucleotides),non -coding RNAs,which play an important role in development and prognosis of age - related neurodegenerative *** clarify the roles of miRNAs in the process of oxidative stress leading to AD and its molecular mechanism,the miRNA expression profile induced by oxidative stress in mouse hippocampal neurons was deter-
AIM:Endothelial dysfunction is a well documented evidence for onset of atherosclerosis and other cardiovascular *** acute regulatory protein(StAR),one of the cholesterol transporters,plays an important role in mainten...
详细信息
AIM:Endothelial dysfunction is a well documented evidence for onset of atherosclerosis and other cardiovascular *** acute regulatory protein(StAR),one of the cholesterol transporters,plays an important role in maintenance of intracellular lipid ***,the effect of StAR in endothelial dysfunction is not completely *** acid(PA) has been shown to decrease eNOS activity and induce inflammation in an endothelial cell culture model,which cause endothelial ***
AIM:To explore the hypothesis that the combined treatment with higenamine(HG) and[6]- gingerol([6]- GR) protects against doxonibicine(DOX) - induced cardiotoxicity at least partly through anti - apoptotic mechanisms e...
详细信息
AIM:To explore the hypothesis that the combined treatment with higenamine(HG) and[6]- gingerol([6]- GR) protects against doxonibicine(DOX) - induced cardiotoxicity at least partly through anti - apoptotic mechanisms exerted on cardiomyocytes. METHODS:All experiments were performed on neonatal rat cardiomyocytes(NRCs).Cell viability was measured by an MTT viabili-
AIM:Some cyclooxygenase-2(COX-2) inhibitors have been suggested to cause increased incidence of cardiovascular events. However,celecoxib,a COX-2 inhibitor that is still in clinical usage,has been showed to be less det...
详细信息
AIM:Some cyclooxygenase-2(COX-2) inhibitors have been suggested to cause increased incidence of cardiovascular events. However,celecoxib,a COX-2 inhibitor that is still in clinical usage,has been showed to be less detrimental to the cardiovascular system or even to improve the outcome of cardiovascular ***,this study aimed to detennine whether celecoxib influences endothelium - dependent contraction independent of its action on COX -2 and,if so,the underlying mechanism(s).METHODS:
AIM:Lipid rafts are cholesterol and sphingolipid - rich microdomains of the plasma membrane which concentrate components of certain signal transduction ***:The tissues and cells were treated with detergent -free metho...
详细信息
AIM:Lipid rafts are cholesterol and sphingolipid - rich microdomains of the plasma membrane which concentrate components of certain signal transduction ***:The tissues and cells were treated with detergent -free method(involving the lysis of whole cells,with the purified plasma membranes sonicated),and detergent method(including NP -40,lubrol,and 1%Triton X - 100).The isolation gradient was routinely comprised of three layers:the bottom sample layer[35%~45%(W/V) iodixanol],the
AIM:The pro -inflammatory cytokine macrophage migration - inhibitory factor(MIF) is known to play a key role in a number of inflammatory ***,its change in the setting of acute myocardial infarct(MI) and significance i...
详细信息
AIM:The pro -inflammatory cytokine macrophage migration - inhibitory factor(MIF) is known to play a key role in a number of inflammatory ***,its change in the setting of acute myocardial infarct(MI) and significance in activating innate immune response remain ***:Using the mouse model of MI,we studied the changes of cardiac and circulating MIF (by ELISA) in C57BL/6 mice and the phenotype of post - MI inflammatory response of MIF - knockout(MIF KO) mice(in C57BL/
暂无评论