AIM:Macrophage migration - inhibitory factor(MIF) is a key mediator in inflammatory or immune - mediated *** studies had proved that angiotensin -converting enzyme 2(ACE2) could modulate the expression of MIF in a hum...
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AIM:Macrophage migration - inhibitory factor(MIF) is a key mediator in inflammatory or immune - mediated *** studies had proved that angiotensin -converting enzyme 2(ACE2) could modulate the expression of MIF in a human endothelial cell line,although this effect in heart diseases is *** study investigated whether ACE2/ACE axis could have some interaction
AIM:Myocardial fibrosis induced by activated cardiac fibroblasts(CFs) is thought to play a key role in the pathogenesis of cardiovascular *** of advanced glycation end products(AGEs),formed by the nonenzymatic gly...
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AIM:Myocardial fibrosis induced by activated cardiac fibroblasts(CFs) is thought to play a key role in the pathogenesis of cardiovascular *** of advanced glycation end products(AGEs),formed by the nonenzymatic glycation reaction of aldose sugars with amino groups of proteins,correlates with accelerated stiffness of the heart and vessels in *** of intermediate -conductance Ca -activated potassium channels(KCa3.1) has been found to promote cell proliferation in diverse types of
AIM:To investigate the protective effect of L - arginine(L - Arg) on function of the myocardial mitochondria during myocardial ischemia - reperfusion(MIR).METHODS:The experimental rabbits were randomly divided into 3 ...
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AIM:To investigate the protective effect of L - arginine(L - Arg) on function of the myocardial mitochondria during myocardial ischemia - reperfusion(MIR).METHODS:The experimental rabbits were randomly divided into 3 groups(n = 10),namely control group,MIR group and L - Arg pre - treatment group(L - Arg + MIR).In control group,the left ventricle coronary artery was separa-
Estrogen sulfotransferase(SULT1E1) is a phaseⅡdrug - metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17p - estradiol(E) plays a pivotal role in attenuating endothelial dysfunction.E2 can be f...
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Estrogen sulfotransferase(SULT1E1) is a phaseⅡdrug - metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17p - estradiol(E) plays a pivotal role in attenuating endothelial dysfunction.E2 can be further sulfated to estradiol sulfate(ES) using *** date,there are no reports of expression and function of SULT1E1 in the *** identified that SULT1E1
AIM:Macrophage migration - inhibitory factor(MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque *** was shown to be highly expressed in advanced atherosclerotic ***...
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AIM:Macrophage migration - inhibitory factor(MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque *** was shown to be highly expressed in advanced atherosclerotic *** MIF with a blocking antibody induced a regression of established atherosclerotic ***,the role of MIF in the endothelia injury from hy-
AIM:KCNE2 is a promiscuous auxiliary subunit of voltage - gated K channels in the *** study investigated the possible role of KCNE2 in regulating L - type Ca current(I) in rdiac myocytes and HEK 293 cells expressing C...
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AIM:KCNE2 is a promiscuous auxiliary subunit of voltage - gated K channels in the *** study investigated the possible role of KCNE2 in regulating L - type Ca current(I) in rdiac myocytes and HEK 293 cells expressing Caα and Caβ/δ. METHODS:Cultured adult rat ventricular myocytes(ARVMs) were infected with recombinant adenovirus vectors carrying KCNE2
To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gra...
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To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gradients 19%to 27% (W/V) iodixanol,30%iodixanol containing HMF or LMF and layer beneath the gradient,and centrifugation at 70000×g for 1.5~
AIM:Previous studies have been proposed acetylcholine(ACh) as an efficient strategy against several cardiovascular diseases. On the other hand,autophagy could be utilized for cell survival in response to *** study was...
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AIM:Previous studies have been proposed acetylcholine(ACh) as an efficient strategy against several cardiovascular diseases. On the other hand,autophagy could be utilized for cell survival in response to *** study was to determine the mechanism underlying ACh -elicited cardioprotection against hypoxia/reoxygenation(HR) injury with a focus on ***:H9c2
AIM:Ranolazine is mainly used to treat patients with chronic stable angina in clinical ***,ranolazine does not significantly lower systemic blood *** direct effect of ranolazine on vascular tone remains *** the presen...
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AIM:Ranolazine is mainly used to treat patients with chronic stable angina in clinical ***,ranolazine does not significantly lower systemic blood *** direct effect of ranolazine on vascular tone remains *** the present study,we investigated the vascular effects and mechanisms of action of ranolazine in isolated rat intrarenal ***:Rings of intra-
AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for ...
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AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for this effect are largely elusive and *** study aimed at addressing the controversial mechanisms for and the functional importance of the interaction of HS
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