AIM:Agonist -evoked[Ca]:oscillations are irregular and *** aim of this study is to address how irregular [Ca]:oscillations dynamically regulate agonist - stimulated transcription and gene ***:NF - kB/STAT3 - GFP nucle...
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AIM:Agonist -evoked[Ca]:oscillations are irregular and *** aim of this study is to address how irregular [Ca]:oscillations dynamically regulate agonist - stimulated transcription and gene ***:NF - kB/STAT3 - GFP nuclear translocation and[Ca]:oscillations were simultaneously monitored in each single cell.[Ca],oscillation models mimicking
To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gra...
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To obtain the function of complete myocardial mitochondria,the isolation procedures started with differential centrifugation of the heart *** were purified by using iodixanol in three different ways:(1) continuous gradients 19%to 27% (W/V) iodixanol,30%iodixanol containing HMF or LMF and layer beneath the gradient,and centrifugation at 70000×g for 1.5~
AIM:Endoplasmic reticulum stress(ERS) may contribute to the pathogenesis of myocardial reperfusion *** purpose of this study was to investigate the detailed time course of ERS induction and to test if resveratrol prev...
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AIM:Endoplasmic reticulum stress(ERS) may contribute to the pathogenesis of myocardial reperfusion *** purpose of this study was to investigate the detailed time course of ERS induction and to test if resveratrol prevents reperfusion injury through inhibition of ERS upon ***:Isolated rat hearts were perfused on a Langendorff apparatus and subjected to 30 min of
In contrast to the traditional belief of an "inside - out" progression of vascular dysfunction,recent evidence suggests an "outside -in" hypothesis,proposing that inflammation can originate from th...
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In contrast to the traditional belief of an "inside - out" progression of vascular dysfunction,recent evidence suggests an "outside -in" hypothesis,proposing that inflammation can originate from the adventitia and develop towards the intima,resulting in vascular wall *** remodeling such as neointima formation is signified by the acquisition of migratory and proliferative ability of
AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for ...
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AIM:The accumulation of hypoxia - inducible factor - la(HIF - la) is under the influence of H2S,which regulates hypoxia responses. The regulation of HIF - lαaccumulation by HS has been shown but the mechanisms for this effect are largely elusive and *** study aimed at addressing the controversial mechanisms for and the functional importance of the interaction of HS
AIM:Macrophages are the major component of the infiltrated leukocytes in tumor and exhibit distinct phenotypes according to the *** have recently found that signal -regulatory protein alpha(SIRPa),the inhibitory molec...
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AIM:Macrophages are the major component of the infiltrated leukocytes in tumor and exhibit distinct phenotypes according to the *** have recently found that signal -regulatory protein alpha(SIRPa),the inhibitory molecule expressed on myeloid cells,plays a critical role in innate immune ***,it is still unknown whether SIRPa expression on tumor-polar-
AIM:AngiotensinⅡ(AngⅡ) -induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study,we determined whether renin - angiotensin system(RAS) activation in the hypot...
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AIM:AngiotensinⅡ(AngⅡ) -induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study,we determined whether renin - angiotensin system(RAS) activation in the hypothalamic paraventricular nucleus (PVN) contributes to the AngⅡ- induced hypertensive response via interaction with neurotransmitters in the ***:Rats
AIM:Our previous studies demonstrated that an anti - apoptotic protein,HS - 1 - associated protein X - 1(HAX - 1),regulated cardiac contractility through interaction with phospholamban and sarcoplasmic reticulum(SR) c...
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AIM:Our previous studies demonstrated that an anti - apoptotic protein,HS - 1 - associated protein X - 1(HAX - 1),regulated cardiac contractility through interaction with phospholamban and sarcoplasmic reticulum(SR) calcium ATPase,the two important proteins in SR calcium ***,the levels of HAX -1 were found to be reduced in cardiac I/R injury induced by myocar-
作者:
LI Zi-jianInstitute of Vascular Medicine
Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of Health and Key Laboratory of Molecular CardiologyMinistry of Education
AIM:Clathrin - depended receptor internalization is a complex,yet delicate process,which is tightly regulated by an intricate complex protein *** far,there are still much unknown about how the multiple components of c...
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AIM:Clathrin - depended receptor internalization is a complex,yet delicate process,which is tightly regulated by an intricate complex protein *** far,there are still much unknown about how the multiple components of clathrin - coated structures are spatially and temporally organized and *** this work,we studied the regulatory role of HIP - 55,an endocytic adaptor pro-
AIM:The receptor of advanced glycation endproducts(RAGE) is a pattern - recognition receptor that binds diverse classes of ligands, and it has been identified as a central player in perpetuating the innate immune *** ...
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AIM:The receptor of advanced glycation endproducts(RAGE) is a pattern - recognition receptor that binds diverse classes of ligands, and it has been identified as a central player in perpetuating the innate immune *** clarify the effects of anti - RAGE antibody on immune function and mortality in a rat model of severe thermal ***:The present study was performed in
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