AIM:The pro -inflammatory cytokine macrophage migration - inhibitory factor(MIF) is known to play a key role in a number of inflammatory ***,its change in the setting of acute myocardial infarct(MI) and significance i...
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AIM:The pro -inflammatory cytokine macrophage migration - inhibitory factor(MIF) is known to play a key role in a number of inflammatory ***,its change in the setting of acute myocardial infarct(MI) and significance in activating innate immune response remain ***:Using the mouse model of MI,we studied the changes of cardiac and circulating MIF (by ELISA) in C57BL/6 mice and the phenotype of post - MI inflammatory response of MIF - knockout(MIF KO) mice(in C57BL/
AIM:Myocardial fibrosis induced by activated cardiac fibroblasts(CFs) is thought to play a key role in the pathogenesis of cardiovascular *** of advanced glycation end products(AGEs),formed by the nonenzymatic gly...
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AIM:Myocardial fibrosis induced by activated cardiac fibroblasts(CFs) is thought to play a key role in the pathogenesis of cardiovascular *** of advanced glycation end products(AGEs),formed by the nonenzymatic glycation reaction of aldose sugars with amino groups of proteins,correlates with accelerated stiffness of the heart and vessels in *** of intermediate -conductance Ca -activated potassium channels(KCa3.1) has been found to promote cell proliferation in diverse types of
AIM:Pluripotent stem cells(PSCs) opens a new era of opportunity for cardiovascular research and ***,to take advantage of the promise of these cells,well understanding of the regulatory mechanism controlling the balanc...
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AIM:Pluripotent stem cells(PSCs) opens a new era of opportunity for cardiovascular research and ***,to take advantage of the promise of these cells,well understanding of the regulatory mechanism controlling the balance between self - renewal and specific lineage commitment of PSCs and efficiently differentiating them to the cell types of interest are *** & RESULTS:To identify regulatory mechanism and efficient inducers for cardiac lineage commitment,we systematically screened cardio-
AIM:To investigate the protective effect of L - arginine(L - Arg) on function of the myocardial mitochondria during myocardial ischemia - reperfusion(MIR).METHODS:The experimental rabbits were randomly divided into 3 ...
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AIM:To investigate the protective effect of L - arginine(L - Arg) on function of the myocardial mitochondria during myocardial ischemia - reperfusion(MIR).METHODS:The experimental rabbits were randomly divided into 3 groups(n = 10),namely control group,MIR group and L - Arg pre - treatment group(L - Arg + MIR).In control group,the left ventricle coronary artery was separa-
Estrogen sulfotransferase(SULT1E1) is a phaseⅡdrug - metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17p - estradiol(E) plays a pivotal role in attenuating endothelial dysfunction.E2 can be f...
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Estrogen sulfotransferase(SULT1E1) is a phaseⅡdrug - metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17p - estradiol(E) plays a pivotal role in attenuating endothelial dysfunction.E2 can be further sulfated to estradiol sulfate(ES) using *** date,there are no reports of expression and function of SULT1E1 in the *** identified that SULT1E1
AIM:Circulating microRNAs(miRNAs) have attracted much attention as promising novel markers for various ***, the biomarker of plasma miRNA for essential hypertension is still *** present study was aimed to screen and v...
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AIM:Circulating microRNAs(miRNAs) have attracted much attention as promising novel markers for various ***, the biomarker of plasma miRNA for essential hypertension is still *** present study was aimed to screen and validate plasma miRNAs as novel diagnostic biomarkers for essential hypertension in hospital - based case - control and a community cohort population. METHODS:An initial screening of plasma miRNA expression by Solexa sequencing was performed using plasma samples pooled from
AIM:Previous studies have been proposed acetylcholine(ACh) as an efficient strategy against several cardiovascular diseases. On the other hand,autophagy could be utilized for cell survival in response to *** study was...
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AIM:Previous studies have been proposed acetylcholine(ACh) as an efficient strategy against several cardiovascular diseases. On the other hand,autophagy could be utilized for cell survival in response to *** study was to determine the mechanism underlying ACh -elicited cardioprotection against hypoxia/reoxygenation(HR) injury with a focus on ***:H9c2
AIM:Macrophage migration - inhibitory factor(MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque *** was shown to be highly expressed in advanced atherosclerotic ***...
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AIM:Macrophage migration - inhibitory factor(MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque *** was shown to be highly expressed in advanced atherosclerotic *** MIF with a blocking antibody induced a regression of established atherosclerotic ***,the role of MIF in the endothelia injury from hy-
AIM:In the vascular wall,the metabolism of arachidonic acid(AA) catalyzed via cyclooxygenase(COX) leads to the formation of prostanoids,including prostacyclin(prostaglandin I,PGI) and thromboxane A that show opp...
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AIM:In the vascular wall,the metabolism of arachidonic acid(AA) catalyzed via cyclooxygenase(COX) leads to the formation of prostanoids,including prostacyclin(prostaglandin I,PGI) and thromboxane A that show opposite biological ***, the exact role and mechanisms of AA metabolism mediated by each COX isoform in regulating local vascular function still remain to be elucidated *** study aimed to reveal pathways and mechanisms for the vasomotor reaction evoked by AA in mouse abdominal
AIM:Ranolazine is mainly used to treat patients with chronic stable angina in clinical ***,ranolazine does not significantly lower systemic blood *** direct effect of ranolazine on vascular tone remains *** the presen...
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AIM:Ranolazine is mainly used to treat patients with chronic stable angina in clinical ***,ranolazine does not significantly lower systemic blood *** direct effect of ranolazine on vascular tone remains *** the present study,we investigated the vascular effects and mechanisms of action of ranolazine in isolated rat intrarenal ***:Rings of intra-
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