AIM:Cumulated evidence have shown that intermittent hypobaric hypoxia(IHH) can protect the heart against ischemia - reperfusion (I/R) injury by improving major manifestations such as infarct size,post - ischemic contr...
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AIM:Cumulated evidence have shown that intermittent hypobaric hypoxia(IHH) can protect the heart against ischemia - reperfusion (I/R) injury by improving major manifestations such as infarct size,post - ischemic contractile dysfunction,ventricular arrhythmias, and myocyte ***,its underlying mechanism is still largely unclear and need to be further ***: Male SD rats were exposed to hypoxia in a hypobaric chamber for one 4 h period each day for 4 weeks to establish IHH adapta-
AIM:Induced pluripotent stem cells(iPSCs) hold great promise for the development of patient - specific therapies for cardiovascular ***,clinical translation will require preclinical optimization and validation of larg...
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AIM:Induced pluripotent stem cells(iPSCs) hold great promise for the development of patient - specific therapies for cardiovascular ***,clinical translation will require preclinical optimization and validation of large animal iPSC *** this study,we aimed to generate endothelial cells from porcine iPSCs and investigate their potential utility for treatment of myocardial ischemia. METHODS:We generated iPSCs from adipose tissue of adult miniswine,and successfully differentiated these cells into endotheli-
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