Aim: Although the tumor suppressive role of EPB41L3 has been discovered in some research, our knowledge towards its molecular biology function and modulatory mechanisms remains ***, the clinical significances of EPB41...
详细信息
Aim: Although the tumor suppressive role of EPB41L3 has been discovered in some research, our knowledge towards its molecular biology function and modulatory mechanisms remains ***, the clinical significances of EPB41L3 expression have never been reported in esophageal squamous carcinoma (ESCC).We aim to find out whether EPB41L3 is a tumor suppressor in *** : We used MSP and pyrosequencing to determine the methylation status of EPB41L3 in ESCC, and then we used tissue microarray and a series of molecular biology experiments to explore the tumor suppresive role of ***: In this study, we confirmed the reduced expression status of EPB41L3 in ESCC tissues and cell lines which was due to partial *** ectopic expression of EPB41L3 in ESCC cells inhibited cell proliferation in vivo and in vitro by activating MAPK ***, EPB41L3 could induce apoptosis by activating caspase3/8/9 and generating G2/M arrest by activating Cdc2/Cyclin B 1 *** clinical samples,ESCC tissues exhibited lower expression level of EPB41L3 compared with normal esophagous *** with higher EPB41L3 expression had a markedly higher overall survival than patients with low EPB41L3 ***: Above all, our results indicate EPB41L3 as a functional tumor suppressive gene in ESCC development, representing a potential therapy target and prognosis indicator for clinical practice.
暂无评论