Pharmaceutical proteins and peptides have become more and more important therapeutic agents to improve the quality of life of ***,these drugs are either enzymatically unstable or *** effective delivery of peptide and ...
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Pharmaceutical proteins and peptides have become more and more important therapeutic agents to improve the quality of life of ***,these drugs are either enzymatically unstable or *** effective delivery of peptide and protein drugs remains a major *** formulation approaches are highly in demand for successful delivery of these pharmaceutical peptides and ***/nanoparticulate systems may provide protein and peptide drugs with a few functionalities,*** effects,improved stability,enhanced bioavailability and reduced side *** particular,micro/nanoparticles in dry forms are very attractive because peptide and protein drugs are more stable in the solid state than in the liquid *** manuscript aims to review current state of the art in particle engineering technologies enabling effective delivery of peptide and protein drugs by formulating them into solid forms.
A mixed micellar system based mainly on the pH-sensitive copolymer of poly (L-histidine)-poly (D,L-lactide)-polyethyleneglycol- poly (D,L-lactide)-poly (L-histidine) (PHis-PLA-PEG-PLA-PHis) and Pluronic(R) F127,some o...
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A mixed micellar system based mainly on the pH-sensitive copolymer of poly (L-histidine)-poly (D,L-lactide)-polyethyleneglycol- poly (D,L-lactide)-poly (L-histidine) (PHis-PLA-PEG-PLA-PHis) and Pluronic(R) F127,some of which was conjugated with folate,was constructed to intracellularly deliver the unimers of Pluronic(R) P85 to MDR *** micelles with inserted Pluronic(R) P85 unimers demonstrated much more cellular uptake and higher cytotoxicity against MDR cells than other tested *** enhanced MDR reversal effect was attributed to the intracellular delivery of Pluronic(R) P85 unimers to the MDR *** intracellular delivery of Pluronic(R) P85 unimers to the MDR cells has been demonstrated as a promising approach to reverse MDR.
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