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检索条件"任意字段=生物颗粒与粉体制备、应用技术研讨会"

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Multifunctional Graphene Oxide as drug delivery carriers for cancer targeted chemo-photothermal therapy

Multifunctional Graphene Oxide as drug delivery carriers for...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Lin Hou Qianhua Feng Yating Wang Zhenzhong Zhang School of Pharmaceutical Sciences Zhengzhou University 100 Kexue AvenueZhengzhou 450001 Henan P.R. China

The covalent functionalization of graphene oxide (GO) with hyaluronic acid (HA) was successfully accomplished by a facile amidation *** HA-GO nanosheets with a good aqueous solubility and biocompatibility were characterized FT-IR and UV/Vis ***,controlled loading of mitoxantrone (MIT) onto the HA-GO via π-π stacking interaction was *** results revealed that drug-loaded nanosheets with high loading efficiency of 50 wt%,exhibited pH-sensitive responses to tumor *** order to investigate the dynamic behaviors and targeting ability of HA-GO nanosheets on tumor-bearing mice,near-infrared fluorescent (NIFR) dye Cyanine 7 (Cy7) was encapsulated into the nanosheets for in vivo optical *** demonstrated that HA-GO nanosheets could enhance the targeting and residence time in tumor ***,the MIT/HA-GO nanosheets may potentially be useful to be further development of synergistic cancer therapy.

关键词： Graphene oxide Drug delivery carrier Photothermal therapy Chemotherapy Cancer

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Biotinylated liposomes as potential carriers for the oral delivery of insulin:Cellular uptake, internalization and endocytosis pathways

Biotinylated liposomes as potential carriers for the oral de...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Xingwang Zhang Yunchang Xie Jianping Qi Yi Lu Wei Wu Key Laboratory of Smart Drug Delivery of Ministry of Education School of Pharmacy Fudan University Shanghai PR China

Objective This study aimed to explore biotinylated liposomes (BLPs) as novel carriers to enhance the oral delivery of *** The hypothesis of specific receptor-ligand interaction was investigated using the Caco-2 cell *** labeled with 5-aminofluorescein was used to specifically bind the biotin receptors,and this event was photographed using a confocal laser scanning microscope (CLSM).Caco-2 cell monolayers and Caco-2/Raji co-cultured monolayers with M cell characteristics were used to assess the transport of the INS *** cellular uptake of fluorescent isothiocyanate-labeled insulin (FITC-INS)-loaded liposomes under different conditions was visualized and quantified by CLSM and flow cytometry,*** The significance of the biotinylation was confirmed by the facilitated absorption of the BLPs through receptor-mediated *** cellular uptake and quick gastrointestinal transport further verified the ability of the BLPs to enhance *** results provide a proof of concept that BLPs can be used as potential carriers for the oral delivery of *** The oral delivery of insulin was enhanced with *** is the biotin receptor mediated transcellular route rather than the paracellular route that INS was transported through the intestinal epithelial cells.

关键词： insulin biotin liposomes oral delivery receptor-mediated endocytosis

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Lipid matrix particles as oral drug delivery vehicles

Lipid matrix particles as oral drug delivery vehicles

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Huiling Mu Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Universitetsparken 2 DK-2100 Copenhagen Denmark

Lipid matrix particles may have great potentials in oral drug delivery,especially for biopharmaceuticals by protecting them from enzymatic degradations in the gastrointestinal tract and thereby enhancing drug absorption and *** vary in their physiochemical properties as well as their digestibility and absorption pathways,therefore selection of lipid excipients has pronounced effects on drug absorption.A better understanding on the mechanisms of drug release from lipid particles is also essential for designing functional drug *** drug release mechanism from lipid matrix particles was studied using an in vitro lipolysis model,desmopressin and lysozyme were used as model peptide/protein *** results showed that the chain-length of fatty acyl groups of lipid excipients affected the rate of drug release,which decreased with the increase of chain-length of fatty acyl groups of *** release of peptide/protein drugs from triglyceride particles was governed by lipase and lipid degradation,whereas the release of drugs from monoglyceride particles was independent on the presence of the *** understanding on drug release mechanisms provides the possibility for designing of lipid carriers with desired drug release profiles.

关键词： biopharmaceuticals in vitro lipolysis lipid matrix particles lymphatic transport poorly water-soluble drugs

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Elucidation of release characteristics of highly soluble drug trimetazidine hydrochloride from chitosan-carrageenan matrix tablets

Elucidation of release characteristics of highly soluble dru...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Liang Li Linlin Wang Yang Shao Shirui Mao School of Pharmacy Shenyang Pharmaceutical University 103 Wenhua Road Shenyang 110016 China

Purpose: The aim of this study was to better understand the underlying drug release characteristics from matrix tablets based on the combination of chitosan (CS) and different types of carrageenans (κ-CG,ι-CG,and λ-CG).Methods: Highly soluble trimetazidine hydrochloride (TH) was used as a model ***,characteristics of drug release from different formulations were investigated,and then in situ complexation capacity of CG with TH and CS was studied by differential scanning calorimetry and fourier transform infrared *** and swelling of matrix were also characterized in order to better understand the drug release *** of pH and ionic strength on drug release were also ***: It was found that not only ι-CG and λ-CG could reduce the burst release of TH by the effect of TH-CG interaction,CS-ι-CG and CS-λ-CG based polyelectrolyte film could further modify controlled release behavior,but not CS-κ-*** pH and high ionic strength resulted in faster drug release from CS-κ-CG and CS-ι-CG based matrix,but drug release from CS-λ-CG based tablet matrix was less sensitive to pH and ionic ***: In conclusion,CS-λ-CG based matrix tablets are quite promising as controlled release drug carrier based on multiple mechanisms.

关键词： chitosan carrageenan trimetazidine hydrochloride release characteristics

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Mutidrug resistance of cancer and drug-loaded liposomes

Mutidrug resistance of cancer and drug-loaded liposomes

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Wan-Liang Lu School of Pharmaceutical Sciences Peking University Beijing 100191

Introduction Cancer drug resistance is referring to the tolerance of cancer cells when treated *** the drug resistance occurs,therapeutic effect of anticancer drugwould decrease ***-drug resistance can be explained as a condition thatonce cancer cells became resistant to one chemotherapy drug,other drugs with differentstructures or mechanisms would also become ***-drug resistance (MDR) is a major obstacle to successful chemotherapy *** overcome the MDR,our research is to develop new liposome andnanomicelle delivery *** are focusing on the aspects,includingresistant cancer cell membranes,cancer stem cells,mitochondria,apoptosis genes,vasculogenic mimicry,and heterogeneity of cancer *** have been performed on the cancer cells,cancer spheroids,and canceranimal *** nano-scale formulations showed an enhanced the chemotherapyefficacy in resistant cancer and cancer stem cells in vitro and in *** resistant cancer cell membraneThere are two kinds of drug resistances on the basis of the sites where the resistanceoccurs,one is due to the impaired delivery pathway of anticancer drugs to cancer cellson the membrane of cancer cell,and the other is from the changed cancer cell itselfincluding genetic and epigenetic *** regarding to this limitation of anticancer drug delivery have been *** developed a new formulation of *** is well known that paclitaxel has apotent efficacy against a wide spectrum of cancers in clinical ***,chemotherapy with paclitaxel has been limited due to serious allergic reactions inpatients caused by cremophor EL,MDR of paclitaxel in many cancers,and restrictedpermeability across the intestinal barrier.A kind of functional paclitaxel nanomicelles,which were prepared using PEG2000-DSPE,TPGS1000 and dequalinium as thenanomicelle forming materials,was developed to overcome these obs

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The pharmacokinetics of chelerythrine solution and chelerythrine liposomes after oral administrations to rats

The pharmacokinetics of chelerythrine solution and cheleryth...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Weifeng Li Wei Xing Xiaofeng Niu Ping Zhou Ting Fan School of Pharmacy Xi'an Jiaotong University Xi'an 710061 P.R. China

Background and Aim: Chelerythrine (CHE) is a quaternary benzo[c]phenanthridine alkaloid which has many potent pharmacological effects and can dissolve in water well,dihydrochelerythrine (DHCHE) has recently been identified as a CHE metabolite in *** aim of this study was therefore to find a suitable formulation to enhance the incorporation of CHE into LPs and improve therapeutic efficacy of ***: The methods of preparation of liposomes (LPs) suffers from the drawback of poor incorporation of water-soluble ***/solvent evaporation method is a relatively simple and efficient way to prepare LPs loaded with hydrophilic ***: The CHE-LPs has been successfully prepared by the emulsion/solvent evaporation method,the entrapment efficiency (EE%) of CHE was higher at 78.6% and the drug loadings (DL%) reached 7.8%.The relative bioavailability of CHE and its dihydro derivative in LPs were significantly increased compared with that of the CHE *** area under the plasma concentration–time curve (AUC) values of CHE and DHCHE after oral administration of CHE-LPs were 4.83-fold and 2.02 higher than those obtained with CHE *** half time (t1/2) and peak concentrations (Cmax) of CHE and DHCHE were also higher for CHE-LPs than that for *** contrast,the total body clearance (CL),apparent volume of distribution (V/f(c)) were lower for CHE-LPs,in comparison to the respective parameter of CHE ***: It can thus be concluded that incorporation into LPs prolonged CHE retention within the systemic circulation.

关键词： chelerythrine liposome emulsion/solvent evaporation pharmacokinetics

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Synergistic Targeted Delivery of Payload into Tumor Cells by Dual-ligand Liposomes Co-modified with Cholesterol Anchored Transferrin and TAT

Synergistic Targeted Delivery of Payload into Tumor Cells by...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Jie Tang Li Zhang Yayuan Liu Qianyu Zhang Huile Gao Zhirong Zhang Qin He Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education West China School of Pharmacy Sichuan University Chengdu Sichuan P. R. China

Objective: This study was mainly focused on developing a dual-ligand liposomal delivery system to enhance both targeting specificity and cellular ***: The specific ligand transferrin (TF) and the cationic cell-penetrating peptide TAT were connected with cholesterol via a polyethylene glycol (PEG) spacer to prepare the dual-ligand liposomes (TAT/TF-PEG-LP).Then the in vitro cellular uptake by three kinds of cells that possessed different expressing levels of transferrin receptor (TFR) was *** Ex vivo fluorescence imaging of tumors,the qualitative observation of tumor frozen section and the quantitative determination of cellular uptake in tumor tissues were used to evaluate the in vivo delivery efficiency of TAT/***: The result of in vitro cellular uptake showed that TAT/TF-PEG-LP exhibited the enhanced cellular uptake and selectivity via the synergistic effect of both ligands in vitro compared to the single-ligand TAT or TF modified liposomes (TAT-PEG-LP or TF-PEG-LP),The ex vivo fluorescence imaging of tumors,the qualitative and quantitative evaluations of cellular uptake in tumor tissues altogether showed the in vivo delivery efficiency of TAT/TF-PEG-LP was higher than that of other ***: the dual-ligand liposomes co-modified with TF and TAT possessed a strong capability for synergistic targeted delivery of payload into tumor cells both in vitro and in vivo.

关键词： dual-ligand synergistic effect transferrin cell penetrating peptide

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The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel

The eradication of breast cancer cells and stem cells by 8-h...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Dong Wang Duxin Sun Guichen Zhou Guoqing Zhang Ying Lu Yanqiang Zhong Jingbin Huang Xinxia Wang Yuan Yu He Zhang Yan Chen Junjie Liu Zhiguo Sun Hao Zou Department of Pharmaceutical Science School of Pharmacy Second Military Medical University 325 Gu Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Ann Arbor MI 48 Department of Pharmacy East Hospital of Hepatobiliary Surgery 225 Changhai Road Shanghai 200433

Breast cancer stem cells (BCSCs),which can fully recapitulate the tumor origin and are often resistant to chemotherapy and radiotherapy,are currently considered as a major obstacle for breast cancer *** achieve the goal of both targeting BCSCs and bulk breast cancer cells,we developed 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticles (MSN)-supported lipid bilayers (HA-MSS) and docetaxel- loaded *** results showed that the size of all the nanoparticles was smaller than 200 *** were enriched from MCF-7 cells by a sphere formation method and identified with the CD44+/CD24- *** and qualitative analysis demonstrated that HA promotes the uptake of HA-MSS in CD44- overexpressing MCF-7 mammospheres,revealing the mechanism of receptor-mediated *** or DTX-loaded MSS showed much enhanced cytotoxicity against MCF-7 cells compared with MCF-7 mammospheres,whereas 8-HQ or 8-HQ-loaded HA-MSS showed much enhanced cytotoxicity against MCF-7 mammospheres compared with MCF-7 *** the MCF-7 xenografts in mice,the combination therapy with DTX-loaded MSS plus 8-HQ- loaded HA-MSS produced the strongest antitumor efficacy,with little systemic toxicity (reflecting by loss of body weight) in ***,this combination therapy may provide a potential strategy to improve the therapy of breast cancer by eradication of breast cancer cells together with BCSCs.

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Preparation of insulin chitosan nanoparticles loaded pellets for small intestine and colon specific delivery and its oral pharmacodynamics evaluation

Preparation of insulin chitosan nanoparticles loaded pellets...

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第一届生物颗粒制备技术与产业化应用技术研讨会

作者： Xiongwei Hu Yi Lu Jianping Qi Wei Wu School of Pharmacy Fudan University Shanghai 201203 China

Objective To prepare insulin loaded chitosan nanoparticles (Ins-Cs-NPs),small intestine and colon specific delivery Ins-Cs-NPs loaded pellets and evaluate its oral pharmacodynamics *** Ins-Cs-NPs were prepared by the polyelectrolyte complexation method,then Ins-Cs-NPs was sprayed onto blank pellets core using Polyvinyl Pyrrolidone k30 as coating material to form Ins-Cs-NPs loaded *** intestine specific delivery was achieved by coating these pellets with Eudragit L30D-55,colon specific delivery was achieved by double-layer coating of chitosan and Eudragit *** appearance,particle size,encapsulation efficiency of Ins-Cs-NPs was observed and determined by relative instruments,the coating weight gain (CWG) of different pellets were optimized by dissolution test,the pharmacodynamics effects of all the preparation were evaluated by determing the plasma glucose level after *** The particle size was increased from (163.2±57.4) nm to (210.4±87.4)nm after solidified into pellets,and encapsulation efficiency decreased from (46.6±5.2)% to (42.9±6.8)%.Ins-Cs-NPs could partial protect insulin from degradation by pepsin or pancreatin within 1 *** test showed that 30% CWG of Eudragit L30D-55 could achieve good small intestine specific dedivery,and 40% CWG of chitosan combine with 30% CWG of Eudragit L100 controlled insulin almost unreleased in enzyme free medium but released when incubated with contents of colon in *** the subcutaneous injected groups showed significant hypoglycemic effect,however,all the oral groups neither nanoparticle suspension nor site specific pellets had such *** The particle size,encapsulation efficiency and bioactivity of insulin can be maintained when processed liquid Ins-Cs-NPs suspension into solid pellets by fluid-bed ***,the inherent structural defect of Ins-Cs-NPs made it less effective after oral administration wherever the gastric intestinal position they were delivered.

关键词： insulin chitosan nanoparticle pellets small intestine and colon specific dellivery

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新型生物质活性炭基Co-B产氢催化剂性能研究

新型生物质活性炭基Co-B产氢催化剂性能研究

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中国颗粒学会第八届学术研讨会暨海峡两岸颗粒技术研讨会

作者：张璇郭庆杰青岛科技大学化工学院清洁化工过程山东省高校重点实验室青岛266042

本文采用花生壳生物质废弃物为原料,在流化床中经炭化、活化制备成生物质活性炭,并将其作为载体负载Co-B催化剂。将该炭基Co-B催化剂用于催化NaBH4水解制氢,考察了不同炭化时间、炭化温度、活化时间、活化温度等因素对生物质炭基Co-B催... 详细信息

本文采用花生壳生物质废弃物为原料,在流化床中经炭化、活化制备成生物质活性炭,并将其作为载体负载Co-B催化剂。将该炭基Co-B催化剂用于催化NaBH4水解制氢,考察了不同炭化时间、炭化温度、活化时间、活化温度等因素对生物质炭基Co-B催化剂的产氢性能影响。利用SEM和EDX对活性炭和催化剂的形貌及结构进行表征分析。结果表明：炭化温度为400℃、炭化时间1 h,活化温度800℃,活化时间为2 h时制得的活性炭为载体催化剂的催化产氢性能远远优于以商业活性炭为载体制备的Co-B产氢催化剂,其平均产氢速率可以达到3200mL·min1·g-1Co-B催化剂。生物质活性炭作为载体制备产氢催化剂可应用于便携式氢燃料电池领域,解决氢燃料电池动力不足问题,能变废为宝,具有很好的环境、社会和经济效益。

关键词：花生壳活性炭 Co-B催化剂 NaBH4水解产氢催化性能

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