Conjugated polymers are novel low-dimensional materials with many interesting optical and electronic *** conjugated polymers display optical amplification effect via fluorescence resonance energy transfer(FRET).In add...
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Conjugated polymers are novel low-dimensional materials with many interesting optical and electronic *** conjugated polymers display optical amplification effect via fluorescence resonance energy transfer(FRET).In addition,they also have large two-photon absorption cross sections compared to the small molecule counterpart. Conjugated polymers can thus act as one-photon and two-photon light harvesting complex to develop various light based applications with enhanced *** this presentation,I will discuss a few applications using cationic conjugated polymers:1).Label free DNA sequence detection with enhanced sensitivity and further improved selectivity[1];2) Enhanced one-photon and two-photon excitation emission ofphotosensitizers[2,3],which may have implications in two-photon sensing and phototherapy.
The interaction between Methylene Blue（MB）/TiO nanocomposites and bovine serum albumin（BSA） was investigated by resonance light scattering（RLS）,fluorescence, three-dimension spectra and UV-vis absorbance *** fac...
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The interaction between Methylene Blue（MB）/TiO nanocomposites and bovine serum albumin（BSA） was investigated by resonance light scattering（RLS）,fluorescence, three-dimension spectra and UV-vis absorbance *** factors of effect on the RLS intensity were investigated detailed before determination of the character of
The MM-PB/SA method has been popular for computing protein-ligand binding free energies in recent *** previous evaluations of the MM-PB/SA method are based upon computer-generated conformational ensembles,which may be...
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The MM-PB/SA method has been popular for computing protein-ligand binding free energies in recent *** previous evaluations of the MM-PB/SA method are based upon computer-generated conformational ensembles,which may be affected by the defective computational methods used for preparing these conformational *** an attempt to reach more convincing conclusions,we have evaluated the MM-PB/SA method on a set of 24 diverse protein-ligand complexes,each of which has a set of conformations derived from NMR *** results indicate that both MM-PB/SA and MM-GB/SA are able to produce a modest correlation between their results and the experimentally measured binding free energies on our test *** particular,both MM-PB/SA and MM-GB/SA produced better results by using a representative structure(R=0.72-0.79) than averaging over the conformational ensemble of each given complex(R=0.61-0.74).A head-to-head comparison with four selected scoring functions(X-Score,PLP,ChemScore and DrugScore) on the same test set reveals that MM-PB/SA and MM-GB/SA results are marginally better than those produced by scoring funcitons,supporting the value of the MM-PB/SA ***, scoring functions are still more cost-effective options especially for high-throughput tasks.
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