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检索条件"任意字段=第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议"

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Effectiveness of non-bioartificial liver on acute fatty liver of pregnancy

Effectiveness of non-bioartificial liver on acute fatty live...

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第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者：喻成波 Jiajia Chen Weibo Du Ping Chen Jianrong Huang Yuemei Chen Hongcui Cao Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalSchool of MedicineZhejiang University.Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

Background Acute fatty liver of pregnancy(AFLP) can lead to fatal liver damage that occur in the third trimester or early postpartum *** effect of traditional therapy is not very ideal for facilitating hepatic *** safety and effect of non-bioartificial liver(NBAL) in application for treating AFLP are lacking systematic introduction. Aim Analysis of the timing and efficacy of non-bioartificial liver(NBAL) in the treatment of acute fatty liver of pregnancy(AFLP). Methods We observed the clinical data of 5 cases of AFLP treated with NBAL from 2007 to 2012 including symptoms,physical signs,adverse effects,and compared all relevant laboratory test results before and after NBAL. Results (1) Side effects during NBAL were slight and well-tolerated,and no patients interrupted treatment because of negligible side effects;Clinical symptoms,signs,and liver and renal functions can be ameliorated significantly after NBAL;(2) In the 5 cases treated,4 were cured,1 succeeded in bridging to transplantation;(3) In the 4 cases cured,the sooner a AFLP patient received NBAL the better the curative effect. Conclusion Treatment of AFLP by NBAL is safe and effective,and early application of NBAL in AFLP patients can effectively treat and reverse progress of the disease.

关键词： Effectiveness of non-bioartificial liver on acute fatty liver of pregnancy

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A comparison of glypican-3 with alpha-fetoprotein as a serum marker for hepatocellular carcinoma:a meta-analysis

A comparison of glypican-3 with alpha-fetoprotein as a serum...

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第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者：徐城 Zhehui Yan Liang Zhou Yuming Wang Institute of Infectious Diseases Southwest Hospitalthe Third Military Medical University

Backgrounds:Glypican-3(GPC-3) has been reported as one of the most promising serum markers for hepatocellular carcinoma(HCC),while several studies have conflicting results for the diagnostic accuracy between GPC-3 and alpha-fetoprotein(AFP). Methods:Studies that explored the diagnostic value of GPC-3 and AFP in HCC were searched in MEDLINE,EMBASE,PUBMED,the Cochrane Library and Chinese BioMedical Literature Database(CBM).Sensitivity,specificity and other measures about the accuracy of serum GPC-3 and AFP in the diagnosis of HCC were pooled using random-effects *** receiver operating characteristic curve(sROC) analysis was used to summarize the overall test performance. Results:Ten studies were included in our *** pooled sensitivity for AFP and GPC-3 are:AFP 51.9%(95%confidence interval(CI):0.47-0.56),GPC-3 59.2%(95%CI:0.55-0.63);while the pooled specificity for AFP and GPC-3 are:AFP 94%(95%CI:92.1%to 95.6%),GPC-3 84.8%(95%CI:82%to 87.3%).The pooled diagnostic odds ratio(DOR):AFP 23.4(95%CI: 10.3-53.2),GPC-3 17.99(95%CI:5.4-60.4).Area under sROC for AFP and GPC-3 are the same as 0.81(95%CI:0.77-0.84). Conclusions:GPC-3 is comparable to AFP as a serum marker for the diagnosis of HCC, combination of AFP and GPC-3 can elevate the sensitivity of diagnosis.

关键词： AFP GPC-3 diagnostic accuracy hepatocellular carcinoma

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Adenovirus-Mediated miRNA against Human Fibrinogen Like Protein 2 Inhibits Hepatocellular Carcinoma Growth

Adenovirus-Mediated miRNA against Human Fibrinogen Like Prot...

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第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者： Ming Wang Junhui Liu Dong Xi Wenwen Ma Zengmin Tan Xiaoping Luo Qin Ning Department of Infectious Disease Tongji Hospital of Tongji Medical CollegeUniversity of Science and Technology

Aims:As a member of fibrinogen-related protein superfamily,Fibrinogen-like protein 2(also called fgl2 prothrombinase) has serine protease activity and directly catalyzes prothrombinase into activated thrombinase,which... 详细信息

关键词： miRNA Adenovirus-Mediated miRNA against Human Fibrinogen Like Protein 2 Inhibits Hepatocellular Carcinoma Growth

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Long-term clinical outcome of patients with chronic hepatitis B after withdrawal of antiviral therapy

Long-term clinical outcome of patients with chronic hepatiti...

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第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者： Dengming He Ke Fan Jie Wang Xianli Chen Guohua Yan Yan Zhu Xiaohong Wang Yuming Wang Department of Infectious Diseases Southwest Hospitalthe Third Military Medical University

Background/aims: By observing long-term clinical outcome of chronic hepatitis B(CHB) patients after withdrawal of antiviral therapy,we aimed to explore the theraputic strategies of CHB patients after achieving ideal/ ... 详细信息

关键词： HBeAg HBV Long-term clinical outcome of patients with chronic hepatitis B after withdrawal of antiviral therapy

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慢性重型乙型肝炎患者血清病毒全长基因特点及其临床意义

慢性重型乙型肝炎患者血清病毒全长基因特点及其临床意义

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第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

目的探讨HBV全长基因组的准种特性与慢性乙型肝炎病毒感染重症化的关系。方法慢性乙型肝炎（CHB）、慢性重型乙型肝炎（CSHB）每组各4名未接受抗病毒治疗的患者纳入本项研究,扩增外周血清中HBV全长基因组并克隆、测序,每个标本随机选取1... 详细信息

目的探讨HBV全长基因组的准种特性与慢性乙型肝炎病毒感染重症化的关系。方法慢性乙型肝炎（CHB）、慢性重型乙型肝炎（CSHB）每组各4名未接受抗病毒治疗的患者纳入本项研究,扩增外周血清中HBV全长基因组并克隆、测序,每个标本随机选取14-16个克隆进行DNA测序并生物信息学分析。结果两组患者共获得120个HBV全长基因组序列。每例患者均为单一基因B型或C型感染。两组全长克隆序列中均发现较多突变,如G1896A突变、T1753C/A1762T/G1764A/C1766T多联突变和preS2、preS1起始密码子缺失等,CSHB组发生一个或多个突变的克隆数占100%,明显多于CHB组的76.7%（χ=15.85,P<0.001）。在核苷酸和氨基酸水平上,CSHB组的全长基因组、S基因、X基因、P基因和rt区的准种复杂度和平均遗传距离均比CHB组大,C基因则较小,但差异均无统计学意义（P>0.05）。结论慢性重型乙肝患者血清中HBV各种突变、准种异质性差异等高于慢性乙型肝炎患者,可能与HBV慢性感染重症化有关,值得扩大样本进一步研究其临床意义。

关键词：肝炎病毒,乙型肝炎,乙型,慢性突变遗传异质性重型肝炎准种

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Salidroside Attenuates LPS-stimulated Activation of THP-1 cell-derived macrophages through Down-regulation of MAPK/NF-κB signaling Pathways

Salidroside Attenuates LPS-stimulated Activation of THP-1 ce...

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第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者：王洪武 Ting Wu Junying Qi Yaqi Wang Xiaoping Luo Qin Ning Department of Infectious Disease Institute of Infectious DiseaseTongji hospital of Tongji Medical CollegeHuazhong University of Science and Technology

Alcoholic liver disease(ALD) is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and *** response to gut-derived lipopolysaccharide(LPS),activation of Kupffer cells plays a key role in the development and progression of ALD by secreting a variety of pro-inflammatory ***, inhibition of macrophage-activation would have therapeutic benefits for alleviating the progression of ***(Sal),one of main bioactive components isolated from Rhodiola Sachalinensis,has been reported to suppress LPS-induced inflammatory response, but the underlying mechanisms in macrophages remain poorly *** this study,we investigate the anti-inflammatory effects of Salidroside and the possible mechanisms in LPS-stimulated phrobol 12-myristate 13-acetate(PMA)-differentiated THP-1 macrophage *** results showed that Sal markedly decreased the expression of inducible nitric oxide synthase(iNOS),cyclooxygenase- 2(COX2),interleukin-1beta(IL-1β),interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) at both mRNA and protein levels,and there was dose-effect relationship between the three Sal pretreated *** studies revealed that Sal strongly suppressed NF-κB activation and down-regulated the phosphorylation of ERK, p38 and *** present study demonstrated that Sal could suppress the production of iNOS,COX2,IL-1β,IL-6 and TNF-αin LPS-stimulated PMA-differetiated THP-1 cells by inhibiting NF-κB activation and MAPK signal pathway phosphorylation.

关键词： Salidroside THP-1 MAPK LPS NF-κB ALD

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Enhanced expression of potassium ion channel gene KCNJ15 is associated with Acute-on-chronic Hepatitis B liver failure

Enhanced expression of potassium ion channel gene KCNJ15 is ...

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第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者：朱琳 Tao Chen Daqin Xu Li Song Xiaoping Luo Qin Ning Institute and Department of Infectious Disease Tongji hospital of Tongji Medical CollegeHuazhong University of Science and Technology Department of Pediatrics Tongji hospital of Tongji Medical CollegeHuazhong University of Science and Technology

Increased KCNJ15 expression has been found in patients with hepatitis B virus （HBV）-induced Acute-on-chronic liver failure（HBV-ACLF） in our previous gene microarray study. However,the mechanism underlying the enhanced expression of KCNJ15 in patients with HBV-ACLF remains *** this study,we further investigate the up-regulated KCNJ15 and its possible regulatory mechanisms in HBV induced liver *** expression of KCNJ15 was studied in patients with HBV-ACLF on both mRNA and protein levels in peripheral blood mononuclear cells（PBMC） and liver tissue,while the function of KCNJ15 was further determined in Jurkat cells in vitro by transfection of a human KCNJ15 expression *** results showed that KCNJ15 was over-expressed on PBMCs and hepatic infiltrating lymphocytes from HBV-ACLF ***,KCNJ15 had an abundant expression in peripheral and hepatic CD4T cells in patients with *** the supernatant of KCNJ15 over-expressed Jurkat cells,increased IL-17A secretion was observed,which was involved with elevated intracellular calcium *** data suggested KCNJ15 may contribute to liver injury through IL-17A production in HBV induced liver ***,we also provide a potential susceptible gene for patients with HBV-ACLF.

关键词： KCNJ15 virus induced liver injury acute on chronic liver failure hepatitis B CD4+ T cell IL-17 calcium

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Enhancing anti-hepatitis B virus mediated immune response by nucleos(t)ide analogs and Thymosin-alphal therapy

Enhancing anti-hepatitis B virus mediated immune response by...

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第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者： Yanfang Jiang Wanyu Li Hongqing Yan Junqi Niu Department of Hepatology First HospitalJilin University

Background:Chronicity of hepatitis B virus(HBV) infection is characterized by a weak immune response to the ***(ETV),adefovir dipivoxil(ADV) and Telbivudine(LDT) are highly effective in the suppression of HBV replication,however,host immune responsible for sustained virological respones in HBV-infected patients treated with nucleos(t)ide analogs are not understood. This study aims to evaluate the immune response and antiviral effect after nucleos(t)ide analogs or

关键词： HBV HBsAg Enhancing anti-hepatitis B virus mediated immune response by nucleos t)ide analogs and Thymosin-alphal therapy

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Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication

Core-APOBEC3C chimerical protein inhibits hepatitis B virus ...

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第二届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者： Dong Li Jinxia Liu Fubiao Kang Weiwei Guan Xiangcui Gao Yuming Wang Dianxing Sun Department of Liver Disease Bethune International Peace Hospital Institute of Infectious Diseases Southwest HospitalThird Military Medical University

Backgrounds and aims:HBV is a major cause of liver disease and has infected approximately 2 billion *** limited success of current therapies for HBV infection has prompted the discovery of alternative *** antiviral strategy known as capsid targeted viral inactivation (CTVI) is shown to be efficient in interfering with viral *** Apolipoprotein B mRNA-editing

关键词： HBV APOBEC Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication

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HCV抗原刺激通过上调A20抑制CD100在巨噬细胞中的表达

HCV抗原刺激通过上调A20抑制CD100在巨噬细胞中的表达

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第三届全国病毒性肝炎慢性化重症化基础与临床研究进展学术会议

作者：范超郭永红何瑜周云贾战生第四军医大学唐都医院传染科

目的与背景:HCV可引起慢性感染并转变为肝硬化和肝癌,在全世界约1.7亿-2.0亿感染丙肝病毒,我国的丙肝感染人数在4000万以上。丙肝通过多种途径逃逸免疫系统清除,其中丙肝及感染过程中产生的抗原刺激影响多种免疫细胞活性,是丙肝慢性感... 详细信息

目的与背景:HCV可引起慢性感染并转变为肝硬化和肝癌,在全世界约1.7亿-2.0亿感染丙肝病毒,我国的丙肝感染人数在4000万以上。丙肝通过多种途径逃逸免疫系统清除,其中丙肝及感染过程中产生的抗原刺激影响多种免疫细胞活性,是丙肝慢性感染建立的重要条件。另一方面,CD100作为免疫活化分子之一,对免疫细胞功能活化有重要作用。本文通过分析HCV抗原对巨噬细胞表达CD100的影响,并分析HCV引起免疫细胞失活的内在机制。材料与方法:应用单核/巨噬细胞系THP1为细胞模型,分别以HCVcc、HCV core、NS3/4刺激细胞,通过qPCR检测CD100、A20、ABIN1、MMP14及相关因子的表达水平,分析HCV抗原对THP1细胞的表达影响。构建含有A20/EGFP和ABIN1/EGFP的双基因共同表达腺病毒载体,转染THP1细胞,荧光观察其表达状况,流式细胞仪检测腺病毒感染的表达水平变化,在优化条件下使A20和ABIN1在THP1细胞中过表达,观察其对CD100的表达影响。分析CD100表达变化的影响因素。结果:HCV不同抗原对CD100的表达影响不尽相同。从总体上看,HCV促使CD100在巨噬细胞中的表达量下降。其中,HCVcc的刺激作用较弱而NS3/4抗原的刺激性最强。同时,实验构建了AD-A20,AD-ABIN1两个表达载体,通过荧光显微镜及流式细胞仪分析确定了腺病毒感染最佳条件,在THP1细胞中过表达A20和ABIN1两种蛋白,发现无论A20或ABIN1的过表达都会引起CD100水平的上升。实验又进一步分析了HCV抗原对A20、ABIN1的表达影响,发现HCV抗原刺激可上调这两种蛋白表达的。讨论与结论:HCV感染可从初期的急性感染转变到慢性感染阶段,说明机体对HCV感染的免疫应答具有阶段性的特点。感染初期,人体免疫系统主要针对HCV病毒颗粒进行应答;后期随着病毒在肝内的感染复制,包括HCV core及NS3、NS4等更多的HCV抗原在肝脏中出现。而人体针对这些混合抗原的不同应答方式,很可能成为HCV慢性感染建立的必要条件。本文通过分析不同的HCV抗原对巨噬细胞CD100的表达影响,从一个侧面反应出HCV逃逸免疫系统的内在机制。CD100作为一种重要的免疫系统活化因子,其表达下降可能引起免疫系统功能受损。在本实验中,不同抗原对CD100的影响程度不同,HCVcc作为正常感染中最早出现的抗原,其对CD100表达的影响较弱。相反,在HCV第二轮感染才会出现的HCV core及NS3、NS4抗原有很强的下调巨噬细胞CD100表达水平的作用。这在一定程度上反应出HCV core及NS3/4对免疫系统可能产生的负面影响。另一方面,NF-Kb作为免疫系统中重要的信号通路,可能在CD100调控中发挥关键性作用,我们构建了NF-Kb通路调控分子的过表达载体ad-A20及ad-ABIN1。实验证明,HCV抗原可上调A20、ABIN1在巨噬细胞中的表达水平,同时,无论过表达d-A20或ad-ABIN1都能抑制CD100的表达水平。由于A20、ABIN1可形成复合物抑制NF-Kb信号通路,而CD100是NF-Kb的下游调控基因之一。即HCV抗原特别是HCVcore和NS3/4对CD100的下调作用很可能是通过上调NF-Kb信号通路抑制性因子A20实现的ABIN1。

关键词： HCV antigen CD100 A20 Microphage NF-kb

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