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检索条件"任意字段=第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议"

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STATE OF THE ART IN RAPID METALLIC MANUFACTURING

STATE OF THE ART IN RAPID METALLIC MANUFACTURING

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Chua Chee Kai

Rapid Metallic Manufacturing(RMM)is the technology that adopts Rapid Prototyping(RP)and Rapid Tooling(RT)and applies them to fabricate a functional metallic part that is able to meet all required parameters such as strength and part density which conventional manufacturing methods are also able to produce but only at a fraction of the time ***,parts manufactured by conventional methods have limited designs and cannot be too *** paper discusses on how such limitations can be overcome using RMM *** Metallic Manufacturing(RMM)has evolved from Rapid Prototyping(RP)and Rapid Tooling(RT)in the past 20 *** RP produces prototypes for visualization,design verification and testing(in some cases),RT produces the die directly or *** has its own limitations as it cannot produce the desired metallic parts ***,parts produced might have unpredictable shrinkages and limited *** technology is essentially the technology that adopts RP techniques and applies them to manufacturing the metallic part *** allows complicated parts to be built with little or no *** RMM techniques discussed in this paper will be Selective Laser Sintering(SLS),Selective Laser Melting(SLM)and 3D Laser Cladding(3DLC).SLM is very much similar to SLS,working on the same method but different concept whereas SDLC is a class on its ***,all three techniques primarily use lasers to fuse metallic particles *** fabricated metallic parts by SLM and 3DLC can meet not only standard requirements,but also offer light weightiness without compromising on part density and ***,fabricated parts are highly *** on the other hand,has its own *** benefits RMM can offer are potentially great as RMM is a one-step process in fabrication of parts compared to RT whereby a die is fabricated to produce the required part *** reduces production time and cost by at least 50%.Anoth

关键词： STATE OF THE ART IN RAPID METALLIC MANUFACTURING

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Design and Manufacture of a Wax Injection Tool for Investment Casting using Rapid Tooling

Design and Manufacture of a Wax Injection Tool for Investmen...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Sadegh RAHMATI Mohamad Reza REZAEI Javad AKBARI Department of Mechanical Engineering Islamic Azad University Majlesi Branch Mechanical Engineering Group Islamic Azad University-Majlesi Branch Enginering Departmant Sharif Technical University Mechanical Enginering Departmant Sharif Technical University

Rapid Prototyping(RP)and Rapid Tooling(RT)are playing an increasingly significant role in responding to intense global markets competition and achieving compressed time-to-market *** these,the process of rapid tooling is significantly important for the *** a consequence of the demand for high quality products,low cost and short development cycles,most industries are looking for ways to improve the speed of the production ***,it is essential that the development teams know and use the new technologies in the product development.A rapid wax injection tool of a gearbox shift fork was designed,simulated and manufactured using rapid prototyping and rapid tooling technology,in order to save time and cost of producing wax models used for the investment casting *** results of this research were compared with conventional wax model production *** criteria of such comparison were based upon parameters such as time,cost and other related characteristics,which resulted in saving of 50% in time and 60% in *** this research,design,assembly and wax injection operation of the wax tool took 10 *** the fact that wax melting temperature is as low as 70oC and injection pressure of 0.5 MPa,the tool may suffer no damage due to the thermal and pressure stresses,leading to the mass production of wax *** CAE simulation softwares such as MoldFlow and ANSYS are significant aids in rapid tooling analysis,acquiring tooling parameters and melt behaviour in the *** particular,MoldFlow is used to get wax injection moulding parameters such as filling parameters,temperature profiles,freeze time,speed,and pressure.

关键词： Rapid Prototyping,Stereolithography,Rapid Tooling,Wax Moulding,Investment Casting

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Control Adipose-derived stromal cells differentiation into adipose and endothelial cells in an 3-D structure established by cell-assembly technique

Control Adipose-derived stromal cells differentiation into a...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Mingen Xu1,2,3,Yongnian Yan1,2,Haixia Liu1,2,Rui Yao1,2,and Xiaohong Wang1,2 1 Key laboratory for Advanced Materials Processing technology,Ministry of Education & Center of Organ Manufacturing,Department of mechanical Engineering,Tsinghua University,Beijing 100084,P.R.China 2 Institute of Life Science & Medicine,Tsinghua University,Beijing 100084,P.R.China 3 Center Laboratory of Tissue Engineering,Hang Zhou Dianzi University,310018,P.R.China

One of the major obstacles in engineering thick and complex tissues is the need to vascularize the tissue in vitro for maintaining cell viability during tissue growth and inducing structural *** we used Adipose-derived stromal cells to establish a multicellular systems by cell-assembly *** attempt to control ADS cells differentiation into different targeted cell types according to their positions within an orderly 3-D *** red o staining showed that ADS cells in the structure differentiated into adipocytes with a spherical *** test demonstrated that EGF induced ADS cells on wall of channels differentiation into mature endothelial cells and then organization into tubular structures throughout the engineered 3-D *** ET-1 and NO release of endothelial cells was accord with that in *** study provides a new approach to engineer orderly endothelial vessel networks in vitro and has potentials in adipose-tissue engineering.

关键词： red Control Adipose-derived stromal cells differentiation into adipose and endothelial cells in an 3-D structure established by cell-assembly technique

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Rapid prototyping a double layer polyurethane-collagen conduit and its schwann cell compatibility

Rapid prototyping a double layer polyurethane-collagen condu...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Tongkui Cui1,2,Xiaohong Wang1,2,Yongnian Yan1,2,Renji Zhang1,2 1Key Laboratory for Advanced Materials Processing Technology,Ministry of Education & Center of Organ Manufacturing,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,P.R.China 2Institute of Life Science & Medicine,Tsinghua University,Beijing 100084,P.R.China

A new double layer conduit combining outer synthetic polyurethane(PU)layer and inner natural collagen layer was fabricated via a double-nozzle low-temperature deposition manufacturing(DLDM)*** outer PU layer can provide a mechanical stable tunnel against scar tissue invasion during in vivo *** inner collagen layer is able to promote Schwann cell adhesion,migration and *** structures were found in both the double *** connection between the double layers was achieved through adjusting the distance between two deposited nozzles and other processing *** cells from rat sciatic nerves were cultured in the double layer PU-collagen conduits for one week and showed significant difference in their retention ability and viability as compared to that in pure PU *** double layer polyurethane-collagen conduit had a better Schwann cell compatibility and potential for clinical peripheral nerve repair.

关键词： nerve conduit polyurethane(PU) collagen rapid prototyping Schwann cell

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A preliminary research on three-dimensional reconstruction of functional fascicular groups inside a segment common peroneal nerve

A preliminary research on three-dimensional reconstruction o...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： ZHANG Yi1,QI Jian2,,XIONG Zuo3,ZHOU Jiaming4,LI Shengjie3,LIANG Yingjie5,LIU Xiaolin2 1 Department of Plastic and Reconstructive Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,P.R.China 2.Department of Microsurgery,the First Affiliated Hospital of Sun Yat-sen University.3 Department of Mechanical Engineering of Tsinghua University,Beijing 100084,China,4 Sun Yat-sen Medical College of Sun Yat-sen University,5Department of Pathology,the First Affiliated Hospital of Sun Yat-sen University.

Objective To explore the possibility of the three-dimensional reconstruction of short segmental common peroneal nerve functional fascicular groups,based on serial histological sections and computer *** 5cm common peroneal nerve was serial horizontally sliced with 0.25mm interval,using Acetycholinesterase(AChE)histochemical stain.2D panorama images were acquired by high-resolution digital camera under 100× microscope and mosaic *** functional fascicular groups were distinguished and marked on each *** topographic database was matched by image processing *** 3D microstructure of the fascicular groups of a 5cm common peroneal nerve was reconstructed using Amira3.1 *** Reconstruction of nerve functional fasicular groups was realistic,it could be rotated or zoomed in any *** intercross and recombination process of nerve bundles could be observed *** functional anatomical discrimination of deep and superficial peroneal nerve inside common peroneal nerve of popliteal fossa was *** Based on serial histological sections and computer technology,the 3D microstructure of short segmental peripheral nerve functional fascicular groups can be reconstructed *** provides the possibility for three-dimensional reconstruction of long segmental peripheral nerve functional fascicular groups.

关键词： Common peroneal nerve Functional fascicular groups Three-dimensional(3D)reconstruction Acetycholinesterase histochemical stain

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To fabricate gradient hydrogel scaffold based on an improved cell assembling system

To fabricate gradient hydrogel scaffold based on an improved...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Shengjie Li,Yongnian Yan,Zhuo Xiong,Chenyang Weng,Xiaohong Wang,Renji Zhang Department of Mechanical Engineering,Tsinghua University,Key Laboratory for Advanced Materials Processing Technology Ministry of Education,P.R.China,Beijing 100084

To manufacture complicated human organs in vitro,it is needed of the fabricating technology for gradient hydrogel scaffold based on rapid prototyping *** material can provide biocompatible and biodegradable bionic extracellular matrix environment for cell *** we proposed a two-step crosslinking method that not only was suitable for forming process,but also caused little harm to *** we developed a forming system which was derived from commercial rapid prototyping *** system contained two types of nozzle *** was double-nozzle unit,used for relatively simple gradient hydrogel scaffold composed of two kinds of nonmiscible hydrogel material *** other was material-mixing single-nozzle unit,used for relatively complicated gradient hydrogel scaffold composed of continuous gradient by mixing two kinds of hydrogel material *** types of gradient scaffolds could be formed by selecting one relevant type of nozzle *** improve the extrusion controlling effect,some accessorial forming parameters were *** proved that the forming accuracy was improved,and both of the two types of nozzle units could work *** at last,a 3D gradient scaffold containing neuron cells and Schwann cells was successfully fabricated,and the scaffold was cultured for 7 *** nerve fibers were not observed,this scaffold was a helpful example for later design of gradient scaffold to study the relations between different cells in *** of these works were elementary for later manufacturing of complicated organ analogs,what might be a meaningful improvement for tissue engineering.

关键词： rapid prototyping tissue engineering biomanufacturing hydrogel scaffold cell assembling neuron cell Schwann cell

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In vitro Cytotoxicity of Bacterial Cellulose Scaffold for Tissue Engineered Bone

In vitro Cytotoxicity of Bacterial Cellulose Scaffold for Ti...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Yanmei Chen Tingfei Xi Yudong Zheng Yizao Wan Jiaquan Hou Tingting Guo School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,P.R.China National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050,P.R.China,School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,P.R.China School of Materials Science and Engineering,Tianjin University,Tianjin 300072,PR China Building Design and Research Institute of the General Logistics Department of PLA,Beijing 100036,PR.China Wenzhou medical college,Wenzhou 325000,PR.China

Bacterial cellulose(BC)secreted by Acetobacter xylinum,is expected to have potential applications in bone tissue ***,the degradation performance and the evaluation of the biological response of biomaterials are required to provide useful information to improve their design and *** this article,the in vitro degradation and cytotoxicity of BC and its degradation residue were *** emission scanning electron microscope(FE-SEM)was used to observe the morphology of original materials and their degradation *** degree of degradation was valued by measuring the concentration of reducing sugar by using ultraviolet ***-forming osteoblasts(OB)and infinite culture cell line L929 fibroblasts were used to measure the cytotocixity of materials with MTT *** kinds of cells in infusion proliferate greatly in a normal form and their relative growth rate(RGR)exceeds by 75 percent,which shows the cytotoxicity of materials is graded as 0～***,bone-forming OB cells,as a kind of target cells,are more susceptive on the cytotoxicity than infinite culture fibroblast cells *** results suggest BC without cytotoxicity is greatly promising as a kind of scaffold materials for bone tissue engineering and tissue functional cells are more suited to evaluate the cytotoxicity of biomedical materials.

关键词： bacterial cellulose(BC)·osteoblast·degradability·biocompatibility

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In Vitro Evaluation of a 3D PLGA-TCP Composite Scaffold in an Experimental Bioreactor

In Vitro Evaluation of a 3D PLGA-TCP Composite Scaffold in a...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Antti A.Mkitie Kaija-Stiina Paloheimo Jukka Tuomi Jari Salo Markku Paloheimo Risto Renkonen Helsinki University of Technology Dept.of Otolaryngology Helsinki University Hospital Dept.of Otolaryngology Turku University Hospital Dept.of Orthopaedics and Traumatology Helsinki University Hospital Haartman Institute University of Helsinki

The development of a technique that enables the formation of three-dimensional(3D)cell/biomaterial complex architectures in a designed pattern is the basis for organ *** scaffold attempts to mimic the structure and functions of extracellular *** 3D living tissue/organ scaffolds/analogies can be used for in vitro *** scaffold serves as an adhesion surface for the cells,and provides temporary mechanical support for the designed tissues or *** tested a 3D PLGA-TCP(poly-lactic acid-co-glycolic acid/tricalcium phosphate)composite *** scaffold was generated with the low-temperature deposition modelling(LDM)RP *** aims were to find optimal cell culture conditions for the selected scaffold material and to monitor cell division,differentiation and migration of selected cell types in this *** further aims were to monitor behaviour and cell-matrix interactions of selected cell types and to monitor the biodegradation rate of the tested scaffold *** used chinese hamster ovary(CHO)cells as well as a human cell line 293 epithelial cells and cultured them on top of the *** also used a variety of different preconditions to prepare the scaffolds before the cultivations as well as various inoculations(on top of the scaffold or into it)to seed the *** cultivations were conducted for 1 to 4 weeks and the coverage of the luminal surfaces were analysed with light *** cultivation periods were required to achieve partial coverage of the luminal surfaces of the *** engineering with 3D cell cultures and biomaterials represents a promising approach for organ manufacturing *** may have potential for eventual on-demand high-throughput production of artificial tissues but the process has many challenges.

关键词： rapid prototyping,scaffold tissue culture biomanufacturing

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PREDICTABILITY OF PLASTIC PARTS BEHAVIOUR MADE FROM RAPID MANUFACTURING

PREDICTABILITY OF PLASTIC PARTS BEHAVIOUR MADE FROM RAPID MA...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Mario Monzón Pedro M.Hernández Antonio N.Benítez María D.Marrero Angel Fernández Departamento de Ingeniería Mecánica.Universidad de Las Palmas de Gran Canaria AITIIP Foundation Parque Tecnológico de CogulladaZaragozaSpain.Spanish Rapid Prototyping Association(ASERM)

Purpose:One of the most important issues to resolve in parts manufactured from Rapid Manufacturing technologies is to know their behavior working under real *** Quality Manufacturing(TQM)is only possible if mechanical and formal properties are well known in designing stages depending on processing *** work is mainly focused on testing of several samples made under different parameters and technologies of *** procedure,developed under design of experiment methodology,is the starting point to establish the pillars of designing for RM and standardization of RM testing Design/methodology/approach:Design of experiments and ANOVA analysis(analysis of variance)has been implemented in order to find the effects of several factors on mechanical and formal *** selected factors were:Layer thickness,laser power,location of the sample into the cabin,amount of recyclable *** SLS technologies were 3Dsystem and ***:Results have shown which factors have a high effect on the variables and the interaction between *** values of factors have been calculated in order to maximize mechanical properties and ***/values:The conclusions are very useful to develop rules for designing(designing for RM)and creating new standard rules(ISO,AISI,DIN,etc)for RM materials and parts *** analysis enables a better knowledge of factors behavior and to remove from the study those negligible *** different SLS technologies have been studied as factors in design of experiment.

关键词： Laser sintering rapid manufacturing anova analysis rapid prototyping additive manufacturing sls

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A novel matching algorithm for a Hand-Held 3D Laser Scanning Sensor

A novel matching algorithm for a Hand-Held 3D Laser Scanning...

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第三届北京国际快速成形及制造会议暨第二届北京国际生物制造会议

作者： Kui Huang,Zhongwei Li,Jianhua Mo,Dahui Qing,Congjun WangState Key Laboratory of Material Processing and Die & Mould Technology,Huazhong University of Science and Technology,Wuhan,430074,China.

A hand-held 3D laser scanning sensor has been gradually used as a novel solution to digitize the 3D shape for a wide variety of objects,as its maneuverability and *** consists of two synchronized CCD cameras and a laser *** current research challenge of a hand-held 3D laser scanning sensor is how to reliably and rapidly find its position and orientation at all times in a global world *** covers a key issue how to reliably and quickly match the list of observed reference points with the sensor's list of scattered reference *** work out this issue,this paper proposes a novel matching algorithm based on Delaunay *** is assumed that all reference points are accurately measured and stored in the sensor's list *** all,all reference points are projected to the X-Y plane and the mapping list is *** usage of Delaunay triangulation in the mapping list can determine which triplets of reference points are grouped together to form a set of triangles in the sensor's list of scattered reference *** last,in order to accelerate matching the triangles in the current stereo frame with the corresponding triangles in the global world frame,the radius of inscribed circle within the triangle is regarded as index and array the set of triangles according to index's ascending *** experiments show that the algorithm can precisely match reference points and furthermore meet real time requirement of the hand-held sensor application.

关键词： 3D shape measurement Self-Referencing Matching algorithm Delaunay triangulation

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