作者：
Xu LiuBaorong ZhangQing WangDepartment of Neurology
The Second Affiliated Hospital of Zhejiang University Hangzhou Zhejiang 310009P.R.China Department of Neurology The Second Affiliated Hospital of Zhejiang University Hangzhou Zhejiang 310009P.R.China Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 GuangzhouGuangdong 510630 P.R.China Department of Neurology
The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 GuangzhouGuangdong 510630 P.R.China
Background Parkinson's disease (PD) is the second most common neurodegenerative disease that is characterized by the progressive loss of doparninergic neurons in the substantia nigra (SN) and depletion of striatal...
Background Parkinson's disease (PD) is the second most common neurodegenerative disease that is characterized by the progressive loss of doparninergic neurons in the substantia nigra (SN) and depletion of striatal dopamine (DA), leading to a range of motor symptoms, including rigidity, resting tremor, bradykinesia and postural *** degeneration is a key component of a variety of neurological diseases, including *** degeneration refers to the process of axonal selfdestruction.
Background Uric acid (UA) is suspected to play a neuro-protective role in Parkinson's disease (PD).This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a rel...
Background Uric acid (UA) is suspected to play a neuro-protective role in Parkinson's disease (PD).This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a relatively large population of Chinese *** Serum UA levels were measured from 411 Chinese PD patients and 396 age-matched controls;following the UA colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function.
作者：
Xiaobo WeiYunqi XuLimin ZhangHuimin GaoJing ZouChao DengXufeng HuangYuanguo YangWeihai YingQing WangDepartment of Neurology
The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong People''s Republic of China Centre for Translational Neuroscience School of Health Sciences University of Wollongong New South Wales Australia Med-X Research Institute Shanghai Jiao Tong University Shanghai People''s Republic of China Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong People''s Republic of China Centre for Translational Neuroscience
School of Health Sciences University of Wollongong New South Wales Australia
Endoplasmic reticulum (ER) stress is associated with the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD).High temperature required A2 (HtrA2), a serine protease resides in mitochondr...
Endoplasmic reticulum (ER) stress is associated with the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD).High temperature required A2 (HtrA2), a serine protease resides in mitochondria and ER, plays an important role in PD by regulating mitochondria *** studies indicated that HtrA2/Omi might exert a neuroprotective function by decreasing protein accumulation through ER-associated *** this study, we conducted our experiment in vitro in 6-OHDA treated dopaminergic SH-SY5Y cells to study the association of HtrA2/Omi and ER stress.
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