Wnt1, initially described as a modulator of embryonic development, has recently been discovered to exert cytoprotective effects in cellular models of several diseases, including Parkinson's disease (PD).We therefo...
Wnt1, initially described as a modulator of embryonic development, has recently been discovered to exert cytoprotective effects in cellular models of several diseases, including Parkinson's disease (PD).We therefore examined the neuroprotective effects of exogenous Wnt1 on dopaminegic SH-SY5Y cells treated with *** we show that 10-500 μmol/L 6-OHDA treatment causes decreased cell viability with increased lactate dehydrogenase (LDH) leakage.
作者：
Qing WangXiaobo WeiHuimin GaoJin LiJinchi LiaoXu LiuBing QinYinghua YuChao DengBeisha TangXufeng HuangDepartment of Neurology
The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 GuangzhouGuangdong 510630 P.R.China Centre for Translational Neuroscience
School of Health Sciences University of Wollongong NSW 2522Australia Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 GuangzhouGuangdong 510630 P.R.China Centre for Translational Neuroscience School of Health Sciences University of Wollongong NSW 2522Australia Department of Neurology Xiangya Hospital of Central South University Changsha Hunan 410008 P.R.China
Background Parkinsons disease (PD) is the most common movement disorder affecting more than 4 million people *** cardinal motor symptoms of resting tremor, bradykinesia, rigidity, and gait abnormalities result from th...
Background Parkinsons disease (PD) is the most common movement disorder affecting more than 4 million people *** cardinal motor symptoms of resting tremor, bradykinesia, rigidity, and gait abnormalities result from the progressive loss of dopaminergic signaling in the nigrostriatal *** etiology of PD is still *** increased age and genetic variation are the principal risk *** pathology, axonal degeneration precedes neuronal cell death in many neurological disorders and now regarded as a major component of many neurodegenerative diseases, including PD.
作者：
Qing WangJin LiXiaobo WeiJinchi LiaoYunqi XuTingting LuBing QinJunqiang XieYinghua YuChao DengXufeng HuangIllawarra Health and Medical Research Institute
School of Health Sciences University of Wollongong NSW 2522 Australia Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 Guangzhou Guangdong 510630 P.R.China Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600Guangzhou Guangdong 510630 P.R.China Illawarra Health and Medical Research Institute School of Health Sciences University of Wollongong NSW 2522 Australia Department of Neurology
The Third Affiliated Hospital of Sun Yat-Sen University Tianhe Road 600 Guangzhou Guangdong 510630 P.R.China
Background Linkage has been reported between allelic variations in HLA-DR and Parkinson's disease (PD), but the polymorphisms were found to be different ethnically and ***-DR and PSMB, TAP loci are all located in ...
Background Linkage has been reported between allelic variations in HLA-DR and Parkinson's disease (PD), but the polymorphisms were found to be different ethnically and ***-DR and PSMB, TAP loci are all located in the HLA class Ⅱ region, and they play important roles in both immune response and protein degradation in neurodegenerative *** date, little research has been performed to investigate the association between PD and polymorphisms of HLA-DRA, PSMB and TAP in Han *** investigate the association between the polymorphism of HLA class Ⅱ region and sporadic PD in Han Chinese population, a case-control study was performed through genotyping single nucleotide polymorphisms (SNPs) in HLA-DRA, PSMB8, PSMB9, TAP1, and TAP2 genes.
暂无评论