Dickkopf-related protein 1(DKK1)is essential to maintain skeletal homeostasis as an inhibitor of Wnt signaling and osteogenic *** purpose of this study was to investigate the molecular mechanisms underlying the develo...
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Dickkopf-related protein 1(DKK1)is essential to maintain skeletal homeostasis as an inhibitor of Wnt signaling and osteogenic *** purpose of this study was to investigate the molecular mechanisms underlying the developmental stage-specific regulation of the DKK1 protein *** performed a series of studies including luciferase reporter assays,microRNA microarray,
The action of bisphosphonates(BP)in promoting fracture resistance and their effect on quality of bone are still being *** studied dose-dependent effect of ibandronate(Ibn)and risedronate(Ris)treatments on bone mass,ar...
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The action of bisphosphonates(BP)in promoting fracture resistance and their effect on quality of bone are still being *** studied dose-dependent effect of ibandronate(Ibn)and risedronate(Ris)treatments on bone mass,architecture,material properties,and strength in aged osteopenic rats usingμCT and biomechanical testing and finite element analyses(FEA).Eighteen months old female rats were divided into 6 groups and underwent either ovariectomy or
目的:调查北京市健康女大学生骨密度和身体成分状况,对其骨量水平和身体成分的关系进行研究,并分析骨密度的影响因素。为女大学生骨健康的促进提供一定的理论帮助。方法:选取北京市19~25岁健康女大学生为研究对象,按年龄分为6个组,每一岁为一个年龄组。用美国GE公司生产的1unar prodigy DEXA骨密度仪测试受试者腰椎、股骨颈及全身骨密度,并测试全身脂肪和肌肉含量。本研究得到首都体育学院学术委员会批准,受试者自愿参加测试,并签订知情同意书。结果:①女大学生腰椎、右股骨、右股骨颈和全身的骨密度随年龄增长呈增加趋势,各年龄组间差异具有显著性(p<0.05)。腰椎、右股骨、右股骨颈和全身的骨密度与年龄具有相关性(r=0.484,p<0.001;r=0.329,p<0.001;r=0.350,p<0.001;r=0.389,p<0.01)。各年龄组之间,B M I、身高、体重无显著性差异(p>0.05);全身及身体各部位(头部、上肢、下肢、躯干)脂肪百分比和瘦体重百分比均无显著性差异(p>0.05),除全身瘦体重含量与年龄具有相关性外(r=0.304,p<0.001),其余均与年龄无相关性。②女大学生腰椎、右股骨、右股骨颈和全身的BMD与全身瘦体重呈中度相关(r=0.552,p<0.001;r=0.447,p<0.001;r=0.510,p<0.001;r=0.626,p<0.01),此相关性明显高于其与全身脂肪量的相关性(r=0.237,p<0.001;r=0.173,p<0.001;r=0.0.095,p<0.001;r=0.284,p<0.01)。③上肢、下肢及躯干部位的BMD与身体相应部位的瘦体重量的相关性(r=0.725,p<0.001;r=0.682,p<0.001;r=0.538,p<0.001)亦高于其与相应部位脂肪量的相关性(r=0.449,p<0.001;r=0.258,p<0.001:r=0.391,p<0.001)。结论:19-25女大学生BMD随年龄增加而增加,25岁达最高,BMI、身高、体重及身体成分在19-25岁间无明显改变;瘦体重是影响骨密度的主要因素之一,女大学生应增强体育锻炼,增加身体各部位的瘦体重量,其有助于提高骨量,增进骨健康。
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