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Baicalin significantly inhibit the herpes simplex virus type 1 alkaline nuclease and stop herpes simplex virus type 1 replication

Baicalin significantly inhibit the herpes simplex virus type...

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第二届世界天然药物和传统药物药理学学术会议

作者： Maria G MASUCCI Department of Cell and Molecular Biology Karolinska InstituteBox 28517177 StockholmSweden

＜正＞AIM In order to find an effective antiviral drug against the herpes simplex virus type 1（HSV-1） and understand its mechanism,we have screened alkalescence endonuclease（AN）-dependent *** We have constructed a plasmid, pET28-UL12,with an insertion of a DNA fragment containing the UL12 gene of HSV-1 SM44,which is 99.2%homologous to the UL12（Gene ID:2703382 from the GenBank）,into the prokaryotic expression vector *** transformation in Escherichia coli,only kalamycin-resistant clones were *** of recombinant proteins in Escherichia coli restored the natural activity of the *** The anti-AN activities detected in several drugs extracted from herbs were confirmed by different degrees of inhibition on the enzymatic activities,similar to the research in Vero cells that exhibited different levels of inhibiting viral infection by these *** result showed that most of these drugs can dramatically interfere with HSV-1 infection on the Vero cells,but only baicalin can significantly inhibit the rAN and stop HSV-1 *** results showed that Baicalin had a strong interaction with critical amino acid residues of AE（identity 21.12%,similar residues 41.35%,compared with rAN by DNAMAN 6.0,data not shown） which was expressed by Epstein-Barr *** This DNA degradation assay is a useful tool to rapidly screen the inhibitors of HSV-1 at the molecular level,also representing a potential target for novel antiviral therapies.

关键词： baicalin herpes virus alkaline nuclease inhibitor

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Curcumin and ginkgolide B inhibit renal cyst development

Curcumin and ginkgolide B inhibit renal cyst development

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第二届世界天然药物和传统药物药理学学术会议

作者： Bao-Xue YANG,Jin-Sheng GAO,Hong ZHOU,Tian-Luo LEI (Department of Pharmacology,School of Basic Medical Sciences,Peking University,and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China)

AIM To develop candidate drugs for treating autosomal dominant polycystic kidney disease(PKD) from natural compound *** An MDCK cyst model,a murine embryonic kidney cyst model and a PKD mouse model were used to screen positive compounds and to evaluate cyst inhibitory *** viability,proliferation,apoptosis,CFTR function and expression, and signaling pathways in MDCK cells were determined to explore the mechanism of cyst *** Curcumin and ginkgolide B were found to significantly inhibit MDCK cyst development in both MDCK cyst model and embryonic kidney cyst model with dose-response *** two compounds neither induced cytotoxicity nor apoptosis in MDCK *** failed to affect the chloride transporter CFTR expression and ***,curcumin and ginkgolide B inhibited forskolin-promoted cell proliferation and promoted the tubule formation in MDCK cells,which indicates they promotes MDCK cell ***, curcumin and ginkgolide B altered Ras/MAPK signaling *** B significantly inhibited cyst enlargement in PKD mouse *** Both curcumin and ginkgolide B inhibit renal cyst formation and enlargement,suggesting that these natural compounds or their analogues might be developed into novel candidate drugs for polycystic kidney disease.

关键词： curcumin ginkgolide B natural product ADPKD renal cyst

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Protect effects of Fufangdengzhanhua dripping pill on PC12 cell injury induced by hydrogen peroxide in culture

Protect effects of Fufangdengzhanhua dripping pill on PC12 c...

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第二届世界天然药物和传统药物药理学学术会议

作者： Lei WAN,Jing-Xia XU (Department of Pharmacology,Guiyang Medical College,Guiyang 550004,China)

AIM To investigate protect effect of Fufangdengzhanhua dripping pill（FDD） 's oxidative stress induced by hydrogen peroxide on PC12 *** PC12 cells were divided into six groups in culture;control group,oxidative damage group, different concentration of FDD group(0.763,3.052,12.207mg·L ),positive drug group(vitamin E,4.307 mg·L ).After drug intervention for 24 h,PC12 cells were injured by 300μmol·L HO except control group for 2 *** the pretreating of FDD at different concentration for 24 h,typical morphological characteristics of PC12 after being exposed to HO could be observed under the inverted *** survival rate of PC12 were detected by *** dehydrogenase（LDH）,superoxide dismutase（SOD） and malondialdelyde（MDA） in the culture *** After being exposed to 300μmol·L HO for 2 h,FDD can decrease LDH,MDA content and increase SOD activity *** increases the survival rate of PC12 cells according to the results of *** with the model group,there was statistically significant difference（P<0.01）.CONCLUSION FDD can protect injury induced by hydrogen peroxide on PC12 cells in *** acting mechanisms may include protecting cell membrance and inhibiting lipid peroxidation.

关键词： FDD PC12 cells H2O2 superoxide dismutase malondialdelyde

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Neuroprotective effect of morroniside on focal cerebral ischemia in rats

Neuroprotective effect of morroniside on focal cerebral isch...

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第二届世界天然药物和传统药物药理学学术会议

作者： Wen WANG~*,Hou-Xi AI,Li ZHANG (Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China)

To examined whether morroniside could protect ischemia/reperfusion-induced brain injury by minimizing oxidative stress and *** was intragastrically administered to rats in doses of 30,90 and 270 mg·kg·d,starting 3 h after the onset of middle cerebral artery *** behavioral test was performed by using the Zea-Longa scores,Prehensile Traction score and Ludmila Belayer *** were sacrificed 3 d after ischemia *** infarction volume of brain was assessed in the brain slices stained with 2,3,5-triphenyl tetrazolium *** tissues were also used for determination of malondialdehyde levels,glutathione levels and superoxide *** treatment with morroniside significantly improved Zea-Longa scores and Prehensile Traction score at the doses of 30,90 and 270 mg·kg,increased Ludmila Belayer score and reduced the infarction volume at the doses of 90 and 270 mg·***(30,90 and 270 mg·kg ) treatment significantly decreased the level of malondialdehyde in ischemic cortex *** 270 mg·kg treatment significantly increased the content of glutathione, enhanced the activity of superoxide dismutase,but decreased the expression of caspase 3 protein in ischemic cortex *** findings demonstrated that morroniside could significantly protect the brain from damage induced by focal cerebral ischemia which might be related to morroniside antioxidant and anti-apoptotic properties in the brain.

关键词： Neuroprotective effect of morroniside on focal cerebral ischemia in rats

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Blood-glucose regulation effect of a salvia polyphenolic acid-salvianolic acid A

Blood-glucose regulation effect of a salvia polyphenolic aci...

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第二届世界天然药物和传统药物药理学学术会议

作者： Xiu-Ying YANG,Li ZHANG,Guan-Hua DU (Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)

AIM Salvianolic acid A（SalA） is one of the main active ingredients of Salvia *** objective of this study was to evaluate the effect of SalA on blood glucose level and the related *** Normal mice,diabetic rats and spontaneously diabetic KKay mice were used to study the role of SalA on animal *** human hepatoma cell line Bel-7401 was also used to study the role of SalA on cell glucose *** Our results showed that SalA slightly reduced the normal mice blood glucose *** at 1 -3 mg·kg reduced blood glucose,GHB,AGEs level in diabetic *** 1 - 3 mg·kg could increase pancreatic islets size and number of diabetic *** could improve the glucose absorption of human hepatoma cell line *** could improve the ATP production,improve the mitochondria function,and Increase the MAPK pathway *** Our data suggested that SalA could decrease the blood-glucose level on diabetic animals. The mechanisms studies suggest that the blood-glucose modulation effect of SalA might contribute to the increased function of mitochondria and enhanced MAPK pathway.

关键词： diabetes salvianolic acid A blood-glucose mitochondrion MAPK

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Protective effects of 5-propargyl-cysteine controlled release formulationon ischemic disease:hydrogen sulfide-mediated mechanism

Protective effects of 5-propargyl-cysteine controlled releas...

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第二届世界天然药物和传统药物药理学学术会议

作者： Cheng-Rong HUANG~1,Jun-Tao KAN~1,Shu-Jun WANG~2,Yi-Zhun ZHU~1 (1.Department of Pharmacology,Fudan University,Shanghai 201203,China 2.Department of Pharmacology, Shenyang Pharmaceutical University,Shenyang 110016,China)

AIM S-propargyl-cysteine（SPRC）,a structural analog of 5-allylcysteine which is a major compound in garlic,has been proved to protect against myocardial ischemia through modulating *** order to produce more stable and sustaining HS,we developed SPRC controlled release formulation(SPRC（RS）],thenelucidated the protective effects on ischemic disease and the involved mechanisms on apoptosis,oxidation and *** Heart failureandhind-limb ischemia model were induced by left coronary artery occlusion and femoral artery *** indexes were recorded to determine the cardiac function. TTC staining was performed to determine the infarct *** level of HS was detected by modified sulfide electrode. Activity of enzyme and expression of protein were determined by colorimetry and Western *** and immunofluorescence were performed to discover the density of *** The cardioprotective effects of SPRC（RS） on HF rats were confirmed by significant reduction of infarct size and improvement of cardiac function,with better effects than normal *** （RS） modulated antioxidant defenses and protected against myocardial *** also promoted angiogenesis in ischemic heart and *** effects of SPRC（RS） were mediated by *** SPRC（RS） played a protective role in ischemic *** important,it exerted better effects than normal SPRC in all respects,providing a new perspective on HS-mediated drug therapy.

关键词： SPRC(RS) H2S oxidation apoptosis angiogenesis

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Investigation on the anti-inflammatory effect of Aconitum brachypodum Diels

Investigation on the anti-inflammatory effect of Aconitum br...

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第二届世界天然药物和传统药物药理学学术会议

作者： Wei REN,Da-Jiang ZHOU,Jun LI,Xian-Ju HUANG~* (College of Pharmacy,South Central University for Nationalities,Wuhan 430074,China )

AIM In order to study the anti-inflammatory effects and its mechanism of extract from Aconitum brachypodum Diels （EABD）.The present study was conducted to observe the effects of the EABD on the proliferation,apoptosis,production of the nitric oxide（NO） and reactive oxygen species（ROS） of mouse peritoneal macrophages induced by lipopolysaccharide（LPS） in vitro. METHODS The mouse peritoneal macrophages was prepared under sterile condition,then the cells were divided into control group, LPS groups and EABD *** different time of incubation,the cell activities of mouse peritoneal macrophages were analyzed by the methods of *** 33258 fluorescent staining was used to detect the effect of EABD on cell apoptosis induced by *** release in the medium were determined by Griess reagent,and ROS production was determined by fluorescence probe DCFH-DA. RESULTS EABD could dose-dependently inhibit the activity and apoptosis of mouse peritoneal macrophages induced by LPS, demonstrating a significant anti-inflammatory effect in *** concentrations of EABD could inhibit the production of NO induced by 10 mg·L of LPS in a dose-dependent ***,the production of ROS in mouse peritoneal macrophages induced by LPS was significantly inhibited by *** The extract from Aconitum brachypodum Diels has significant antiinflammatory effect in vitro,which may due to an anti-oxidative mechanism of the folk plant.

关键词： Aconitum brachypodum Diels anti-inflammatory apoptosis nitric oxide reactive oxygen species

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Effect of saikosaponin b1 on collagen production by dermal fibroblasts in dermal tissue model and in culture at confluent

Effect of saikosaponin b1 on collagen production by dermal f...

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第二届世界天然药物和传统药物药理学学术会议

作者： Toshihiko HAYASHI Toshio NISHIYAMA Yasukazu NAKAYAMA China-Japan Research Institute of Medical and Pharmaceutical Sciences Shenyang Pharmaceutical University Scleroprotein Research Institute Tokyo University of Agriculture and Technology3-5-8 Saiwai-choFuchu-shiTokyo 183-8509Japan Scientific Research Section SHISEIDO CO.LTD.2-2-1HayabuchiTsuzuki-kuYokohama-shiKanagawa 224-8558Japan

AIM Human dermal fibroblasts in a dermal tissue model show reduced proliferation or cell-matrix contact inhibition (CMI),distinct from cell-cell contact inhibition(CCI) at *** growth factor(EGF) reinitiate the growth of CCI cells, while it can not stimulate CMI cell proliferation though EGF can bind with the *** bl in combination with EGF can reinitiate the proliferation of CMI *** present study compares the effects of saikosapnin bl on collagen synthesis by CMI fibroblasts with that by CCI *** Isotope labeled proteins synthesized are classified into collagen and noncollagen with bacterial collagenase *** EGF binding to CCI cells in the presence of saikosaponin bl indicated that EGFR numbers increased without changing the affinities,which eventually promotes EGFR *** acid stimulated CCI fibroblasts to synthesize collagen,while it did not affect CMI *** combination of saikosaponin bl and EGF reduced collagen production by CCI *** further decreased collagen synthesis by CMI *** The effect of saikosaponin b1 on CMI fibroblasts is most conspicuous with EGF in repressing collagen synthesis as well as in growth stimulation presumably through enhancing EGFR signaling.

关键词： fibroblast contact inhibition collagen epidermal growth factor protein synthesis

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The up-regulation of BDNF mRNA on focal cerebral ischemia-reperfusion injury in rats with polysaccharides from Opuntia Milpa Alta

The up-regulation of BDNF mRNA on focal cerebral ischemia-re...

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第二届世界天然药物和传统药物药理学学术会议

作者： Xiao-Hui XIE,Yang CHEN,Zhi-Da CHEN,Qing LU,Xu-Lin XU,Lian-Jun GUO (Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China)

AIM To study the effect of polysaccharides from Opuntia Milpa Alta（MAPs） on mRNA expression of brain-derived neurotrophic factor（BDNF） and N-methyl-D-aspartate（NMDA） receptors in cerebrum cortex after 2VO/R（middle cerebral artery occlusion-reperfusion） injury in rat by *** SD male rats were randomly divided into sham-operated,ischemiareperfusion, MAPs 200 mg·kg *** 2VO/R model was made by bilateral common carotid arteries occlusion for 15 min and reperfusion 24 *** RNA were isolated from cerebrum *** investigated the effect of MAPs on the mRNA expression of BDNF,NR1 and NR2B detected with *** Compared with the sham group,BDNF and NR2B mRNA levels decreased（P<0.05 ） while NR1 mRNA showed a slight increase（P>0.05 ） in ischemia-reperfusion group,and they were all significantly up-regulated by treatment with MAPs（P<0.05）.CONCLUSION MAPs treatment can promote to up-regulating the expressions of BDNF and NMDA receptors in genetic transcription levels in the cerebrum cortex,which can give rise to protective effects for ischemic neurons.

关键词： Opuntia Milpa Alta polysaccharides neuroprotection brain-derived neurotrophic factor N-methyl-D-aspartate receptor subunits NR1 NR2B

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Protective effect of curcumin on high-glucose induced cardiac myocytes injury

Protective effect of curcumin on high-glucose induced cardia...

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第二届世界天然药物和传统药物药理学学术会议

作者： Wei YU~(1,2),Chao LIU~1,Ji-Liang WU~1,Ji-Zhou XIANG~2,Fei CAI~1,Wen-Liang ZHA~1 (1.Hubei Province Key Laboratory on Cardiovascular,Cerebrovascular,and Metabolic Disorders,Hubei University of Science and Technology,Xianning 437100,China 2.Department of Pharmacology,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030,China)

AIM To investigate the effects of curcumin on neonatal rat cardiac myocytes exposure to high-glucose and the mechanisms *** Neonatal rat cardiomyocytes were cultured in normal-glucose(NG,5.5 mmol·L) or high-glucose (HG,30 mmol·L) *** HG-cultured cardiomyocytes were treated with the concentration of 10μg·L *** to and after the HG injury the following were determined;the cell viability was assayed by CCK8,LDH activity and ROS generation was examined by biochemical tests,cardiomyocyte death and apoptosis were detected by TUNEL and *** the interrelated proteins were measured by Western blot to investigate the involved signaling *** Compared with NG-cultured cardiomyocytes, the LDH level and ROS generation were increased significantly in HG-cultured ***,HG induced apoptotic cell *** could significantly increased the cell viability,decrease the activity of LDH and inhibit the ROS ***,curcumin decreased HG-induced apoptosis through upregulating Bcl-2 and downregulating Bax proteins *** Collectively,these results strongly suggest that curcumin could reduce cardiac myocytes apoptosis exposure to high-glucose by scavenging ROS and attenuating cell death.

关键词： curcumin apoptosis high-glucose reactive oxygen species

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