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检索条件"任意字段=第二届世界天然药物和传统药物药理学学术会议"

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New inspiration on vitiligo pathogenesis and anti-vitiligo drug development

New inspiration on vitiligo pathogenesis and anti-vitiligo d...

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第二届世界天然药物和传统药物药理学学术会议

作者： Jing SHANG Qian WANG Sha LIAO Jia ZHOU Feng-Feng PING Di HAO Drug Screening Center State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China

Lots of studies have shown that many dermatoses are caused by the disturbances of the dynamic equilibrium established between the nervous, endocrine and immune systems instead of single reason, which make dermatosis difficult to cure and raise complicated problems in the development of new *** it the way offering new ideas for the development of drugs against vitiligo? The results showed that the psychic stress can inhibit the hair follicle melanin synthesis in C57BL/6 *** stress could inhibit the melanin synthesis by increasing the expression of neuropeptide SP and decreasing the level of 5-HT in mice skin *** stress could promote mast cell degranulation and release several kinds of mediates which activated mast cell by SP and CGRP, result in promoting melanocytes *** plays an important role in the melanocytes apoptosis induced by chronic *** antidepressant fluoxetine could directly promote the melanin synthesis, which was mediated partly by 5-HT1A ***, fluoxetine and AV extraction could promote the melanin synthesis via neural system regulation.

关键词： chronic stress melanin synthesis substance P 5-HT1A receptor mast cell fluoxetine

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Inhibitory effect of atractylon on hepatitis B virus in vitro

Inhibitory effect of atractylon on hepatitis B virus in vitr...

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第二届世界天然药物和传统药物药理学学术会议

作者： Feng WANG Guang-Ming CAI Hui-Ling GUO Yan-Ling ZHAO Jiangxi College of Traditional Chinese Medicine Nanchang 330006China Institution of Chinese Medicine of 302 Hospital of PLABeijing 100039China Jiangxi College of Traditional Chinese MedicineNanchang 330006China Institution of Chinese Medicine of 302 Hospital of PLA Beijing 100039China

AlM To study the inhibited effect of atractylon on HBsAg and HBeAg in the cultured hepatocarcinoma cell line 2215 (HepG2) which was genetransfered with hepatitis B virus(HBV) and its *** The 2215 cells were treated with the varied concentration of Atractylon below the maximum nontoxic concent ration for 8 *** fluid was collected and the contents of HB-sAg and HBeAg were determined by using radioimmunoassay kit *** The TC50 of atractylon were 500 mg· *** maximum nontoxic concentration (TC0) were 250 rmg·*** nontoxic concentration (250 mg· L-1) , the inhibitions of Atractylon on HBsAg and HBeAg were 54.5% (IC50 =211.4 mg·L-1) and 59.98% (IC50 =185.3 mg·L-1), respectively (P <0.01).CONCLUSION Atractylon is effective in inhibiting HBV replication in vitro.

关键词： atractylon hepatitis B virus

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Effects of salvianolic acid B on survival,self-renewal and neuronal differentiation of bone marrow derived neural stem cells

Effects of salvianolic acid B on survival,self-renewal and n...

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第二届世界天然药物和传统药物药理学学术会议

作者： Yu HU,Nan ZHANG,Xiao-Dan ZHANG,Hong-Yan LI,Hai-Guang HAO,Dan ZHAO, Dong SUN,Jing-Xian YANG~* (Department of Pharmacology,School of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalia 116600,China)

AIM Our previous study has demonstrated the therapeutic potential of bone marrow derived-neural stem cells （BM-NSCs） in CNS disorders;however,the beneficial effects are modest duo to the poor survival and low neural differentiation *** this study,a new pharmacologic strategy targeted at anti-inflammation and anti-oxidation to promote the survival and differentiation of BM-NSCs thereby enhancing their therapeutic efficacy was *** We firstly generated and identified the BM-NSCs,then investigated the influnence of Sal B on proliferation and differentiation of the cells in the non-permissive circumstances by immunocytochemical staining,flow cytometry and ELISA *** We demonstrate that Sal B possesses the ability to promote BM-NSCs proliferation in a dose dependent manner;While in differentiation medium,Sal B promoted nestin BM-NSCs differentiated into greater numbers of NeuN and NF-M neurons;upon exposure to HO,Sal B exerted neuroprotective effects against HO-induced cytotoxicity,facilitating the cells survival in oxidative stress,inhibiting the apoptosis and LDH leakage, displaying a dose-dependent protective effects on *** of the above activities may be associated with the induction of a crucial NSC-related growth factor,brain-derived neurotrophic factor expression in *** Sal B may be a potential drug to upgrade the therapeutic efficiency of BM-NSCs in CNS diseases.

关键词： bone marrow derived-neural stem cells salvianolic acid B self-renewal differentiation brain-derived neurotrophic factor

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Cardiovascular protection of salvianolic acid A:epoxyeicosatrienoic acids and soluble epoxide hydrolase

Cardiovascular protection of salvianolic acid A:epoxyeicosat...

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第二届世界天然药物和传统药物药理学学术会议

作者： Shou-Bao WANG,Xiao-Bin PANG,Yue-Hua WANG,Li ZHANG,Xiu-Ying YANG, Lian-Hua FANG,Guan-Hua DU (Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

AIM To investigate whether Salvianolic acid A（SAA） exhibits its protective effects in rats through epoxide hydrolase （sEH） and Epoxyeicosatrienoic acids（EETs）.METHODS Heart and cerebral ischemia in rats were established through the occlusion of left anterior descending coronary artery（LAD） and middle cerebral artery occlusion（MCAO） *** 0.3,1 and 3 mg·kg was administrated before and after operation *** SAA treatment reduced infarct volume in heart and brain,improved cardiac function,and ameliorated neurological ***,the beneficial effects of SAA were attenuated by co-administration of 14,15-EEZE,a putative selective EETs ***,SAA increased the 14,15-EET levels in the blood, heart and brain of sham and ischemic *** for hydrolase activity showed that SAA 1 and 3 mg·kg significantly diminished heart and brain sEH activity of ischemic rats.A fluorescent assay in vitro indicated that SAA could inhibit recombinant human sEH activity in a concentration-dependent manner(IC_(50 = 1.62μmol·L ).Immunohistochemical analysis showed that SAA 1 and 3 mg·kg significantly decreased sEH protein expression in heart and hippocampus CA1 region of ischemic *** Cardiovascular protection of SAA is mediated at least in part via inhibiting sEH to increase EETs levels.

关键词： salvianolic acid A cardiovascular protection soluble epoxide hydrolase epoxyeicosatrienoic acids

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Therapeutic effects of icarrin on amyloid-β burden in a mouse model of Alzheimer's disease

Therapeutic effects of icarrin on amyloid-β burden in a mou...

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第二届世界天然药物和传统药物药理学学术会议

作者： Lan ZHANG,Jin CHU,Ru-Yi ZHANG,Ying XING,Lin LI~* (Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China)

AIM To investigate the effect and pharmacological mechanism of icarrin（ICA）,which is the main component extracted from a traditional Chinese epimedium herb,on Aβproduction in AD-like APP transgenic *** PDAPPV717I transgenic （Tg） mice were randomly divided into model group and ICA treated(at doses 30 and 100μmol·kg·d) *** was orally administered to Tg mice with an age range 4-10 *** burden of Aβwas measured by ELISA and *** amyloid senile plaques were detected by Congo red staining and Bielschowsky silver *** expression of APP and BACE-1 were measured by immunohistochemistry and Western *** co-expression of Aβwith amyloid fibers was detected by applying double labeled *** Orally administered ICA decreased the number of amyloid senile plaques in hippocampus of Tg *** immunohistochemical examination of brain sections stained with polyclonal anti-Aβantibody showed reduced Aβburden, and Aβlevels were also decreased in the insoluble fractions of brain homogenates,as determined by *** expression of APP and BACE-1 in hippocampus was significantly decreased in ICA treated *** ICA could reduce the Aβburden and plaque deposits in the hippocampus of APP transgenic mice through depressing the expression of APP and *** may have a promising application prospect in treatment of AD.

关键词： Alzheimer's disease APPV717I transgenic mice β-amyloid icarrin

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Why botanicals are considered safer?

Why botanicals are considered safer?

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第二届世界天然药物和传统药物药理学学术会议

作者： Anwar H.GILANI Natural Products Research Unit Department of Biological and Biomedical SciencesAga Khan University Medical CollegeKarachi-74800Pakistan

The use of plants,plant extracts or plant-derived pure chemicals to treat disease is a therapeutic modality,which has stood the test of *** today many pharmacological classes of drugs include a natural product ***,there is a revival of interest in using medicinal plants in their crude form(botanicals or standardized extracts) partly because botanicals are considered safer compared to pure compounds isolated from *** an attempt to provide rational for the safer nature of botanicals,we observed the co-existence of CCBs and acetylcholinesterase inhibitors constituents in some plants with therapeutic potential in Alzheimer's ***,combination of CCBs with phosphodiesterase inhibitors(PDEIs) or anticholinergic constituents shown in some plants have the therapeutic potential in spasmodic and asthmatic conditions,where the inhibitory effect of CCBs on the heart is likely to offset the cardiac stimulation usually seen with PDEIs or *** co-existance of CCBs with cholinergics in herbs traditionally used in hypertension and/ or constipation offers unique therapeutic potential,where both components are inhibitory in cardiovascular system acting through endothelium dependent and independent vasodiltaor effect(desirable in hypertension) but with opposing effects in other systems offering side-effects neutralizing *** antispasmodic component seen at high dose is likely to offset the abdominal cramps usually observed at high dose of gut stimulants used in ***,the cholinergic activity was more evident in quiscent gut preparations,while antispasmodic(CCB) more evident in hyperactive preparations,which explains the medicinal use of herbs like ispaghol and ginger for their dual efficacy in constipation and diarrhoea,two oppositte disease states of the gut. The literature shows that Saw palmato used in prostate benign hyperplasia and ***'s Wart in depression act through multiple pathways with effec

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Metabolites study of salvianolic acid L,a novel phenolic acid constituent from Salvia miltiorrhiza,in rats

Metabolites study of salvianolic acid L,a novel phenolic aci...

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第二届世界天然药物和传统药物药理学学术会议

作者： Wei LI,Shu-Ming LI,Yuan-Peng JIN,Xue-Jun LUO,Xiang-Yang WANG,Yang CHU,Xiao-Hui MA, Shui-Ping ZHOU,Yong-Hong ZHU (Tasly R&D Institute,Tasly Group Co.,Ltd.,Tianjin 300410,China)

AIM To identify salvianolic acid L（SAL） metabolites in *** Bile duct of wistar rats（n =6,male） was cannulated with PE tubing after *** bile samples were collected for 24 h after intravenous injection of 20 mg·kg *** group of 6 male Wistar rats were kept in metabolism cage after intravenous injection of 20 mg·kg SAL,urine samples were collected for 24 h and blood samples were drawn from ophthalmic veins of the rats by sterile capillary *** samples were acidized by HCl 1 mol·*** extraction of SAL and its metabolites were conducted with ethyl *** removal of organic solvent by nitrogen gas blowing,samples were reconstituted in mobile phase solvent before subjected to liquid chromatography-mass spectrometry *** About 60%of SAL and its metabolites was excreted from *** monomethylation metabolites, four dimethylation metabolites,1 monoglucuronidation metabolites,monoglucuronidation-monmethylation metabolites and monoglucuronidation -dimethylation metabolites were discovered in bile of wistar rats,and the metabolites were also detected in plasma and urine. CONCLUSION The main metabolic pathway of SAL in Wistar rats was methylation and *** excretion was the main excretion pathway,indicating that liver played a very important role in the metabolism of SAL.

关键词： Salvia miltiorrhiza salvianolic acid L metabolites methylation glucuronidation

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Alterations in the intracellular Ca2+ concentration and vimentin in endothelial cells following tumor cell-endothelial cell interactions

Alterations in the intracellular Ca2+ concentration and vime...

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第二届世界天然药物和传统药物药理学学术会议

作者： Yan PAN,Xue-Jun LI (State Key Laboratory of Natural and Biomimetic Drugs,Department of Pharmacology,School of Basic Medical Sciences,Peking University and Institute of System Biomedicine,Peking University, Beijing 100191,China)

AIM Interactions of tumor cells with endothelial cells（EC）,for example tumor cell adhesion and migration through the EC layer,are essential components of tumor *** calcium regulation and cytoskeletal proteins in both tumor cells and EC provide important signaling mechanisms for the growth,angiogenesis and metastasis of tumor *** the present study, we investigated the influence of tumor cell-EC interactions on the intracellular calcium ion concentration([Ca]) and vimentin in ***[Ca] was measured by confocal microscopy in human umbilical vein endothelial cells（HUVEC） before and after the addition of PC-3M prostate carcinoma *** expression and structural organization of vimentin in HUVEC was analyzed by immunofluorescence *** effect of heparin and nifidipine on EC[Ca] and vimentin were ***,a known disruptor of intermediate filaments,was used to induce the collapse of vimentin filaments,and the distribution of calcium ions in ECs was *** PC-3M cells induced a rapid[Ca] elevation and lead to altered vimentin distribution in EC at the sites of tumor cell-EC *** cell-induced[Ca] elevation was significantly inhibited by heparin and nifidipine;however, heparin and nifidipine had no obvious effects on the expression and organization of ***-induced collapse of vimentin filaments shifted the distribution of calcium ions from the cytoplasm to the nucleus and perinuclear field in *** Rapid [Ca] elevation and alterations in vimentin distribution occur in EC at the sites of tumor cell-EC contact;the structural integrity of vimentin is partly related to the intracellular calcium ion distribution and concentration.

关键词： calcium ions vimentin tumor cell-endothelial cell interaction

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In vitro studies on anti-influenza viral effect and anti-inflammation of flavonoid derivatives

In vitro studies on anti-influenza viral effect and anti-inf...

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第二届世界天然药物和传统药物药理学学术会议

作者： Mian ZU~1,Wei-Ling ZHOU~1,Ai-Lin LIU~(1,2*),Guan-Hua DU~(1,2*) (1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China 2.Beijing Key Laboratory of Drug Target and Screening Research,Beijing 100050,China)

AIM Influenza A virus(IAV) resistance to available antiviral agents urges us to discover new *** flavonoids have been reported for their antiviral *** this paper,the anti-influenza viral and anti-inflammatory effects of a series of synthesized flavonoid derivatives were *** The cellular protective effects of the flavonoid derivatives were evaluated by cytopathic effect(CPE) *** direct antiviral replication effects of "Hits" were studied by neuraminidase(NA) activity reduction assay,a real-time quantitative PCR assay for the intracellular gene expression of viral haemagglutination(HA),and an immunofluorescence assay for the intracellular protein expression of viral NP and ***,their inhibitory effects on the production of proinflammatory cytokines induced by influenza infection were *** More than 100 synthesized flavonoid derivatives were evaluated,J27113 and J27116 from these compounds exhibited the most protective effects in the CPE reduction *** Inhibited the NA activity,and decreased HA gene and NP,M2 protein ***,they showed inhibitory effects on the production of IL-6,IL-8,MCP-1 and *** The inhibition on the replication of influenza virus and their antiinflammatory effects of J27113 and J27116 may be considered as the major components for their cellular protective effects against influenza, which will provide information for novel antiviral drug development.

关键词： antiviral anti-inflammatory influenza flavonoid derivatives

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Perspectives and challenges of traditional Chinese medicines pharmaceutical businesses in Africa

Perspectives and challenges of traditional Chinese medicines...

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第二届世界天然药物和传统药物药理学学术会议

作者： Ernest TAMBO Jean Rousseau DJOUAKA Olalubi OLUWASOGO Ngouakam HERMAN National Institute for Parasitic Diseases Chinese Center for Disease Control and PreventionShanghaiChina Entomology & Pathology Unit International Institute of Tropical AgricultureCalaviRepublic of Benin

AIM To evaluate the perspectives of Traditional Chinese Medicines(TCM) pharmaceutical businesses in Africa continent with the increasing Sino-Africa *** AND METHODS Reviewed publications,Sino-Africa forum proceedings, papers and internet search data from 2001- end 2011 on Sino-Africa cooperation impact on TCM pharmaceutical businesses on healthcare services delivery across *** Similarities in the holistic healing,interconnectness and harmony with the universe of both continents allow successfully acceptability of TCM in the Africa community and have created an unprecedented TCM market reaching US＄100.000 millions in value,*** mounting pressure of population growth makes Africa,the second populous continent after Asia by 2025,coupled with implementation of the health integrated approach with Traditional medicine in diseases management in national health program,increasingly health demands and drugs shortages offer untapped and great opportunities for TCM pharmaceutical markets,which are more *** had acceptability of 81%and of good preventive effect(89%) on the high prevalence hypertension,diabetes and tropical *** findings documented that the disease severity in Africa patients was part consequence of the hihher cost of western medicines and medical *** Practitioner's foreign language proficiency eases local integration and adaptation and understanding of the therapeutic options as firms promote brand building strategy and *** Official incorporated of TCM into the primary health care delivery in whole of Africa by increasing investment flows is urgently needed. The perspectives and challenges of TCM pharmaceutical industries are enlisted in enhancing TCM exportation.

关键词： Perspectives and challenges of traditional Chinese medicines pharmaceutical businesses in Africa

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