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Inhibitory effect of atractylon on hepatitis B virus in vitro

Inhibitory effect of atractylon on hepatitis B virus in vitr...

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第二届世界天然药物和传统药物药理学学术会议

作者： Feng WANG~(1,2),Guang-Ming CAI~(1*),Hui-Ling GUO~2,Yan-Ling ZHAO~1 (1.Institution of Chinese Medicine of 302 Hospital of PLA,Beijing 100039,China 2.Jiangxi College of Traditional Chinese Medicine,Nanchang 330006,China)

AIM To study the inhibited effect of atractylon on HBsAg and HBeAg in the cultured hepatocareinoma cell line 2215 （HepG2） which was genetransfered with hepatitis B virus（HBV） and its *** The 2215 cells were treated with the varied concentration of Atractylon below the maximum nontoxic concent ration for 8 *** fluid was collected and the contents of HB-sAg and HBeAg were determined by using radioimmunoassay kit *** The TC of atractylon were 500 mg·*** maximum nontoxic concentration（TC） were 250 mg·*** nontoxic concentration(250 mg·L ),the inhibitions of Atractylon on HBsAg and HBeAg were 54.5%(IC =211.4 mg·L ) and 59.98%(IC = 185.3 mg·L ),respectively（P<0.01 ）.CONCLUSION Atractylon is effective in inhibiting HBV replication in vitro.

关键词： atractylon hepatitis B virus

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Content of hcy in the high homocysteine rats to affecting carbon monoxide/add oxygen enzyme 2 in penis

Content of hcy in the high homocysteine rats to affecting ca...

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第二届世界天然药物和传统药物药理学学术会议

作者： Wen-Bo QIN~1,Wen-Jun HUANG~1,Bao-Jin CHI~2,Hao-Lin HE~1,Da-Ren CHEN~1,Shu-Qiu,WANG~2 (1.Department of Urology,The Second Affiliated Hospital of Jiamusi University,2.Jiamusi University, Jiamusi 154007,China )

AIM To study the high homocysteine rats,to explore the sponge body homocysteine hemoglobin content of carbon monoxide/add oxygen enzyme 2(CO/HO-2) the influence of the *** The forty male wistar rats divided into normal control group(group A),hey rats way of treatment(group B),hcy betaine hydrochloride treatment group(group C) and zinc porphyrinⅨinterention group(D group).RESULTS The rat models whether raised homocysteine levels in the blood increased significantly,penile erectile rate reduced significantly,and CO content and HO-2 activities were to drop,and homocysteine levels was negatively related(P<0.01).The penis sponge body treatment group HCY CO and HO-2 content and the treatment group is obviously higher,penile erectile rate increased significantly(P<0.01),there is statistical *** hcy cause penile erectile function is reduced,may and CO content and the penis sponge body HO-2 express reduce relevant,added to hcy betaine produced a certain role influence ED relief.

关键词： Content of hcy in the high homocysteine rats to affecting carbon monoxide/add oxygen enzyme 2 in penis

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Screening on hypoglycemic effective components of the Yao minority folk medicine Melastoma dodecandrum Lour.

Screening on hypoglycemic effective components of the Yao mi...

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第二届世界天然药物和传统药物药理学学术会议

作者： Li LI,Xiu-Fen YANG,Ze-Ping LUO,Huan-Di ZHOU (Department of Pharmacology,Guangxi Traditional Chinese Medical University,Nanning 530001,China)

AIM To screen the active components of the Yao minority folk medicine Melastoma dodecandrum *** reducing blood *** Extracted with 95%ethanol,the drugs Melastoma dodecandrum *** subsequently extracted by skellysolve G,acetic ether,re-butyl alcohol and distilled water *** diabetes mellitus models were induced by alloxan in mice,adrenaline and high concentration glucose were administrated respectively to induce experimental hyperglycemic *** mice were treated with corresponding drugs for 10 d and then the blood glucose levels were *** The blood glucose levels were reduced significantly after 10 d in the mice that were treated with acetic ether extract and re-butyl alcohol extract respectively, compared with the model *** The acetic ether extract and n-butyl alcohol extract of Melastoma dodecandrum *** lower the blood glucose in hyperglycemic mice,and the acetic ether extract was more effective.

关键词： Melastoma dodecandrum Lour. active components hypoglycemic effect

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Endotoxin- and D-galactosamine-induced fulminant hepatic failure improved by the administration of cryptotanshinone

Endotoxin- and D-galactosamine-induced fulminant hepatic fai...

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第二届世界天然药物和传统药物药理学学术会议

作者： Li-Hua LIAN~△,Quan JIN~△,Yan-Ling WU,Ting BAI,Ji-Xing NAN~* (College of Pharmacy,Yanbian University,Yanji 133002,China)

AIM Cryptotanshinone（CTN）,one of the major constituents of tanshinones,was investigated for hepatoprotective effects in D-galactosamine（D-GalN）/lipopolysaccharide（LPS）-induced fulminant hepatic failure mouse *** CTN (20 or 40 mg·kg ) was orally administered 12 and 1 h prior to D-GalN(700 mg·kg )/LPS(10μg·kg ) *** Prelreatment with CTN markedly protected mice from lethal liver injury,which has known to be associated with a massive hepatocyte ***,CTN significantly blocked the elevation of TNF-αand alanine aminotransferase（ALT） and aspartate aminotransferase （AST） as *** also remarkably reduced DNA fragmentation in the liver,which correlated with blockade of caspase 3, caspase 8,and caspase 9 ***,increased cytosolic cytochrome c protein was reduced by *** addition,CTN significantly suppressed the activation of JNK,ERK and p38 induced by D-GalN/LPS,and phosphorylation of TAK1 as ***, CTN significantly inhibited the activation of nuclear factor（NF）-κB and suppressed production of inflammatory mediators. CONCLUSION These findings suggested that CTN prevents D-GalN/LPS-induced fulminant hepatic failure,and this protection is likely associated with its anti-apoptotic activity and the down-regulation of MAPK activity associated at least in part with suppressing NF-κB.

关键词： cryptotanshinone fulminant hepatic failure apoptosis NF-κB

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Pinocembrin protects neurons against beta-amyloid-induced toxicity through inhibiting RAGE-mediated pathways and regulating mitochondrion-mediated apoptosis

Pinocembrin protects neurons against beta-amyloid-induced to...

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第二届世界天然药物和传统药物药理学学术会议

作者： Rui LIU,Cai-Xia WU,Dan ZHOU,Li ZHANG,Tian-Tai ZHANG,Guan-Hua DU~* (Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China)

AIM To investigated the effects and potential mechanisms of pinocembrin on the cognitive function against Aβ-induced *** Mice received an intracerebroventricular fusion of Aβ.The behavioral performance,cerebral cortex neuropil ultrastructure,and neuronal degeneration were *** mechanism was conducted using fluorescence-based multiparametric technologies on a high-content analysis *** Pinocembrin improved cognitive function,preserved ultrastructural neuropils and decreased neurodegeneration of cerebral cortex in Aβ-treated *** did not provide sufficient effect on inhibiting Aβ production and scavenging intracellular ROS,but significantly inhibited the upregulation of RAGE transcripts and protein ***,pinocembrin depressed the activation of p38MAPK-MK2-HSP27 and SAPK/JNK-c-Jun pathways and the downstream NF-κB inflammatory *** also alleviated mitochondrial dysfunction and regulated mitochondrion-mediated apoptosis. CONCLUSION Pinocembrin showed cognitive improvement in AD *** mechanisms were illustrated on RAGE-dependent transduction inhibition and mitochondrion protection.

关键词： Alzheimer's disease amyloid-βpeptide RAGE pinocembrin

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Multitarget anti-tumor effects of Ganoderma lucidum from basic to clinic

Multitarget anti-tumor effects of Ganoderma lucidum from bas...

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第二届世界天然药物和传统药物药理学学术会议

作者： Zhi-Bin LIN (Department of Pharmacology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China)

＜正＞The multitarget anti-tumor effects of Ganoderma lucidum{ ***) is reviewed by data from our laboratory and references. Anti-tumor effects of *** involve action targets as following:①Anti-tumor effect of *** extract and *** polysaccharide peptide on transplantated tumors mediated by immunological mechanism in vivo;②*** polysaccharide peptide can enhance the proliferation and cytotoxicity of cytokine-induced killer cells（CIK） in vitro and in vivo;③*** extract and G. lucidum polysaccharide peptide can inhibit the adhesion and migration of tumor cells in vitro;④*** triterpenes can inhibit the proliferation of tumor cells in vitro;⑤*** extract and *** polysaccharide peptide can inhibit the tumor angiogenesis in vitro;⑥*** extract and *** polysaccharide peptide can reverse the multidrug resistance（MDR） in the chemotherapeutic drugs-resistant tumor cells;⑦*** extract has protective effect on radiation injury;⑧*** extract and *** polysaccharide peptide have protective effect on the damage of chemotherapeutical *** results suggest that anti-tumor effect of Ganoderma lucidum and its active ingredients have multiple targets,and accordingly could explain the mechanism of Ganoderma lucidum enhancing the efficacy of radiotherapy and chemotherapy and reducing the injury of these therapy on the blood,gastrointestinal tract,liver,kidney and so on in clinical practice.

关键词： Ganoderma lucidum extract polysaccharide peptides triterpenoids anti-tumor multiple target

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Synergistic antiproliferative of paclitaxel and an ent-kaurene diterpenoid compound on human gastric cancer cells in vitro and in vivo

Synergistic antiproliferative of paclitaxel and an ent-kaure...

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第二届世界天然药物和传统药物药理学学术会议

作者： Cong WANG,Ran DONG,Sai-Qi WANG,Liu-Bin GUO,Hong-Min LIU~* (School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China)

AIM Investigation of the synergetic effect of paclitaxel and an ent-kaurene diterpenoid compound in human gastric cancer cell line MGC *** Cell proliferation was determined by MTT *** blot were performed to monitor the expression change of Bax,Bcl-2 and *** in vivo study,human gastric cancer cell line MGC 803 were injected into nude mice as xenograft tumor models,and the tumor weights were measured after treatment with paclitaxel,the compound or combined together for 21 d to evaluate the in vivo inhibition *** For in vitro study,the result of MTT assay showed that the cell growth was significantly inhibited when they were synergistically used in quite small dose(inhibition rate<25%) and the expression of Bax and p53 were significantly increased in the synergetic treatment,whereas the expression of Bcl-2 was *** the synergetic group, the inhibition rate(90.0%) which is evaluated by tumor weights is much higher than that of paclitaxel(72.4%) and the compound (11.7%).CONCLUSION Synergetic use of paclitaxel and the ent-kaurene diterpenoid compound may be a promising method for the treatment of gastric *** the side effects of paclitaxel can be minimized in the synergetic treatment.

关键词： synergetic paclitaxel ent-kaurene diterpenoid nude mice

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Association between the pharmacology and herbal quality in Chinese medicine

Association between the pharmacology and herbal quality in C...

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第二届世界天然药物和传统药物药理学学术会议

作者： Simon Ming Yuen LEE State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau

＜正＞Focusing on the critical academic areas that restricting the quality of Chinese medicine,the project has carried out systematic study on the association between the pharmacology and herbal quality in Chinese medicine aiming at dissecting their relationships based on modern scientific *** and formulas under the three classical categories,Huoxue,Fuzheng and Qingre,were chosen for investigation of their pharmacological properties with latest ideas and novel technologies in the *** project performed systematic investigations of the beneficial effects of Chinese medicine such as anti-cancer,cardio- and cerebrovascular protection, anti-virus activities and the associated quality evaluation on more than ten representative regional Chinese herbs,including Panax notoginseng,Salvia miltiorrhiza,Angelica sinensis,Ganoderma lucidum,Coptis chinensis Franch,Radix Puerariae and so *** than thirty pharmacological assays have been established and several thousands herb samples have been systematically ***, more than 10 major active ingredients have been identified from Chinese *** pharmacological efficacy of the Chinese herbs in the three main classical categories and their potential mechanisms of actions have been *** addition,the association of drug safety and drug delivery systems on systematic quality evaluation has also been *** project provides new insight into mechanism of action of Chinese medicine and rationales for further development of clinical use of Chinese medicine.

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NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects

NHBA isolated from Gastrodia elata exerts sedative and hypno...

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第二届世界天然药物和传统药物药理学学术会议

作者： Ying ZHANG,Min LI,Jian-Jun ZHANG~* (State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

The rhizomes of Gastrodia elata have been used for the treatment of insomnia in oriental countries.N6-(4-hydroxybenzyl) adenine riboside(NHBA) was originally isolated from *** the first time we report a detailed study on the effects and mechanisms of NHBA on its sedative and hypnotic ***,an endogenous sleep factor,regulates sleep-wake cycle via interacting with adenosine A1/A2A *** radioligand binding studies and cAMP accumulation assays,our results show that NHBA may be a functional ligand for the adenosine Al and A2A *** significantly decreases spontaneous locomotor activity and potentiates the hypnotic effect of sodium pentobarbital in *** architecture analyses reveal that NHBA significantly decreases wakefulness time and increases NREM sleep ***,NHBA does not affect the amount of REM *** with the adenosine Al receptor antagonist DPCPX or the A2A receptor antagonist SCH 58261 significantly reverses the increase in sleeping time induced by NHBA in sodium pentobarbital treated *** studies show that NHBA increases c-Fos expression in GABAergic neurons of the ventrolateral preoptic area(VLPO),which suggests that NHBA activates the sleep center in the anterior ***,these results indicate that NHBA produces significant sedative and hypnotic *** effects might be mediated by the activation of adenosine A1/A2A receptors and stimulation of the sleep center VLPO.

关键词： NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects

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Effects of Xuefu Zhuyu Decoction on antioxidant and drug-metabolizing enzymes in liver of rats

Effects of Xuefu Zhuyu Decoction on antioxidant and drug-met...

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第二届世界天然药物和传统药物药理学学术会议

作者： Xing-Hua FAN,Wei-Zhou SHI,Yun-Xiang CHENG,Xiu-Fen YANG~* (Department of Pharmacology,College of Pharmacy,Guangxi University of Chinese Medicine, Nanning 530001,China)

AIM To study the effects of Xuefu Zhuyu Decoction（ZFZYD） on antioxidant and drug metabolism enzymes （DMEs） in liver of *** Treatment of rats with 3.51,7.02,and 14.04 g·kg ZFZYD per day for 15 d,microsomes and cytosols isolated from liver tissues were *** activities of several antioxidant enzymes and phaseⅠandⅡDMEs were *** The activities of antioxidant enzymes GPx and CAT were not significantly affected by these treatments,SOD were significantly increased following treatment with XFZYD 3.51 and 7.02 g·kg,respectively,XFZYD 3.51 g·kg could significantly induce GST in *** microsomes,the activities of NADPH-cytochrome P450 reductase,cytochrome b5,CYP 3A,CYP 2E1 and UGT were not affected,but GST were significantly induced with the dosage of 3.51 and 7.02 g·kg and the level of GSH were enhanced in all *** XFZYD could induce the activities of GST and SOD in liver of rats.

关键词： Xuefu Zhuyu Decoction antioxidant enzymes drug-metabolizing enzymes

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