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检索条件"任意字段=第二届世界天然药物和传统药物药理学学术会议"

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Potential of fruit-derived polyphenols to improve vascular protection

Potential of fruit-derived polyphenols to improve vascular p...

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第二届世界天然药物和传统药物药理学学术会议

作者： Valérie SCHINI-KERTH Faculty of Pharmacy StrasbourgUniversityIllkirchFrance

Endothelial cellshave a pivotal role in the control of vascular homeostasis, in part, by releasing potent vasodilators such as nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and protacyclin (PGI2).The most important one is NO,which is generated from L-arginine by the enzyme termed endothelial NO *** also strongly inhibits platelet activation and prothrombotic and pro-atherosclerotic *** endothelial dysfunction characterized by a reduced generation of these endotheliumdependent vasodilators associated to vascular oxidative stress and the formation of endothelium-dependent contracting factors such as contractile prostanoids is often observed in most types of cardiovascular diseases, and physiological ***-derived polyphenols from a variety of fruits, tea and cocoa increase the endothelial formation of NO by causing the redox-sensitive Src/PI3-kinase/Aktdependent activation of endothelial NO synthase leading to a sustained formation of ***, these polyphenols are also able to both improve an established ageing-related endothelial dysfunction and retard the induction of ageing-related endothelial dysfunction in the *** protective effect is mostly due to their ability to reduce vascular oxidative stress by inhibiting the overexpression of NADPH oxidase and the angiotensin ***, nutritional-derived polyphenols may be an interesting approach to retard ageing-related endothelial dysfunction and, hence, the initiation and development of cardiovascular diseases.

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A comparison between two methods of myelin staining in cuprizone-induced demyelination model mice

A comparison between two methods of myelin staining in cupri...

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第二届世界天然药物和传统药物药理学学术会议

作者： Li ZHANG Lin-Lin YIN Lin LI Department of Pharmacology Xuanwu Hospital of Capital Medical University Key Laboratory for Neurodegenerative Diseases of Ministry of Education Beijing 100053China

AIM To compare two methods of myelin staining for detecting the morphological changes in the brain of cuprizoneinduced demyelination model *** Demyelination model was induced by cuprizone which was mixed in forage and fed to mice for 4 *** the brain tissue sections were made, Luxol Fast Blue (LFB) and oil red O staining methods were used to observed demyelination changes in the corpus callosum on striatum and hippocampus *** The results from both LFB and oil red O staining showed that demyelination occurred in the corpus callosum of cuprizome-induced model mice, but the morphological changes in the striatum section were clearer detected by oil red O staining than that measured by LFB staining, and the margin of demyelination with the surrounding tissue was not clear on the section stained by *** Compared with the LFB staining, oil red O staining shows clearer demyelination and is a simple myelin staining method.

关键词： cuprizone demyelination oil red O staining Luxol fast blue staining

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A new compound TCD inhibits the growth and migration of cancer cells and its molecular mechanisms of action in vitro and in vivo

A new compound TCD inhibits the growth and migration of canc...

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第二届世界天然药物和传统药物药理学学术会议

作者： Guo-Ying ZHANG~*,Jian-Wen YAO,Kun LIU,Lin-Lin CHEN,Xin LIU,Fu-Jia SUN,De-Xin JI, Hua-Rong ZHANG~1 (Laboratory of Molecular Pharmacology,School of Pharmacy,Yantai University,Yantai 264005,China)

Our previous results indicated that theanine and courmarin have some anticancer activities although the activities are not very *** order to enhance the anticancer activity of theanine and develop new anticancer agents,we synthesized new compounds, theanine-courmarin-derivatives(TCD) with theanine and *** results have shown that TCD has much stronger activity than either theanine or courmarin on reduction of the viability and migration as well as tumor growth in the tumor-bearing *** results indicated that TCD strongly reduced a serial of protein expressions and/or phosphorylation related to the growth and migration as well as metastasis of the cancer *** enhanced the expressions of Bax,caspase 3,PARP-1,p53 and p21 proteins and decreased the expressions and/or phosphorylation of Bcl-2,vascular endothelial growth factor receptor(VEGFR),cyclin D,AKT,and NF-κ*** further confirmed that inhibition of the signaling pathway of VEGFR-PDK/Alct-NF-κB is the important molecular mechanism of action of TCD against the cancer cell growth and *** results suggest that TCD may have the wide therapeutic and/or adjuvant ther- apeutic application in the treatment cancer.

关键词： theanine-courmarin-derivatives cancer growth and migration suppression vascular endothelial growth factor receptor PI3K/Akt-NF-κB pathway

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NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects

NHBA isolated from Gastrodia elata exerts sedative and hypno...

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第二届世界天然药物和传统药物药理学学术会议

作者： Ying ZHANG,Min LI,Jian-Jun ZHANG~* (State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

The rhizomes of Gastrodia elata have been used for the treatment of insomnia in oriental countries.N6-(4-hydroxybenzyl) adenine riboside(NHBA) was originally isolated from *** the first time we report a detailed study on the effects and mechanisms of NHBA on its sedative and hypnotic ***,an endogenous sleep factor,regulates sleep-wake cycle via interacting with adenosine A1/A2A *** radioligand binding studies and cAMP accumulation assays,our results show that NHBA may be a functional ligand for the adenosine Al and A2A *** significantly decreases spontaneous locomotor activity and potentiates the hypnotic effect of sodium pentobarbital in *** architecture analyses reveal that NHBA significantly decreases wakefulness time and increases NREM sleep ***,NHBA does not affect the amount of REM *** with the adenosine Al receptor antagonist DPCPX or the A2A receptor antagonist SCH 58261 significantly reverses the increase in sleeping time induced by NHBA in sodium pentobarbital treated *** studies show that NHBA increases c-Fos expression in GABAergic neurons of the ventrolateral preoptic area(VLPO),which suggests that NHBA activates the sleep center in the anterior ***,these results indicate that NHBA produces significant sedative and hypnotic *** effects might be mediated by the activation of adenosine A1/A2A receptors and stimulation of the sleep center VLPO.

关键词： NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects

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Unani medicine in the management of cardiovascular disorders

Unani medicine in the management of cardiovascular disorders

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第二届世界天然药物和传统药物药理学学术会议

作者： Syed Mahtab ALI Faculty of Unani Medicine Jamia HamdardNew Delhi-62India

Cardiovascular diseases(CVDs) are the leading causes of death and disability in the *** have emerged as a major health threat in developing countries contrary to the prior belief that they were confined primarily to industrialized *** estimated 17.3 million people died from CVDs in 2011 and over 80%of CVD deaths take place in low and middle-income countries. By 2030,almost 23.6 million people will die from ***,finding ways to reduce the mortality of cardiovascular disease remains an important public health *** Medicines have been an integral part of the healthcare system since time *** reports indicate that around eighty percent of the global population still relies on botanical drugs and several herbal medicines have advanced to clinical use in modern *** occupies an important place in the rich traditional heritage of indigenous systems of medicine in India and contributes significantly to the health *** core of treatment in Unani System of Medicine is based on drugs of herbal,mineral and animal *** ancient classical literature of Unani has mention of numerous drugs possessing cardioprotective and cardiotonic activity as well as catering to various aspects of *** Unani physicians have been using such drugs successfully since ages and this is possible only by inherent quality and safety standards specified in the *** the advent of new techniques and recent upsurge towards scientific exploration of traditional medicines,empirical data substantiating their safety and efficacy has been generated and had lead to better understanding of their role to prevent and cure *** aim of paper is to review and highlight the work done on some Unani single and compound cardioprotectives and cardiotonics as well as highlight the scientific exploration of the same.

关键词： unani indigenous cardiovascular diseases cardioprotective

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NMDA receptor regulation by Liu-Wei-Di-Huang Decoction accounts for its enhancement of LTP in SAMP8 hippocampal slices

NMDA receptor regulation by Liu-Wei-Di-Huang Decoction accou...

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第二届世界天然药物和传统药物药理学学术会议

作者： Yan HUANG,He-Ping ZHANG,Zeng-Yao HU,Gang LIU,Sheng YANG,Wen-Xia ZHOU~* Yong-Xiang ZHANG~* (Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

AIMPrevious pharmacological studies demonstrated that LW could ameliorate the decline of the learning and memory in senescence accelerated mouse/prone 8（SAMP8）,but the mechanism has not been well ***-containing serum（LWCS） was used in this study to elucidate the possible *** 6-month-old SAMP8 was used in this study to investigate the effect of LWCS on the induction of long-term potentiation（LTP）.Primary cultured hippocampal neurons were used in this study to investigate the effects of LWCS on[Ca];I and N-methyl-D-aspartate（NMDA）-evoked currents.[Ca],was imaged using Fluo-3 and whole-cell patch recordings were applied to study the I and NMDA-evoked *** We find that LWCS facilitates the induction of LTP in hippocampal slices of 6-month-old *** primary cultured hippocampal neurons,LWCS increases intracellular[Ca],the I is suppressed by LWCS,and NMDA-evoked currents are *** These results indicate that LW improves the synaptic plasticity by inhibiting voltage-dependent caiciumchannels and promoting the function of NMDA *** improvement might be one of the mechanisms contributing to cognitive improvement effect of LW.

关键词： Liu-Wei-Di-Huang Decoction long-term potentiation

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Baicalin significantly inhibit the herpes simplex virus type 1 alkaline nuclease and stop herpes simplex virus type 1 replication

Baicalin significantly inhibit the herpes simplex virus type...

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第二届世界天然药物和传统药物药理学学术会议

作者： Maria G MASUCCI Department of Cell and Molecular Biology Karolinska InstituteBox 28517177 StockholmSweden

＜正＞AIM In order to find an effective antiviral drug against the herpes simplex virus type 1（HSV-1） and understand its mechanism,we have screened alkalescence endonuclease（AN）-dependent *** We have constructed a plasmid, pET28-UL12,with an insertion of a DNA fragment containing the UL12 gene of HSV-1 SM44,which is 99.2%homologous to the UL12（Gene ID:2703382 from the GenBank）,into the prokaryotic expression vector *** transformation in Escherichia coli,only kalamycin-resistant clones were *** of recombinant proteins in Escherichia coli restored the natural activity of the *** The anti-AN activities detected in several drugs extracted from herbs were confirmed by different degrees of inhibition on the enzymatic activities,similar to the research in Vero cells that exhibited different levels of inhibiting viral infection by these *** result showed that most of these drugs can dramatically interfere with HSV-1 infection on the Vero cells,but only baicalin can significantly inhibit the rAN and stop HSV-1 *** results showed that Baicalin had a strong interaction with critical amino acid residues of AE（identity 21.12%,similar residues 41.35%,compared with rAN by DNAMAN 6.0,data not shown） which was expressed by Epstein-Barr *** This DNA degradation assay is a useful tool to rapidly screen the inhibitors of HSV-1 at the molecular level,also representing a potential target for novel antiviral therapies.

关键词： baicalin herpes virus alkaline nuclease inhibitor

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Curcumin and ginkgolide B inhibit renal cyst development

Curcumin and ginkgolide B inhibit renal cyst development

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第二届世界天然药物和传统药物药理学学术会议

作者： Bao-Xue YANG,Jin-Sheng GAO,Hong ZHOU,Tian-Luo LEI (Department of Pharmacology,School of Basic Medical Sciences,Peking University,and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China)

AIM To develop candidate drugs for treating autosomal dominant polycystic kidney disease(PKD) from natural compound *** An MDCK cyst model,a murine embryonic kidney cyst model and a PKD mouse model were used to screen positive compounds and to evaluate cyst inhibitory *** viability,proliferation,apoptosis,CFTR function and expression, and signaling pathways in MDCK cells were determined to explore the mechanism of cyst *** Curcumin and ginkgolide B were found to significantly inhibit MDCK cyst development in both MDCK cyst model and embryonic kidney cyst model with dose-response *** two compounds neither induced cytotoxicity nor apoptosis in MDCK *** failed to affect the chloride transporter CFTR expression and ***,curcumin and ginkgolide B inhibited forskolin-promoted cell proliferation and promoted the tubule formation in MDCK cells,which indicates they promotes MDCK cell ***, curcumin and ginkgolide B altered Ras/MAPK signaling *** B significantly inhibited cyst enlargement in PKD mouse *** Both curcumin and ginkgolide B inhibit renal cyst formation and enlargement,suggesting that these natural compounds or their analogues might be developed into novel candidate drugs for polycystic kidney disease.

关键词： curcumin ginkgolide B natural product ADPKD renal cyst

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Protect effects of Fufangdengzhanhua dripping pill on PC12 cell injury induced by hydrogen peroxide in culture

Protect effects of Fufangdengzhanhua dripping pill on PC12 c...

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第二届世界天然药物和传统药物药理学学术会议

作者： Lei WAN,Jing-Xia XU (Department of Pharmacology,Guiyang Medical College,Guiyang 550004,China)

AIM To investigate protect effect of Fufangdengzhanhua dripping pill（FDD） 's oxidative stress induced by hydrogen peroxide on PC12 *** PC12 cells were divided into six groups in culture;control group,oxidative damage group, different concentration of FDD group(0.763,3.052,12.207mg·L ),positive drug group(vitamin E,4.307 mg·L ).After drug intervention for 24 h,PC12 cells were injured by 300μmol·L HO except control group for 2 *** the pretreating of FDD at different concentration for 24 h,typical morphological characteristics of PC12 after being exposed to HO could be observed under the inverted *** survival rate of PC12 were detected by *** dehydrogenase（LDH）,superoxide dismutase（SOD） and malondialdelyde（MDA） in the culture *** After being exposed to 300μmol·L HO for 2 h,FDD can decrease LDH,MDA content and increase SOD activity *** increases the survival rate of PC12 cells according to the results of *** with the model group,there was statistically significant difference（P<0.01）.CONCLUSION FDD can protect injury induced by hydrogen peroxide on PC12 cells in *** acting mechanisms may include protecting cell membrance and inhibiting lipid peroxidation.

关键词： FDD PC12 cells H2O2 superoxide dismutase malondialdelyde

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Blood-glucose regulation effect of a salvia polyphenolic acid-salvianolic acid A

Blood-glucose regulation effect of a salvia polyphenolic aci...

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第二届世界天然药物和传统药物药理学学术会议

作者： Xiu-Ying YANG,Li ZHANG,Guan-Hua DU (Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)

AIM Salvianolic acid A（SalA） is one of the main active ingredients of Salvia *** objective of this study was to evaluate the effect of SalA on blood glucose level and the related *** Normal mice,diabetic rats and spontaneously diabetic KKay mice were used to study the role of SalA on animal *** human hepatoma cell line Bel-7401 was also used to study the role of SalA on cell glucose *** Our results showed that SalA slightly reduced the normal mice blood glucose *** at 1 -3 mg·kg reduced blood glucose,GHB,AGEs level in diabetic *** 1 - 3 mg·kg could increase pancreatic islets size and number of diabetic *** could improve the glucose absorption of human hepatoma cell line *** could improve the ATP production,improve the mitochondria function,and Increase the MAPK pathway *** Our data suggested that SalA could decrease the blood-glucose level on diabetic animals. The mechanisms studies suggest that the blood-glucose modulation effect of SalA might contribute to the increased function of mitochondria and enhanced MAPK pathway.

关键词： diabetes salvianolic acid A blood-glucose mitochondrion MAPK

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