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Protective effect of Diaoxinxuekang-containing serum on hydrogen peroxide injured cardiomyocytes of neonate rats

Protective effect of Diaoxinxuekang-containing serum on hydr...

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第二届世界天然药物和传统药物药理学学术会议

作者： Yi KANG,Xin LI,Xi ZHANG,Yun WANG,Jun-Qiu SONG (Department of Pharmacology,School of Bask Medical Sciences,Tianjin Medical University,Tianjin 300070,China)

AIM To study the effects and mechanism of Diaoxinxuekang on hydrogen peroxide（HO） injured cardiomyocytes with a serum pharmacological *** Prepared the serum containing Diaoxinxuekang(600 mg·kg) with serum pharmacological *** derived from neonatal rats were cultured in Dulbecco Modified Eagle Medium（DMEM）.The cardiomyocytes were injured with hydrogen peroxide（HO）,and treated with the serum containing different concerntration of Diaoxinxuekang. The survival rates of cardiomyocytes was measured with MTT *** content of malondialdehyde（MDA） and lactate dehydrogenase（LDH）,and the activity of total superoxide dismutase（T-SOD） and catalase（CAT） were *** The survival rates of cardiomyocytes injured with HO for 2 h were decreased significantly compared with normal cells（P<0.01 ）.The content of MDA and LDH were increased significantly,but the activity of T-SOD and CAT were *** treated with the different concentrations of drug-containing serum,the survival rate were increased with a dose-dependant manner（P<0.01 ）.The content of MDA and LDH were decreased and the activity of SOD and CAT were significantly increased（P<0.01 ）.CONCLUSION Diaoxinxuekang can protect the HO injured cardiomyocytes by increasing antioxidation capability.

关键词： Diaoxinxuekang serum pharmacologic method cardiomyocyte anti-oxidant activity

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New inspiration on vitiligo pathogenesis and anti-vitiligo drug development

New inspiration on vitiligo pathogenesis and anti-vitiligo d...

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第二届世界天然药物和传统药物药理学学术会议

作者： Jing SHANG,Qian WANG,Sha LIAO,Jia ZHOU,Feng-Feng PING,Di HAO (Drug Screening Center,State Key Laboratory of Natural Medicines,China Pharmaceutical University, Nanjing 210009,China)

Lots of studies have shown that many dermatoses are caused by the disturbances of the dynamic equilibrium established between the nervous,endocrine and immune systems instead of single reason,which make dermatosis difficult to cure and raise complicated problems in the development of new *** it the way offering new ideas for the development of drugs against vitiligo? The results showed that the psychic stress can inhibit the hair follicle melanin synthesis in C57BL/6 *** stress could inhibit the melanin synthesis by increasing the expression of neuropeptide SP and decreasing the level of 5-HT in mice skin *** stress could promote mast cell degranulation and release several kinds of mediates which activated mast cell by SP and CGRP,result in promoting melanocytes *** plays an important role in the melanocytes apoptosis induced by chronic *** antidepressant fluoxetine could directly promote the melanin synthesis,which was mediated partly by 5 -HT1A ***,fluoxetine and AV extraction could promote the melanin synthesis via neural system regulation.

关键词： chronic stress melanin synthesis substance P 5-HT1A receptor mast cell fluoxetine

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Effects of astragaloside Ⅳ on action potentials and ionic currents in Guinea pig ventricular myocytes

Effects of astragaloside Ⅳ on action potentials and ionic c...

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第二届世界天然药物和传统药物药理学学术会议

作者： Mei-Mi ZHAO~1,Jin-Sheng ZHAO~1,Gui-Lin HE~1,Xue-Fei SUN~1,Xue-Shi HUANG~2,Li-Ying HAO~(1*) (1.Department of Pharmaceutical Toxicology,School of Pharmaceutical Science,China Medical University, Shenyang 110001,China 2.Ministry of Health Key Laboratory of Congenital Malformation, China Medical University,Shenyang 110001,China)

AIM AstragalosideⅣ（AS-Ⅳ） is one of the main active constituents of astragalus membranaceus,the present study is to investigate the effects of AS-Ⅳon action potentials and membrane *** The electrophysiologic effects of AS-Ⅳwere checked in freshly isolated guinea pig ventricular myocytes with whole-cell patch clamp *** AS-Ⅳ1×10 mol·L significantly prolonged the action potential duration at 95%repolarization(APD) from（313.1±38.9） ms to（785.3±83.7）***-Ⅳat 1×l0 mol·L enhanced the inward rectified potassium currents(I) and inhibited the delayed rectified potassium currents（I）.AS-IV at 1×l0 mol·L depressed Ca current(I) from（-607.3±37.5）pA to（-321.1±38.3）pA. AS-Ⅳincreased the intracellular Ca release by 3 *** AS-Ⅳprolonged APD of guinea pig ventricular myocytes,and might handle Ca signaling through suppression of I and strengthening the intracellular Ca release.

关键词： astragalosideⅣ ventricular myocytes ion channels action potential patch clamp

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Baicalin significantly inhibit the herpes simplex virus type 1 alkaline nuclease and stop herpes simplex virus type 1 replication

Baicalin significantly inhibit the herpes simplex virus type...

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第二届世界天然药物和传统药物药理学学术会议

作者： Maria G MASUCCI Department of Cell and Molecular Biology Karolinska InstituteBox 28517177 StockholmSweden

＜正＞AIM In order to find an effective antiviral drug against the herpes simplex virus type 1（HSV-1） and understand its mechanism,we have screened alkalescence endonuclease（AN）-dependent *** We have constructed a plasmid, pET28-UL12,with an insertion of a DNA fragment containing the UL12 gene of HSV-1 SM44,which is 99.2%homologous to the UL12（Gene ID:2703382 from the GenBank）,into the prokaryotic expression vector *** transformation in Escherichia coli,only kalamycin-resistant clones were *** of recombinant proteins in Escherichia coli restored the natural activity of the *** The anti-AN activities detected in several drugs extracted from herbs were confirmed by different degrees of inhibition on the enzymatic activities,similar to the research in Vero cells that exhibited different levels of inhibiting viral infection by these *** result showed that most of these drugs can dramatically interfere with HSV-1 infection on the Vero cells,but only baicalin can significantly inhibit the rAN and stop HSV-1 *** results showed that Baicalin had a strong interaction with critical amino acid residues of AE（identity 21.12%,similar residues 41.35%,compared with rAN by DNAMAN 6.0,data not shown） which was expressed by Epstein-Barr *** This DNA degradation assay is a useful tool to rapidly screen the inhibitors of HSV-1 at the molecular level,also representing a potential target for novel antiviral therapies.

关键词： baicalin herpes virus alkaline nuclease inhibitor

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Blood-glucose regulation effect of a salvia polyphenolic acid-salvianolic acid A

Blood-glucose regulation effect of a salvia polyphenolic aci...

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第二届世界天然药物和传统药物药理学学术会议

作者： Xiu-Ying YANG,Li ZHANG,Guan-Hua DU (Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)

AIM Salvianolic acid A（SalA） is one of the main active ingredients of Salvia *** objective of this study was to evaluate the effect of SalA on blood glucose level and the related *** Normal mice,diabetic rats and spontaneously diabetic KKay mice were used to study the role of SalA on animal *** human hepatoma cell line Bel-7401 was also used to study the role of SalA on cell glucose *** Our results showed that SalA slightly reduced the normal mice blood glucose *** at 1 -3 mg·kg reduced blood glucose,GHB,AGEs level in diabetic *** 1 - 3 mg·kg could increase pancreatic islets size and number of diabetic *** could improve the glucose absorption of human hepatoma cell line *** could improve the ATP production,improve the mitochondria function,and Increase the MAPK pathway *** Our data suggested that SalA could decrease the blood-glucose level on diabetic animals. The mechanisms studies suggest that the blood-glucose modulation effect of SalA might contribute to the increased function of mitochondria and enhanced MAPK pathway.

关键词： diabetes salvianolic acid A blood-glucose mitochondrion MAPK

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Curcumin and ginkgolide B inhibit renal cyst development

Curcumin and ginkgolide B inhibit renal cyst development

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第二届世界天然药物和传统药物药理学学术会议

作者： Bao-Xue YANG,Jin-Sheng GAO,Hong ZHOU,Tian-Luo LEI (Department of Pharmacology,School of Basic Medical Sciences,Peking University,and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100191,China)

AIM To develop candidate drugs for treating autosomal dominant polycystic kidney disease(PKD) from natural compound *** An MDCK cyst model,a murine embryonic kidney cyst model and a PKD mouse model were used to screen positive compounds and to evaluate cyst inhibitory *** viability,proliferation,apoptosis,CFTR function and expression, and signaling pathways in MDCK cells were determined to explore the mechanism of cyst *** Curcumin and ginkgolide B were found to significantly inhibit MDCK cyst development in both MDCK cyst model and embryonic kidney cyst model with dose-response *** two compounds neither induced cytotoxicity nor apoptosis in MDCK *** failed to affect the chloride transporter CFTR expression and ***,curcumin and ginkgolide B inhibited forskolin-promoted cell proliferation and promoted the tubule formation in MDCK cells,which indicates they promotes MDCK cell ***, curcumin and ginkgolide B altered Ras/MAPK signaling *** B significantly inhibited cyst enlargement in PKD mouse *** Both curcumin and ginkgolide B inhibit renal cyst formation and enlargement,suggesting that these natural compounds or their analogues might be developed into novel candidate drugs for polycystic kidney disease.

关键词： curcumin ginkgolide B natural product ADPKD renal cyst

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Preparation and characterization of a new certified reference material of puerarin(GBW09511)

Preparation and characterization of a new certified referenc...

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第二届世界天然药物和传统药物药理学学术会议

作者： Yang LU~(1,2),Ning-Bo GONG~1,Yong-Hui GUO~1,Ning YANG~1,Zhao-lin GAO~(1,2),Guan-Hua DU~(1,2) (1.Center of Pharmaceutical Polymorph,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China 2.Key Laboratory of Polymorph Pharmaceutical of Shandong Province,Tengzhou 277500,China)

AIM To prepare and research the characteristics of puerarin as a certified reference materials(CRMs) for the crucial quality assurance to validate measurementmethods which deliver reliable and accurate *** Sample preparation, homogeneity study,stability study,value characterization,and evaluation of uncertainty of a new CRM of puerarin are *** homogeneity was checked by differential scanning calorimetry *** under differentstorageconditions. RESULTS The CRM described above was homogeneousandstable at 25℃for at least one *** certified value of puerarin CRM is 99.66%with an extended uncertainty of 0.48%(k = 2).CONCLUSION The new CRM of puerarin can be used to validate analytical methods,improve the accuracy and comparability of measurement data,establish meteorological traceability of analytical resultsas well as control the quality of puerarin in relevant food and pharmaceutical formulations.

关键词： puerarin differential scanning calorimetry

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Synergistic proliferation-inhibiting effects of GP and paclitaxel on MGC80-3 cells

Synergistic proliferation-inhibiting effects of GP and pacli...

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第二届世界天然药物和传统药物药理学学术会议

作者： Cong WANG,Sai-Qi WANG,Ran DONG,Liu-Bin GUO,Hong-Min LIU~* (School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China)

AIM To investigate the proliferation-inhibiting effects and mechanisms of the combination of an active ingredient from Rabdosia rubescens GP and paclitaxel（PTX） on human gastric cancer MGC80-3 cells in *** After administration of GP(0.5 -4μmol·L ) or PTX(1-8 nmol·L ),or the combination for 48 h,MTT assay was used to detect the inhibition rates and the drug combination was determined by Chou-Talalay method through calculating combination index（CI） *** expression of p53 was evaluated by Western *** The inhibition rates of combination groups were remarkablely higer than that of the respective single-agent *** the inhibition rate was higer than 30%,the combination of GP and PTX produced the CI below 1,suggesting a synergy between GP and PTX in inhibiting cell *** blot results showed that the combination treatment caused an increased expression of p53 in a dose-dependent manner compairing to either GP or PTX *** GP synergistically enhanced the proliferation-inhibiting effect of PTX in human gastric cancer MGC80-3 cells in vitro and the potential mechanism may be the activation of p53 pathway.

关键词： GP MGC80-3 combination index p53

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Effect of resveratrol on neonatal rat cardiac myocytes exposure to high-glucose

Effect of resveratrol on neonatal rat cardiac myocytes expos...

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第二届世界天然药物和传统药物药理学学术会议

作者： Ji-Liang WU,Chao LIU,Shuang GUO (Hubei Province Key Laboratory on Cardiovascular,Cerebrovascular,and Metabolic Disorders,Xianning University, Xianning 437100,China)

AIM Through culturing cardiac myocytes of neonatal Sprague-Dawley rats in vitro,observe the effects of resveratrol （Res） on cardiac myocytes exposure to high-glucose（HG）,and then explore the possible *** Ventricular myocytes were isolated from neonatal rat and *** cells were divided into three groups:normal-glucose(NG,5.5 mmol·L ) group,the HG 30 mmol·L group,and the HG + Res(50μmol·L ) *** cell viablity was calculated by CCK8 measurement. The activity of LDH and the fluorescence intensity of ROS were determined by biochemical *** and FCM detected the rate of apoptosis;Bcl-2 and Bax protein expression were measured by Western *** Compared with NG group,the LDH level and ROS generation increased significantly in HG *** could inhibit the releasing of LDH and attenuate intracellular ROS generation, ***,HG induced apoptotic cell *** decreased the apoptosis evidently through up-regulating Bcl-2 and down-regulating Bax proteins *** It seemed that Res could reduce cardiac myocytes apoptosis exposure to *** underlying mechanism may be result from its capacity of scavenging ROS and up-regulating the ratio of Bcl-2 and Bax ratio.

关键词： resveratrol high-glucose damage reactive oxygen species apoptosis

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番茄红素对糖尿病模型大鼠肾损伤的治疗及血管紧张素转换酶的作用

番茄红素对糖尿病模型大鼠肾损伤的治疗及血管紧张素转换酶的作用

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第二届世界天然药物和传统药物药理学学术会议

作者：吴博江海燕王一龙朱加银赵惠玲温州医学院实验动物中心温州医学院眼视光学院

目的观察番茄红素对糖尿病性肾病的治疗作用及其可能的作用机制。方法采用高糖高脂饮食加链脲佐菌素法制备2型糖尿病大鼠模型。2型糖尿病大鼠分别ig给予番茄红素5,10和20 mg·kg每天1次,连续8周。8周后取尾尖血用罗氏血糖仪测定空... 详细信息

目的观察番茄红素对糖尿病性肾病的治疗作用及其可能的作用机制。方法采用高糖高脂饮食加链脲佐菌素法制备2型糖尿病大鼠模型。2型糖尿病大鼠分别ig给予番茄红素5,10和20 mg·kg每天1次,连续8周。8周后取尾尖血用罗氏血糖仪测定空腹血糖（FBG）含量,腹主动脉采血后分离血清和血浆,用全自动生化分析仪测定血清肌酐（Scr）、尿素氮（BUN）和24 h尿蛋白（UP）含量,放免法检测血浆胰岛素（Ins）、血管紧张素Ⅱ（AngⅡ）和肾组织AngⅡ含量。HE染色观察肾组织病理形态的变化,RT-PCR法检测肾组织血管紧张素转换酶（ACE）和ACE2 mRNA的表达,Western印迹法检测肾组织ACE2蛋白的表达。结果与正常对照组相比,模型对照组FBG,Ins,Scr,BUN,AngⅡ和24 h UP含量均明显升高（P<0.05）;与模型对照组相比,番茄红素10和20 mg·kg组Scr,BUN,AngⅡ和24 h UP含量均显著降低,Scr由（54.2±4.3）μmol·L分别降低到40.3±2.0和（34.4±3.8）μmol·L,BUN由（17.7±2.3）mmol·L分别降低到15.5±1.2和（13.1±0.5）mmol·L,血浆中AngⅡ由（858±56）ng·L分别降低到680±62和（623±64）ng·L,肾组织AngⅡ由（19.8±2.9）ng·g分别降低到16.7±2.6和（13.6±2.4）ng·g蛋白,24 h UP由（16.4±3.5）mg分别降低到13.7±1.9和（9.9±2.3）mg（P<0.05）。与正常对照组相比,模型对照组ACE2,ACE mRNA和ACE2蛋白表达水平显著降低（P<0.01）,与模型对照组相比,番茄红素5,10和20 mg·kg组ACE2 mRNA和蛋白表达水平则显著升高（P<0.05）,其中番茄红素20 mg·kg组效果更为明显（P<0.01）;ACE mRNA表达水平与模型对照组无明显差异。结论番茄红素能降低糖尿病模型大鼠蛋白尿,改善肾功能,减轻肾组织病理变化,增强肾组织ACE2 mRNA和蛋白的表达,提示番茄红素对糖尿病性肾病的治疗作用可能与抑制肾局部肾素-血管紧张素系统的途径有关。

关键词：番茄红素糖尿病性肾病血管紧张素转换酶

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