Background and Purpose:Pseudoginsenoside-F11(PF11),an ocotillol-type saponin,is one of the ingredients of Panax quinquefolium(American ginseng), previously isolated from leaves of Panax pseudoginseng *** HARA (Himalay...
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Background and Purpose:Pseudoginsenoside-F11(PF11),an ocotillol-type saponin,is one of the ingredients of Panax quinquefolium(American ginseng), previously isolated from leaves of Panax pseudoginseng *** HARA (Himalayan Panax),but not in Panax *** previous experiments showed that
Aim:The aim of this study was to investigate the cognition-enhancing activity and underlying mechanisms of a triterpenoid saponin (polygalasaponin XXXII,PGS32) isolated from the roots of Polygala tenuifolia Willd.
Aim:The aim of this study was to investigate the cognition-enhancing activity and underlying mechanisms of a triterpenoid saponin (polygalasaponin XXXII,PGS32) isolated from the roots of Polygala tenuifolia Willd.
人参皂苷作为人参的代表性成分,对中枢神经系统具有显著的调控作用,表现为:1.人参皂苷可显著提高啮齿类动物的学习记忆能力,例如由Aβ模拟的老年痴呆模型,由脑缺血导致血管性痴呆模型,由衰老导致的学习记忆功能减退、人参皂苷Rg1和Rb1均表现出良好的保护作用;2.人参皂苷可显著促进新突触的形成,具有增强细胞之间的通讯的潜能;3.人参皂苷Rg1和Rb1可显著提高突触传递水平,诱导海马-齿状回长时程增强(Long term potential,LTP)的出现。4.人参皂苷Rg1和Rb1可显著促进谷氨酸的释放,但两者分别通过PKA介导的信号转导途径和CaMKⅡ介导的信号转导途径;5.人参皂苷可显著上调NMDA受体在突触上的分布,激活细胞内保护作用机制。基于以上研究,提示我们人参皂苷可通过提高兴奋性神经传递发挥神经保护作用。有趣的是,人参皂苷在提高兴奋性传递的同时,亦可拮抗兴奋性神经毒性。例如在大鼠脑缺血模型、慢性不可预知应激抑郁模型,由内毒素引起的脑内炎症反应,均存在谷氨酸兴奋性毒性机制,而人参皂苷亦表现出良好的保护作用,其机制有待于进一步深入探讨。
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