A critical decision faced by cells is whether or not to *** organisms evaluate environmental and cellular conditions to make the *** investigate the strategy and mechanism of this process in budding yeast,through a co...
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A critical decision faced by cells is whether or not to *** organisms evaluate environmental and cellular conditions to make the *** investigate the strategy and mechanism of this process in budding yeast,through a combination of mathmatical modeling and single cell *** found that in yeast cells the decision making is dependent on the time integration of a signaling molecule that is sensitive to the environmental *** a strategy takes into account not only the present status but also the past history of the environment,thus filtering out noise in a fluctuating enviroment. Our findings also shed light on the mechanism of the cell size control at the Start checkpoint.
系统生物学是系统性地研究一个生物系统中所有组成成分的构成以及在特定条件下这些组分间的相互关系,并分析生物系统的动力学过程的科学。系统生物医学是采用系统论方法研究生物医学,也就是系统生物学的医学应用研究。系统生物医学全方位,立体化,多视角研究生命全过程与疾病全过程,揭示人体的生理和病理机制,并提出疾病的诊断和防治措施与方法。系统生物医学是一种整合型大科学。需要实现不同构成要素(基因、mRNA、蛋白质、生物小分子等)的整合;同时,要实现从基因到细胞、到组织、到个体的不同层次上的整合。基于系统生物医学的整合性,以及其高难度和高复杂度,需要医学家、生物学家、数学、计算机科学等多学科领域进行交叉研究。系统生物医学的概念在上世界90年代有所涉及。1992年,日本。Kamada T.发表了题头为系统生物医学(system bio-medicine)词汇的论文,同时,中国曾邦哲(ZengBJ.)1992年4月于首届全国中西医学比较研讨会(广州)阐述了系统医药学(systemsmedicine and pharmacy)的概念与模型,提出需要多学科交叉系统生物学还是典型的多学科交叉研究,它需要生命科学、信息科学、数学、计算机科学等各种学科的共同参与。然而,由于生物学方面的高通量研究手段的缺乏,系统生物医学的概念当时并未受到广泛关注。近年来,随着现代生命科学理论与技术的发展,为生命现象的系统、科学评估提供了准确的技术手段,产生了诸如组学研究等生物信息学的技术方法,系统生物医学日益受到重视和普及。21世纪的医学模式是生物-心理-社会的医学模式,其研究对象不仅是自然的人体,还包括人的状态和人所处的社会和自然环境,人体健康是建立在人与环境的和谐适应的基础上。系统生物医学探讨如何将生物信息学与系统生物学的新研究手段与成果应用到整体医学的科学问题研究中去,通过组学研究和计算分析的方法,在分子和细胞水平上基本清晰亚临床、临床的致病原因;理解机体状态以及机体和环境相互作用对于健康状态和对于疾病发生发展的影响;揭示复杂疾病的致病机理、并探索诊断与治疗的新方法。同时,系统生物医学的发展将使得个体化治疗成为可能,可以预测个体治疗效果,设计个体化预防与治疗的综合方案;并且可以在症状出现前有效持久地保持正常健康状态,最后达到促进全民健康的目的。
The traditional 16S rRNA sequence analysis and DNA-DNA hybridization experiment lack resolution power at the species level and ***,in clinic practice and environmental studies there is an urgent need to distinguish st...
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The traditional 16S rRNA sequence analysis and DNA-DNA hybridization experiment lack resolution power at the species level and ***,in clinic practice and environmental studies there is an urgent need to distinguish strains at species level and *** whole-genome-based and alignment-free CVTree approach provides the required *** use the examples of the Shigella-Escherichia,Yersinia pestis - Yersinia pseudotuberculosis problems to demonstrate the potential application of the CVTree method.
Background:Introduce high throughput drug screening technology research progress. Methods:According to the papers published in recent years,this paper introduced relative knowledge about medicine researching and high ...
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Background:Introduce high throughput drug screening technology research progress. Methods:According to the papers published in recent years,this paper introduced relative knowledge about medicine researching and high throughput screening *** last,application of this technology was stated. Results:Cell level screening is in a natural living cell conditions,close to the biochemical process of the body,and have much more targets,index to detect and can shorten the cycle of drug discovery. Conclusions:High throughput drug screening technology has broad prospects.
The application of ChlP-seq and DNase-seq in recent years has greatly expedited the mechanistic understanding of transcriptional and epigenetic gene *** epigenetic profiles are often considered a reflection of the ove...
The application of ChlP-seq and DNase-seq in recent years has greatly expedited the mechanistic understanding of transcriptional and epigenetic gene *** epigenetic profiles are often considered a reflection of the overall transcriptional activities, the dynamics of epigenetic profiles can be effectively mined to reveal novel transcriptional mechanisms.I will introduce approaches using the dynamics of DNase-seq to infer prostate cancer gene regulatory network,and dynamics of ChlP-seq to infer the gene activation function of EZH2 in hormone independent prostate cancers.
Somatic cells can be reprogrammed to embryonic stem cell-like state by introducing few reprogramming *** by the phenomenological reprogramming model of Artyomov et al.(2010),we proposed a novel Markov model with more ...
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Somatic cells can be reprogrammed to embryonic stem cell-like state by introducing few reprogramming *** by the phenomenological reprogramming model of Artyomov et al.(2010),we proposed a novel Markov model with more realistic gene regulation rules and explored various properties of the model with Monte Carlo ***,we demonstrated the utility of our model by testing it with the real dynamic gene expression data spanning across different intermediate stages in the iPSC reprogramming *** data can be predicted and explained by our model reasonably well;in turn,it lands further support on our general rules of gene regulation in iPSC reprogramming.
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