Nanotechniques - techniques submicron in size - permit interaction with the nervous system at the cellular or subcellular level. Three nanotechniques with great promise for neurorestoration are carbon nanotubes/nanofi...
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Nanotechniques - techniques submicron in size - permit interaction with the nervous system at the cellular or subcellular level. Three nanotechniques with great promise for neurorestoration are carbon nanotubes/nanofibers, nanoparticles, and nanoscaffolds. After introducing the nanoscale and the fabrication of these nanodevices, the clinical application of these three nanotechniques is considered. Carbon nanotubes/nanofibers enable the efficient
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to possess neuroprotective and neuroregenerative activity in the adult central system, particula...
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Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to possess neuroprotective and neuroregenerative activity in the adult central system, particularly for midbrain dopamine neurons (MDN). There is a considerable recent literature on trophic properties of TGF-β superfamily proteins for MDN's, including glial cell-derived neurotrophic factor (GDNF), neurturin, and bone morphogenetic
It is a great honour and a great pleasure to welcome this distinguished gathering. What thoughts can I-as a scientist-offer to congratulate and to encourage this international assemblage of pioneers here in Xian? As a...
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It is a great honour and a great pleasure to welcome this distinguished gathering. What thoughts can I-as a scientist-offer to congratulate and to encourage this international assemblage of pioneers here in Xian? As a scientist, I seek to consider two questions: Why do we think of transplanting cells? And: Why is any more science needed? Underlying our optimism is the concept that the nerve cells and nerve fibres of the adult brain and spinal
Chronic Spinal Cord Injured patients have lost potential of recover neurologic functions innervated under the affected area. Rehabilitation programs are oriented only to preserve and maximize function of innervated mu...
Chronic Spinal Cord Injured patients have lost potential of recover neurologic functions innervated under the affected area. Rehabilitation programs are oriented only to preserve and maximize function of innervated muscle. Denervated muscles suffer progressive atrophy associated to muscle fibrosis. Many regenerative therapies fail for the mentioned rehabilitation programs. To overcome this problem, we have developed a rehabilitation approach that seems to
Background Following a nerve crush, restoring neurological function requires the damaged axons to regenerate in association with the Schwann cells and their extracellular matrix of the old nerve pathway from the injur...
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Background Following a nerve crush, restoring neurological function requires the damaged axons to regenerate in association with the Schwann cells and their extracellular matrix of the old nerve pathway from the injury site to their original denervated targets. When trauma creates a nerve gap, restoration of function requires the severed axons be promoted to regenerate across the nerve gap to reach their distal nerve pathway, through which they
Olfactory ensheathing cells (OECs) are considered to be the most suitable cells for transplantation in the spinal cord injury (SCI), which have been used as a therapeutic strategy to repair the anatomical structure an...
Olfactory ensheathing cells (OECs) are considered to be the most suitable cells for transplantation in the spinal cord injury (SCI), which have been used as a therapeutic strategy to repair the anatomical structure and promote the function recovery of injured spinal cord in both animal and human after the administration of cells in different forms (either alone or in combination with other cells, drugs, products or devices) (Doucette JR, 1984;Barnett SC,
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