cSCI patients have not an appropriate vascularization of the damaged area, neither the Spinal Cord distal segment that, as consequence of the lack of brain connections, is also atrophied. The activity of pro repair in...
cSCI patients have not an appropriate vascularization of the damaged area, neither the Spinal Cord distal segment that, as consequence of the lack of brain connections, is also atrophied. The activity of pro repair inflammatory activity has disappeared. Conversely, there is a chronic inflammation that has generated an extracellular matrix which prevents repair. Stem Cells are not attracted to the injured area. The brain cortex disrupted the normal
Protein kinases regulate diverse cellular functions through the orchestrated propagation and amplification of cellular stimuli into distinct biological responses via coordinated signal transduction cascades. With seve...
Protein kinases regulate diverse cellular functions through the orchestrated propagation and amplification of cellular stimuli into distinct biological responses via coordinated signal transduction cascades. With several hundred kinases encoded in the human genome, almost every signal transduction process is influenced by interconnected phosphorylation events. Deregulation of kinase activity has been implicated in various diseases, ranging from vascular
Distraction osteogenesis (DO) techniques have been widely accepted and practiced in orthopaedics, traumatology, and craniofacial surgery over the last two decades, using DO methods, many previously untreatable conditi...
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Distraction osteogenesis (DO) techniques have been widely accepted and practiced in orthopaedics, traumatology, and craniofacial surgery over the last two decades, using DO methods, many previously untreatable conditions have been successfully managed with outstanding clinical outcomes. Although the biological mechanisms of DO are still not yet fully defined, it is generally accepted that mechanical stimulation is the key in promoting and maintaining
Because of recent advances in cell biology, neuroregenerative interventions, neural injury and repair, and development of neurorestorative interventions,using comprehensive measument tool is very important. Based on t...
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Because of recent advances in cell biology, neuroregenerative interventions, neural injury and repair, and development of neurorestorative interventions,using comprehensive measument tool is very important. Based on the complexity of the processes of demyelination and remyelination, degeneration and regeneration, damage and repair, functional loss and recovery,different assessment measures for evaluation of the patients before and
A. Background Cognition is occupying more and more centre stage in neuro-science and neurorehabilitation for following reasons. 1. Increasingly long life expectancy associated with a high incidence of cognitive impair...
A. Background Cognition is occupying more and more centre stage in neuro-science and neurorehabilitation for following reasons. 1. Increasingly long life expectancy associated with a high incidence of cognitive impairments. According to World Bank, age-related cognition impairment is a problem more associated with economical development and more commonly seen in the developed world. Special attention should be paid to insulin-resistant receptor that
Carlos Lima et al. who are pioneers in this field reported their clinical pilot study of olfactory mucosa transplantation for chronic spinal cord injury. They showed the safety and feasibility of it. Olfactory mucosa ...
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Carlos Lima et al. who are pioneers in this field reported their clinical pilot study of olfactory mucosa transplantation for chronic spinal cord injury. They showed the safety and feasibility of it. Olfactory mucosa contains the olfactory ensheathing cells and neural stem cells. Recent studies have demonstrated the potential therapeutic role of both cells in spinal cord injury. We have already reported the effectiveness of olfactory mucosa
Several stem cell based therapeutic tools are being investigated for regeneration of CNS injuries and neurodegenerative diseases.. In contrast to the majority of cells isolated from adult tissues stem cells (SC) in um...
Several stem cell based therapeutic tools are being investigated for regeneration of CNS injuries and neurodegenerative diseases.. In contrast to the majority of cells isolated from adult tissues stem cells (SC) in umbilical cord and cord blood (CB) possess several unique characteristics. The main drawback of CB is the limited number of cells available from the single unit. Therefore the development of methods of direct expansion of certain lineages
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