Objective:This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplanta-tion (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Methods: Patie...
Objective:This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplanta-tion (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Methods: Patients whose recovery had plateaued for longer than 6 months were enrolled. Six thoracic patients were tested for safety and five cervical patients for efficacy. OEGT was performed according to the method developed by Huang. Results: Average
There is increasing evidence that cerebrovascular dysfunction plays a role in vascularcauses of cognitive impairment (VCI) and also in Alzheimer's disease (AD). Coexistenceof ischemic and neurodegenerative patholo...
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There is increasing evidence that cerebrovascular dysfunction plays a role in vascularcauses of cognitive impairment (VCI) and also in Alzheimer's disease (AD). Coexistenceof ischemic and neurodegenerative pathology was found to have a profound impact onthe expression of the dementia, suggesting reciprocal interactions. This presentation will highlight some important molecular mechanisms involved in thecomplexity of vascular changes underlying
Motor disability continues to be a major cause of morbidity after stroke. The neural underpinnings of disability and of functional recovery are still unclear. Here, we review recent evidence obtained using behavioral ...
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Motor disability continues to be a major cause of morbidity after stroke. The neural underpinnings of disability and of functional recovery are still unclear. Here, we review recent evidence obtained using behavioral paradigms and different techniques including transcranial magnetic stimulation (TMS) that provides new insight into these mechanisms.. We briefly discuss the use of these techniques in the diagnosis, prognosis, and therapy of post-stroke
Spinal cord injury (SCI) is a disastrous illness which has bad effect on health and society. Researchers have always been looking for a suitable and effective treatment of SCI. Myelotomy using for SCI treatment has ov...
Spinal cord injury (SCI) is a disastrous illness which has bad effect on health and society. Researchers have always been looking for a suitable and effective treatment of SCI. Myelotomy using for SCI treatment has over a hundred-year history. Because there are lots of new researches about SCI treatment and myelotomy has higher risks during operation, scientific researches about myelotomy have not been paid enough attention. But facing with SCI
A Clinical study was carried out on seventy five chronic spinal cord injury patients to know the effects of Neuroregenerative Neurorehabilitation therapy using autologous bone marrow derived mononuclear cells which we...
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A Clinical study was carried out on seventy five chronic spinal cord injury patients to know the effects of Neuroregenerative Neurorehabilitation therapy using autologous bone marrow derived mononuclear cells which were transplanted intrathecally. Out of seventy five cases, 48 were paraplegics and the rest 27 were quadriplegics. The parameters used to evaluate the patients were ASIA (American Spinal Injury Association) scale, FIM (Functional Independence
Various in vitro studies have provided evidence that terminally differentiated mammalian cells can undergo dedifferentiation upon injury or when the cells are cultured under special conditions. Our previous study demo...
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Various in vitro studies have provided evidence that terminally differentiated mammalian cells can undergo dedifferentiation upon injury or when the cells are cultured under special conditions. Our previous study demonstrated that after in vitro induction and differentiation into 5 hydroxytryptamine (5-HT)-sensitive neurons, rat bone marrow derived mesenchymal stem cells (MSCs) could revert back, or dedifferentiate, to a morphological and phenotypical state
Traumatic spinal cord injuries (TSCI) are life-changing events from medical, physical, psychological, social, financial, vocational, environmental & matrimonial effects. The combination of consequent general physi...
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Traumatic spinal cord injuries (TSCI) are life-changing events from medical, physical, psychological, social, financial, vocational, environmental & matrimonial effects. The combination of consequent general physiological impairment, multi-system malfunction, multiple disabilities, wide range of potential complications, sensory impairment together with the non-medical effects impose challenges to patients, carers and clinicians. 1 Although
Bromocriptine, a potent D2 receptor agonist, appears to have neuroprotective actions. To determine whether bromocriptine prevents motor neuron death in vitro and in vivo. In vitro experiment Decreased SOD could contri...
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Bromocriptine, a potent D2 receptor agonist, appears to have neuroprotective actions. To determine whether bromocriptine prevents motor neuron death in vitro and in vivo. In vitro experiment Decreased SOD could contribute neuron damage in vitro model of spinal cord cultures. Simultaneous treatment with bromocriptine and DDC, which is decreased level of SOD activity prevent motor neuron damage. In vivo experiment To investigate whether bromocriptine
Transplantation of neural stem cells (NSCs) prevents functional deterioration following traumatic brain injury (TBI). Previously we demonstrated that human NSCs, via releasing glial cell line-derived neurotrophic fact...
Transplantation of neural stem cells (NSCs) prevents functional deterioration following traumatic brain injury (TBI). Previously we demonstrated that human NSCs, via releasing glial cell line-derived neurotrophic factor (GDNF), preserved cognitive function in rats following fluid percussion TBI. However, the underlying mechanisms remain elusive. In this study, we report that NSC grafts prevent TBI-induced axonal degeneration in fimbria by
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