Objective To establish a simple and practical (SP) scoring system to predict the prognosis of hepatitis B related acute-on-chronic liver failure(HBV-ACLF) and study the predictive value of the model for end-stage live...
Objective To establish a simple and practical (SP) scoring system to predict the prognosis of hepatitis B related acute-on-chronic liver failure(HBV-ACLF) and study the predictive value of the model for end-stage liver disease (MELD) scoring system in patients with *** A total of 191 patients with HBV-ACLF were recruited between January 1,2010 and December 31,2011 and followed up for 3 months, 105 patients died and 89 patient survived.
Objective The oral microbiota plays a critical role in the maintenance of a normal oral physiological environment and in development of oral diseases, such as periodontal disease and tooth *** direct and indirect meta...
Objective The oral microbiota plays a critical role in the maintenance of a normal oral physiological environment and in development of oral diseases, such as periodontal disease and tooth *** direct and indirect metabolism of chemical carcinogens and through systemic inflammatory effects, the oral microbiome might be important in other chronic *** which species are present and how the community is composed in healthy oral microbiome is the first step towards understanding how changes can lead to disease.
Background and Aims A recent genome-wide small interfering RNA (siRNA) screen in our laboratory identified a network of host factors mediating antiviral effects against HCV, which included the Elongation factor Tu GTP...
Background and Aims A recent genome-wide small interfering RNA (siRNA) screen in our laboratory identified a network of host factors mediating antiviral effects against HCV, which included the Elongation factor Tu GTP binding domain containing 2 (EFTUD2) *** studies have reported EFTUD2' s role in regulating the innate immune ***, we sought to determine how EFTUD2 mediates its anti-HCV activity.
Objective The aim of this study was to evaluate the one-month immune response to two different doses (10 and 20 μg) of recombinant hepatitis B vaccine in adults aged 25-46 *** Among 739 subjects, 62 (9.70%) were posi...
Objective The aim of this study was to evaluate the one-month immune response to two different doses (10 and 20 μg) of recombinant hepatitis B vaccine in adults aged 25-46 *** Among 739 subjects, 62 (9.70%) were positive for HBsAg, and 317 subjects were eligible.
Paneth cells are a highly-specialized secretory cells at the bottom of the crypt in small *** cells play an essential role in maintaining intestinal homeostasis by secreting large amount of microbicidal peptides into ...
Paneth cells are a highly-specialized secretory cells at the bottom of the crypt in small *** cells play an essential role in maintaining intestinal homeostasis by secreting large amount of microbicidal peptides into gut *** many professional secretory cells, Paneth cells secrete microbicidal peptides through dense-core vesicles (DCVs).Currently, the mechanisms governing DCV cargo sorting are highly ***, we present evidence showing Dardarin, a highly interesting gene implicated in both Parkinson's disease and inflammatory bowel disease, plays an indispensable role in lysozyme sorting in Paneth *** deficient Paneth cells lack lysozyme in DCVs, which renders the mice more susceptible to intestinal *** mechanistic investigation has shown Dardarin forms a platform on the surface of DCVs to recruit important components governing cargo *** deficiency leads to the failure of such *** results not only illustrate the important physiological function of Dardarin, but also could shed light on the general mechanism governing DCV cargo sorting.
Objective The treatment of liver diseases associated with chronic hepatitis B virus (HBV) infection has become a major clinical challenge, partly due to the many drug-resistant HBV mutants induced by wide application ...
Objective The treatment of liver diseases associated with chronic hepatitis B virus (HBV) infection has become a major clinical challenge, partly due to the many drug-resistant HBV mutants induced by wide application of nucleoside/nucleotide *** the rate of resistance to adefovir dipivoxil (ADV) is relatively low, but in China is steadily *** investigated the loci of ADV-induced resistance of HBV isolates obtained from patients with chronic HBV infection-related liver diseases.
Background Metabolomics studies hold promise for the discovery of pathways linked to disease *** clinical practice, many cases often cause disruption of the gut *** aim of this work was to evaluate the effects of micr...
Background Metabolomics studies hold promise for the discovery of pathways linked to disease *** clinical practice, many cases often cause disruption of the gut *** aim of this work was to evaluate the effects of microflora variations on the body' s metabolic *** Sprague-Dawley rats received either saline, probiotics, Escherichia coli, Salmonella enteritidis, Gentamicin or MgS02 via daily gavage for 7 days, GC/MS analysis the serum metabolic profiles and intestinal bacteria was *** Probiotics can markedly reduce the content of Alanine , and in the nonpathogenic *** group, it significantly increase in alanine;orally administered *** caused many of these amino acids (alanine, leucine , isoleucine, serine)significantly reduce;an overall reduction in gut microflora due to orally administered Gentamicin resulted in a meaningful reduction in proline and butyric ***(s) The changed gut microflora have diverse effects on the serum metabolic profiles , especially on the Ammonia.
HBV is the causative agent of B-type hepatitis and accounts for a serious viral threat *** infection is associated with the appearance of many serological and molecular markers, that commonly detected with enzyme immu...
HBV is the causative agent of B-type hepatitis and accounts for a serious viral threat *** infection is associated with the appearance of many serological and molecular markers, that commonly detected with enzyme immunoassays (EIAs) and polymerase chain reaction (PCR)-based DNA ***,nanogolds and their bio-hybrid structures are attracting a wide body of interest as novel probing structures in biological detection and sensing applications.
Background and Aim Many studies suggested that the TGF-β1/IL-23 pathway play an important role in the progression of bleomycin-induced pulmonary fibrosis in ***, it remains unclear about the role of the TGF-β1/IL-23...
Background and Aim Many studies suggested that the TGF-β1/IL-23 pathway play an important role in the progression of bleomycin-induced pulmonary fibrosis in ***, it remains unclear about the role of the TGF-β1/IL-23 pathway in the mechanism of human disease, especially in hepatitis B virus (HBV) related acute -on-chronic liver failure (ACLF).
Objective Dental caries is the most common chronic childhood disease in the ***,there has been few knowledge about the oral microbiota of childhood from different *** aim of the study is to explore the microbiota in d...
Objective Dental caries is the most common chronic childhood disease in the ***,there has been few knowledge about the oral microbiota of childhood from different *** aim of the study is to explore the microbiota in dental plaque from chinese Han and She children by pyrosequencing *** Supragingival plaque were collected from 66 She and 60 Han children (3-6 years old) with or without dental *** V1-V3 hypervariable regions of bacterial 16S rDNA genes were amplified by multiply primers and analyzed by 454 high-throughput pyrosequencing.
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