Despite decades of intensive investigation,little,if any,progress has been made in slowing down disease progression of any major neurodegenerative disorders,including Alzheimer's disease(AD)and Parkinson's dis...
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Despite decades of intensive investigation,little,if any,progress has been made in slowing down disease progression of any major neurodegenerative disorders,including Alzheimer's disease(AD)and Parkinson's disease(PD).One of the major issues appears to be that by the time when AD or PD can be diagnosed definitively based on clinical evaluations,the
Parkinson’s disease(PD)is a kind of typical neurodegenerative ***,several studies have showed that deficits in olfactory and cognitive functions precede motor-symptoms in ***,the mechanisms of olfactory discriminatio...
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Parkinson’s disease(PD)is a kind of typical neurodegenerative ***,several studies have showed that deficits in olfactory and cognitive functions precede motor-symptoms in ***,the mechanisms of olfactory discrimination deficits in
Neurons change their synaptic connectivity by experience,which is fundamental to brain maturation and functions such as learning and *** elucidate the molecular mechanisms,one common approach is to study the changes o...
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Neurons change their synaptic connectivity by experience,which is fundamental to brain maturation and functions such as learning and *** elucidate the molecular mechanisms,one common approach is to study the changes of synapses in primary
Astrocyte-derived ATP,together with its degradation product adenosine,is known to regulate synaptic transmission through a presynaptic ***,little attention has been paid to the direct effect of gliotransmitters on the...
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Astrocyte-derived ATP,together with its degradation product adenosine,is known to regulate synaptic transmission through a presynaptic ***,little attention has been paid to the direct effect of gliotransmitters on the excitability of neuronal networks beyond *** found that selective stimulation of astrocytes expressing
Neural circuits process information by transmitting and computing signals at *** circuits thus critically depend on the number and location of synapses between the neurons that form the circuit and on the properties o...
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Neural circuits process information by transmitting and computing signals at *** circuits thus critically depend on the number and location of synapses between the neurons that form the circuit and on the properties of these *** a circuit for feedforward inhibition,for example,activity-dependent changes in the number of synapses
The conventional bioprobe design has been carried out by so-called hypothesis-driven *** basic assumption of hypothesis-driven approach is that the scientist"knows the target"in advance,and then design the r...
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The conventional bioprobe design has been carried out by so-called hypothesis-driven *** basic assumption of hypothesis-driven approach is that the scientist"knows the target"in advance,and then design the recognition motif for *** alternative approach
To explore the expression and distribution of PKA-Cβin the lateral dorsal thalamic nucleus of rats when learning and *** this experiment,we choose forty adult,male wistar rats,divided into experimental group and cont...
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To explore the expression and distribution of PKA-Cβin the lateral dorsal thalamic nucleus of rats when learning and *** this experiment,we choose forty adult,male wistar rats,divided into experimental group and control group,The two groups were asked five
Perceptual training plays an important role in improving the perceptual ***,a study[1]has found by recording the activities of neurons in monkeys performing a contour detection task that the response properties of the...
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Perceptual training plays an important role in improving the perceptual ***,a study[1]has found by recording the activities of neurons in monkeys performing a contour detection task that the response properties of the primary visual cortex(V1)change
Peripheral pain signal are coded by the electrical signals prorogating from the nociceptors to the central nerve *** channels are the fundamental determinants for these electrical *** such it is crucial to understand ...
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Peripheral pain signal are coded by the electrical signals prorogating from the nociceptors to the central nerve *** channels are the fundamental determinants for these electrical *** such it is crucial to understand the underlying ionic mechanisms for
Human autosomal recessive primary microcephaly(MCPH)is a neural developmental disorder hallmarked by significantly reduced brain size and variable intellectual *** of WD40-repeat protein 62(WDR62)is the second major c...
Human autosomal recessive primary microcephaly(MCPH)is a neural developmental disorder hallmarked by significantly reduced brain size and variable intellectual *** of WD40-repeat protein 62(WDR62)is the second major cause of ***
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