检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

1,102 篇 会议
2 篇 期刊文献

馆藏范围

1,104 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

709 篇 医学
- 647 篇 临床医学
- 70 篇 基础医学(可授医学...
- 43 篇 中西医结合
- 14 篇 药学(可授医学、理...
- 13 篇 中药学(可授医学、...
- 10 篇 中医学
- 3 篇 公共卫生与预防医...
- 3 篇 医学技术（可授医学...
- 2 篇 口腔医学
- 2 篇 护理学（可授医学、...
352 篇 理学
- 351 篇 生物学
- 1 篇 物理学
12 篇 工学
- 3 篇 计算机科学与技术...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
- 2 篇 生物医学工程（可授...
- 1 篇 机械工程
- 1 篇 光学工程
- 1 篇 仪器科学与技术
- 1 篇 电子科学与技术（可...
- 1 篇 公安技术
7 篇 教育学
- 3 篇 教育学
- 3 篇 体育学
- 1 篇 心理学(可授教育学...
6 篇 农学
- 4 篇 作物学
1 篇 法学
- 1 篇 公安学
1 篇 文学
- 1 篇 外国语言文学

主题

37 篇 parkinson's dise...
31 篇 hippocampus
28 篇 alzheimer's dise...
22 篇 microglia
16 篇 depression
15 篇 synaptic plastic...
14 篇 apoptosis
14 篇 learning and mem...
13 篇 neuroinflammatio...
13 篇 autophagy
12 篇 optogenetics
12 篇 astrocyte
12 篇 dopamine
12 篇 neuropathic pain
12 篇 neurogenesis
12 篇 proliferation
11 篇 anxiety
11 篇 epilepsy
10 篇 zebrafish
10 篇 ischemic stroke

机构

27 篇 university of ch...
16 篇 institute of neu...
14 篇 institute of neu...
12 篇 key laboratory f...
11 篇 neuroscience res...
10 篇 beijing institut...
10 篇 北京大学
8 篇 cell electrophys...
8 篇 school of biomed...
7 篇 national laborat...
7 篇 graduate school ...
7 篇 center for neuro...
7 篇 上海交通大学
7 篇 department of ph...
6 篇 shaanxi provinci...
6 篇 college of life ...
6 篇 department of ne...
6 篇 南方医科大学
6 篇 key laboratory o...
6 篇 institute of neu...

作者

12 篇 yun wang
12 篇 wei wang
11 篇 hong jiang
10 篇 meng-ya wang
9 篇 yong gu
9 篇 junxia xie
9 篇 jiu-lin du
9 篇 jing wang
9 篇 xiaomin wang
8 篇 zhong chen
8 篇 gang chen
8 篇 feng wang
8 篇 li wang
7 篇 jun wang
7 篇 jun zhang
7 篇 li yuan
7 篇 zhuan zhou
7 篇 hui li
7 篇 xiong-li yang
7 篇 jin-shun qi

语言

1,025 篇 英文
78 篇 中文
1 篇 法文

检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

共 1104 条记录，以下是1041-1050 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Somatostatin receptor-mediated suppression of GABAergic synaptic transmission in cultured rat retinal amacrine cells

Somatostatin receptor-mediated suppression of GABAergic syna...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Wen Chen Jiang-Bin Ke Hang-Jing Wu Yanying Miao Fang Li Xiong-Li Yang Zhongfeng Wang Institutes of Brain Science Institute of Neurobiology and State Key Laboratory of Medical NeurobiologyFudan University

Somatostatin(SRIF) is widely distributed in the central nervous system, which may modulate neurotransmitter release via activating the specific receptors(sst1-sst5). Our previous study showed that sst5 receptors are expressed in rat retinal GABAergic amacrine cells(ACs). In the present studies, we investigated modulation of GABA release by SRIF in cultured ACs, using patch-clamp techniques. We first characterized the spontaneous inhibitory postsynaptic currents(s IPSCs) recorded in the ACs. s IPSCs were completely blocked by application of either bicuculline or gabazine, and the reversal potential of s IPSCs was close to ECl-, indicating that these events were exclusively mediated by GABAA receptors. Increase of external Ca2+ concentrations from 2 m M to 5 m M significantly enhanced the frequency, but did not change the amplitude of s IPSCs. In contrast, perfusion of Ca2+-free external solution greatly reduced the events of s IPSCs and decreased the amplitude of sI PSCs. Furthermore, the ryanodine receptor antagonist dantrolenefailed to affect s IPSCs, while the inositol 1,4,5-trisphosphate(IP3) receptor antagonists 2-APB and xestospongin C significantly decreased the frequency of sI PSCs. In the presence of SKF96365, a non-specific transient receptor potential channel blocker, 2-APB persisted to show its effect on s IPSCs. Further experiments showed that the frequency of s IPSCs in the ACs was significantly reduced by SRIF, which was partially reversed by BIM 23056, an sst5 receptor antagonist, and was further rescued by addition of CYN-154806, an sst2 receptor antagonist. Both nimodipine, an L-type Ca2+ channel blocker, and omega-conotoxin GVIA, an N-type Ca2+ channel blocker, suppressed the s IPSC frequency, and in the presence of nimodipine and omega-conotoxin GVIA, SRIF failed to further suppress the sI PSC frequency. Extracellular application of forskolin, an activator of adenylate cyclase, increased the s IPSC frequency, while the membrane permeable protein k

关键词： Somatostatin sst5/sst2 receptors spontaneous inhibitory postsynaptic currents cAMP-PKA signaling pathway patch-clamp calcium channels IP3 receptor GABAergic amacrine cell inner retina

来源：评论

学校读者我要写书评

暂无评论

Impact of tea and coffee consumption on stroke and Parkinson disease:A Sri Lankan perspective

Impact of tea and coffee consumption on stroke and Parkinson...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Attanayake M.K.D.K Amaratunga D Gamage R Ragunathan M.K Fernando H Liyanage J Kulthunga A Gunasekara H Dissanayake L Suriyakumara S.V.T Udawatte N.S De Silva K.R.D Genetic Diagnostic & Research Laboratory Faculty of Medical SciencesUniversity of Sri Jayewardenepura Department of Non Clinical Statistics Johnson & Johnson Pharmaceutical Research & Development

Introduction: Tea & coffee consumption could potentially reduce the risk of Stroke & Parkinson Disease(PD) due to their antioxidant properties. However cigarette smoking is lead to oxidative stress that may alter the cellular antioxidant defense system. Method: Study population of 1415 individuals;Stroke:n=772;[Stroke in young patients(<45 yrs) accounted for 16%(124/772), median age of onset 38Yrs;male 12%(94/124) 37 Yrs, female 4%(30/124) 38Yrs;sex ratio of 3.31: 1. Stroke with age≥46;male 56%(402/648) & female 34%(246/648) sex ratio of 1.63: 1], PD: n=143;[Male 61%(87/143), female 39%(56/143), median age of onset 57Yrs] & age matched controls: n=500. Tea, coffee & cigarette consumption were assessed by a stranded questionnaire. Results: Stroke with tea consumption: ≥3cups/day 63%(490), 2cups/day 23%(177), 1cup/day 9%(70), median age of onset: 62, 59 & 56 Yrs respectively. Stroke with coffee drinkers 36%(278), non–drinkers 64%(494), median age of onset: 61 & 62 Yrs respectively. Stroke with smoking 27%(211), non- smoking 37%(288), median age of onset: 60 & 61 Yrs respectively. PD with tea consumption: ≥3cups/day 51%(73), 2cups/day 36%(51), 1cup/day 12%(17), median age of onset was 57 Yrs in all categories. PD with coffee drinkers 41%(58), non–drinkers 55%(80), median age of onset: 56 & 57 Yrs respectively. PD with smoking 29%(42), non- smoking 71%(101) median age of onset: 57 Yrs in both categories. Conclusion: Results suggestive of regular consumption of Ceylon tea is associated with a decreased risk of early onset of Stroke & PD, where coffee consumption plays a protective role towards early onset of PD, study lay steppingstone on developing neuroprotective nutraceuticals based on unique regional natural products.

关键词： stroke PD tea coffee smoking

来源：评论

学校读者我要写书评

暂无评论

Identification of specific targets of a command-like interneuron reveals novel roles of pattern-generating interneurons in Aplysia feeding network

Identification of specific targets of a command-like interne...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Song-An Chen Ting-Ting Chen Ke Yu Dan-Dan Liu Ferdinand S Vilim Elizabeth C Cropper Klaudiusz R Weiss Jian Jing State Key Laboratory of Pharmaceutical Biotechnology Nanjing Advanced Institute for Life SciencesNanjing University School of Life Sciences Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai

Activity of multifunctional networks is commonly initiated and modulated by a population of higher-order interneurons. In Aplysia the cerebral ganglion is essential for the feeding behavior. This has motivated efforts to identify and characterize cerebral higher order interneurons that project to the buccal ganglion, where the pattern generator is located. Backfill studies have determined that there are approximately 13 cerebral buccal interneurons(Xin et al 1999). Most of these cells have been studied, at least to some extent. For example, cerebral buccal interneuron 2(CBI-2) has been particularly well characterized. One CBI that has not been extensively investigated however is the neuron CBI-10. CBI-10 is located on the dorsal surface of the cerebral ganglion. Similar to CBI-2, CBI-10 is command-like, i.e., when it is stimulated buccal motor programs are triggered. The ability of CBI-10 to trigger motor programs is however weak. CBI-10 is like CBI-2 in that it contains the peptide CP-2 and it can drive both ingestive and egestive motor programs. We characterized synaptic connections between CBI-10 and buccal pattern-generating interneurons and found that CBI-10 elicits fast excitatory PSPs in buccal interneurons B34 and B40. The CBI-10-B34 connection is chemical and cholinergic, +2whereas the CBI-10-B40 connection is electrical, i.e., it persists in Ca- free saline. As expected B34 and B40 are both strongly active in motor programs elicited by CBI-10. Interestingly, hyperpolarization of either cell blocks the expression of CBI-10-elicited programs. This contrasts with CBI-2. Thus, although hyperpolarization of either B34 or B40 changes parametric features of CBI-2 induced activity, program expression is not blocked. In summary, we have characterized a novel command-like neuron that interacts with buccal pattern-generating interneurons in a unique manner. This increases the potential for diversity in motor program initiation, which may be important for meeting comp

关键词： Aplysia,feeding,command neurons,cholinergic

来源：评论

学校读者我要写书评

暂无评论

Calpain-2 contributes to the up-regulation of interleukin-6 in the spinal cordearly after motor nerve injury

Calpain-2 contributes to the up-regulation of interleukin-6 ...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Shao-Xia Chen Guang-Jie Liao Shao-Kun Wang Xiao-Dong Na Yong-Yong Li Ying Zang Xian-Guo Liu Pain Research Center and Department of Physiology Department of Pathology The Red Cross Hospital of Yulin Department of Pathophysiology Zhongshan Medical School of Sun Yat-Sen University

Objective Our previous work has shown that motor nerve injury by a lumber5 ventral root transection(L5-VRT) leads to the overexpression of interleukin-6(IL-6)in the bilateral spinal cord and intrathecal administration of IL-6 neutralizing antibody delays the induction of mechanical allodynia in bilateral ***, what factors contribute to the spinal IL-6 secretion following L5-VRTare still not very clear yet. Methods We accessed the role of calpain-2 and IL-6 in the spinal cord with immunohistochemistry and western blot analysis early after L5-VRT. Drug administration was performed to evaluate the effect of calpian-2 on spinal IL-6 secretion. Results Here we evidence for the first timethatboth IL-6 and calpain-2(CALP2, a calcium-dependent protease) are increased in ipsilateral lumbar spinal cord as early as 0.5 h after L5-VRT. IL-6 but not CALP2 is also increased on contralateral side at the same time point. The increased IL-6 is co-localized with CALP2-immunoreactivity neurons in both the spinal dorsal horn and the ventral horn. Pretreatment with calpain inhibitor MDL28170 partially suppresses the VRT-inducedspinal IL-6 onipsilateralside. Without any nerve injury, addition of recombinant rat CALP2(rr-CALP2)onto the surface of the L5 nerve rootdirectly leads to the up-regulation of IL-6protein level in the bilateral spinal cord at post-drug day 3. Furthermore, the elevated IL-6 is also obtained in the activated spinal microglia cells, combined with no co-localization between CALP2 and Iba1(a microglia marker), implicating another potential factor of microglia in IL-6 secretion early after VRT *** The increased CALP2 and activated microglia cells in the spinal cordmight play the causative role in spinal IL-6 secretionearly aftermotor nerve *** agents blocking CALP2and/or microglia actions might be a therapy of neuropathic pain.

关键词： calpain-2 interleukin-6 microglia L5 ventral root transection spinal cord

来源：评论

学校读者我要写书评

暂无评论

Sensory cortex neurons drive anticipatory motor responses

Sensory cortex neurons drive anticipatory motor responses

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jingcheng Li Xiang Liao Jian Lu Ran Ding Meng Wang Xingyi Li Zhiqi Yang Jianxiong Zhang Yu Guang Hongbo Jia Shaoqun Zeng Zhian Hu Israel Nelken Xiaowei Chen Brain Research Center Third Military Medical University Department of Physiology Third Military Medical University Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology Brain Research Instrument Innovation Center Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of Sciences Department of Neurobiology Silberman Institute of Life Sciences and the Edmond and Lily Safra Center for Brain SciencesHebrew University CAS Center for Excellence in Brain Science Shanghai Institutes for Biological SciencesChinese Academy of Sciences

The ability of the brain to predict future events based on the pattern of recent sensory experience is critical for cognition, decision making, and motor actions1-4. For example, following rhythmic sensory stimulation that normally triggers the movement, animals often "over-react" by moving once or more at the expected time interval. In mammals, sensory neocortical circuits for immediate processing of sensory stimuli are well understood5-7, but whether and how these circuits may contribute to the anticipation of upcoming sensory stimuli remains unclear. Here we report the existence of ensemble neuronal activities in the mouse auditory cortex(ACx) that code for anticipation of the sound stimulus following rhythmic auditory stimulation. We show that such activity could drive anticipatory movement of the mice. Using in vivo two-photon Ca2+ imaging, we found that following a train of rhythmic sound stimulation, a subgroup of mouse layer(L) 2/3 and L5 ACx neurons exhibited one or a few repetitions of "echo" responses at the expected time interval in the absence of sound. These echo responses occurred preferentially at sound stimulus frequency that matched the best tuned frequency of the neuron. After learning to perform a sound-triggered licking task, mice showed "echo licking" responses following rhythmic sound stimulation that were highly correlated with ACx neuronal echo responses. Optogenetic activation8,9 of L5 ACx neurons, which provide the major ACx output, could substitute sound stimulation and reliably produce echo licking responses. Thus, anticipation of sound stimulus immediately following rhythmic sound stimulation is reflected by correlated activities of ACx neuronal ensembles, which are capable of driving anticipatory motor behavior

关键词： echo response anticipatory behavior auditory cortex circuit frequency selectivity two-photon

来源：评论

学校读者我要写书评

暂无评论

The genetics of Parkinson's Disease

The genetics of Parkinson's Disease

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Beisha Tang Department of Neurology Xiangya HospitalCentral South University State Key Laboratory of Medical Genetics Hunan Province Key Laboratory of Neurodegenerative Disorders Parkinson's Disease Center Beijing Institute for Brain DisordersCapital University of Medical Sciences

Parkinson's disease(PD) is the second most common neurodegenerative disorder nowadays, which is clinically characterized by resting tremor, bradykinesia, rigidity, postural instability and a positive response to dopamine replacement therapy. The classic pathological findings of PD are the loss of dopaminergic neurons and cytoplasm inclusions of aggregated proteins Lewy bodies. The specific mechanism of PD is still not very clear;it is associated with aging, environmental and genetic factors, and genetics have been paid more and more attentions. In our preliminary studies, we found that Parkin mutations are the most commonly identified genetic variations in Chinese patients with AREP(48.3%) or EOP(12.6%). Mutations in the PINK1, DJ-1, and PLA2G6 genes were also found in cases of AREP(6.9%, 3.4%, 3.4%, respectively) and sporadic EOP(3.1%, 2.4%, 0.79%, respectively). Thus far, no pathogenic mutations have been detected in the ATP13A2 and FBXO7 genes in the Chinese population. In our study, sixteen SNPs located in the 8 genes and/or loci(SNCA, LRRK2, MAPT, GBA, HLA-DR, BST1, PARK16, and PARK17) were analyzed in a Chinese cohort consisting of 1061 well-characterized PD patients and 1066 control subjects from Central South of China's mainland. We found that Rep1, rs356165, and rs11931074 in SNCA gene;G2385 R in LRRK2 gene;rs4698412 in BST1 gene;rs1564282 in PARK17;and L444 P in GBA gene were associated with PD with adjustment of sex and age(p < 0.05) in the analysis of 16 variants. PD risk increased when Rep1 and rs11931074, G2385 R, rs1564282, rs4698412;rs11931074 and G2385 R, rs1564282, rs4698412;G2385 R and rs1564282, rs4698412;and rs1564282 and rs4698412 were combined for the association analysis. In addition, PD risk increased cumulatively with the increasing number of variants(odds ratio for carrying 3 variants, 3.494). We sequenced the exomes of EOPD families to depict the de novo mutational paradigm for PD. We found the probands are enriched in nonsynonymous and l

关键词： Parkinson,genetics,early-onset parkinson' disease,gene,SNP

来源：评论

学校读者我要写书评

暂无评论

Moderate alcohol preconditioning activates neuronal BKCa channels to protect brain damage-induced by cerebral ischemia and reperfusion

Moderate alcohol preconditioning activates neuronal BKCa cha...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yi-Long Zhao Fang Su Wei-Wei Li An-Chen Guo Yong-Jun Wang Qun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical University Beijing Key Laboratory of Translational Medicine for Cardiovascular Diseases Beijing Institute for Brain Disorder

Objective Stroke is the third most common cause of death after heart attack and cancer and has profound negative social and economic effects. Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. The results of a large number of epidemiologic studies indicate that consumption of red wine at low to moderate levels is cardioprotective and neuroprotective, reducing the incidence and severity of myocardial infarction and stroke. Studies conducted in cultured cell and intact animal models attributed these beneficial effects to "Ethanol preconditioning". Ethanol preconditioning(Et OH-PC) refers to a phenomenon in which tissues are protected from the deleterious effects of ischemia/reperfusion(I/R) by prior ingestion of ethanol at low to moderate levels. Recent studies have shown that activation of large conductance calcium activated potassium channels(BKCa) plays a key role in the protection of cerebral protection with moderate alcohol preconditioning. Thus, we propose the following hypothesis: moderate alcohol preconditioning activates neuronal BKCa channels to protect brain damage-induced by cerebral ischemia and reperfusion. In this experiment, we use cerebral ischemia reperfusion model to clarify this viewpoint through pharmacological intervention of BKCa channel agonist(NS11021, NS) and inhibitor(Paxilline, PX).Methods The SD rat were randomly divided into the following six groups(n=10):Sham,Ischemia?reperfusion(I/R),Et OH-PC+I/R,NS11021-PC+I/R,Paxilline+Et OH-PC+I/R,Paxilline+NS11021-PC+I/R. The volume of 95% ethanol to be instilled(in μL) was calculated as follows: [body weight(g)×0.6] + 0.3. This volume of ethanol was mixed in 0.3m L of sterile distilled water just before administration to the animals by gavage. Both Et OH-PC and NS11021-PC(0.1mg/kg;ip) were induced 24 h before I?R. The Paxilline(2.5mg/kg;ip) was administered 10 min

关键词： ethanol preconditioning neuroprotection cerebral ischemia/reperfusion BKCa channels

来源：评论

学校读者我要写书评

暂无评论

Induction of spinal GluN2B-dependent LTP via BDNF contributes to the development of neuropathic pain

Induction of spinal GluN2B-dependent LTP via BDNF contribute...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xu Ding Wei Yang Hong Qin Huan-Min Wang Ke-Min Qi You Wan Guo-Gang Xing Beijing Pediatric Research Institute Beijing Children’s HospitalCapital Medical University Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical SciencesPeking University Health Science Center

In previous studies, we have found that the Glu N2B-containing NMDA(NMDA-Glu N2B) receptors-mediated long-term potentiation(LTP) in the spinal cord play an important role in the development of central sensitization and neuropathic pain. Furthermore, we discovered that the brain-drived neurotrophic factor(BDNF) was likely the upstream signaling molecule for the activation of NMDA-Glu N2 B receptors. Recently, we investigated the signalling pathway for the activation of NMDA-Glu N2 B receptors by the spinal BDNF and to clarify its role in the development of neuropathic pain. We revealed that BDNF induces spinal LTP at C-fiber synapses via functional up-regulation of Glu N2B-NMDA receptors in the spinal dorsal horn, and this BDNF-mediated LTP-like state is responsible for the occlusion of spinal LTP elicited by subsequent highfrequency electrical stimulation(HFS) of the sciatic nerve in spinal nerve ligation(SNL) rats. We demonstrated that BDNF-evoked Src homology-2 domain-containing protein tyrosine phosphatase 2(SHP2) phosphorylation is required for subsequent Glu N2B-NMDA receptors up-regulation and spinal LTP induction, and also for pain allodynia development. Blockade of SHP2 phosphorylation in the spinal dorsal horn using NSC-87877 or SHP2 si RNA, not only prevents BDNF-mediated GluN 2B-NMDA receptors activation as well as spinal LTP induction and pain allodynia elicitation in intact rats, but also reduces the SNL-evoked Glu N2B-NMDA receptors up-regulation and spinal LTP occlusion, and ultimately alleviates pain allodynia in neuropathic rats. Taken together, our recent results suggest that the BDNF/SHP2/Glu N2B-NMDA signaling cascade plays a vital role in the development of central sensitization and neuropathic pain after peripheral nerve injury.

关键词： Brain-derived neurotrophic factor,SHP2,GluN2B-containing NMDA receptor,Long-term potentiation,Neuropathic pain,Spinal dorsal horn

来源：评论

学校读者我要写书评

暂无评论

Up-regulation of belta4 subunit of large-conductance Ca2+-activated potassium channels contributes to anxiety-like behaviors in the anterior cingulate cortex

Up-regulation of belta4 subunit of large-conductance Ca2+-ac...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Huan Zhao shichao Han Fancheng Meng Ming Zhang Hui Xu Department of Neurobiology and Collaborative Innovation Center for Brain Science School of Basic MedicineFourth Military Medical University Center for Neuron and Disease Frontier Institute of Science and TechnologyXi’an Jiaotong University

The large-conductance Ca2+- and voltage-gated K+ channels or BK channels are ubiquitously expressed throughout the central nervous system including the cingulate cortex and contribute to action potential repolarization and fast afterhyperpolarization(f AHP), both of which influence firing rates at the neuronal cells and neurotransmitter release through some Ca2+ transients. It has been found that a significant reduction in BK channels expression in the amygdala of mice accompanied anxiety-like behavior. However, little has been known about the expression of BK channel subunits that modify the channel's properties in the anterior cingulate cortex(ACC). In our present study, BK-mediated f AHP was altered in ACC pyramidal neurons accompanied anxiety-like behavior in the m CCD rat. With the method of whole-cell patch-clamp method, the amplitude of f AHP was reduced and the AP duration was increased in pyramidal neurons which induce the hyperexcitability of ACC neurons accompanied anxiety-like behavior. NS1619(10μM),an opener of BK channels,significantly rescued the alteration of f AHP and AP duration in ACC pyramidal neurons in the m CCD rat. Meanwhile, by bath-applied the BK channels inhibitor iberiotoxin(IBTX,100 nM) the f AHP was reduced and the APduration was increased in ACC pyramidal neurons of the sham rat. ACC neurons of the anxious animals revealed a pronounced reduction in the BK currents in the m CCD rats compared with the sham rats. Interestingly, we did not find reduction in BK channel expression in ACC of m CCD rats, while a significant increase of accessory belta4 subunit of BK channel expression in the ACC accompanied anxiety-like behavior in the m CCD rat by using RT-PCR and Western blotting. These data demonstrate that the belta4 subunit is related to reduction of the BK channels' function and that anxiety-like behavior induced by chronic pain could at least partly be explained by up-regulation in the belta4 subunit of BK channels in the ACC.

关键词： large-conductance Ca2+-activated potassium channel belta4 subunit anxiety excitability anterior cingulate cortex

来源：评论

学校读者我要写书评

暂无评论

Behavior deficits and region specific alterations in local field potential oscillations in APP/PS1 mice in vivo

Behavior deficits and region specific alterations in local f...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jiajia Zhang Cheng Long Li Yang School of Psychology South China Normal University School of Life Sciences South China Normal University

Alzheimer's disease(AD) is the leading cause of dementia, estimated to affect more than 30 million individuals worldwide. The accumulation of neuritic plaques composed of amyloid-β(Aβ) peptides is a key pathological feature of AD. However, AD is not only characterized by cognitive decline and neuropathological changes, but also by non-cognitive behavioral symptoms. Several neurocognitive symptoms seen in the course of AD are also characteristic of obsessive compulsive disorder(OCD). But it remains unknown whether obsessive-compulsive symptomatology would be risk factors for AD. Complex stereotypic and repetitive behaviors may reflect early and specific deficits in prefrontal cortex(PFC) and basal ganglia, such as striatum. Nonetheless the underlying neurobiological bases are unclear. In the present study, APP/PS1 transgenic mice and wild-type(WT) littermate controls were evaluated. Our data indicate that 2-4 month old APP/PS1 transgenic mice(without Aβ) exhibited an abnormal ability to discriminate and recall social cues in three-chamber sociability and social novelty test, increased repetitive behavior phenotypes in nestlet-shredding test, but no anxiety-like behavior in open field test. In the marble-burying test, 8-10 month old APP/PS1 mice(with Aβ) showed an increased number of marble buried compared with WT, indicating more repetitive digging behavior. To determine whether PFC and striatal dysfunction may be involved in behavioral deficits, we simultaneously measured the spontaneous local field potential(LFP) in the PFC and striatum via extracellular dual channel recording in urethane-anesthetized APP/PS1 and WT mice. 2-4 month old APP/PS1 mice showed reduced delta oscillatory power within PFC and striatum but increased beta oscillatory power within striatum. No significant differences in cross-correlation and coherence were shown between APP/PS1 and WT mice. In contrast, 8-10 month old APP/PS1 mice exhibited decreased coherent theta and beta activity and no ch

关键词： Alzheimer's disease obsessive-compulsive symptomatology social deficits prefrontal cortex striatum local field potential oscillation

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共111页 << < 101 102 103 104 105 106 107 108 109 110 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：