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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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Time-specific micro RNA changes during spinal motoneuron degeneration in adult rats following unilateral brachial plexus root avulsion:ipsilateral *** changes

Time-specific micro RNA changes during spinal motoneuron deg...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ying Tang Ze-Min Ling Rao Fu Ying-Qin Li Xiao Cheng Fa-Huan Song Hao-Xuan Luo Li-Hua Zhou Department of Anatomy Zhongshan School of MedicineSun Yat-sen University

Elucidation of the pathophysiological events underlying spinal root avulsion is expected to discover effective therapeutic methods. Currently, micro RNAs, which are a novel class of short non-coding RNA molecules that repress target m RNA at posttranscriptional levels, is thought to play an important role in the gene changes involved in spinal cord injury. Therefore, the mi RNA expression patterns in different injury sites and the response to the root-avulsion injury of the spinal motoneurons were compared between the ipsilateral cervical spinal cord and those in the contralateral cervical spinal cord following a brachial ventral combined dorsal root avulsion injury model. Furthermore, bioinformatics analysis was employed to determine the functional roles of target genes regulated by altered mi RNAs, which further revealed the effect of mi RNA dysregulation on the key processes of the brachial root avulsion injury. The present data showed that the a total of 3,361 mi RNAs in the spinal cord of adult rats was identified. In the rats with right brachial plexus root avulsion, the mi RNA expression patterns of the ipsilateral ventral horn were significantly changed in the ipsilateral cervical spinal cord compared to those in the contralateral cervical spinal cord. On the 3rd day after the injury, 55 mi RNAs were upregulated, and 24 were downregulated, and on the 14 th day after the injury, 36 mi RNAs were upregulated, and 23 were downregulated. The upregulation of mi R-146b-5p and mi R-31a-3p and the downregulation of miR-324-3p and miR-484 were observed. Eleven of the miRNAs,including mi R-21-5p, demonstrated a sustained increase;however, only mi R-466c-3p presented a sustained decrease 3 and 14 days after the injury. More interestingly, 4 of the mi RNAs, including mi R-18 a, were upregulated on the 3rd day but were downregulated on the 14 th day after injury. Some of these mi RNAs target inflammatory-response genes in the early stage of injury, and others target neuro

关键词： Brachial root avulsion MicroRNA Microarray Inflammatory response nNOS c-jun ATF-3 Calpain 2

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Electro-acupuncture improves social behavior and increases oxytocin and arginine-vasopressin expressions in the hypothalamus of rats

Electro-acupuncture improves social behavior and increases o...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Hong-Feng Zhang Han-Xia Li Yu-Chuan Dai Xin-Jie Xu Song-Ping Han Rong Zhang Ji-Sheng Han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical SciencesPeking University Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking University School of Basic Medical Sciences Peking University

Objective Oxytocin(OXT) and arginine-vasopressin(AVP) are two closely related neuropeptides and implicated in regulation of mammalian complex social cognition and behaviors. Results of several clinical studies indicated that long-term acupuncture treatment improved social communication, social interaction and emotional response in autistic patients characterized by social behavior impairment. However, the underlying mechanism of therapeutic effects of acupuncture remains unclear. Herein we hypothesized that electro-acupuncture(EA) may elevate the expressions of OXT and AVP in the brain thus influencing social behaviors. Methods Thirty-eight low social interacting(LSI) rats were selected based on their social interaction time spent in the three-chamber test from a total of ninety-six rats. The LSI rats were randomized into two groups: the repeated EA(rE A) group and control group. Animals in the r EA group were subjected to 30 min 2/15 Hz EA treatment every other day(on the 1st, 3rd, 5th, 7th and 9th day) for a total of 5 sessions. The rats in the control group went through the same procedure without needle insertion. Following the stimulation, sociability of LSI rats in the two groups were determined the three-chamber test. After the social behavior test, m RNA and peptide levels of OXT and AVP in paraventricular nucleus(PVN) and supraoptic nucleus(SON) were detected by Real-Time PCR and Enzyme immunoassay, respectively. Results LSI rats underwent r EA showed significant improvement of social behavior characterized by spending more time investigating the strange rats and less time staying in the empty cage side in three-chamber sociability test. Meanwhile, the improved sociability was accompanied by a selective up-regulation of m RNA and the peptide levels of OXT or AVP in hypothalamus where the peptides were produced, as well as a significant increase of serum AVP level. In addition, the OXT and AVP m RNA levels in SON was found to be positively correlated to rat's

关键词： electro-acupuncture oxytocin arginine-vasopressin social behavior hypothalamus supraoptic nucleus

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A study of astrocyte activation and implications for tumor formation

A study of astrocyte activation and implications for tumor f...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jiang Shan Zhan Hsi Cheng Liu Kai Gao Xi Hua Jia Rui Chao Chai Yuan Jin Feng Jiang Jiao Hua Jiang Albert Cheung Hoi Yu Neuroscience Research Institute Peking University and Department of NeurobiologySchool of Basic Medical Sciences Key Laboratory for Neuroscience of the Ministry of Education and Key Laboratory for Neuroscience of the National Health and Family Planning Commission Peking University

Under injury and pathological conditions, quiescent astrocytes are rapidly activated and form glial scars, a process called astrogliosis. Astrogliosis is a hallmark of central nervous system(CNS) insults, including ischemia, trauma, degenerative diseases and aging. Astrogliosis is usually accompanied by the upregulation of glial fibrillary acidic protein(GFAP), hypertrophy(cell process migration) and hyperplasia. ?Recent findings in our laboratory? suggest the possibility that loss of the dynamic regulation of astrogiosis may provide an explanation for tumor progress. Matrix metalloproteinase(MMPs) family and cellular adhesion molecules(CAM) ? have an important role at the initial stage of tumor metastasis. In our laboratory, we used an in vitro scratch model to induce astrogliosis for studying migration. We compared astrocytes, a benign tumor cell line(DU145) and malignant tumor cell line(A549, MCF7) in cell migration after scratch. We also detected MMP9, F-actin and vimentin m RNA levels in astrocytes and cancer cells using qR T-PCR. In order to distinguish the endogenous response and exogenous influence after scratch injury, we set two experimental conditions, scratching & changing the media(S&C) group and scratching without changing the media(S) group. We found that the levels of MMP9 m RNA are elevated while the levels of F-actin and vimentin m RNA are decreased in S group. We also observed that the levels of MMP9, F-actin and vimentin m RNA level differ between the S&C and S group, indicating that exogenous influence is important in genes expression in scratch injured astrocytes. In conclusion, we found that ? cell mobility involves both endogenous response and exogenous influence after scratch injury.

关键词： astrogliosis,MMP,actin,vimentin,astrocyte,scratch model

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The effect of high frequency repetitive transcranial magnetic stimulation(rTMS) on the cognitive behavior and hippocampal synaptic plasticity in aged Kunming mice

The effect of high frequency repetitive transcranial magneti...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yuan GENG Bing HAN Yan-Yong WANG Pei-Zhi WANG Ming-Wei WANG Department of Neurology the First Hospital of Hebei Medical University Brain Aging and Cognitive Neuroscience Key Laboratory of Hebei

Objective To observe the effect of high frequency repetitive transcranial magnetic stimulation(rT MS) on the cognitive behavior and hippocampal synaptic plasticity in aged mice. Methods 45 Kunming mice(15-month-old) were randomly divided into three groups: sham, subthreshold and upthreshold. Two sessions of 25 Hz r TMS comprising of 1000 pulses in 10 trains were delivered every day for 14 days. Sham group were treated by the reverse side of the coil. Spontaneous motor activity, step-down test and Morris water maze(MWM) were conducted following the r TMS. The synaptic structure of hippocampal CA1 region were observed by TEM and the changes of 84 synaptic plasticity related genes were tested by PCR Array. Results Compared with sham group, spontaneous motor activity were no significant difference between each test group(p >0.05). In step-down test,the latency of reaction increased and the number of errors decreased in both test groups(p<0.05). In hidden platform trials of MWM, compared with sham group, the mean escape latency were significantly shorter in subthreshold group(p<0.05), however, in spatial probe test, the time spend in and the number of crossing original platform were significantly increased in upthreshold group(p<0.05). Shown by TEM, compare with the sham group, the thickness of postsynaptic density(PSD) was increased, the synaptic cleft width and the synaptic curvature were decreased, the ratio of perforated synapse was increased(p<0.05), moreover, upthreshold group was more significant than subthreshold group. Gene expression profiles of each groups compared with sham group were identified with a >3-fold difference. In upthreshold group, Jun-β was up-regulated while Ntf5, Inhba and Fos were down-regulated. In subthreshold group, Jun-β, Egr2 and Nr4a1 were up-regulated while Ywhaq and kif17 were down-regulated. Conclusion 25 Hz high frequency r TMS has no significant effect on the emotion of aged Kunming mice. Up- and sub-threshold intensity of rT MS bot

关键词： High frequency repetitive transcranial magnetic stimulation aged Kunming mouse cognitive behavior synaptic plasticity PCR-array

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Tau hyperphosphorylation stimulated by GSK3 critically modulates chronic stress-induced depressive disorder in mice

Tau hyperphosphorylation stimulated by GSK3 critically modul...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zhi-Yong He Ya-Shu Yang Ke-Lu Li Wen-Yue Wang Wei-Yan Hu Zhi-Cheng Xiao Ming Zhang The Key Laboratory of Stem Cell and Regenerative Medicine Institute of Molecular and Clinical MedicineKunming Medical University

The hyperphosphorylation of Tau, a microtubule-associated protein, in the central nervous system has been shown as a remarkable pathogenetic factor in Alzheimer's disease, causing the destabilization of axonal microtubules and synaptic dysfunction. Similarly, recent studies imply that the increased level of Tau phosphorylation may also play a role in the pathogenesis of depressive disorder. In the present study, we investigated how the phosphorylation of Tau protein in hippocampus changes following the onset of depressive behaviors and the related molecular mechanism. The paradigm of chronic unpredictable mild stress(CUMS) was used to induce depression-like behaviors in C57BL/6 mice. A total of ten mild stressors were applied in the CUMS procedure, but only one stressor was introduced on a specific day for the CUMS group(s). Animals of the control group were kept in their homecages without engaged in CUMS. Sucrose PreferenceTest(SPT), Forced Swimming Task(FST), and Tail Suspension Task(TST) were used to evaluate depression-like behaviors. Western blotting and immunoblotting assays were employed to examine the phosphorylation levels of Tau and its related protein kinases. After CUMS treatments for 14, 21, and 35 days, respectively, mice exhibited depression-like behaviors in both the SPT and TST tasks. However, only the CUMS group treated for 35 days showed longer immobility time in the FST task than the control group did. Consistent with the behavioral changes in the FST task, the increases of hippocampal Tau phosphorylation at AT8, AT100, AT180, AT270, Ser199, and Ser396 were mainly after 35 days of CUMS treatment. The phosphorylation levels of p38 MAPK, ERK and Ca MKII, which all are known as protein kinases of Tau, were down-regulated after 35 days of chronic stress. On the other hand, the activation of GSK3alpha/beta was significantly elevated in the hippocampus of CUMS mice. We further found that two anti-depressants, lithium and fluoxetine, significantly atten

关键词： Depression Tau protein GSK3 signaling Lithium

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Role of 5-HT1B receptors in hippocampal CA1 on learning and memory

Role of 5-HT1B receptors in hippocampal CA1 on learning and ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Menghe Zhou Huibin Chen Chang Xu Hui Qiao Xin-Ming Ma Shucheng An College of Life Science Shaanxi Normal University University of Connecticut Health Center Department of Neuroscience

Objective: The CA1 region of the hippocampus has been demonstrated as key brain zone in learning and memory. The direct entorhinal projection(temporoammonic, TA) input to hippocampal area CA1 was involved in the acquisition and retention of spatial memory. 5-HT1 B receptors in CA1 pyramidal cells could be activated by endogenous serotoninergic projection of TA, but the role of 5-HT1 B receptors here in learning and memory remain unclear. Kalirin-7 is an essential component of excitatory synapses and required for synaptic functions. The aim of this study was to investigate the role of CA1 5-HT1 B receptors and kalirin-7 in spatial memory. Methods: Male SD rats were trained in Morris water maze after a bilateral CA1 injection of saline, CP 93129(a selective agonist of5-HT1 B receptor), or GR 55562(a selective antagonist of 5-HT1 B receptor) into the dorsal CA1 region. Kalirin-7 was determined by Western blot analysis. Results: Pretreated with CP 93129(25 μg/μl) into CA1 daily before training, rats spent significantly more time in the latency to platform and less time in the correct quadrant than saline-treated animals on the 3rd and 5th probe days(p < 0.01), accompanied by a 32 % reduction of kalirin-7 level. Two-week treatment of CP 93129 after training significantly reduced the quadrant preference percentage(p < 0.05) and the expression of kalirin-7(10% lower than control). Pretreated with GR 55562(25 μg/μl) into CA1 daily before training, rats showed no differences in swimming performance, the latency to platform and time spend in the correct quadrant compared with saline-treated animals on the 5th probe day(p > 0.05), while two-week treatment of GR 55562 after training increased the quadrant preference percentage(p < 0.05) and the expression of kalirin-7(15% higher than control). These results indicated that activation of 5-HT1 B receptors in CA1 could impair the acquisition and consolidation of spatial memory, while antagonist of 5-HT1 B receptors enhanced memory

关键词： learning and memory,hippocampus Serotonin 1B receptor(5-HT1B R),kalirin-7

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A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning

A distinct entorhinal cortex to hippocampal CA1 direct circu...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yiding Li Jiaming Xu Jia Zhu Yafeng Liu Shaoqun Zeng Chengyu Li Xiaohui Zhang Institute of Neuroscience and State Key Laboratory of Neuroscience Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience &Learning IDG/McGovern Institute for Brain ResearchBeijing Normal University Shanghai Institute of Brain Functional Genomics East China Normal University Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology

The dorsal hippocampus is a medial temporal lobe structure that critically involved in declarative memory formation and spatial navigation. The lateral- and medial- entorhinal cortex(EC) provide major inputs to the dorsal hippocampus through the two separated perforant paths(PP). The first PP connection is from EC layer 2 to hippocampal dentate gyrus(DG) and the other is from EC layer 3 to hippocampal CA1, forming the tri- and di-synaptic pathways, respectively. In comparison to extensive knowledge about the PP–DG trisynaptic loop, little is known about the fine-scale connectivity and function of the direct PP–dorsal CA1 circuit. Here, we report that a distinct circuit from lateral-EC PP to a subpopulation of CA1 calbidin-expressing pyramidal cells(PCs) in the dorsal hippocampus is required for olfactory associative learning. Using light-activated channel rhopdopsin(Ch R2)-assisted circuitry mapping, we found that medial-EC layer 3 neurons homogeneously project to all examined hippocampal CA1 PCs, while neurons from the same layer of lateral-EC selectively target to the subpopulation of hippocampal CA1 cells which are preferentially located in the superficial layer and posses more complex dendritic morphology. These morphologically complex CA1 PCs(complex PCs, cP Cs) specifically express an intracellular Ca2+-binding protein calbindin(Calb). Selective optogenetic inactivation of either Calb-expressing PCs or direct lateral-EC PP synaptic transmission in the dorsal hippocampal CA1 region over the training days severely impairs a learning process of associating specific olfactory cues to go/no-go behaviors. On contrast, similar inactivation of Calb-expressing granule cells and lateral-EC PP synapses in the dorsal hippocampal DG area does not affect the associative learning, respectively. Thus, these findings reveal a distinct synaptic circuit from the lateral-EC PP to hippocampal CA1 Calb-expressing PCs for the olfactory associative learning, and suggest the existence

关键词： entorhinal cortex dorsal hippocampus hippcampal CA1 region perforant synaptic pathway associative learning optogentics

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P2Y12 receptor-mediated IL-1β and TNF-α release from cultured microglia

P2Y12 receptor-mediated IL-1β and TNF-α release from cultu...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zhe ZHAO Shi-Hao GAO Hui-Zhong WEN Yan-Dong ZHAO Jian CUI Huai-Zhen RUAN Department of Neurobiology Chongqing Key Laboratory of NeurobiologyThird Military Medical University

Adenosine triphosphate(ATP) and its hydrolysis product, adenosine diphosphate(ADP), have been proved to be significant neurotransmitters on neuronal signal transmission. ATP and ADP play important roles in CNS through the specific receptor, the P2 purinergic receptors, which could be divided into P2 X receptors and P2 Y receptors according to their physical characters. P2Y12 receptor(P2Y12R) is a member of P2 Y family, which is expressed on the surface of microglia and widely distributed in the CNS. There has been series of researches indicated that P2Y12 R is participated in the delivery and modulation of pain related information. Activated by ADP or ATP, a series of proinflammatory cytokines and neuroactive substances would be discharged from the activated microglia. There has been little concentration on the relations between P2Y12Rand activation of microglia, as well as the following mechanisms, which need to be studied further. In this study, we used primary cultured microglia, and combined methods containing morphology and calcium image, to detect the intracellular concentration of Ca2+ and release of proinflammatory cytokines from microglia after the activation of P2Y12R;to investigate the relationship between P2Y12 R and the activation of primary cultured microglia. The immunofluorescence results indicated directly that the primary cultured microglia cell expressed the P2Y12 R protein, and the positive was located in cell body. The agonist of P2Y12 R, 2Me SADP can evoked an increase in [Ca2+]i of microglia in a dose-dependent manner, which can be cut off by pretreatment with an selective P2Y12 antagonist AR-C66096, which also is in a dose dependent manner. The surface and branches of the cultured microglia remarkably altered after administration of the P2Y12 R agonist, 2Me SADP, for 24 hours. And the function of 2Me SADP can be reversed by the pre-treatment of AR-C66096. The concentration of interlukin-1β(IL-1β) and tumor necrosis factor–α(TNF-α) in the supe

关键词： microglia,P2Y12 receptor,IL-1β,TNF-α

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EA alleviates depressive-like behaviors and pathological changes in hippocampus in chronic unpredictable stress-induced rat model of depression

EA alleviates depressive-like behaviors and pathological cha...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Na Yue Xiao-Cang Hui-Jie Huang Jing Wang Rui Yu Bing Li Liu Yang Gen-Cheng Wu Jin Yu Department of Integrative Medicine and Neurobiology State Key Lab of Medical NeurobiologyInstitutes of Brain ScienceShanghai Medical CollegeFudan University

Depression is a leading cause of mortality and morbidity worldwide and results from a combination of genetic and environmental risk factors. Electroacupuncture(EA) is an ancient and effective antidepressant strategy. However, the exactly mechanism of EA on depression is poorly understood. Here, we observed the effect of EA on depressive-like behaviors induced by chronic unpredictable stress(CUS). We also investigated the pathological changes in hippocampus after the CUS and EA treatment. The experiments were performed on 40 male Sprauge-Dawley(SD)rats. At the beginning of chronic unpredictable stress(CUS), the rats were randomly divided into four groups : Normal( n=10), Model( n=10), CUS+ EA( n=10), CUS + Sham EA( n=10). During CUS, rats were submitted once every two days to the following stressors for a total of ten weeks : food and water deprivation( 24h), inversion of light / dark cycle( 24h), cold water swimming( 4 °C for 5 min), intermittent illumination( 24h). In order to prevent habituation and maintain the aspect of unpredictability, each week stressors and stressor sequences tookplace at different times. Then EA and sham EA treatments were given to depressive rat once daily for 4 weeks from the 7th week of the CUS procedure. During this period, rats belong to Normal group were left undisturbed in their home cages with the exception of behavioral tests. The depressive-like behaviors were evaluated in the open field test(OPT), forced swimming test(FST) at the weekend of the 6th week and after the entire paradigm. After exposed to 6 or 10 weeks of CUS, the rats displayed significant depressive-like behaviors(i.e., decreased struggling time in FST(## p < 0.01), decreased rearing and total distance in OFT(## p < 0.01, # p < 0.05)). And, 4 weeks of EA treatment can significant alleviate CUS-induced depressive-like behaviors(i.e., increased struggling time in FST(*p<0.05), increased rearing and total distance in OPT(* p < 0.05, *p < 0.05)). Similarly, after exposu

关键词： depression,animal model,chronic unpredictable stress,P2XR7,microglia,astrocyte,NLRP3 inflammasome

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Dendritic Morphology of periaqueductal gray projecting retinal ganglion cells and its function in the regulation of neuronal activity of PAG region in rat

Dendritic Morphology of periaqueductal gray projecting retin...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Lu Huang Ting Zhang Li Zhang Mingliang Pu Qi Cui Kwok-Fai So Chaoran Ren Guangdong-Hongkong-Macau Institute of CNS Regeneration Jinan University GHM Collaboration and Innovation Center for Tissue Regeneration and Repair Jinan University Department of Anatomy School of Basic Medical SciencesPeking University

Purpose: Periaqueductal gray(PAG) in the midbrain is a multifunctional non-visual center. It receives afferents from a wide range of areas in the brain including several mood related centers such as amygdala and prefrontal cortex, and participates in the regulation of a series of important functions, such as conditioned fear. Direct retinal innervation to PAG has been described in many rat, Mongolian gerbil. However, the function of PAG-projecting RGCs(p-RGCs) in the regulation of fear related behavior is unclear so far. This study aims to investigate the morphological features of p-RGCs, and reveal the function of p-RGCs in the modulation of neuronal activity in PAG. Method: Cholera toxin B subunit(CTB) retrograde labeling, in vitro intracellular injection, confocal microscopy and three-dimensional reconstruction approaches were used to investigate the morphological features of p-RGCs. immunotoxin anti-CTB-SAP was used to selectively ablate CTB labeled p-RGCs. c-Fos immunofluorescence was used to describe the neuron activity in both of p-RGCs and neurons of PAG region under either dark treatment or light exposure(1.5 hours after 12-hour dark phase). Results: p-RGCs exhibit small somata(10–17 mm) and irregular dendritic fields(201–298 mm). Sizes of somata and dendritic fields do not show obvious variation at different distance from the optic disk(eccentricity). Dendrites aremoderately branched. Morphological analysis reveals that cP AG projecting RGCs ramified in sublamina a and b in the inner plexiform layer. There were large amounts of c-Fos activities in both p-RGCs and PAG region in light-exposed rats but not in in dark-treated animals. After the ablation of p-RGCs, light exposure failed to induce the c-Fos expression in PAG region. Conclusion: Substantial behavioral evidence has indicated that PAG neurons could regulate fear-related behavior. Furthermore, research found that light could enhance learned fear in the mice. The discovery of these p-RGCs proposes a

关键词： non-image-forming system cholera toxin B subunit retrograde labeling periaqueductal gray fear

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