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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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Up-regulation of hippocampal NR2B subunit in response to behavioral training contributes to memory consolidation in adult rats

Up-regulation of hippocampal NR2B subunit in response to beh...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yan-Yan Sun Wei Cai Jie Yu Shu-Su Liu Min Zhuo Bao-Ming Li Xue-Han Zhang Institute of Neurobiology and State Key Laboratory of Medical Neurobiology Institutes of Brain ScienceFudan University Center for Neuron and Disease Frontier Institutes of Science and TechnologyXi’an Jiaotong University Department of Physiology Faculty of MedicineUniversity of Toronto1 King’s College Circle Toronto Center for Neuropsychiatric Diseases Institute of Life ScienceNanchang University

Despite genetic evidence showing that increased or decreased incorporation of the NR2B subunit into N-methyl-d-aspartate receptors(NMDARs)affects hippocampus-dependent memory in the adult brain,NR2B is not necessary f... 详细信息

关键词： Up-regulation of hippocampal NR2B subunit in response to behavioral training contributes to memory consolidation in adult rats

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Dissecting the Neural Circuit Underlying Motor Control in ***

Dissecting the Neural Circuit Underlying Motor Control in **...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Tianqi Xu Quan Wen School of Life Sciences University of Science and Technology of China

Locomotion requires coordinated rhythmic motor activity throughout an animal's body. By combining microfluidics and optical neurophysiology, we first discovered that forward locomotion in C. elegans is both driven and coordinated by a novel form of proprioceptive coupling within the motor circuit. Guided by this principle, we develop a simple computational model of worm locomotion and provide a biophysical explanation of why the speed and the shape of body undulation in C. elegans adapt to the mechanical load imposed by the environment. Second, we identified a reciprocal excitation and inhibition circuit motif in the worm head motor circuit that provides a gain control mechanism for modulating the amplitude as well as the frequency of undulation. I will also discuss on-going endeavors aiming at developing a complete understanding of motor control in C. elegans from both algorithmic and mechanistic standpoint of view.

关键词： locomotion,optogenetics,mechanical load,C.elegans

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Pigmented choroid plexus papilloma in sellar region:case report and literature review

Pigmented choroid plexus papilloma in sellar region:case rep...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xuan Gong Longbo Zhang Song Lan Zhixiong Liu Department of Neurosurgery Xiangya HospitalCentral South University

Choroid plexus papillomas are the rare benign tumors and the pigmented disease is even less common, the one located in sellar region is hardly seen, we present the case of a 43-year-old women with complains of headache and progressive visual deterioration in the left eye, whose plain CT showed an ovate high density tumor located in sellar region and MRI represented a homogeneously contrast-enhancing tumor extending from sellar turcica to upsellar cistern. Single-nostril transsphenoidal endoscopic surgery was performed in this patient with a subtotal resection, postoperative histological examination indicated that hyperchromatic tissue filled with cytoplasmic pigment, hyperplasic columnar epithelial cells cover with it, some of it showed papillary partially. These findings combined with immunohistochemistry, proved that the lesion was a pigmented choroid plexus papilloma. We reviewed the current literature, and discussed the origin, the differential of diagnosis and the role of surgery and radiotherapy in the disease.

关键词： Choroid plexus papilloma,Pituitary,sellar,pigment,Melanotic

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A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy

A decrease of ripples precedes seizure onset in mesial tempo...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Cenglin Xu Shuang Wang Yi Wang Zhenghao Xu Jorge Gonzalez-Martinez Feng Gao Xiaohua Wu Shihong Zhang Juan C.Bulacio Imad M.Najm Jianhong Luo Weiwei Hu Norman K.So Zhong Chen Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaCollege of Pharmaceutical SciencesSchool of MedicineZhejiang University Epilepsy Center Second Affiliated HospitalSchool of MedicineZhejiang University Epilepsy Center Neurological InstituteCleveland Clinic

Objective:High-frequency oscillations(HFOs)are promising biomarkers of epilepsy;however,their characteristic changes during the pre-ictal period remain ***,we investigated the pre-ictal changes of HFOs in mesial tempo... 详细信息

关键词： HYP A decrease of ripples precedes seizure onset in mesial temporal lobe epilepsy

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Difficulty modulates microsaccades during a selective visual attention task

Difficulty modulates microsaccades during a selective visual...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Linyan Xue Dan Huang Meijian Wang Yao Chen School of Biomedical Engineering Shanghai Jiao Tong University

Objective Microsaccades are involuntary eye movements with small amplitude and fast velocity during visual fixation. While frequency, amplitude and direction of microsaccade exhibit distinct modulation by selective attention, the mechanisms for these modulations are still under debate. Methods To better understand physiological processing underlying microsaccadic generation and modulation, we examined effects of task difficulty on microsaccade while monkeys were performing an attentional task with two levels of color detection difficulty. Results Our results indicated that task difficulty can decrease microsaccadic rate and enhance its direction bias towards the focus of spatial attention induced by an endogenous cue. Furthermore, we found that task difficulty make a trend of prolonged microsaccadic inhibition. We also found the proportion of microsaccades with high amplitude increased after the appearance of peripheral stimulus while monkeys were doing the hard attention task. Conclusion Taken together, our findings further support that microsaccades are modulated by attentional load.

关键词： Visual attention Eye movement Attentional load Microsaccade

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About turn:How FLIP affects neural processing of Mirrored stimuli in Mental Rotation

About turn:How FLIP affects neural processing of Mirrored st...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Cheng Quan Ji-Guo Xue Chun-Yong Li Jing-Wei Yue Cheng-Gang Zhang Beijing Institute of Radiation Medicine Academy of Military Medical Sciences

Rotated mirror or normal letter discriminations are thought to elicit mental rotation in neural processing. Rotation out of the picture plane, which is called the 'FLIP', has been accounted for the longer response time in mirror letters than normal ones. While little work has been focused on whether or not mirrored stimuli are rotated at the same time as the normal except the hypothesis with few direct evidence that following process will be unnecessary if mental rotation occurs at different times for the two stimulus types. We examined High-density ERPs evoked by rotated letters to determine the relationship between the FLIP and rotation in the picture plane in different types. Both the behavioral and electrophysiological findings suggest that the emergence of FLIP partially overlaps with rotation in the picture plane and leads to the delay of rotation-related negativity which occurs only if mental rotation is required.

关键词： Mental rotation Event-related potentials(ERP) Mirrored letters Parity-judgment task

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Homeostasis regulation of Rhodopsin in Fly Phototransduction

Homeostasis regulation of Rhodopsin in Fly Phototransduction

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiao Wang Junhai Han Institute of Life Sciences the Key Laboratory of Developmental Genes and Human DiseaseSoutheast University

Homeostasis of the components in phototransduction cascades is essential for visual function. The visual pigment rhodopsin is the key component in phototransduction cascade. However, the mechanism of rhodopsin homeostasis is totally unknown. Here, we investigated the dynamic of rhodopsin and showed that rhodopsin undergoes rapid degradation upon saturated light expulsion and fast biosynthesis with dark adaptation. Furthermore, we revealed that adult flies transcript abundant rhodopsin m RNA, which are locked in monoribosomes and polyribosomes. We further identified that phosphorylated FMR1 binds with rhodopsin m RNA and suppresses the biosynthesis of rhodopsin. Moreover, we demonstrated that light-stimulation switches the phosphorylation status of FMR1 and identified the potential phosphatase that controls the dephosphorylation process of FMR1. Our studies support a model in which light-exposure triggers the degradation of rhodopsin. Meanwhile, light-exposure also regulates the phosphatase activity and stimulates dephosphorylation process of FMR1, which subsequently abolish the biosynthesis suppression of rhodopsin.

关键词： Rhodopsin FMR1 dephosphorylation regulation protein biosynthesis phosphatase

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Aggregation of Reelin protein in entorhinal cortex of aged mice

Aggregation of Reelin protein in entorhinal cortex of aged m...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Pan Wang Chunli Hu Shuman Zhang Yiheng Lv Lili Ren Jing Bi Department of Neurobiology Key Laboratory of Neurodegenerative Diseases of Liaoning ProvinceLiaoning Medical University

Entorhinal cortex(EC) is one of selectively vulnerable brain areas in normal aging and Alzheimer's disease. The EC is one of selectively vulnerable brain areas in normal aging and Alzheimer's disease. The EC have widespread connections with hippocampus and neocortex, and different layers of EC have distinct functions and interaction. Reelin plays fundamental role in synaptic plasticity and cognitive function in adult brain. In aged brain, the role of Reelin signaling pathway in EC still remain to be fully determined. In present study, we examined the morphology, synaptic plasticity, neuronal degeneration and Reelin expression in the all layers of EC of adult and aged mice. Our results demonstrated that the number of Reelin positive neurons was reduced in the superficial layers of EC, but Reelin protein was accumulated in deep layer of EC. These results suggest that aging may affect the connection of EC with hippocampus and neocortex, and interaction between layers within EC.

关键词： Entorhinal cortex aging Reelin protein aggregation mice

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Axonally synthesized transcription factors SMAD1/5/8 regulate neuronal subtype specification

Axonally synthesized transcription factors SMAD1/5/8 regulat...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Sheng-Jian JI Department of Biology South University of Science and Technology

Neuronal specification is fundamental for proper assembly of neuronal circuits. While pre-specified genetic programs play important roles in the early steps of neuronal specification, many neurons acquire distinct identities as their axons navigate toward target cells and encounter target-derived signaling molecules. Mechanisms by which axons convert the complex milieu of signaling molecules into retrograde signals are not fully understood. We find that neuronal specification in trigeminal ganglia requires the sequential action of two target-derived factors, BDNF and BMP4. BDNF induces the translation of axonally localized SMAD1/5/8 transcripts. Axon-derived transcription factors SMAD1/5/8 are then translocated to the cell body, where it is phosphorylated to a transcriptionally active form by BMP4-induced signaling endosomes. Our data raise the intriguing possibility that the axonal translation and retrograde trafficking of transcription factors may be a recurrent feature in neuronal subtype specification and patterning.

关键词： local translation,retrograde signaling,SMAD,BMP,BDNF,trigeminal ganglion

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Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking

Identification of a Vav2-dependent mechanism for GDNF/Ret co...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jiawei Zhou Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain ScienceShanghai Institutes for Biological SciencesChinese Academy of Sciences

Dopamine(DA) homeostasis is essential for a variety of brain activities. Dopamine transporter(DAT)-mediated DA reuptake is one of the most critical mechanisms for the control of normal DA homeostasis. However, the molecular mechanisms underlying the regulation of DAT activity in the brain remain poorly understood. Here, we showed that a Rho family GEF protein Vav2 is required for glial cell line-derived neurotrophic factor(GDNF) and its cognate receptor Ret-modulated DAT cell surface expression and transporter activity Mice deficient in either Vav2 or Ret displayed an elevation of DAT activity, which was accompanied with a significant increase in the intracellular DA levels selectively in the nucleus accumbens. Vav2–/– mice exposed to cocaine showed reduced DAT activity and diminished behavioral cocaine response. Our data demonstrate that Vav2 is a determinant of DAT trafficking in vivo and contributes to the maintenance of DA homeostasis in limbic DA neuron terminals.

关键词： Vav2 dopaminergic neuron dopamine transporter cocaine GDNF Ret

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