Objective:High-frequency oscillations(HFOs)are promising biomarkers of epilepsy;however,their characteristic changes during the pre-ictal period remain ***,we investigated the pre-ictal changes of HFOs in mesial tempo...
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Objective:High-frequency oscillations(HFOs)are promising biomarkers of epilepsy;however,their characteristic changes during the pre-ictal period remain ***,we investigated the pre-ictal changes of HFOs in mesial temporal lobe epilepsy(mTLE).
Majority of studies on synaptic and cognitive functions have been focusing on the critical role of calcium ion and its channels in such *** di-ions such as Zinc and Magnesium are essential for proper functioning of ma...
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Majority of studies on synaptic and cognitive functions have been focusing on the critical role of calcium ion and its channels in such *** di-ions such as Zinc and Magnesium are essential for proper functioning of many tissues and organs including the
Recently, increasing evidence, including ours, suggested that dysfunction of RNA metabolism may play a key role in etiology of a range of neurodegenerative disorders, especially motor neuron disease. However, the basi...
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Recently, increasing evidence, including ours, suggested that dysfunction of RNA metabolism may play a key role in etiology of a range of neurodegenerative disorders, especially motor neuron disease. However, the basis of RNA metabolism in specific neuron types and their subcellular compartments during both physiological and pathological conditions is largely unknown. Currently, we focus on three RNA-binding proteins, IGHMBP2, TDP43, and FUS, and study how dysfunction of these genes results in motor neuron degeneration. In addition, we are interested to learn RNA species and their metabolism in specific cell type in the brain, including motor neurons, in different experimental paradigm and pathological conditions. To gain our understanding on these aspects, we combine neurobiology, molecular and cell biology, RNA biochemistry, high through-put sequencing, and mouse forward genetics.
Objective AD is the most common form of dementia among older people. Recent studies have demonstrated that melatonin may be a potentially therapeutic agent in delaying AD, but its exact mechanism still not fully under...
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Objective AD is the most common form of dementia among older people. Recent studies have demonstrated that melatonin may be a potentially therapeutic agent in delaying AD, but its exact mechanism still not fully understood. Notch signaling pathway plays a critical role during brain development. Methods neuroprotective effect of melatonin was investigated by Mirror water maze, WB, IHC, Golgi and Q-PCR. The role of notch signaling in regulating neuroprotective effect of melatonin was further demonstrated in intro study. Results melatonin play neuroprotective effective on Aβ1-42 mediated neurotoxicity via Notch signaling pathway. Conclusion melatonin plays a potential role in neurodegenerative through regulating notch signaling pathway.
A variety of external stimuli and internal psychological states, collectively called stressors, activate the hypothalamic-pituitary stress axis to regulate physiology(e.g. cortisol release). Additionally, these stress...
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A variety of external stimuli and internal psychological states, collectively called stressors, activate the hypothalamic-pituitary stress axis to regulate physiology(e.g. cortisol release). Additionally, these stressors trigger anxiety-like behavioral responses(e.g. fight or flight). Corticotropin releasing factor(CRF) neurons have been identified as a central regulator of both physiological and behavioral responses to stressors. However, how stressors regulate CRF neuron activity are not well understood. We have developed genetic and transgenic tools to address this question employing zebrafish, a vertebrate organism with transparent and highly accessible brains, as well as simple robust physiological and behavioral responses.
In the last 20 years, there have been significant advances in the molecular, cellular, and systems mechanisms underlying the storage of single memories. Real-world memory, however, involves the integration of multiple...
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In the last 20 years, there have been significant advances in the molecular, cellular, and systems mechanisms underlying the storage of single memories. Real-world memory, however, involves the integration of multiple memories across time, with one memory affecting how others are processed and stored. Using a number of techniques including in vivo calcium imaging(with head-mounted fluorescent microscopes in freely behaving mice), the TetT ag transgenic system, optogenetics, electrophysiology, 2-photon microscopy and novel behavioral designs, we showed that memory allocation mechanisms can trigger increases in excitability that then affect both the allocation and strength of subsequent memories, thus providing a mechanism that links the memories across time.
Alzheimer’s disease(AD)is an aging-associated chronic neurodegenerative *** productions ofβ-amyloid(Aβ)peptides and oligomerization of Aβpeptides can induce stress responses in the mitochondria in *** undergo fiss...
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Alzheimer’s disease(AD)is an aging-associated chronic neurodegenerative *** productions ofβ-amyloid(Aβ)peptides and oligomerization of Aβpeptides can induce stress responses in the mitochondria in *** undergo fission and
Despite genetic evidence showing that increased or decreased incorporation of the NR2B subunit into N-methyl-d-aspartate receptors(NMDARs)affects hippocampus-dependent memory in the adult brain,NR2B is not necessary f...
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Despite genetic evidence showing that increased or decreased incorporation of the NR2B subunit into N-methyl-d-aspartate receptors(NMDARs)affects hippocampus-dependent memory in the adult brain,NR2B is not necessary for memory in some experimental
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