检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

1,088 篇 会议
2 篇 期刊文献

馆藏范围

1,090 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

709 篇 医学
- 647 篇 临床医学
- 70 篇 基础医学(可授医学...
- 43 篇 中西医结合
- 14 篇 药学(可授医学、理...
- 13 篇 中药学(可授医学、...
- 10 篇 中医学
- 3 篇 公共卫生与预防医...
- 3 篇 医学技术（可授医学...
- 2 篇 口腔医学
- 2 篇 护理学（可授医学、...
352 篇 理学
- 351 篇 生物学
- 1 篇 物理学
12 篇 工学
- 3 篇 计算机科学与技术...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
- 2 篇 生物医学工程（可授...
- 1 篇 机械工程
- 1 篇 光学工程
- 1 篇 仪器科学与技术
- 1 篇 电子科学与技术（可...
- 1 篇 公安技术
7 篇 教育学
- 3 篇 教育学
- 3 篇 体育学
- 1 篇 心理学(可授教育学...
6 篇 农学
- 4 篇 作物学
1 篇 法学
- 1 篇 公安学
1 篇 文学
- 1 篇 外国语言文学

主题

37 篇 parkinson's dise...
31 篇 hippocampus
28 篇 alzheimer's dise...
22 篇 microglia
16 篇 depression
15 篇 synaptic plastic...
14 篇 apoptosis
14 篇 learning and mem...
13 篇 neuroinflammatio...
13 篇 autophagy
12 篇 optogenetics
12 篇 astrocyte
12 篇 dopamine
12 篇 neuropathic pain
12 篇 neurogenesis
12 篇 proliferation
11 篇 anxiety
11 篇 epilepsy
10 篇 zebrafish
10 篇 ischemic stroke

机构

27 篇 university of ch...
16 篇 institute of neu...
14 篇 institute of neu...
12 篇 key laboratory f...
11 篇 neuroscience res...
10 篇 beijing institut...
10 篇 北京大学
8 篇 cell electrophys...
8 篇 school of biomed...
7 篇 national laborat...
7 篇 graduate school ...
7 篇 center for neuro...
7 篇 department of ph...
6 篇 shaanxi provinci...
6 篇 college of life ...
6 篇 department of ne...
6 篇 key laboratory o...
6 篇 institute of neu...
6 篇 institute of pha...
6 篇 shaanxi engineer...

作者

12 篇 yun wang
12 篇 wei wang
11 篇 hong jiang
10 篇 meng-ya wang
9 篇 yong gu
9 篇 junxia xie
9 篇 jiu-lin du
9 篇 jing wang
9 篇 xiaomin wang
8 篇 zhong chen
8 篇 gang chen
8 篇 feng wang
8 篇 li wang
7 篇 jun wang
7 篇 jun zhang
7 篇 li yuan
7 篇 zhuan zhou
7 篇 hui li
7 篇 xiong-li yang
7 篇 jin-shun qi

语言

1,022 篇 英文
67 篇 中文
1 篇 法文

检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

共 1090 条记录，以下是191-200 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Modulation of task difficulty on microsaccades during covert selective attentional tasks

Modulation of task difficulty on microsaccades during covert...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Lin-Yan Xue Dan Huang Qi-Yi Hu Yao Chen College of Quality and Technical Supervision Hebei University School of Biomedical Engineering Shanghai Jiao Tong University

Microsaccades are involuntary eyemovements with small amplitude and fast velocity during attempted visual fixation. While microsaccadic rate and direction during fixation exhibit distinct modulation by attention, the mechanisms for these modulations are still debated. To better understand the physiological and mechanistic processes underlying microsaccade generation, we examined the effects of task difficulty on microsaccadic parameters during the performance of a visual attention task with two levels of color detection difficulty. Our results indicate that high task difficulty can decrease microsaccadic rate and enhance the direction bias towards the orienting of the spatial attention induced by an endogenous attentional cue. Furthermore, we show that task difficulty make a trend of prolonged microsaccadic inhibition. Finally, we also found the proportion of large amplitude microsaccades increasement after the appearance of peripheral stimulus during the hard task. Taken together, our findings further support the idea that microsaccades are modulated by the attentional load.

关键词： microsaccade covert attention task difficulty

来源：评论

学校读者我要写书评

暂无评论

Autophagy and Synaptic Activity Mechanism in Parkinson's disease

Autophagy and Synaptic Activity Mechanism in Parkinson's dis...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zhenyu Yue Neurology and Neuroscience Director Basic and Translational Research in Movement Disorders Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York

Emerging evidence has implicated dysfunctional autophagy in a growing number of neurodegenerative diseases, including Parkinson's disease(PD). The identification of PD genetic risk factors provides unprecedented opportunities for the dissection of the pathogenic mechanisms of PD and the development of therapeutics. Mutations in many PD associated genes are associated with the disruption of autophagy and increasing autophagy offers protection to neurons by maintaining neuronal protein homeostasis and prevention of toxic accumulation of lpha-synuclein. We have examined the role of autophagy essential genes in dopaminergic neurons using genetic animal models and our results implicate dysfunctional autophagy as one of the failing cellular mechanisms involved in the pathogenesis of idiopathic PD. Furthermore, our study of LRRK2, which is linked to the most common familial form of PD as well as sporadic cases, reveals LRRK2-mediated cellular pathways that regulate synaptic activity(plasticity) and is expected to assist in elucidating the pathogenic mechanisms of the familial PD and identifying better therapeutic targets.

关键词： Parkinson's disease,autophagy,LRRK2,lpha-synuclein,synaptic activity,neurodegenerative disease

来源：评论

学校读者我要写书评

暂无评论

APP but not Aβ is the major factor affecting adult hippocampal neurogeneis in an animal model of Alzheimer's disease

APP but not Aβ is the major factor affecting adult hippocam...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Hongyu Pan Dongpi Wang Dongming Zhou Binggui Sun Institute of Neuroscience School of MedicineZhejiang University

New neurons are generated continuously in the dentate gyrus(DG) of hippocampus throughout adulthood in rodents and most other mammals. Newly generated neurons can integrate into the preexisting synaptic circuitry and are associated with learning and memory and other cognitive functions such as mood regulation. Previous studies showed that adult hippocampal neurogenesis was impaired in several lines of animal models of AD, and amyloid β(Aβ) was believed to be the major culprit. In the present study, we compared the effects of amyloid protein precursor(hA PP) and Aβ on the neurogenesis in adult hippocampus by using two different lines of mice which express similar amount of h APP but very different levels of Aβ. We found that while neurogenesis was impaired in both lines of mice, the degree of neurogenesis reduction was more prominent in the hippocampus of mice expressing h APP with much lower levels of Aβ. Our data suggested that APP but not Aβ might be the major factor affecting neurogeneis in the adult hippocampus.

关键词： Alzheimer's disease,APP,adult neurogenesis,mice

来源：评论

学校读者我要写书评

暂无评论

Mechanism of memory deficit in mouse models of Noonan syndrome

Mechanism of memory deficit in mouse models of Noonan syndro...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yong-Seok Lee Department of Life Science Chung-Ang University

Noonan syndrome（NS） is a neurodevelopmental disorder associated with congenital heart disease, short stature, facial abnormalities and cognitive deficits such as learning disabilities. Mutations in Ptpn11 which encodes SHP-2, a positive regulator for Ras-Erk signaling are responsible for ~ 50% of NS cases. We found that the mutant mice harboring NS-associated mutant Ptpn11 show increase in Erk signaling and enhanced excitatory synaptic function, suggesting that the imbalance between excitatory and inhibitory synaptic transmission could be the cellular mechanism underlying learning and memory deficits in the NS mouse models. Importantly, the behavioral and cellular deficits could be reversed in the adult by a FDA-approved drug lovastatin. We also examined the effect of cell type-specific ectopic expression of a NS-associated mutant SHP-2 on LTP and spatial memory in adult mice. Our results show that SHP-2 in the excitatory neuron is critically involved in hippocampus-dependent learning and memory.

关键词： Mechanism of memory deficit in mouse models of Noonan syndrome

来源：评论

学校读者我要写书评

暂无评论

Role of β-1,3-galactosyltransferase 2 in Rat Dental Pulp Inflammation

Role of β-1,3-galactosyltransferase 2 in Rat Dental Pulp In...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yiheng Lv Lili Ren Yunjie Fu Keqiang Huang Jing Bi Department of Neurobiology Key Laboratory of Neurodegenerative Diseases of Liaoning Province Second Affiliated Hospital Liaoning Medical University

Objective Glycosyltransferases are enzymes that catalyze the formation of a variety of Glycoconjugates. The role of β-1,3-galactosyltransferase 2(b3galt2)in inflammation of nervous system is unknown. Dental pulp inflammation can be used as an inflammatory model of peripheral nervous system. In present study, we investigate the role of b3galt2 in neuroinflammation. Methods Expression of b3galt2 is examined by RT-PCR and western blot, NFk B signaling pathway is determined by immunohistochemistry. Results Inflammation induced upregulation of b3galt2, and b3galt2 has a pro-inflammatory role in dental pulp inflammation. Conclusion b3galt2 may play an important role in mediating peripheral neuroinflammation.

关键词： b3galt2 peripheral neuroinflammation NFkB

来源：评论

学校读者我要写书评

暂无评论

Induction of New Neurons in Adult Injured Spinal Cord

Induction of New Neurons in Adult Injured Spinal Cord

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zhida Su Wenze Niu Meng-Lu Liu Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical Center Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education Second Military Medical University

Spinal cord injury(SCI) leads to irreversible neuronal loss and glial scar formation, which ultimately result in persistent neurological dysfunction. Cellular regeneration could be an ideal approach to replenish the lost cells and repair the damage. However, the adult spinal cord has limited ability to produce new neurons. Here we show that resident astrocytes can be converted to doublecortin(DCX)-positive neuroblasts by a single transcription factor, SOX2, in the injured adult spinal cord. Importantly, these induced neuroblasts can mature into synapse-forming neurons in vivo. Neuronal maturation is further promoted by treatment with a histone deacetylase inhibitor, valproic acid(VPA). The results of this study indicate that in situ reprogramming of endogenous astrocytes to neurons might be a potential strategy for cellular regeneration after SCI.

关键词： astrocytes,neurons,SOX2,in vivo reprogramming,spinal cord injury

来源：评论

学校读者我要写书评

暂无评论

The development of inhibitory circuits involving somatostatin-expressing interneurons

The development of inhibitory circuits involving somatostati...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Wuqiang Guan Junwei Cao Yinhui Fu Yong-chun Yu Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University

In adult rodentneocortex, somatostatin-expressing interneurons densely inhibit pyramidal neuorns, but the amplitudeof monosynaptic SST-Pyr is significantly smaller that that of *** this is developmently established is poorly *** transgenic mouse lines and multi-channel patch-clamp, here we found that the amplitude of adult monosynaptic SST-Pyr synapse issignificantly smaller than that of juvenile micin layer2/3 of primaryvisual *** developmental transformation wasrapid and occuredjust one day after eye-opeing. The magnitude of SST-Pyr synapses in P14-15 wasone third that of P12-13. In contrast, the magnitude of SST-L1 IN remained constant between the second and third postnatal *** analysis suggestedthat this developmental transformation was *** results indicated that the SST-Pyr inhibitory circuit was rapidly regulated after eye-opening. More work should be done to explore the functional difference between juvenile and adult somatostatin-expressing interneurons.

关键词： somatostatin-expressing interneuron,circuitdevelopment

来源：评论

学校读者我要写书评

暂无评论

RNA-sequencing Reveals Corticosterone Mechanism in PC12 Cell Model of Depression

RNA-sequencing Reveals Corticosterone Mechanism in PC12 Cell...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Mingzhen Li jialin qian xiaoyan cheng Mingzhen Li Introduction of Beijing Center for Physical and Chemical Analysis

Stress, acting through glucocorticoids(GC), has profound effects on brain physiology and pathology and is causally implicated in depressive illness. To date, the exact cellular and molecular mechanisms underlying the pathophysiology of MDD have not been identified. Here we use RNA-seq profiling of PC-12 cell treated with or without Corticosterone and demonstrate significantly increased expression of mitogen activated protein kinase(MAPK) phosphatase-1(MKP-1) in the high concentration of Corticosterone subjects compared to matched controls. MKP-1, also known as DUSP1, is a member of a family of dual-specificity phosphatases(DUSP) that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of MAPK cascade, a major signaling pathway involved in neuronal plasticity, function and survival. These in vitro studies identify MKP-1 as a critical factor in MDD pathophysiology and as a novel target for therapeutic interventions.

关键词： MDD RNA-seq Corticosterone PC-12 cell MKP-1

来源：评论

学校读者我要写书评

暂无评论

The stoichiometry and assembly of heteromeric AMPA receptors

The stoichiometry and assembly of heteromeric AMPA receptors

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yun Shi Xue-Yan He Yan-Jun Li MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterNanjing Biomedical Research Institute

AMPA-type glutamate receptors(AMPARs) mediate fast excitatory neurotransmission in brain. The subunit composition of the receptors determines their synaptic targeting and functional properties, and thus is a fundamental parameter for neuronal computations. AMPARs in brain predominantly assemble as heterotetramers. However, the stoichiometry and assembly of heteromeric AMPARs remain unclear. Using the recently solved crystal structure of Glu A2 full-length AMPAR as a template, we performed cysteine mutant cross-linking experiments in full-length Glu A1/A2 to draw the picture of the heteromeric AMPAR architecture. Using non-reducing cross-linking assay, we demonstrate that the heterodimer formation has a preferred architecture. By swapping the critical domains, we further reveal the critical domains that control the heteromeric assembly pattern. Our study sheds light on the stoichiometry and assembly of an important type of glutamate receptor in brain.

关键词： AMPA receptors Assembly GluA1/GluA2

来源：评论

学校读者我要写书评

暂无评论

Orbitofrontal cortex and its contribution to decision-making

Orbitofrontal cortex and its contribution to decision-making

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ai-Ai Ji Hui Xu Sha-Sha Yang KeYi Sun Ping Yu Capital Normal University

Damage to orbitofrontal cortex(OFC) produces an unusual pattern of deficits. Patients have intact cognitive abilities but are impaired in making everyday decisions. Here we review anatomical, neuropsychological, and neurophysiological evidence to determine the neuronal mechanisms that might underlie these impairments. We suggest that OFC plays a key role in processing reward: It integrates multiple sources of information regarding the reward outcome to derive a value signal. In effect, OFC calculates how rewarding a reward is. This value signal can then be held in working memory where it can be used by lateral prefrontal cortex to plan and organize behavior toward obtaining the outcome, and by medial prefrontal cortex to evaluate the overall action in terms of its success and the effort that was required. Thus, acting together, these prefrontal areas can ensure that our behavior is most efficiently directed towards satisfying our needs.

关键词： risk decion rat gambling task orbitofrontal cortex medial prefrontal cortex

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共109页 << < 16 17 18 19 20 21 22 23 24 25 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：