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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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Dopaminergic modulation of reverberatory activity in cultured neuronal networks

Dopaminergic modulation of reverberatory activity in culture...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiaowei Li Pak-Ming Lau Guo-Qiang Bi School of Life Science University of Science and Technology of China

Reverberatory activity has been theoretically considered as neural process underlying short term memory. Dopamine input can regulate aspects of neural activity associated with learning and memory, but its precise effects on network reverberation are still unclear. We have shown previously that small networks of cultured hippocampal neurons could elicit rhythmic persistent activity following a single brief stimulus, and thus could be used as an in vitro model system to study network reverberation. Here we investigated the effect of dopamine on reverberation in these small networks. We found that dopamine(1～100u M) could reduce the occurrence of reverberation in a dose-dependent way with higher concentration of dopamine suppressing more. This suppression was not affected in thepresence of GABAA receptor antagonist bicuculline. Furthermore, dopaminergic inhibition of reverberation was completely rescued by D2-like receptor antagonist sulpiride, suggesting that dopaminergic regulation may act through a D2-like receptor mediated pathway.

关键词： reverberation dopamine neuronal networks

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A coherent neuronal pathway from sensory input to motor output in Drosophila light preference

A coherent neuronal pathway from sensory input to motor outp...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Caixia Gong Yatao Xiao Zhefeng Gong Institute of neuroscience Zhejiang University

Animals' behavioral response to environmental stimulation is under the control of neural circuit that spans sensory neurons, interneurons and motor neuron. In Drosophila melanogaster, larva avoids light whereas adult prefers light. In larvae, visual signals is sensed by Bolwig's organs(BOs) and delivered subsequently to lateral neurons and ptth neurons to elicit a avoidance response. But how the visual signal is converted to behavioral output in downstream circuit is still unknown. Here, we found that eclosion hormone(EH) producing neurons(EH neurons), are required for normal light avoidance. Larvae with EH neurons silenced exhibited defective phototaxis while hyperactivating EH neurons significantly enhanced light avoidance. EH neurons are innervated by ptth neurons. On the other hand, EH neurons innervate octopaminergic/tyraminergic motor neurons directly to maintain normal locomotion and light avoidance behavior. Our results revealed a coherent neural circuit underlying larval light preference behavior that extends from sensory input to motor output.

关键词： Drosophila larvae light preference eclosion hormone

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Translational Control in Cognitive Function and Brain Disorders

Translational Control in Cognitive Function and Brain Disord...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Eric Klann Center for Neural Science New York University

De novo protein synthesis is required for multiple forms of long-lasting synaptic plasticity and the consolidation long-term memory. Over the past decade, signaling cascades that couple cell surface receptors to the translation regulatory machinery during synaptic plasticity and memory have been identified. Interestingly, mutations in genes that encode RNA-binding proteins, proteins that are upstream of and regulate translation factors, as well as translation factors themselves have been shown to be associated with intellectual disability(ID) and autism spectrum disorder(ASD). We have identified several nodes of dysregulated translational control in mouse models of ID and ASD, which has resulted in novel therapeutic targets for these neurodevelopment disorders and have revealed interesting links between translational control pathways, synaptic plasticity, and behavior. We also have identified nodes of dysregulated translational control in a mouse model of Alzheimer's disease(AD). Finally, we have developed techniques for identifying proteins whose synthesis is dysregulated in ID, ASD, and AD. Overall, these studies have provided insight into the mechanisms of translational control in normal synaptic function and behavior, and the molecular basis of neurodevelopmental and neurodegenerative disorders.

关键词： ASD Translational Control in Cognitive Function and Brain Disorders

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Structure and Function of Non-image Vision Neural Circuits

Structure and Function of Non-image Vision Neural Circuits

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Tian Xue School of life Sciences University of Science and Technology of China

Light is captured by eyes and mediates two types of visual function. One is to form images of the world, and the other is non-image vision function which is critical for the survival of the animal and the maintenance of homeostasis, for example, circadian rhythm, sleep, pulillary light reflex and mood. Recent studies have suggested that projections from retina to brain areas that mediate non-image vision are mainly carried by intrinsic photo sensitive retinal ganglion cells(ip RGCs). To study the structure of neural circuits underlying non-image vision, we have combined genetically encoded fluorescent neural tracers and transsynaptic virus to label terminals of ip RGCs in various brain regions and their postsynaptic neurons. A complete map of retinal projections to non-image vision areas can be described. We also performed functional analysis of the neural circuit that encodes light-mediated mood and light affected cross modal cortical development. To understand how a specific neural circuit mediates a certain non-image vision function, we performed electrophysiology study in vitro to describe the neuronal and synaptic properties in the circuit, and optogenetic control of the circuit in vivo.

关键词： Non-image vision viral tracing neural circuits

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周期素依赖性蛋白激酶5通过磷酸化AP2μ2干扰TRPV1内吞进而调控炎症热痛觉敏化

周期素依赖性蛋白激酶5通过磷酸化AP2μ2干扰TRPV1内吞进而调控炎...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：刘皎杜军霞王韵北京大学神经科学研究所教育部及卫生部神经科学重点实验室北京大学麦戈文脑科学研究所

目的本课题组前期研究工作表明,完全弗氏佐剂(complete freund’s adjuvant,CFA)诱导大鼠炎症痛模型中,背根神经节(dorsal root ganglion,DRG)周期素依赖性蛋白激酶5(cyclin-dependent kinase 5,Cdk5)活性增强,并参与炎症热痛觉敏化的... 详细信息

目的本课题组前期研究工作表明,完全弗氏佐剂(complete freund’s adjuvant,CFA)诱导大鼠炎症痛模型中,背根神经节(dorsal root ganglion,DRG)周期素依赖性蛋白激酶5(cyclin-dependent kinase 5,Cdk5)活性增强,并参与炎症热痛觉敏化的形成。本研究旨在进一步对Cdk5激活的下游信号分子进行探讨,证明瞬态感受器电位香草酸受体1(Transient Receptor Potential Vanilloid-1,TRPV1)存在网格蛋白(clathrin)/发动蛋白(dinamin)依赖的组成型内吞,Cdk5可通过磷酸化适配器蛋白Adaptor protein complex 2的μ亚基(AP2μ2)第45位丝氨酸干扰TRPV1的内吞进而调控炎症热痛觉敏化。方法通过生物素标记及免疫荧光染色检测TRPV1在膜表面的分布及内吞现象,GST pull-down及免疫共沉淀检测TRPV1与AP2μ2蛋白的相互作用,体外同位素激酶实验检测Cdk5对AP2μ2的磷酸化,鞘内给药及CFA炎症痛模型观察AP2μ2的S45突变对大鼠痛行为的影响,钙成像实验检测DRG膜表面TRPV1的功能。结果 (1)TRPV1存在组成型内吞现象。(2)TRPV1的内吞是通过Clathrin/Dynamin依赖的途径完成的。(3)TRPV1的内吞需要与AP2μ2相互作用。(4)Cdk5活性影响TRPV1内吞过程。(5)Cdk5能够磷酸化AP2μ2第45位丝氨酸。(6)干扰Cdk5对S45的磷酸化可使TRPV1的内吞增多。(7)大鼠鞘内给予靶向S45的融合肽,可明显减缓其CFA诱导的炎症热痛觉敏化行为。(8)急性分离鞘内给药的大鼠的DRG,TAT-S45组的钙内流信号比TAT-S45A对照组降低。结论 TRPV1存在clathrin/dymain/AP2μ2依赖的组成型内吞,Cdk5通过磷酸化AP2μ2的S45干扰TRPV1的内吞,使其膜上分布增多功能增强,进而参与CFA诱导的热痛觉敏化的形成。这一发现有可能为镇痛药物研发提供新的靶点。

关键词：炎症热痛敏 Cdk5 TRPV1 AP2μ2 磷酸化

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Regulation of major neurotransmitter receptor expression in early stage of migraine

Regulation of major neurotransmitter receptor expression in ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Dongqing Ma John Quinn Minyan Wang Biological Sciences Department Xi'an Jiaotong-Liverpool University Institute of Translational Medicine Liverpool University

Both excitatory and inhibitory neurotransmitter receptors play vital roles in mediating genesis and propagation of cortical spreading depression(CSD), which is migraine aura in man and may lead to migraine pain. Previous studies show that NMDA receptor activation contributes to CSD elicitation, while GABAA receptor activation reduces CSD propagation. How these receptors are regulated post CSD remains clarification. This study investigates whether CSD alters both gene and protein expression level of major subunits of NMDA and GABAA receptor. The results showed that GABAA receptor subunit α2 gene expression was not altered within 72 hours after CSD. On contrast, NMDA receptor subunit NR2 A gene expression was significantly reduced 24 hours post CSD, which returned to normal level 72 hours post CSD. This data suggests that the inhibitory effect of CSD on NR2 A gene was not persistent and NMDA receptor is involved in the development of migraine possibly via a negative feedback mechanism. The protein expression level of GABAA receptor subunit α2 and NR2 A will be also investigated and presented in the poster.

关键词： NR2A GABAA α2 CSD

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GPCR regulation of quantal transmitter release:modulation by membrane potential in chromaffin cells

GPCR regulation of quantal transmitter release:modulation by...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Quanfeng Zhang Xiaoxuan Sun Qihui Wu Bin Liu Xuanyang Chen Zhengtao Zi Changhe Wang Zhuan Zhou State Key Laboratory of Biomembrane-Center for Life Sciences-McGovern Brain Research Institute Institute of Molecular MedicinePeking University

G-protein coupled receptor(GPCR) is a 7-transmembrane receptor, and a major target of drugs. We previous find that activation of GPCR-Gi reduces quantal catecholamine release through gating vesicle fusion pore from full fusion to kiss-and-run in adrenal chromaffin cells(Chen et al., 2005). By using electrochemical carbon fiber electrode(CFE) and total internal reflection fluorescence microscopy(TIRF) to record single vesicle release, here we report that membrane depolarization can remove the Gi-effect on fusion pore, termed vGi. Activation of P2Y-Gi decreases the quantal size, while depolarization removes the vGi effect and significantly increase the quantal size. When P2 Y receptor is blocked, vGi effect is also gone. TIRF imaging shows that vGi is mainly made by switching vesicle fusion from kiss-and-run to full fusion.

关键词： GPCR regulation of quantal transmitter release:modulation by membrane potential in chromaffin cells

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首发未治疗缺陷型和非缺陷型精神分裂症患者脑结构进展性改变的差异:1年随访研究

首发未治疗缺陷型和非缺陷型精神分裂症患者脑结构进展性改变的差...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：雷威邓伟李名立李娜黄朝华任虹燕李寅飞张程程杨潇余华李涛四川大学华西临床医学院四川大学华西医院心理卫生中心

目的:大量研究表明,精神分裂症患者在疾病的进程中存在显著的进展性脑结构改变。目前尚不清楚这种进展性脑结构改变会否受到缺陷综合征(即原发持续的阴性症状)的调控。本研究通过神经影像学方法考察缺陷型和非缺陷型精神分裂症患者脑结... 详细信息

目的:大量研究表明,精神分裂症患者在疾病的进程中存在显著的进展性脑结构改变。目前尚不清楚这种进展性脑结构改变会否受到缺陷综合征(即原发持续的阴性症状)的调控。本研究通过神经影像学方法考察缺陷型和非缺陷型精神分裂症患者脑结构进展性改变模式的差异。方法:本研究采用纵向随访研究设计。34名首发未治疗精神分裂症(14例缺陷型,20例非缺陷型)患者和32名性别,年龄匹配的健康对照参与了基线结构磁共振扫描和测试,患者还参与了12个月之后的第二次扫描和测试。本研究采用基于体素的形态学分析方法来考察患者灰质和白质体积的进展性改变模式。采用阳性和阴性症状量表(PANSS量表)考查患者首发和随访12个月后的临床症状严重程度。结果:临床症状方面,一年治疗之后两组患者的症状均得到显著改善,但治疗一年之后缺陷型患者仍表现更严重的阴性症状。灰质体积方面,基线对比中仅缺陷型患者在小脑前叶表现灰质体积的缺损,非缺陷型患者未见基线灰质体积异常。一年随访与基线相比,缺陷型患者的左侧海马灰质体积进展性减少;非缺陷型患者灰质体积除了在海马之外,还在额顶叶的广泛区域表现灰质体积的进展性减少,并且在基底节表现灰质体积的增加。白质体积方面,基线对比中仅缺陷型患者在小脑前叶、内囊后肢区域表现白质体积的缺损,非缺陷型患者未见基线白质异常。一年随访与基线相比,非缺陷型患者在内囊后肢,枕叶和颞中回深部白质表现白质体积的进展性减少;缺陷型患者则未见显著的白质进展性改变。上述影像学结果均不受药物治疗的影响。结论:缺陷型精神分裂症可能是一种脑结构异常出现较早且不随病程进展性改变的精神分裂症亚型。

关键词：精神分裂症白质体积灰质体积随访

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Role of NMDA receptor trafficking in hippocampal synaptic plasticity,learning and memory

Role of NMDA receptor trafficking in hippocampal synaptic pl...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Nan Cheng Jinyun Zhang Xueting Zhang Ning Wang Tian Tian Yu Liu Wei Lu Department of Neurobiology Nanjing Medical University Institute of Life Sciences MOE Key Laboratory of Developmental Genes and Human Disease Southeast University

Given the NMDA receptor(NMDAR) plays a central role in various brain functions, the trafficking of NMDAR in response to synaptic activation that changes the strength of synaptic NMDAR is expected to have profound implications. Surprisingly, the exact role of NMDAR trafficking in these brain functions is still elusive. Here, we report that classical forms of long-term potentiation(LTP) are always accompanied by long-lasting potentiation in NMDAR-mediated synaptic responses. Interestingly, similar to the role of AMPA receptor(AMPAR) trafficking in LTP of AMPA responses(LTPAMPA), NMDAR trafficking underlies LTP of NMDA responses(LTPNMDA). Dissecting the relationship between AMPAR and NMDAR trafficking as well as their potential roles in LTP reveals an asymmetric rule: specially inhibiting NR2A-containing NMDAR trafficking reverses the enhancement in the expression of postsynaptic AMPAR and LTPAMPA, but not vice versa. Moreover, disturbing NR2A-containing NMDAR trafficking in dorsal hippocampal in vivo causes deficits in fear memory. We conclude that NMDA receptor trafficking is essential to hippocampal synaptic plasticity, learning and memory.

关键词： NMDA receptor LTP synaptic plasticity,memory maintenance

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Cholinergic Modulation of Projection Neurons in Songbirds' Forebrain Song Control Nucleus RA

Cholinergic Modulation of Projection Neurons in Songbirds' F...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Wei MENG Song-Hua WANG Dong-Feng LI School of Life Science South China Normal University School of Life Science Jiangxi Science and Technology Normal University

Objective Birdsong is a learned behavior. The robust nucleus of the arcopallium(RA) is an important pre-motor nucleus in song control system of songbirds. The RA is innervated by the cholinergic fibers which originate from the ventral paleostriatum(VP) in the basal forebrain. Cholinergic modulation of neurons in nucleus RA remains unclear. In the present study, cholinergic modulation of projection neurons in songbirds' forebrain song control nucleus RA has been investigated. Methods Cholinergic modulation of projection neurons in RA has been investigated using in vitro whole cell patch clamp recordings. Results(1) The nonselective cholinergic receptor agonist carbachol significantly decreased the frequency of both the spontaneous and evoked action potential firing of projection neurons in RA.(2) The membrane potential of projection neurons in RA was hyperpolarized by carbachol.(3) Carbachol significantly decreased membrane input resistance of projection neurons in RA. Conclusion These results demonstrate that carbachol reduces activity of projection neurons in RA by inducing membrane hyperpolarization, indicating that cholinergic regulation mechanisms may play an important role in song control.

关键词： cholinergic modulation songbirds song control nucleus projection neurons RA

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