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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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GPCR regulation of quantal transmitter release:modulation by membrane potential in chromaffin cells

GPCR regulation of quantal transmitter release:modulation by...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Quanfeng Zhang Xiaoxuan Sun Qihui Wu Bin Liu Xuanyang Chen Zhengtao Zi Changhe Wang Zhuan Zhou State Key Laboratory of Biomembrane-Center for Life Sciences-McGovern Brain Research Institute Institute of Molecular MedicinePeking University

G-protein coupled receptor(GPCR) is a 7-transmembrane receptor, and a major target of drugs. We previous find that activation of GPCR-Gi reduces quantal catecholamine release through gating vesicle fusion pore from full fusion to kiss-and-run in adrenal chromaffin cells(Chen et al., 2005). By using electrochemical carbon fiber electrode(CFE) and total internal reflection fluorescence microscopy(TIRF) to record single vesicle release, here we report that membrane depolarization can remove the Gi-effect on fusion pore, termed vGi. Activation of P2Y-Gi decreases the quantal size, while depolarization removes the vGi effect and significantly increase the quantal size. When P2 Y receptor is blocked, vGi effect is also gone. TIRF imaging shows that vGi is mainly made by switching vesicle fusion from kiss-and-run to full fusion.

关键词： GPCR regulation of quantal transmitter release:modulation by membrane potential in chromaffin cells

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Role of NMDA receptor trafficking in hippocampal synaptic plasticity,learning and memory

Role of NMDA receptor trafficking in hippocampal synaptic pl...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Nan Cheng Jinyun Zhang Xueting Zhang Ning Wang Tian Tian Yu Liu Wei Lu Department of Neurobiology Nanjing Medical University Institute of Life Sciences MOE Key Laboratory of Developmental Genes and Human Disease Southeast University

Given the NMDA receptor(NMDAR) plays a central role in various brain functions, the trafficking of NMDAR in response to synaptic activation that changes the strength of synaptic NMDAR is expected to have profound implications. Surprisingly, the exact role of NMDAR trafficking in these brain functions is still elusive. Here, we report that classical forms of long-term potentiation(LTP) are always accompanied by long-lasting potentiation in NMDAR-mediated synaptic responses. Interestingly, similar to the role of AMPA receptor(AMPAR) trafficking in LTP of AMPA responses(LTPAMPA), NMDAR trafficking underlies LTP of NMDA responses(LTPNMDA). Dissecting the relationship between AMPAR and NMDAR trafficking as well as their potential roles in LTP reveals an asymmetric rule: specially inhibiting NR2A-containing NMDAR trafficking reverses the enhancement in the expression of postsynaptic AMPAR and LTPAMPA, but not vice versa. Moreover, disturbing NR2A-containing NMDAR trafficking in dorsal hippocampal in vivo causes deficits in fear memory. We conclude that NMDA receptor trafficking is essential to hippocampal synaptic plasticity, learning and memory.

关键词： NMDA receptor LTP synaptic plasticity,memory maintenance

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Thalamus-habenula pathway controls light-dark preference behavior in zebrafish larvae

Thalamus-habenula pathway controls light-dark preference beh...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Bai-bing Zhang Yuan-yuan Yao Jiu-lin Du Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain ScienceShanghai Institutes for Biological SciencesChinese Academy of Sciences Graduate School University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University

Appropriate preference for light or dark is crucial for animal's survival, but the underlying circuit mechanism is largely unknown. Here, by combining behavioral assay, in vivo optoand electro-physiological recording, optogenetic manipulation and morphological tracing in zebrafish larvae, we demonstrated that a circuitry consisted of retinal ganglion cells(RGCs), thalamus and left dorsal habenula(ld Hb) mediates the light-dark preference. Lesion or dysfunction of RGCs, thalamus or ld Hb diminished light preference, while optogenetic activation of the habenula recovered light preference of larvae with removal of both eyes. At anatomical level, a sub-region of the thalamus locating at the arborization field 4(AF4) of RGCs receives direct RGC innervation. Thalamic neurons at this region send projections to the ld Hb directly and form functional synapses with ld Hb neurons. Thus, our study identifies a neural circuitry which mediates light-dark preference behavior in vertebrates.

关键词： light-dark preference,thalamus,habenula,zebrafish

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Cholinergic Modulation of Projection Neurons in Songbirds' Forebrain Song Control Nucleus RA

Cholinergic Modulation of Projection Neurons in Songbirds' F...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Wei MENG Song-Hua WANG Dong-Feng LI School of Life Science South China Normal University School of Life Science Jiangxi Science and Technology Normal University

Objective Birdsong is a learned behavior. The robust nucleus of the arcopallium(RA) is an important pre-motor nucleus in song control system of songbirds. The RA is innervated by the cholinergic fibers which originate from the ventral paleostriatum(VP) in the basal forebrain. Cholinergic modulation of neurons in nucleus RA remains unclear. In the present study, cholinergic modulation of projection neurons in songbirds' forebrain song control nucleus RA has been investigated. Methods Cholinergic modulation of projection neurons in RA has been investigated using in vitro whole cell patch clamp recordings. Results(1) The nonselective cholinergic receptor agonist carbachol significantly decreased the frequency of both the spontaneous and evoked action potential firing of projection neurons in RA.(2) The membrane potential of projection neurons in RA was hyperpolarized by carbachol.(3) Carbachol significantly decreased membrane input resistance of projection neurons in RA. Conclusion These results demonstrate that carbachol reduces activity of projection neurons in RA by inducing membrane hyperpolarization, indicating that cholinergic regulation mechanisms may play an important role in song control.

关键词： cholinergic modulation songbirds song control nucleus projection neurons RA

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Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice

Age-dependent neuron loss is associated with impaired adult ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Shanshan Cheng Chen Zhang Congyu Xu Long Wang Xiaoxia Zou Guiquan Chen Model Animal Research Center MOE Key Laboratory of Model Animal for Disease StudyNanjing Biomedical Research InstituteNanjing University

Impairment in the micro RNA(mi RNA) network causes a number of neurodegenerative diseases. Endoribonuclease Dicer is a key RNase to produce mature mi RNAs. It has been shown that Dicer is important for the maintenance of excitatory neuron survival during early postnatal period. However, the role of Dicer in adult mature excitatory neuron survival is not clear. In this study, we generated a mouse model in which Dicer is conditionally inactivated in forebrain excitatory neurons from a mature stage, and this line is termed Dicer conditional knockout(c KO). Significant age-dependent neurodegeneration was observed in the cortex of Dicer c KO mice, indicating an important role of Dicer in the maintenance of mature excitatory neuron survival in the adult cortex. Impairment in adult neurogenesis was found in 6-month but not in young Dicer c KO mice. However, astrocytosis was detected in young Dicer c KO mice displaying no apparent neuron loss. Overall, neurogenesis impairment and neuroinflammation may play pivotal roles in the progression of neurodegeneration.

关键词： Neuron loss Mouse model miRNA Dicer Neuronal survival

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首发未治疗缺陷型和非缺陷型精神分裂症患者脑结构进展性改变的差异:1年随访研究

首发未治疗缺陷型和非缺陷型精神分裂症患者脑结构进展性改变的差...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：雷威邓伟李名立李娜黄朝华任虹燕李寅飞张程程杨潇余华李涛四川大学华西临床医学院四川大学华西医院心理卫生中心

目的:大量研究表明,精神分裂症患者在疾病的进程中存在显著的进展性脑结构改变。目前尚不清楚这种进展性脑结构改变会否受到缺陷综合征(即原发持续的阴性症状)的调控。本研究通过神经影像学方法考察缺陷型和非缺陷型精神分裂症患者脑结... 详细信息

目的:大量研究表明,精神分裂症患者在疾病的进程中存在显著的进展性脑结构改变。目前尚不清楚这种进展性脑结构改变会否受到缺陷综合征(即原发持续的阴性症状)的调控。本研究通过神经影像学方法考察缺陷型和非缺陷型精神分裂症患者脑结构进展性改变模式的差异。方法:本研究采用纵向随访研究设计。34名首发未治疗精神分裂症(14例缺陷型,20例非缺陷型)患者和32名性别,年龄匹配的健康对照参与了基线结构磁共振扫描和测试,患者还参与了12个月之后的第二次扫描和测试。本研究采用基于体素的形态学分析方法来考察患者灰质和白质体积的进展性改变模式。采用阳性和阴性症状量表(PANSS量表)考查患者首发和随访12个月后的临床症状严重程度。结果:临床症状方面,一年治疗之后两组患者的症状均得到显著改善,但治疗一年之后缺陷型患者仍表现更严重的阴性症状。灰质体积方面,基线对比中仅缺陷型患者在小脑前叶表现灰质体积的缺损,非缺陷型患者未见基线灰质体积异常。一年随访与基线相比,缺陷型患者的左侧海马灰质体积进展性减少;非缺陷型患者灰质体积除了在海马之外,还在额顶叶的广泛区域表现灰质体积的进展性减少,并且在基底节表现灰质体积的增加。白质体积方面,基线对比中仅缺陷型患者在小脑前叶、内囊后肢区域表现白质体积的缺损,非缺陷型患者未见基线白质异常。一年随访与基线相比,非缺陷型患者在内囊后肢,枕叶和颞中回深部白质表现白质体积的进展性减少;缺陷型患者则未见显著的白质进展性改变。上述影像学结果均不受药物治疗的影响。结论:缺陷型精神分裂症可能是一种脑结构异常出现较早且不随病程进展性改变的精神分裂症亚型。

关键词：精神分裂症白质体积灰质体积随访

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Effects of Exhaustive Treadmill Running on Synaptic Ultrastructure in Dorsolateral Striatum of Rat

Effects of Exhaustive Treadmill Running on Synaptic Ultrastr...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jiali Cheng Lijuan Hou Xiaoli Liu Decai Qiao Exercise Physiology Lab Beijing Normal University

Background: The striatum is a major component of the basal ganglia and is associated with motor and cognitive functions. Neurons projecting from the striatum receive a large convergence of afferents from all areas of the cortex,which has a crucial integrative and computational role, leading to the acquisition *** this work, the synapticultrastructure variations in dorsolateral striatum(DLS) of rat is investigated to discuss central nervous system role of exercise fatigue. Methods: Male SD rats were randomly divided into a control group(CG) and fatigue group(FG).We selecttreadmill incremental exercise program to establish exercise-induced fatigue model. The transmission electron microscope(TEM) is detected to synaptic ultrastructure in dorsolateral ***:(1) Synaptic vesicle amount in DLS was significantly increased in FG(p<0.05).(2) Thickness of post-synaptic density(PSD) increased in FG(p<0.05), and the width ofsynaptic cleft is remarkably decreased in FG(p<0.05).(3) The amount of mitochondria locatinginpresynaptic is decreased in FG(p<0.05).Conclusions: This study demonstrate that exhaustive exercise result in the synaptic ultrastructure variations in dorsolateral striatum. It suggests that DLS plays an important role in synaptic plasticity during exercise fatigue.(31171138/31401018)(5142012).

关键词： exhaustive exercise synaptic ultrastructure dorsolateral striatum

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Anterior auditory cortex strengthened sound selectivity via cortical computation

Anterior auditory cortex strengthened sound selectivity via ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Can Tao Guang-Wei Zhang Chang Zhou Su-Mei Yan Li-Juan Wang Yi Zhou Ying Xiong Department of Neurobiology Chongqing Key Laboratory of NeurobiologyThird Military Medical University

Anterior auditory field(AAF) and primary auditory cortex(A1) constitute the core region of auditory cortex yet how the information been coded in AAF remained to be elucidated. The present work is to functionally localize AAF and study its evoked responses by sound stimulation. Multi-unit extracellular recording was applied to obtain the frequency gradient of AAF. In vivo loose-patch was performed to study the evoked single neuron activity and synaptic responses were acquired by in vivo whole-cell recording. AAF is rostral and ventral to AI and has a mirror frequency gradient with A1. Robust tonal evoked responses could be observed in 30% recorded excitatory neurons in AAF and they are highly selective to both sound frequency and intensity. In vivo voltage-clamp recording revealed that temporal profile and frequency tuning of tonal evoked excitation and inhibition is different. The evoked excitatory postsynaptic current(EPSC) showed a long duration compared with inhibitory postsynaptic current(IPSC), this suggest that complex cortical computation is involved. Our results suggested that cortical computation in AAF strengthened the sound selectivity.

关键词： anterior auditory cortex tonal receptive field in vivo patch clamp

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Resting state fMRI and viral neuronal tracing in the FMR1 gene knockout rat model

Resting state fMRI and viral neuronal tracing in the FMR1 ge...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yue Liu Fu-Qiang Xu Wuhan National Laboratory for Optoelectronics Huazhong university of science and technology

Objective FMR1(fragile X mental retardation 1) is a gene that codes for a protein called fragile X mental retardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development. We try to investigate the influences on brain function and relevant neural circuits induced by FMR1 gene. Methods Using resting state(RS) functional magnetic resonance imaging(f MRI), the connectivity patterns of cognitive relevant brain regions were explored in FMR1 rat models and wild type controls. Neuronal tracing with HSV(Herpes Simplex virus) and Pr V(Pseudorabies) were also used for demonstrating the structure connectivity in some of these brain areas. Results(1) We found that some regions like the CA2 region of hippocampus appeared an obviously decrease of interhemispheric functional connectivity.(2)The viral neural circuit results also supported the phenomenon by the abnormal structure connectivity. Conclusion FMR1 gene deletion may lead to an unusual connectivity of hemispheres.

关键词： Fmr1 gene resting state fMRI neural tracing HSV PrV

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The Method of Attaining high transfection efficiency of plasmid into neural stem cells by electroporator

The Method of Attaining high transfection efficiency of plas...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiaohua Jiang Jingrui Tian Yanxia Tian Junling Gao School of Basic Medicine Hebei Key Lab For Chronic DiseasesNorth China University of Science and Technolgy

Objective: To optimize the conditions of transfecting eukaryotic expression vector p EGFP-N1 into neural stem cells(NSCs) from rat's by CUY21 EDITII electroporator, in order to improve the transfection efficiency of exogenous gene into NSCs and provide a basis for the follow-up experiments. Methods: Using different PpV, but same Pd V, pulse time and cycle time, pE GFP-N1 which expresses green fluorescence protein(GFP) was transfected into NSCs by CUY21 EDITII electroporator. Then the transfection efficiency was calculated by counting the NSCs with green fluorescent at 48 h after transfection. Results: The satisfactory transfection efficiency was acquired under the condition of PpV(350 V), Pd V(20 V), pulse time(10 ms), number of cycles(20). The average transfection rates of electroporation was 81.0% and the survival rate was 72.0%. Conclusion: The high transfection rate could be acquired by optimizing the transfection conditions. It suggested that electroporation by CUY21EDITⅡelectroporator was a more efficient method for plasmid into NSCs than lipofectamine.

关键词： neural stem cells electroporation lipofectamine transfection

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