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The relationships between neuroticism,adult attachment and depression of college students

The relationships between neuroticism,adult attachment and d...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Simeng Gu Yu Lei Chen Ying Benyu Guo Fushun Wang Tifei Yuan Dept of Psychology Nanjing Normal UniversityNanjing Dept of Psychology Nanjing University of Traditional Chinese Medicine Dept of Neuroscience University of RohcesterRochester

Purpose: The paper aimed to explore the relationships between neuroticism, adult attachment and depression, in which adult attachment should be mediated as the intermediary variable affecting the relations between neuroticism and depression. Methods: 1677 college students were recruited for the tests, the Center for Epidemiological Studies Depression Scale(CES-D), Experiences in Close Relationships Inventory(ECR) and NEO Five Factor Inventory-Neuroticism Subscale(FFI-N). Results: Correlation analysis: neuroticism, avoidant attachment and anxiety attachment were significantly correlated with depression positively(r = 0.673, p < 0.01;r = 0.232, p < 0.01;r = 0.390, p < 0.01), both avoidant attachment and anxiety attachment were significantly correlated with neuroticism positively(r = 0.238, p < 0.01;r = 0.470, p < 0.01). Structural equation model: insecure adult attachment was a mediator of neuroticism and depression, and avoidant attachment had more significant mediating effect than anxiety attachment. Conclusion: Neuroticism and insecure adult attachment affected depression directly, and insecure adult attachment played a mediator role in the effect of neuroticism on depression.

关键词： Neuroticism,avoidant attachment,anxiety attachment,depression

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Sustained activity of PAK1 maintains GABAergic synaptic transmission in the hippocampus

Sustained activity of PAK1 maintains GABAergic synaptic tran...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zikai Zhou Shuting Xia Yuehua Zhu Wei Xie Zhengping Jia Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast University Neurosciences & Mental Health Program The Hospital for Sick Children

Mental retardation related gene PAK(p21-activated kinase) family play important roles in neurodevelopment, synaptic transmission and plasticity. Various genetic and pharmacological manipulations on PAK have successfully reversed multiple neurobiological and behavioral deficits in transgenic mouse models of autism, e.g. Fmr1 KO and Nf1+/-mice. However the mechanisms underlying the rescue of these autistic phenotypes remain unclear. In this study, we found that sustained kinase activity of PAK1, a major form of PAK expressed in the brain, is critical for the maintenance of GABAergic synaptic transmission and short-term plasticity in the hippocampus, which is achieved by regulating retrograde endocannabinoid signaling. Using synthetic inhibitors and proteomic analysis, we further examined potential regulatory effects of PAK1 on key signaling molecules in the endocannabinoid pathway. We identified the target of PAK1 as a degradation enzyme of endocannabinoid 2-arachidonoylglycerol(2-AG). This study may provide new insights into regulatory machinery of the endocannabinoid system and PAK-mediated regulation of brain functions.

关键词： p21-activated kinase endocannabinoid GABAergic transmission

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Learning-based stable memory

Learning-based stable memory

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiu-Zhen Wang Wei Zhao Hong-Yu Li Xiao-Juan Chang Yan-Ling Cui Hong-Xia Wang Guohui Zhou Wei-Quan Gu Rifeng Wang Cognitive Learning Laboratory College of Computer Science and Information EngineeringHarbin Normal University College of Computer Science and Communication Engineering Guangxi University of Science and Technology

During memory formation, granular cortex is reconstructed by re-learning the same or similar tasks. The effect of repetition learning is thought to reflect a progressive optimization of memory structure. Previous functional magnetic resonance imaging(f MRI) evidence has suggested that the information granule could be at an advantage for stable memory. As expected, the learning-dependent involvement of neural systems and information granule enhance the memory effects. However, f MRI studies haven't investigated that the effects of temporary memory and lasting memory are supported by the different associative cortex following different learning systems. This paper gives a good overview that, in parallel to stable memory, the neural systems mediate the influences of learning and re-learning on memory consolidation. The highly polymerized form among elements enhances memory effects of information granule following learning, suggesting that interactions between memory and learning are associated with information integration of similar tasks like Arabic arithmetic multiplication formulas.

关键词： stable memory information granule learning granularity

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自发性颈部动脉夹层与缺血性卒中发生的关系研究

自发性颈部动脉夹层与缺血性卒中发生的关系研究

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：刘娟许志强周华东第三军医大学大坪医院野战外科研究所神经内科

目的自发性颈部动脉夹层(spontaneous cervical arterydissection,SCAD),是青中年人缺血性卒中的主要病因之一。SCAD是遗传、环境及其他内源性因素所致的多因素疾病,高血压、糖尿病、吸烟等血管危险因素在SCAD发病形式中扮演着重要的角... 详细信息

目的自发性颈部动脉夹层(spontaneous cervical arterydissection,SCAD),是青中年人缺血性卒中的主要病因之一。SCAD是遗传、环境及其他内源性因素所致的多因素疾病,高血压、糖尿病、吸烟等血管危险因素在SCAD发病形式中扮演着重要的角色。目前对SCAD与缺血性卒中发生的相关性研究报道较少。本研究对161例SCAD患者进行缺血性卒中发生的相关因素分析。方法选择我科2007.1-2012.6经颈部血管影像学检查确诊的SCAD患者161例,按照是否发生缺血性卒中分为卒中组和非卒中组,对两组患者的基线特征、临床症状、影像学特征进行比较,并对卒中的发生进行多因素Logistic回归分析。结果 161例SCAD患者中,发生缺血性卒中77例,占47.8%,平均年龄54.52岁,女性占57.1%,高血压占51.6%,糖尿病占20.5%,高血脂占19.9%,吸烟占37.9%,36.0%患者伴随头颈部疼痛。卒中和非卒中组在年龄、性别、吸烟、高血脂、头颈部疼痛无明显差异(p>0.05),卒中组高血压、糖尿病明显多于非卒中组(p<0.05)。161例患者中,颅外颈动脉夹层89例,椎动脉夹层72例,卒中组颈动脉夹层少于非卒中组(p<0.05),对卒中组和非卒中组影像学特征比较,非卒中组合并夹层动脉瘤、双腔征显著多于卒中组(p<0.05),卒中组重度狭窄显著多于非卒中组(p<0.05)。多因素Logistic回归分析提示糖尿病(OR=3.095,95%CI 1.273-7.524,p=0.013)、重度狭窄(OR=4.335,95%CI 2.123-8.854,p<0.001)是SCAD的卒中发生呈正相关,而夹层动脉瘤与卒中呈负相关(OR=0.429,95%CI 0.198-0.930,p=0.032)。结论随着血管影像学技术的迅速发展,SCAD检出率逐渐增加。本研究入组SCAD患者中,47.8%合并缺血性卒中,与国外的两项大样本研究结果一致。糖尿病、重度狭窄病变与SCAD的卒中发生呈正相关,而夹层动脉瘤与SCAD的卒中发生呈负相关。对SCAD进行卒中的相关危险因素分析,有利于对SCAD进行最优治疗,减少卒中的复发、死亡率。

关键词：自发性动脉夹层缺血性卒中

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Proteasome activity contributes to the self-renewal and maintenance of neural stem/progenitor cells

Proteasome activity contributes to the self-renewal and main...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Chan-Ting He Yun-He Zhao Xue-Qin Liu Xiao-Jie Niu Rong Jiang Li Lu Department of Anatomy Shanxi Medical University

Protein turnover and homeostasis is regulated by proteasomal system, which is essential in keeping cell viability and normal function. Pluripotency of stem cells relies on proteasome activity to counteract senescent effect along prolonged expansion, as demonstrated in human bone marrow stem cells. In this study, we perform experiment to investigate if proteasome contributes to self-renewal and cell viability of neural stem/Progenitor cells(NSPCs). Through both in vivo and in vitro analysis, we found that proteasome subunit expressions are progressively decreased during aging process. Cell proliferation and self-renewal of NSPCs are impaired in aged mice, indicating downregulation of proteasome activity may be responsible for this senescence phenotype. Manipulation of proteasomal activity by loss of function study could mimic the senescence effects of NSPCs in vitro and in vivo. On the other hand, gain of function analysis could restore and improve self-renewal ability of senescent NSPCs. These results indicate proteasome activity may play a role in maintaining or promoting self-renewal of NSPCs, supposing a potent therapeutic target by activating proteasome activity to anti-brain aging.

关键词： respiratory cannabinoid potassium channels,ATP

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The Distribute and Nature of the Lipid Droplets within Hensen's Cells in the Guinea-pig Cochlea

The Distribute and Nature of the Lipid Droplets within Hense...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Yang Fengbo Cheng Xiaoting Ding Daxiong Lv Ping Ren Hongmiao Zhang Yue Cong Tao Yang Shiming Zhai Suoqiang Yu Ning Department of Otolaryngology Head and Neck Surgery in Affiliated Hospital of North Sichuan Medical College Department of Otorhinolaryngology Head and Neck Surgery the First Affiliated Hospital of Fujiang Medical University Department of Otorhinolaryngology Head and Neck Surgery the Second Xiangya HospitalCentral South University Department of Otorhinolaryngology Head and Neck Surgery&Institute of Otorhinolaryngolgoy the PLA General Hospital

Objective: To study the distribute and nature of the lipid droplets within Hensen's Cells(HCs) of guinea-pig Coti's organ;by Bodipy 493/503: one of the flurescent molecular probes for staining fats. Methods: The cells or organ of cochlea were marked by Bodipy493/503, Sudan III, Oil red O, and Osmium tetroxide. Results: The lipid droplets within the guinea-pigs HCs and Hensen's straps are green standing by Bodipy493/503. They are jacinth by Sudan III. They are Ruby red by Oil red *** are black globules stripe which post-fixed in 2% osmium tetroxide. Conclusions: This four marker have common finded that the droplets within guinea-pigs HCs' s cytoplasm are lipid droplets.

关键词： Cochlea Supporting cells Hensen's cell Lipid Droplets Bodipy

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Epigenomic regulation of metabolism by circadian clock through HDAC3

Epigenomic regulation of metabolism by circadian clock throu...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zheng Sun Department of Molecular and Cellular Biology

Both kinetic metabolic fluxes and expression of metabolic genes display robust circadian rhythms across all major metabolic tissues such as liver, pancreas, brain, heart, and muscle. The internal circadian clock is dictated by a molecular clock composed of several transcription factors and cofactors in intertwined negative feedback loops. We found that the genome-wide recruitment of histone deacetylase 3(HDAC3) in liver displays robust circadian rhythm and is orchestrated by molecular circadian clock through nuclear receptors Rev-erbs. Liver-specific deletion of HDAC3 reroutes metabolic precursors away from glucose production, and towards lipid synthesis and sequestration within lipid droplets, challenging the prevailing dogma regarding association of fatty liver and diabetes, and providing a unifying framework to explain the intricate interrelationship between lipogenesis and gluconeogenesis that is governed by the internal circadian clock through epigenomic mechanisms. Intriguingly, major metabolic functions of HDAC3 in liver is independent of its enzymatic activity but requires its interaction with nuclear receptor corepressor(NCORs). Metabolic function of circadian clock and HDAC3 in other tissues will also be discussed.

关键词： epigenetics,histone deacetylase,circadian rhythm,metabolism,diabetes

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Inverted optical intrinsic responses do not imply suppressed activity in all cortical neurons

Inverted optical intrinsic responses do not imply suppressed...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zeng-Guang Ma Peng-Jia Cao Peng-Cheng Sun Yao Chen Xin-Yu Chai Biomedical Engineering Shanghai Jiao Tong University

Objective Using optical intrinsic signal(OIS) imaging we found an antagonistic spatial pattern of positive and negative OIS responses(POR and NOR) in cat's visual cortex by transcorneal electrical stimulation(Tc ES). We then further investigated the spatial-temporal properties of this antagonistic OIS response and its relationship to local neuronal activity. Methods Multiwavelength OIS response was recorded from area 17/18 in cats to investigate cortical activation to Tc ES through an ERG-jet electrode. Linear microelectrode array was used to measure the laminar neuronal activity throughout the depth of the cortex, while Utah microelectrode array was used to measure the planar differences in neuronal activity. Results(1) The amplitude and activated areas of NOR were related to electrical stimulation.(2) Decreased multiunit activity(MUA) was detected in the middle cortical layers in the NOR region by spectral power analysis.(3) The Utah array recordings showed that not all the MUA in the NOR region was suppressed. Conclusion The negative hemodynamic response may be related to the balance changes between neuronal inhibition and excitation.

关键词： Antagonistic optical intrinsic response Neuronal activity Electrical stimulation

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Transplantation of miR-219-overexpressed oligodendrocyte precursor cells improves myelination and promotes functional recovery after demyelination

Transplantation of miR-219-overexpressed oligodendrocyte pre...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Li Ma Mengjiao Luo Rui Guo Xuebin Qu Ruiqin Yao Research Center for Neurobiology Xuzhou Medical College

We focus on the potential of mi R-219 for stimulating oligodendrocytes lineage cells production from mouse embryonic stem cells(m ESCs) and myelination after transplanting mi R-219-overexpressed OPCs to cuprizone-induced demyelination rodent model. Mouse ESCs were infected by mi R-219-GFP-expressing lentiviruses. The characteristics of ESCs, OPCs and OLs were analyzed by expression of stage-specific cell markers Nanog, Oct4, nestin, A2B5, GFAP, Tuj1, O4 and MBP. Transplantation OPCs into demyelinated rodent brains results in well contained OLs grafts that migrate along corpus callosum in the host and mature to express MBP. New myelin sheaths were detected by electron microscopy. Furthermore, learning and memory function was also improved. Thus, we propose that mi R-219 could transit m ESCs to OLs rapidly and promotes myelination and functional recovery after OPCs transplantion.

关键词： mouse embryonic stem cell(mESCs) line miR-219 overpression oligodendrocyte lineage cells differentiation Cuprizone(CPZ) demyelination and remyelination

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Genetic Manipulation of Human Embryonic Stem Cells:An Efficient Way in Studying Early Human Neural Development

Genetic Manipulation of Human Embryonic Stem Cells:An Effici...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ling Liu Zhenyu Chen Xudong Ren Zhongliang Liu Liankai Chi Xiaoqing Zhang Department of Regenerative Medicine Tongji University Scool of Medicine

Most of our understandings about human neural lineage development were directly translated from other species, such as chicken, frog and mouse. It is extremely important to tease out the specificity of human brain development considering the central nervous system is the most evolutionarily advanced organ in our body. Human embryonic stem cells(h ESCs) can be efficiently targeted to neuroectoderm cells, regional progenitors, a broad spectrum of neuronal subtypes and glia. Therefore, h ESCs represent an invaluable tool in studying early human neural developmental events. By taking advantage of homologous recombination(HR)-based genetic manipulation technologies, such as gene knockout, inducible overexpression, knockin-based reporter system and lineage tracing system, we analyzed singling and transcriptional regulatory mechanisms during early human neural development. Results showed that early human brain development uses a different transcriptional network in specifying neural lineage fate from a pluripotent state. And as of extracellular signals guiding human neural induction, the "default" model may apply but needs to be improved.

关键词： hESCs brain development neural differentiation transcriptional regulation signal transduction

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