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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs

X chromosome-linked intellectual disability protein PQBP1 as...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Didi Wan ZiChao Zhang Xiaoyan Zhang Qian Li Junhai Han Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast University Co-innovation Center of Neuroregeneration Nantong University

X chromosome-linked intellectual disability is a common developmental disorder, and mutations of the polyglutamine-binding protein 1(PQBP1) gene have been linked to this disease. In addition to existing in the nucleus as a splicing factor, PQBP1 is also found in cytoplasmic RNA granules, where it associates with RNA-binding proteins. However, the roles of cytoplasmic PQBP1 are largely unknown. Here, we show that the Drosophila homolog of PQBP1(dP QBP1) is present in the cytoplasm of photoreceptor cells, and its loss results in defective rhabdomere morphogenesis, which is due to impaired Chaoptin translation. We also show that d PQBP1 regulates m RNA translation by interacting with d FMR1, which binds to specific m RNAs and facilitates their assembly into translating ribosomes, a function that is conserved for human PQBP1 and FMRP. Our findings reveal the conserved function of PQBP1 in m RNA translation and provide molecular insights into the pathogenic mechanisms underlying Renpenning syndrome.

关键词： RNA X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs

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Connexin 26 and connexin 43 between excitatory neurons differentially impact neural synchronous activity and development in mouse neocortex

Connexin 26 and connexin 43 between excitatory neurons diffe...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jingjing Chen Xin Su Xiaoyang Li Linyun Liu Yongchun Yu Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University

Previous studies have shown that excitatory neurons form transient gap junctions with each other at early postnatal stages. These gap junctions regulate the subsequent formation of chemical synapse. However, it remains largely unclear whether eliminating gap junctions between excitatory neurons in early postnatal neocortex have effect on subsequent neural synchronous activity and development. Here we showed in mice that conditional knockout of Connexin 26(Cx26) in excitatory neurons of neocortical layer 2/3 from postnatal day 1(P1), but not Connexin 43(Cx43), can significantly reduce the neural local synchronous activity and giant depolarizing potentials(GDPs) in neocortical layer 2/3 during P5-8. Moreover, deletion of Cx26 remarkably attenuates neurite outgrowth, branching and spine density. We also observed thatthe frequency of micro excitatory postsynaptic currents are impaired when Cx26 is *** results indicate that Cx26 and Cx43 in early postnatal neocortex play different roles in neocortex development.

关键词： synchronous activity,excitatory neuron,neocortex,connexin

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Exposure to Swainsonine impairs adult neurogenesis and spatial learning and memory

Exposure to Swainsonine impairs adult neurogenesis and spati...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jiutao Wang Lingzhen Song Qi Zhang Wei Zhang Lei An Yamei Zhang Dewen Tong Baoyu Zhao Shulin Chen Shanting Zhao College of Veterinary Medicine Northwest A&F University

Swainsonine(SW) is an indolizidine triol plant alkaloid isolated from the species Astragalus, colloquially termed locoweed. Ingestion induces severe neurological symptoms of livestock and wildlife, including ataxia, trembling, exaggerated fright reactions. Toxicity to the central and peripheral nervous system is caused by inhibition of lysosomal a-mannosidase(AMA) and accumulation of intracellular oligosaccharide. However, the effects of SW onadult neurogenesis and cognition have remained unclear. Therefore, the present study was conducted to examine the effects of SW on adult neurogenesis and learning as well as memory performance in adult mice. SW(10 μg/m L in drinking water) was administered orally to mice for 4 weeks. Our results showed that SW reduced proliferation and survival of neural progenitor cells(NPCs) in culture, and in the hippocampus of adult mice. In addition, exposure to SW led to down-regulation of doublecortin(DCX) and synaptophysin(SYP) in the hippocampus. However, caspase3 and glial fibrillary acidic protein(GFAP) levels were significantly increased in SW-treated mice. Finally, SW-treated mice exhibited deficits in hippocampus-dependent spatial learning and memory. Our findings suggest that SW affects adult neurogenesis and cognitive function.

关键词： Swainsonine neural progenitor cells adult neurogenesis learning and memory

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The neuroprotective effects of Klotho on spinal cord injury

The neuroprotective effects of Klotho on spinal cord injury

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Dong-He Han Yun-Jie Fu Li-Li Ren Pan Wang Peng Wang Mei-Hua Jin Jing Bi Department of Neurobiology Liaoning medical university Department of Immunology Liaoning medical university

Studies on the pathology of secondary spinal cord injury(SCI) have been recently focused on oxidative radicals stress and inflammation associated with neuronal apoptosis. It is the main reason for the repair and regeneration of the post-traumatic neurological dysfunction. Klotho, an anti-aging gene, has been extensively studied and shown a wide variety of health beneficial effects by counteracting oxidative stress, inflammation and apoptosis. However, the roles in SCI has not been reported. The aim of this study is to investigate the effects of Klotho on the process of secondary spinal cord injury. Male SD Rats(160-180g) were used and SCI model was make by Allen's method. The expression of Klotho was observed by ELISA, RT-PCR, Western Blot, and Immunohistochemistry. Oxidative stress was measured by ELISA(8-ohdg), and apoptosis was analyzed by Flow cytometry(Annexin V/PI) in primary neuron cell culture. Our results show that Klotho expressed in the neuron of spinal cord was decreased in SCI rats as time dependent manner;Over-expression of Klotho improved the neurological function in SCI model;Over-expression of Klotho decreased apoptosis and oxidative stress in primary neuron cells. The results suggest that Klotho can improve the neurological function after spinal cord injury.

关键词： Klotho Spinal cord injury Oxidative stress

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Some neuron in dorsal premotor cortex related to grasp planning

Some neuron in dorsal premotor cortex related to grasp plann...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Guanghao Sun Shaomin Zhang Lichao Wang Xiaoxiang Zheng Qiushi Academy for Advanced Studies & Innovation Joint Research Center for Cyber-Physical-Society System Zhejiang University

Recently, some studies have demonstrated that the dorsomedial pathway is not only involved in arm reaching but also hand grasping. Grasp types can be decoded with multiunit activity(MUA) collected from dorsal premotor cortex(PMd) in dorsomedial pathway. However, these studies analyze and decode the neural activity during the whole grasp period. The precise function of PMd during the movement planning period has not been systematically investigated. In this study, neural signals were collected from a monkey's PMd by microelectrode array when it was performing a grip-specific task. With single neural activity(SUA) analysis, we found that 11.9% of neurons in PMd were selective to gestures during the planning period, which illustrated some neurons in PMd are related to planning. Furthermore, four grasp gesture types prediction were classified using support vector machines model(SVM) and k-nearest neighbor model(k NN) from neuron population activities. The results showed that the gesture classification accuracy reaching 60.8% by SVM and 63.9% by k NN. It infers that grasp planning is modulated by PMd neurons and that the PMd may play a central role in all phases of reach-to-grasp planning action.

关键词： grasp planning PMd neural activity Rhesus

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MicroRNA-30a alleviates autoimmune inflammation by reducing inflammatory T cell development

MicroRNA-30a alleviates autoimmune inflammation by reducing ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ming Zhao Dingya Sun Yangtai Guang Zhihong Wang Mingdong Liu Li Cao Cheng He Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Minister of Education Department of NeurobiologySecond Military Medical University

Multiple sclerosis(MS) is an autoimmune demyelination disease. IL-17–producing Th17 cells play a critical role in the development of MS. The contribution of micro RNA(miR NA) to Th17 development during MS remains unclear. In the present study, we found that the expression of mi RNA-30 a was lower in CD4+ cells from MS and its animal model experimental autoimmune encephalomyelitis(EAE). The expression of mi RNA-30 a in CD4 + T cells was inversely related to the expression of IL-17 a. Moreover, mi RNA-30 a was reduced in Th17 cells. Overexpression of mi RNA-30 a inhibited Th17 differentiation, while interference of miR NA-30 a promoted Th17 differentiation. Finally, we demonstrated that mi RNA-30 a bound to the 3'UTR region of IRF-4 and inhibited the IRF-4 expression at the m RNA and protein levels. In vivo administration of mi R-30 a reduced EAEseverity. Our study provides new clues for the treatment of MS.

关键词： multiple sclerosis EAE Th17 miRNA-30a

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Adaptation in Thalamic Reticular Nucleus

Adaptation in Thalamic Reticular Nucleus

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiong-jie Yu Interdisciplinary Institute of Neuroscience and Technology Qiushi Academy for Advanced StudiesZhejiang University

Responses to repeated auditory stimuli were examined in the auditory region of the thalamic reticular nucleus(TRN) and in medial geniculate(MGB) neurons of anesthetized rats. The TRN neurons showed strong responses to the first trial and weak responses to the subsequent trials of repeated auditory stimuli and electrical stimulation of the MGB and auditory cortex when the interstimulus interval(ISI) was short. They responded to the second trial when the interstimulus interval was lengthened to 3 s. These responses contrasted to those of MGB neurons, which responded to repeated auditory stimuli of different ISIs. The TRN neurons showed a significant increase in the onset auditory response from 9.5 to 76.5 Hz when the ISI was increased from 200 ms to 10 s(P=0.001,ANOVA). The duration of the auditory-evoked oscillation was longer when the ISI was lengthened. The slow recovery of the TRN neurons after oscillation of burst firings to fast repetitive stimulus was a reflection of a different role than that of the thalamocortical relay neurons. Supposedly the TRN is involved in the process of attention such as attention shift;the slow recovery of TRN neurons probably limits the frequent change of the attention in a fast rhythm. We further explore the temporal property of the fast adaptation in two kinds of adaption: "what" information adaptation and "where" information adaptation.

关键词： Adaptation Thalamic Reticular Nucleus "what" information "where" information selective attention

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Zeb1 regulates the proliferation of neural progenitor cells in the developing mouse forebrain

Zeb1 regulates the proliferation of neural progenitor cells ...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Huanhuan Wang Qin Shen Tsinghua-Peking Center for Life Sciences Tsinghua University Center for Stem Cell Biology and Regenerative Medicine School of MedicineTsinghua University

Zinc finger E-box binding homeobox 1(Zeb1) is a key regulator of epithelial-mesenchymal transition(EMT), which is critical for invasion and metastasis of carcinoma cells, as well as embryonic development and cell differentiation such as gastrulation, neural crest delamination, muscle differentiation and T-cell differentiation. Previous studies have shown that Zeb1 is expressed in the developing mammalian brain, however relatively little is known about Zeb1's function in brain development. Here we show that Zeb1 is specifically expressed in neural progenitor cells in the developing mouse forebrain, as early as neurogenesis begins. Perturbation of Zeb1 expression using lentivirus-mediated shR NA and overexpression in cortical progenitor cell culture affects neural progenitor cell growth in vitro. By in utero electroporation in the embryonic cerebral cortex, we have found that knock-down of Zeb1 reduce the number of proliferating cells while overexpression of Zeb1 causes delayed cell migration in the mouse cortex in vivo. Our data suggests Zeb1 may play an important role in cortical development.

关键词： Zeb1 neural progenitor cell cerebral cortex

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To explore the role of vestibular factors in spatial orientation among normal adults

To explore the role of vestibular factors in spatial orienta...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Peng Zou Linjie Wang State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center

Vestibular afferent information is important clue for spatial orientation(SO). In the case of aviation, marine, microgravity and vestibular lesions, individuals may experience spatial disorientation(SD) because of the changed vestibular afferents. Previous studies have revealed the important role of the vestibular system in maintaining visual stability and postural control. Recent discoveries have emphasized the role of the vestibular system in cognitive processes such as memory, spatial navigation and bodily self-consciousness. A wide range of different vestibular cortical projection areas and several pathways have been ascertained. However, most of these evidences are from animal researches and most of the studies are limited to behavioral data. The functionality of the vestibular cortices still is scarcely understood. In this paper, we reviewed the researches about SO of human that were developed in the microgravity and terrestrial environment, and comprehensive research method consists of psychological tests and virtual reality based complex tasks were suggested. We also emphasized the advantages and necessity of brain EEG, brain imaging and vestibular stimulation technology in the SO research. Besides, we determine it's necessary to observe the physiological changes in SO activities and will be helpful in exploring the role of vestibular system in SO. It is also of great significance for rehabilitation of vestibular diseases and aerospace and maritime exploration activities.

关键词： spatial orientation vestibular system spatial disorientation spatial cognition virtual reality

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The proteomic study of protein and secreted protein of primary cultured rat Schwann cells

The proteomic study of protein and secreted protein of prima...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Mi Shen Tang Wei L Fei Ding Jiangsu Key Laboratory of Neuroregeneration Nantong University

Schwann cells(SCs) are the principal glial cells of the peripheral nervous system(PNS) with a wide range of biological functions. In our study Two-dimensional liquid chromatography coupled with tandem mass spectrometry(2D LC-MS/MS) was performed to identify the protein expressions in primary cultured SCs of rats. We identified a total of 1,232 proteins, which were categorized into 20 functional classes. We also used quantitative real time RT-PCR and Western blot analysis to validate some of proteomics-identified proteins. We showed for the first time the proteome map of SCs. On this basis of the study we collected secreted proteins from SCs and more than 600 kinds of proteins were indentified by 2D LC-MS/MS. According to the data, we found Sema3 E which is one of the neural guidance molecule family members is secreted by SCs. By Western blot, real time PCR, immunocytochemistry and Enzyme Linked Immunosorbent Assay(ELISA) we verified the secretion and expression of Sema3 E in rat SCs. We supposed to provide basic information for further study of biological function of Schwann cell.

关键词： Schwann Cell proteome secreted protein

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