检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

1,102 篇 会议
2 篇 期刊文献

馆藏范围

1,104 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

709 篇 医学
- 647 篇 临床医学
- 70 篇 基础医学(可授医学...
- 43 篇 中西医结合
- 14 篇 药学(可授医学、理...
- 13 篇 中药学(可授医学、...
- 10 篇 中医学
- 3 篇 公共卫生与预防医...
- 3 篇 医学技术（可授医学...
- 2 篇 口腔医学
- 2 篇 护理学（可授医学、...
352 篇 理学
- 351 篇 生物学
- 1 篇 物理学
12 篇 工学
- 3 篇 计算机科学与技术...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
- 2 篇 生物医学工程（可授...
- 1 篇 机械工程
- 1 篇 光学工程
- 1 篇 仪器科学与技术
- 1 篇 电子科学与技术（可...
- 1 篇 公安技术
7 篇 教育学
- 3 篇 教育学
- 3 篇 体育学
- 1 篇 心理学(可授教育学...
6 篇 农学
- 4 篇 作物学
1 篇 法学
- 1 篇 公安学
1 篇 文学
- 1 篇 外国语言文学

主题

37 篇 parkinson's dise...
31 篇 hippocampus
28 篇 alzheimer's dise...
22 篇 microglia
16 篇 depression
15 篇 synaptic plastic...
14 篇 apoptosis
14 篇 learning and mem...
13 篇 neuroinflammatio...
13 篇 autophagy
12 篇 optogenetics
12 篇 astrocyte
12 篇 dopamine
12 篇 neuropathic pain
12 篇 neurogenesis
12 篇 proliferation
11 篇 anxiety
11 篇 epilepsy
10 篇 zebrafish
10 篇 ischemic stroke

机构

27 篇 university of ch...
16 篇 institute of neu...
14 篇 institute of neu...
12 篇 key laboratory f...
11 篇 neuroscience res...
10 篇 beijing institut...
10 篇 北京大学
8 篇 cell electrophys...
8 篇 school of biomed...
7 篇 national laborat...
7 篇 graduate school ...
7 篇 center for neuro...
7 篇 上海交通大学
7 篇 department of ph...
6 篇 shaanxi provinci...
6 篇 college of life ...
6 篇 department of ne...
6 篇 南方医科大学
6 篇 key laboratory o...
6 篇 institute of neu...

作者

12 篇 yun wang
12 篇 wei wang
11 篇 hong jiang
10 篇 meng-ya wang
9 篇 yong gu
9 篇 junxia xie
9 篇 jiu-lin du
9 篇 jing wang
9 篇 xiaomin wang
8 篇 zhong chen
8 篇 gang chen
8 篇 feng wang
8 篇 li wang
7 篇 jun wang
7 篇 jun zhang
7 篇 li yuan
7 篇 zhuan zhou
7 篇 hui li
7 篇 xiong-li yang
7 篇 jin-shun qi

语言

1,025 篇 英文
78 篇 中文
1 篇 法文

检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

共 1104 条记录，以下是631-640 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Electrophysiological and behavioral effects of angiotensin Ⅱ on pallidal neurons in normal rats

Electrophysiological and behavioral effects of angiotensin ...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Hong-Xia Liu Yan Xue Xiu-Ping Shang Yu-Ting Yang Lei Chen Department of Physiology Qingdao University

The globus pallidus plays a critical role in movement regulation. More recent studies suggested the brain RAS exerted a major role in dopaminergic neuron degeneration of Parkinson's disease. Previous studies revealed the expression of angiotensin Ⅱm RNA in the globus pallidus. However, little is known about the functions of angiotensin Ⅱ in the globus pallidus. In the present studies, in vivo and in vitro electrophysiological recordings, as well as behavioral test were used to investigate the effects of angiotensin Ⅱ in the globus pallidus. In normal rats, micro-pressure ejection of angiotensin Ⅱ increased the frequency of spontaneous firing in a dose-dependent manner. Angiotensin Ⅱ at 10μM increased the frequency of spontaneous firing from 16.4±3.1 Hz to 23.4±4.5 Hz in 14 out of the 20 pallidal neurons. The average increase in firing rate was 44.7±8.7%, which was significantly increased(P<0.001) compared to that of vehicle group. Angiotensin Ⅱ did not change the firing pattern significantly. Consistent with the in vivo studies, preliminary results showed that when the cells were voltage clamped at-70 mV, angiotensin Ⅱ induced a small inward current in the presence of 0.5μM TTX. Furthermore, angiotensin Ⅱ increased the frequency of miniature inhibitory postsynaptic currents(m IPSCs) in some pallidal neurons. Finally, behavioral studies revealed that angiotensin Ⅱ(10μM) alleviated the symptoms of rigidity caused by haloperidol. Losartan, the blocker of angiotensin Ⅱ type 1 receptor, blocked both the electrophysiological and behavioral effects induced by angiotensin Ⅱ. The present results suggested that activation of pallidal angiotensin Ⅱ type 1 receptor may be involved in angiotensin Ⅱ-induced antiparkinsonian effects by increasing the activity of pallidal neurons.

关键词： globus pallidus angiotensin Ⅱ spontaneous firing

来源：评论

学校读者我要写书评

暂无评论

The design and application of a non-electric and minimally invasive cranial drilling device for rodents operation

The design and application of a non-electric and minimally i...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Sheng-Xiao Zhang Ding-Chao Hua Xiao-Guang Yan Jun Zhang Li Yuan Xiao-Wen Ma Yu-Feng Li Shu-Le Wang Jin-Shun Qi Second Affiliated Hospital Shanxi Medical University Department of Physiology Shanxi Medical University

The craniotomy of rats and mice is an indispensable operation for intracranial administration of drugs and neuroelectrophysiological recording(such as Hippocampus LTP and local field potential recording). The traditional craniotomy methods with electric cranial drill not only have difficulty adjusting the aperture size on the opening skull, but also have no capability of controlling the drill depth, resulting in the susceptibility to intracranial infection and brain damage. Meanwhile, the electric drill induced concussion may result in an inevitable harmfulness to nerve cells and nerve fibers. Aimed to solve these issues of traditional craniotomy methods with electric cranial drill, we designed a non-electric and minimally invasive cranial drill device for rodents operation. The device has a concave triangular pyramid tip with different diameter to control the size of the skull opening and a double nut fixing baffle to control the drilling depth while drilling on the cranial skull. Compared with traditional electric drill device, the device has multiple advantages including simpleness, efficacy, minimal invasion, controlled aperture and adjustable depth. So it can be efficiently used in the intracerebral administration of drugs and neuroelectrophysiological recording. We have successfully finished 50 cases of cranial drilling operations in SD rats by using the non-electric and minimally invasive cranial drilling device, without any obvious harmfulness and infection case observed. In addition, we also designed a minimallyinvasive intracerebral injection device. On the basis of designing skull drilling device, a slender quartz capillary tube was used as an injection pole. The transparent capillary tube is connected to a stereotaxic apparatus to accurately go into specific intracerebral nuclei in the visual condition. Compared with traditional delivery methods such as micro-needle administration and stainless-cannal implant, the characteristics of the quartz capillary

关键词： craniotomy intracranial administration neuroelectrophysiological recording

来源：评论

学校读者我要写书评

暂无评论

MiR-181-regulates retinal cell fate by targeting Prox1 in Xenopus eye development

MiR-181-regulates retinal cell fate by targeting Prox1 in Xe...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Kaili Liu Zilong Li Ying Liu Xiumei Wang Rongqiao He The State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of Sciences

Retinal cell fate determination is modulated by both signaling molecules and transcriptional factors, however, the roles of micro RNAs(mi RNAs) in this network are far from clear. By gain- and loss-of-functional analysis, we show that mi R-181 plays important roles in regulating retinal cell fate during Xenopus development. Mi R-181 a and mi R-181 b, belong to the retina-specific mi R-181 cluster/family, we show that both members are initially expressed in developing retinoblast cells and then remain at a high level in the inner nuclear cell layer of mature retina. Loss of miR-181 a or mi R-181 b promotes the production of horizontal cells at the expense of bipolar cells. By screening the bipolar/horizontal cells-related genes predicted to be the targets of mi R-181, Prox1 expression was found to be negatively regulated by mi R-181 at both the transcripts and protein levels. In situ hybridization analysis shows that mi R-181 and Prox1 are expressed in an apparently complementary pattern within the retina, and the in vitro assay with Luciferase reporter system proves that mi R-181 can repress gene expression by directly targeting a conserved element in the 3'UTR of Prox1. Furthermore, the effect of mi R-181 downregulation on retinal cell fates can be compromised by coinjection of Prox1 si RNA. These results indicate that the Prox1-mi R-181 interaction plays important roles in retinal cell fate determination.

关键词： MiR-181,Prox1,bipolar cells,horizontal cells,Xenopus laevis

来源：评论

学校读者我要写书评

暂无评论

Multi-target strategy and new drug development of traditional Chinese medicine for Alzheimer's disease therapy

Multi-target strategy and new drug development of traditiona...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Lin Li Lan Zhang Department of Pharmacology Xuanwu Hospital of Capital Medical University

Alzheimer's disease(AD) is a multifactorial complex disease. The failure of recent development of AD therapeutic agents in clinical trials is partly due to their single-target effect. The multi-target therapeutic characteristics of traditional Chinese medicine(TCM) have advantages over the single-target treatment. Shen-wu capsule(SW) is a new compound containing 6 kinds of traditional Chinese herbs. 2,3,5,4'-Tetrahydroxystilbene glucoside(TSG) is a main component extracted from Polygonum multiflorum, which is also a major ingredient of SW capsule. The results from our experiments showed that in 7 kinds of AD or dementia animal models SW and TSG improved learning and memory ability;decreased cholinergic cell death in hippocampus;decreased Ab content and b-secretase expression;inhibited microglial activation and decreased IL-1b and TNFa content;inhibited tau protein hyperphosphorylation and increased expression of protein phosphortase 2A(PP2A);increased the ratio of cholinacetyl-transfetase(Ch AT) / cholinesterase(Ach E) and M-receptor density;enhanced expression of nerve growth factor(NGF) and brain derived neurotrophic factor(BDNF), and their receptors Trk A and Trk B;protected synaptic structure and functions and increased expression of synaptophysin;and inhibited the overexpression and aggregation of alpha-synuclein in hippocampus and cerebral cortex. These results demonstrate that SW and TSG can act on multiple targets in the complicated pathogeneses of AD. Completed phase III clinical trial of SW in China demonstrated that SW treatment effectively improved cognitive impairment in patients with mild to moderate AD. These results suggest that a multi-target strategy may be beneficial in AD therapy.

关键词： Alzheimer's disease multi-target traditional Chinese medicine tetrahydroxystilbene glucoside

来源：评论

学校读者我要写书评

暂无评论

Spatiotemporal imaging and detection of biophotonic activities in retina

Spatiotemporal imaging and detection of biophotonic activiti...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Zehua Li Jiapei Dai Department of Neurobiology The College of Life SciencesSouth Central University for Nationalities Wuhan Institute for Neuroscience and Neuroengineering South Central University for Nationalities

Objective Biophoton is an extremely weak photon beam radiated spontaneously by the organisms under the physiological or pathological conditions. The photoreceptors in retina have a large number of oxygen consumption, suggesting that the biophotonic activities of them may be extensive. The retinal dark noises are random small fluctuations of membrane potential in most vertebrate photoreceptors under the dark conditions. The origin of the discrete dark noise is traditionally believed to be produced by the random spontaneous thermal activation of the visual pigment. However, a large number of studies have found that the Arrhenius thermal activation energy of the rhodopsin is not enough to activate its photoisomerization. Such an energy barrier is the key problem for the original mechanism of the discrete dark noise. The present study is to explore the biophotonic origin of the discrete dark noise in the retinas. Methods We use a high-sensitive ultra-weak biophoton imaging system to detect the biophotonic activities of rat and bullfrog retinas. The effects of temperature change, phosphodiesterase 6 inhibitor and removing intra- and extracellular Ca2+ on biophotonic activities were also investigated. Results(1) It was found that the biophoton emissions of rat and bullfrog retinas were gradually increased as the temperature increased from 34℃to 36℃and 38℃.(2) Such temperature-dependent effects in biophotonic activities were completely blocked either by removing intracellular and extracellular Ca2+ together or applying a PDE6 inhibitor. Conclusion Active biophotonic emission exists in retina, suggesting that the photon-like component of the discrete dark noise may be due not to directly the thermal activation of rhodopsin, but rather to an indirect thermal induction of biophotonic activities which then activate the retinal chromophore of rhodopsin.

关键词： Retinal dark noise Biophotons Phosphodiesterase Ca2+

来源：评论

学校读者我要写书评

暂无评论

Optogenetic activation of anterior cingulate cortex inhibits the heroin seeking behavior in rats

Optogenetic activation of anterior cingulate cortex inhibits...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Miaojun Lai Huaqiang Zhu Weisheng Chen Huifeng Liu Fuqiang Zhang Wenhua Zhou Laboratory of Behavioral Neuroscience Ningbo Addiction Research and Treatment CenterSchool of MedicineNingbo University

The aims of present study were to investigate effects of optogenetic activation of anterior cingulate cortex(ACC) on heroin self-administration, heroin seeking behavior induced by cues or heroin priming and learning and memory in rats. The rats in ACC optogenetic activation group were microinjected with 1μl pA AV-CaM KⅡα-hC hR 2-EYFP into ACC(AP:+2.7mm,ML:0.5mm,DV:2.5mm), then implanted optical fiber 0.5mm above site of microinjection. The rats in sham operation group were microinjected with AVV-EYFP into ACC. The rats were placed in operant chambers for a daily 4h heroin self-administration session under FR1 for consecutive 14 days. Then memory was taken eight-arms maze test. Optogenetic activation of ACC by illuminated by light(470 nm,5mW) decreased the enhancement of reference memory errors, working memory errors induced by heroin exposure. Moreover, optogenetic activation of ACC inhibited the heroin seeking behavior induced cues, which could be reversed partially by pretreatment with LY341495. While, Optogenetic activation of NAc core(AP:+1.2mm,ML:±3.2mm,DV:-6.7mm)also inhibited the heroin seeking induced by cues. In conclusion, these data demonstrate that activation of ACC can improve the cognitive dysfunction induced by heroin chronic exposure, and projective pathway from ACC to NAc core may be involved in the heroin seeking behavior induced by cues.

关键词： optogenetic cognitive fuction anterior cingulate cortex nucleus accumbens heroin metabotropic glutamate receptor

来源：评论

学校读者我要写书评

暂无评论

Spatial structure of neuronal receptive field in awake monkey secondary visual cortex(V2)

Spatial structure of neuronal receptive field in awake monke...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Lu Liu Liang She Ming Chen Tianyi Liu Haidong Lu Yang Dan Mu-ming Poo Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain ScienceShanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Division of Neurobiology Department of Molecular and Cell BiologyHoward Hughes Medical InstituteHelen Wills Neuroscience InstituteUniversity of California

Visual processing depends critically on the receptive field(RF) properties of visual neurons. However, comprehensive characterization of RFs beyond primary visual cortex(V1) remains a challenge. Here we report fine RF structures in secondary visual cortex(V2) of awake macaque monkeys, identified through a projection pursuit regression analysis of neuronal responses to natural images. We found that V2 RFs could be broadly classified as "V1-like"(typical Gabor-shaped subunits), "ultralong"(subunits with high aspect ratios), or "complex-shaped"(e.g., L- or T-junction-like subunits). Furthermore, single-unit recordings from functional domains identified by intrinsic optical imaging showed that neurons with ultralong RFs were primarily localized within pale stripes, whereas neurons with complex-shaped RFs were more concentrated in thin stripes. Thus, by combining single-unit recording with optical imaging and a novel computational approach, we have identified RF subunits underlying spatial feature selectivity of V2 neurons and demonstrated the functional organization of these RF properties.

关键词： receptive field,second visual cortex(V2),natural images,single-unit recording,opticalimaging of intrinsic signals

来源：评论

学校读者我要写书评

暂无评论

The role of ceruloplasmin on the Alzheimer's disease

The role of ceruloplasmin on the Alzheimer's disease

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ya-shuo Zhao Li-hong Zhang Pan-pan Yu Yu-jing Gou Jing Zhao Lin-hao You Peng Yu Yan-Zhong Chang Laboratory of molecular iron metabolism College of Life ScienceHebei Normal University Instrumental Analysis Center Hebei Normal University

Objective: Ceruloplasmin(CP), with ferrous oxidase activity, plays an important role in regulating iron metabolism and redox reaction. Previous studies have confirmed that the lack of CP gene(CP-/-), which could contribute to the pro-oxidant iron accumulation in the substantia nigra(SN) of Parkinson disease(PD). However, it's not very clear that whether CP-/- has influence on the occurrence and progression of Alzheimer's disease(AD).Methods: We collected the brain slices of AD patients, and detected the GPI-CP in hippocampus. At the same time, we set up two kinds of AD animal models with CP-/- : lateral ventricle injection of Aβ25-35 and APP transgenic mice(APP-CP-/-). Multivariable tests were used to examine the associations between CP-/- and AD neuropathological damage in hippocampus. In addition, we constructed CP plasmids, which was specifically expressed in astrocyte, and pre-treated exogenous CP plasmid into the ventricle of Aβ-induced AD model. Results: We found that the level of CP was decreased in the hippocampus of AD patients and AD models. Results from APP-CP-/- mice found that the absence of CP aggravated the memory impairment. The lack of CP furtherly induced the iron accumulation, which caused elevated oxidative free radicals and led to apoptosis through Bcl-2/Bax and Er K/P38 signaling pathway. The exogenous CP plasmid could alleviate the Aβ-induced nerve damage in hippocampus. Interpretation: These datas indicated that the deficiency of CP gene could aggravate the AD and exogenous CP could attenuate the Aβ-induced damage.

关键词： Alzheimer's disease,Amyloid-β,Ceruloplasmin,Oxidative stress,Iron

来源：评论

学校读者我要写书评

暂无评论

GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PP2A

GBA deficiency promotes SNCA/α-synuclein accumulation throu...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xue Wang Ting-Ting Du Yong-Quan Lu Chun-Li Duan Hui Yang Center of Parkinson's Disease Beijing Institute for Brain Disorders Key Laboratory for Neurodegenerative Disease of the Ministry of Education Department of Neurobiology Capital Medical University

Objective Loss-of-function mutations in the gene encoding glucocerebrosidase(GBA), the enzyme deficient in the lysosomal storage disorder Gaucher disease, elevate the risk of Parkinson's disease(PD), which is characterized by the misprocessing of α-synuclein(SNCA). However, the mechanistic link between GBA deficiency and SNCA accumulation remains poorly understood. The present study is to explore the relation between GBA deficiency and SNCA accumulation. Methods For Western blot analysis, we analyzed the level of GBA, PP2 A and SNCA. For immunofluorescence experiments, we detected the accumulation of SNCA. Results(1) Loss of GBA function resulted in increased levels of SNCA via inhibition of the autophagic pathway in SK-N-SH neuroblastoma cells, primary rat cortical neurons, or the rat striatum..(2) BECN1 was downregulated as a result of the GBA knockdown-induced decrease in glucocerebrosidase activity.(3) GBA knockdown-induced SNCA accumulation was reversed by C2 or rapamycin. Conclusion These findings demonstrate that loss of GBA function may contribute to SNCA accumulation through inhibition of autophagy via PP2 A inactivation.

关键词： Parkinson's disease(PD) α-synuclein(SNCA) glucocerebrosidase(GBA) protein phosphatase(PP2A) autophagy

来源：评论

学校读者我要写书评

暂无评论

通过非条件性刺激激活记忆特异性消除尼古丁相关记忆

通过非条件性刺激激活记忆特异性消除尼古丁相关记忆

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：薛言学邓佳慧陈亚云孙世超张力博张立群时杰陆林北京大学中国药物依赖性研究所北京大学精神卫生研究所北京大学第六医院

目的:在物质滥用过程中形成的条件性刺激(如周围的环境或同伴)和非条件性刺激(精神活性物质的奖赏效应)关联记忆是成瘾者对精神活性物质的心理渴求难以消除的根本原因。已有大量研究发现通过条件性刺激线索短暂暴露可诱导记忆激活进入... 详细信息

目的:在物质滥用过程中形成的条件性刺激(如周围的环境或同伴)和非条件性刺激(精神活性物质的奖赏效应)关联记忆是成瘾者对精神活性物质的心理渴求难以消除的根本原因。已有大量研究发现通过条件性刺激线索短暂暴露可诱导记忆激活进入再巩固阶段(conditioned stimulus-induced memory reconsolidation,CS-MR),通过药理学方法干预此不稳定期可消除成瘾记忆,进而预防复吸。但是这种破坏作用仅仅局限于被暴露的条件性刺激线索,而对于未暴露的线索则没有作用。由于现实生活存在大量的条件性刺激线索,因此CS-MR模式难以彻底消除所有的成瘾记忆。在本研究中,利用尼古丁成瘾动物模型,我们发现了一种新的非条件性刺激诱导成瘾记忆激活进入不稳定阶段的新模式(unconditioned stimulus-induced memory reconsolidation,US-MR)。方法:在动物研究中,分别利用尼古丁条件性位置偏爱模型(conditioned place preferences,CPP)和自身给药模型(self-administration,SA)训练大鼠建立巴普洛夫条件性记忆和操作性记忆。记忆激活操作是将动物暴露于之前训练的环境(CS-MR)或者给予小剂量的尼古丁(US-MR)。在人体实验中,指导吸烟者在吸烟时观察电脑屏幕上的图像进而建立关联记忆。记忆激活操作是让吸烟者吸一口烟。结果:在动物实验中,我们发现在CS-MR和US-MR操作后立即脑室给予蛋白合成酶抑制剂可以破坏24小时后尼古丁CPP记忆的表达,而在记忆激活操作9小时后或者不进行记忆激活操作直接给予蛋白合成酶抑制剂则对记忆表达没有影响。同时我们在SA模型上也得到了相同的发现,这表明和CS-MR操作一样,US-MR操作也可以诱导记忆进入不稳定期。接下来,我们发现在US-MR操作后立即腹腔给予β肾上腺素受体阻滞剂普萘洛尔可以破坏24小时后尼古丁CPP记忆或者SA记忆的表达;同时我们还发现,在训练动物同时习得CPP记忆或者SA记忆后,进行US-MR操作,然后腹腔给予普萘洛尔可以同时破坏24小时后尼古丁CPP记忆和SA记忆的表达,而将大鼠暴露于SA训练环境进行CS-MR操作后给予普萘洛尔仅可以破坏尼古丁SA记忆的表达,而对CPP记忆的表达没有影响。在人体实验中,我们发现在指导吸烟者获得吸烟与电脑屏幕上的多个图像的多个关联性尼古丁记忆后进行US-MR操作,然后口服普萘洛尔,可以显著降低所有吸烟线索相关联的记忆,包括在实验中习得的尼古丁线索记忆以及在现实生活中存在的尼古丁记忆。结论:我们的研究表明在US-MR后进行药理学干预可以破坏所有的尼古丁相关记忆,US-MR记忆靶向抑制模式可能是一种新的治疗物质滥用的新策略。

关键词：尼古丁成瘾记忆非条件性刺激再巩固普萘洛尔

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共111页 << < 60 61 62 63 64 65 66 67 68 69 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：