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检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

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Cerebral ischemia-induced occludin degradation promotes blood brain barrier endothelial cell apoptosis

Cerebral ischemia-induced occludin degradation promotes bloo...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ting Wang Yuan Zhang Wenlan Liu The Central Laboratory Shenzhen Key Laboratory of NeurosurgeryShenzhen Second People's Hospital Shenzhen University 1st Affiliated Hospital

Intracerebral hemorrhage is the most dangerous complication in tP A thrombolytic therapy for ischemic stroke, which occurs as a consequence of endothelial cell apoptosis of the blood brain barrier(BBB) during thrombolytic reperfusion. However, what drives the evolution of endothelial cell injury toward apoptosis remains unclear. We have recently shown that cerebral ischemia(2 h) induced BBB disruption, tight junction protein occludin degradation and a concurrent increase of blood levels of cleaved occludin fragments. Moreover, we found that occludin degradation was accompanied by the reduction of anti-apoptotic molecule c-Yes and the activation of caspase-8, which has led to the formation of the hypothesis of this study that occludin degradation in the early phase of cerebral ischemia is the "trigger" to initiate the evolution of endothelial injury toward apoptosis during thrombolytic reperfusion. Brain microvascular endothelial cells(BMVECs) were exposed to oxygen glucose deprivation(OGD) for 2 hours follow by 24 hours of reoxygenation. TNF-2O2 was added as apoptotic stimuli during reoxygenation. Apoptosis was assessed by TUNEL staining and flow cytometry. Caspase-3, 8, 9, occudin and c-Yes were analyzed by western blot. We have demonstrated that cerebral ischemia induced occludin degradation renders BMVECs more vulnerable to apoptotic stimuli. Exposure of BMVECs to OGD for 2 hours significantly decreased the levels of occudin and c-Yes proteins, which rendered the cells more vulnerable to apoptotic stimuli during reoxygenation. Similarly, knockdown of occludin with si RNA also led to the reduction of c-Yes and sensitized BMVECs to apoptotic stimuli. Apoptosis was accompanied by the activation of the caspase-3, 8 and 9. Of note, overexpression of c-Yes abolished the sensitization of BMVECs to apoptosis resulting from occludin degradation as well as the activation of caspases. Taken together, our data demonstrate that cerebral ischemia-induced occludin degradation i

关键词： Ischemic stroke blood brain barrier occludin endothelial cell apoptosis thrombolysis

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Drug addiction and sleep disorders

Drug addiction and sleep disorders

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Si-Zhi Ai Jie Chen Ping Wu Lin Lu Jie Shi National Institute on Drug Dependence Peking University Sixth Hospital/Institute of Mental Health and Key Laboratory of Mental Health Peking University Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University

Drug addiction is a chronic relapsing brain disease and has close interaction with sleep disorders which are its significant risk factors and may lead to drug addiction and relapse. Previous studies have found that the incidence of alcohol abuse in patients with insomnia is about 2.3 times higher than that in normal populations, and the incidences of drug abuse and nicotine abuse are about 7.2 times and 2.4 times higher than that in normal populations, separately. A prospective study has indicated that there is a positive correlation between sleep disorders in children aged 3-8 years and substance abuse during adolescence, and sleep disorders in childhood may predict the possibility of future substance abuse to a certain extent. In addition, the persistence of sleep disorders is an important risk factor that causes the relapse. Clinical studies have found that a large number of patients with alcohol dependence have insomnia, and once the insomnia symptom is alleviated after treatment, the rate of alcohol re-drinking also decreases significantly. Hospitalized cocaine addicts with improved sleep quality after two weeks of treatment show a better abstinence rate during the follow-up of 6 weeks. Sleep disordersare very common in drug abuse and withdrawal, especially insomnia. Drug addicts often feel difficult to fall asleep and maintain sleep. Acute administration of cocaine significantly damages sleep continuity and sleep architecture, prolongs sleep latency, declines total sleep time and sleep efficiency, and reduces proportion of rapid eye movement(REM) sleep in cocaine addicts. Long-term intake of cocaine may cause more serious damage to sleep quality, including decreased proportions of both slow-wave sleep(SWS) and REM sleep, and increased total number and total time of awakening in night. Compared with traditional addictive drugs, the abuse of new synthetic drugs such as methamphetamine, ecstasy and ketamine is spreading rapidly in our country. This type of drugs

关键词： drug addiction sleep disorders sleep quality relapse

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Activity and activity pattern in human visual cortex could reveal the contents of visual awareness

Activity and activity pattern in human visual cortex could r...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Lei Hao Jiang Qiu Tai-Yong Bi Key Laboratory of Cognition and Personality (SWU) Ministry of EducationFaculty of PsychologySouthwest University

Under certain circumstance people perceive an image as two or more competing perceptions. This phenomenon, termed multistable perception, provides an ideal approach to probe the visual processing of awareness, as the subjective experience changes while visual input holds constant. Previous studies showed that perception fluctuation in binocular rivalry and ambiguous image correlates to the fluctuation of activity in human visual cortex(Tong, 1998;Andrew, 2002). Multivariate pattern analysis also showed that the representations of bistable percepts could be decoded from the activity patterns in visual cortex(Wang, 2013). However, it is still elusive how these activities and activity patterns induced by changing perception relate to the neural representation of real objects. In the current study, we investigated the neural correlates of bistable perception using f MRI. Rubin face-vase figure was adopted as the ambiguous stimulus. Subjects were asked to report their subjective experience of face or vase while scanning. Activity and activity patterns induced by face and vase perceptions were extracted from a series of visual areas including both low-level visual cortex(V1/V2/V3/V4) and high-level face/object selective cortex(LO/OFA/FFA/STS), as well as attention related cortex(IPS). To compare the neural representations of bistable perception with the representations of real face and vase, subjects also participated in other scanning sessions which consisted of blocked face and vase stimuli. Beta weights for these real face and vase blocks were estimated with GLM. Activities and activity patterns were also extracted from the same ROIs as in bistable experiment. For regional activity analysis, our results showed that in bistable perception experiment, when subjects perceived faces, the amplitudes of BOLD signals in most face selective areas(lO FA/l FFA/r FFA/l STS/r STS) were significantly larger than those when subjects perceived vase. For pattern correlation analysis,

关键词： visual awareness bistable perception fMRI MVPA category information

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Neurobiological basis of head motion in brain imaging

Neurobiological basis of head motion in brain imaging

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Ling-Li Zeng Dewen Hu Hesheng Liu College of Mechatronics and Automation National University of Defense Technology Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General Hospital

Individual differences in brain metrics, especially connectivity measured with functional MRI(f MRI), can correlate with differences in motion during data collection. The assumption has been that motion causes artifactual differences in brain connectivity that must and can be corrected. Here we propose that differences in brain connectivity can also represent a neurobiological trait that predisposes to differences in motion. We support this assertion with an analysis of intra- versus inter-subject differences in connectivity comparing high to low motion subgroups from a large database of 3000+ participants, many of whom were scanned multiple times. We first investigated whether head motion is a reliable behavioral measure across f MRI sessions in 118 subjects scanned on two separate days. The results revealed that head motion across sessions was significantly correlated, suggesting that the tendency to move is generally a stable trait across subjects. Then we carefully selected 26 pairs of healthy young adults who were matched in all scanning parameters and demographics but differed in the averaged head motion for inter-subject analysis. The analysis identified a biomarker for head motion consisting of reduced distant functional connectivity primarily in the default network in individuals with high head motion. Similar connectivity differences were not found in analysis of intra-subject data from an independent dataset of 26 subjects who were scanned twice on separate days but exhibited more sporadic head motion in one scanning session than the other. Instead, this biomarker was a stable property in individuals across time. These findings suggest that the differences in brain connectivity cannot be simply attributed to motion artifacts but also reflect individual variability in functional organization. Differentiating the true disease biomarkers from the biomarker of motion tendency as reported here is critical for identifying the treatment targets and the developme

关键词： head motion functional connectivity individual difference biomarker default network

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Neuroprotective effect of microRNA-99a against focal cerebral ischemia-reperfusion injury in mice

Neuroprotective effect of microRNA-99a against focal cerebra...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Hai-Ping Zhao Zhen Tao Rong-Liang Wang Ping Liu Yu-Min Luo Cerebrovascular Diseases Research Institute Xuanwu Hospital of Capital Medical University Key Laboratory of Neurodegenerative Diseases (Capital Medical University) Ministry of Education

MicroRNA-99a(mi R-99a) has been reported to function as a tumor suppressor through regulating cell cycle and apoptosis. But its clinical significance in ischemic stroke and its function in cerebral ischemia-reperfusion(I/R) injuryremained unknown. Herein transient middle cerebral artery occlusion was built on C57BL/6 mice, followed by intracerebroventricular injection of mi R-99 a agomir or antagomir before reperfusion for 24 h. Our clinical analysis indicates that plasma mi R-99 a level was significantly decreased in ischemic stroke patients as compared to healthy subjects, and a significant correlation was observed between miR-99 a and clinical parameters. And miR-99 a overexpression mitigated I/R injury in mice, as evidenced by reduced brain infarct volume and neural apoptosis, whereas mi R-99 a downregulation aggravates brain injury. In vitro, miR-99 a protected neuro-2a cells against hydrogen peroxide-induced oxidative stress injury, by improving cell viability, suppressing LDH release and cell apoptosis. In addition, mi R-99 a overexpression inhibited H2O2 induced G1/S phase transition in neuro-2a cells, accompanied by a significant decrease in cyclin D1 level and a tendency of down-regulation of CDK6. It was further proved in mice that mi R-99 a inhibited cyclin D1 and CDK6 expressions following cerebral I/R injury. These findings indicate that mi R-99 a reduces neuronal damage following cerebral I/R through regulating cell cycle progression and preventing apoptosis, suggesting that mi R-99 a could be used as a new therapeutic agent targeting neuronal cell cycle re-entry following stroke.

关键词： CDK6 cell cycle cerebral ischemia Cyclin D1 MiR-99a oxidative stress

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MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

MicroRNA let-7c-5p protects against cerebral ischemia injury...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jia Jia Jingshu Ni Xuechu Zhen Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences Soochow University

The present study was designed to reveal the potential role of let-7c-5p, a highly conserved mi RNA in stroke. We found that the content of let-7c-5p was significantly decreased in the plasma of patients with ischemic stroke as well as in experimental animals. Moreover, we also observed a significant decrease of let-7c-5p in ipsilateral cortex and striatum in mice that were subjected to middle cerebral artery occlusion(MCAO) at 24 hours reperfusion. Overexpression of let-7c-5p via ICV injection decreased the infarction volume and attenuated the neurological deficits, and most interestingly, inhibited microglial activation. To further explore the mechanism, we checked let-7c-5p expression in BV2 cells and primary microglia in an OGD condition and in LPS-induced microglial activation. The results indicated that decreased let-7c-5p was evidenced in the activated microglia. Overexpression of let-7c-5p in BV2 cells remarkably inhibited the microglial activation. The inhibition of microglial activation by overexpression of let-7c-5p was also observed in mice with experimental stroke, which is in line with the decreased infarction volume and improved neurological deficits. We identified that let-7c-5p directly targeted to the 3’-untranslated region of the caspase 3 mR NA to reduce caspase 3 levels, which may underline the mi RNA-modulated microglial activity. The present study revealed that suppression of microglia activation by let-7c-5p overexpression may be involved in the protection effects of ischemic damage. The mechanism may include the mi RNA-mediated caspase 3 pathway.

关键词： microRNA let-7c-5p ischemic stroke microglia

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Electroencephalographic (EEG) Measurements of Long-Term Meditators:A Pilot Study

Electroencephalographic (EEG) Measurements of Long-Term Medi...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Kumari K.G.K.G Ranathunga L Jayasinghe J.M.P.P Edirimanna C.L Wimalasiri L.S.M Srikanth S De Silva K.R.D Genetic Diagnostic & Research Laboratory Faculty of Medical SciencesUniversity of Sri Jayewardenepura

Introduction Alpha rhythm is an EEG correlate for a state of relaxed wakefulness best obtained with eyes closed, generally with higher voltage over occipital region. Meditation practices have gained increasing attention as a non-pharmacological intervention for mind relaxation. However, the effects of meditation on brain activity still need to be fully characterized. Objective To investigate frontal and occipital EEG wave pattern variations of long-term meditators before and during meditation Method Meditators with long-term(>5 years) experience in several meditation techniques participated in the study. EEG was recorded for 15 minutes in two phases;prior and during meditation, using the technique;Tranquil Wisdom Insight Meditation(TWIM) with eyes closed. Fast Fourier Transformed EEG signals of frontal region(AF3 and F3 channels) in six meditators and of occipital region(O1 channel) in five meditators were extracted considering the clearness of signals. Raw power values and log*10* μV2/Hz values of frontal and occipital regions respectively were analyzed with respect to multiple frequency bands and their percentage variations in energy levels. Results Average percentage energy variations were contributed by;Frontal-[(delta;50% decrement),(theta;10%, alpha;33%, beta;5%, gamma;1%) increments], Occipital-[(gamma;30.9% decrement),(theta;3.7%, alpha;20.3%, beta;3.3%, delta;3.5%) increments] Conclusion Frontal and occipital alpha power increment may suggest a mind relaxation effect, a signal analysis from other brain regions needs to be performed for confirmation. The increment may be due to TWIM or other meditation techniques, practiced in past or due to combination of both. This warrants comparative studies exploring differences between various approaches and techniques(i.e. Samatha & Vipassana) with larger sample size to delineate effects of meditation on brain activity.

关键词： meditation mind relaxation EEG

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基于分数低频振荡振幅(fALFF)分析的单、双相抑郁障碍患者功能磁共振研究

基于分数低频振荡振幅(fALFF)分析的单、双相抑郁障碍患者功能磁...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：邱美慧黄悦琦张建业吴志国洪武粟幼嵩彭代辉上海交通大学医学院附属精神卫生中心上海市精神卫生中心

目的:双相障碍的抑郁发作与单相抑郁在临床症状上有许多相似点,相关量表并不能辨别单、双相抑郁障碍。既往有关静息态功能磁共振研究提示,在静息条件下一些脑区有持续的神经活动信号,即自发的低频振荡信号。本研究采用分数低频振荡振幅(... 详细信息

目的:双相障碍的抑郁发作与单相抑郁在临床症状上有许多相似点,相关量表并不能辨别单、双相抑郁障碍。既往有关静息态功能磁共振研究提示,在静息条件下一些脑区有持续的神经活动信号,即自发的低频振荡信号。本研究采用分数低频振荡振幅(fractional amplitude of low frequency fluctuation,f ALFF)方法分析单、双相抑郁障碍患者的各脑区自发神经活动异常,以探索两种疾病之间可以辅助临床诊断的生物学标识。方法:利用DSM-IV的诊断标准,分别入组单、双相抑郁障碍患者51例、29例,同时入组31例健康对照进行大脑静息态功能磁共振扫描。应用DPARSF(Data Processing Assistant for Resting-State f MRI)软件计算f ALFF,分析各脑区自发神经活动的变化,并结合REST(Resting-State f MRI Data Analysis Toolkit)软件对单、双相抑郁障碍患者及健康对照组f ALFF均值进行ANOVA检验,以年龄、教育程度以及颅内总体积为协变量,计算三组之间f ALFF显著差异的脑区(p<0.001(未矫正),K>10体素)。提取三组之间有显著差异的脑区f ALFF值进行post hoc检验(p<0.05),并与临床变量(24项汉密尔顿抑郁量表评分及因子分、首发年龄、发病次数、病程)进行相关分析。结果:1、排除头动等数据影响因素,单、双相抑郁患者组及正常对照组分别有47例、28例及29例完成f ALFF分析。2、对单、双相抑郁障碍患者与健康对照组之间mf ALFF进行ANVOA分析,结果发现三组被试之间显著性差异脑区包括左侧后扣带回、楔前叶、左侧颞中回、舌回。3、与健康对照组相比,单相抑郁障碍组左侧后扣带回、楔前叶及左侧颞中回f ALFF值显著降低;与双相抑郁障碍组相比,单相抑郁障碍组楔前叶、左侧颞中回及舌回f ALFF值显著降低;与健康对照组相比,双相抑郁障碍患者组左侧扣带回f ALFF值显著降低,同时舌回f ALFF值显著增强。4、单相抑郁障碍患者楔前叶的f ALFF值与HAMD因子3认知障碍评分呈负相关(r=-0.405,p=0.026);双相抑郁障碍患者舌回的f ALFF值与HAMD因子4日夜变化评分呈负相关(r=-0.295,p=0.044)。结论:后扣带回作为默认网络的关键脑区,在单、双相抑郁障碍患者中均存在f ALFF值降低,这可能与两种疾病之间都具有相似的认知功能障碍有关。单、双相抑郁障碍在多个脑区均存在f ALFF值降低,如左侧颞中回、楔前叶及舌回,上述脑区自发神经活动的异常可能是引起单、双相抑郁障碍之间临床症状的差异脑功能基础。单相抑郁障碍患者f ALFF异常的脑区全部集中在默认网络相关脑区,推测默认网络的自发神经活动异常可能是单相抑郁障碍的病理生理机制之一。深入研究上述脑区及相关脑网络的异常,有助于理解单、双相抑郁障碍的病理生理机制差异。

关键词：关键词:抑郁症双相障碍分数低频振荡振幅功能磁共振静息态

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SREBF1和SCAP基因多态性与非典型抗精神病药物相关代谢综合症的关联研究

SREBF1和SCAP基因多态性与非典型抗精神病药物相关代谢综合症的关...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者：杨琳陈剑华杨卫敏李岩吴海苏左赛王琰梁世桥施慎逊徐一峰上海交通大学医学院附属精神卫生中心复旦大学附属华山医院精神医学教研室

目的:在单用非典型抗精神病药物的中国汉族精神分裂症患者人群中,探讨SREBF1基因及SCAP基因多态性与非典型抗精神病药物相关代谢综合症的关系。方法:入组722例精神分裂症患者,单用非典型抗精神病药物一年以上(氯氮平:631例,奥氮平:59例... 详细信息

目的:在单用非典型抗精神病药物的中国汉族精神分裂症患者人群中,探讨SREBF1基因及SCAP基因多态性与非典型抗精神病药物相关代谢综合症的关系。方法:入组722例精神分裂症患者,单用非典型抗精神病药物一年以上(氯氮平:631例,奥氮平:59例,利培酮:32例),收集病史及临床资料,采集静脉血,进行代谢指标等测定。在国际人类基因组单体型图计划(Hap Map)的中国北京汉族人群数据库中,下载SREBF1、SCAP基因单核苷酸多态性(SNP)的数据,使用Haploview 4.2挑选出标签SNP(tagS NP)。使用单碱基延伸技术和基质辅助激光解吸附电离飞行时间质谱(MALDI-TOF)技术在Seqeunom Mass ARRAY i PLEX平台上进行SNP分型检测。统计分析采用SPSS 17.0统计软件包,所有样本分为代谢综合症组及非代谢综合症组进行t检验、秩和检验及卡方检验等。使用在线统计软件SHEsis比较组间每个SNP的等位基因、基因型和单倍型分布频率的差异,并计算比值比(OR)和95%可信区间(95%CI)。进行多重假设检验时,采用错误发现率(FDR)校正,并采用Logistic回归调整校正性别、年龄、吸烟、基础体重指数、用药时间、用药剂量及代谢综合征家族史等主要混杂因素。结果:(1)722例单用非典型抗精神病药物的患者中出现代谢综合症的比率为40.3%;氯氮平组为41.3%,奥氮平组为35.5%,利醅酮组为28.1%。(2)经过FDR校正后,SREBF1基因的rs11654081-T等位基因在代谢综合症组的分布频率明显高于非代谢综合症组,差异具有统计学意义(P=0.010,OR=2.27,95%CI:1.32～3.90)。经Logistic回归校正主要混杂因素后,rs11654081-T等位基因在两组间分布频率的差异仍具有统计学意义(P=0.019,OR=2.56,95%CI:1.44～4.54)。SREBF1基因的rs11654081-TT基因型在代谢综合症组分布频率更高,差异具有统计学意义(P=0.026);其TT基因型比CT基因型的OR为2.37(95%CI:1.36～4.12)。(3)经FDR校正分析及Logistic回归校正分析后,SCAP基因的各等位基因及基因型分布频率在两组间均未见统计学差异(P>0.05)。结论:SREBF1基因多态性可能与非典型抗精神病药物相关的代谢综合症存在关联,可能是非典型抗精神病药物引起代谢副反应的相关机制之一。

关键词：精神分裂症代谢综合症非典型抗精神病药物 SREBF1 SCAP

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Inhibitory interneuron subtypes differentially regulate beta and gamma band oscillatory activity in primary visual cortex of awake mice

Inhibitory interneuron subtypes differentially regulate beta...

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第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Guang Chen Malte J.Rasch Qian Ye Xiao-Hui Zhang Institute of Neuroscience Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience & Learning IDG/McGovern Institute for Brain ResearchBeijing Normal University

Neuronal population activity in the intact brain often exhibits different rhythmic patterns of distinct frequency ranges(0.01–120 Hz). The neuronal oscillations reflect different brain states and participate in specific sensory functions or behavioral tasks. In the awaking states, the most ubiquitous oscillations are rhythms in the beta(12–35 Hz) and gamma frequency(35–90 Hz) bands. Inhibitory GABAergic interneurons, though constituting 15–20% of the population in the cortex, possess diverse subtypes and play important roles in modulating cortical oscillations. However, how different interneuron subtypes gate the generation of distinct band of oscillations remains elusive. We combined extracellular electrophysiological recording and optogenetic methods to examine the contribution of distinct GABAergic interneuron subtypes, somatostatin(SOM)- and parvalbumin(PV)-expressing interneurons, to rhythmic activities in primary visual cortex of head-fixed awake mice. We found that drifting grating visual stimulus can significantly induce slower beta(15-35Hz) and modulate faster gamma band(50-80Hz) oscillations simultaneously. With the optogenetic tagging, the identified SOM+ interneuron shows an involvement to induced beta but not gamma band oscillatory activity, however, PV+ interneuron possesses two subtypes: one preferentially involves into beta oscillation, and the other involves into both beta and oscillations. Optogenetic silencing or activating one type of interneuron uncovered that SOM+ and PV+ interneuron paces lower(<20Hz) and higher(20-80Hz) frequency band activity respectively. Inactivation of SOM+ interneuron abolished only the visual induced beta oscillation, however, inactivating PV+ interneuron abolished both the visual induced beta and gamma oscillations. Computational modeling results quantitatively show that beta oscillation is preserved only under balanced activity between SOM+ and PV+ interneurons, meanwhile, visual modulated gamma oscillation can be sim

关键词： beta gamma oscillations inhibitory interneuron local field potential single units optogenetics awake mice

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