检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

1,102 篇 会议
2 篇 期刊文献

馆藏范围

1,104 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

709 篇 医学
- 647 篇 临床医学
- 70 篇 基础医学(可授医学...
- 43 篇 中西医结合
- 14 篇 药学(可授医学、理...
- 13 篇 中药学(可授医学、...
- 10 篇 中医学
- 3 篇 公共卫生与预防医...
- 3 篇 医学技术（可授医学...
- 2 篇 口腔医学
- 2 篇 护理学（可授医学、...
352 篇 理学
- 351 篇 生物学
- 1 篇 物理学
12 篇 工学
- 3 篇 计算机科学与技术...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
- 2 篇 生物医学工程（可授...
- 1 篇 机械工程
- 1 篇 光学工程
- 1 篇 仪器科学与技术
- 1 篇 电子科学与技术（可...
- 1 篇 公安技术
7 篇 教育学
- 3 篇 教育学
- 3 篇 体育学
- 1 篇 心理学(可授教育学...
6 篇 农学
- 4 篇 作物学
1 篇 法学
- 1 篇 公安学
1 篇 文学
- 1 篇 外国语言文学

主题

37 篇 parkinson's dise...
31 篇 hippocampus
28 篇 alzheimer's dise...
22 篇 microglia
16 篇 depression
15 篇 synaptic plastic...
14 篇 apoptosis
14 篇 learning and mem...
13 篇 neuroinflammatio...
13 篇 autophagy
12 篇 optogenetics
12 篇 astrocyte
12 篇 dopamine
12 篇 neuropathic pain
12 篇 neurogenesis
12 篇 proliferation
11 篇 anxiety
11 篇 epilepsy
10 篇 zebrafish
10 篇 ischemic stroke

机构

27 篇 university of ch...
16 篇 institute of neu...
14 篇 institute of neu...
12 篇 key laboratory f...
11 篇 neuroscience res...
10 篇 beijing institut...
10 篇 北京大学
8 篇 cell electrophys...
8 篇 school of biomed...
7 篇 national laborat...
7 篇 graduate school ...
7 篇 center for neuro...
7 篇 上海交通大学
7 篇 department of ph...
6 篇 shaanxi provinci...
6 篇 college of life ...
6 篇 department of ne...
6 篇 南方医科大学
6 篇 key laboratory o...
6 篇 institute of neu...

作者

12 篇 yun wang
12 篇 wei wang
11 篇 hong jiang
10 篇 meng-ya wang
9 篇 yong gu
9 篇 junxia xie
9 篇 jiu-lin du
9 篇 jing wang
9 篇 xiaomin wang
8 篇 zhong chen
8 篇 gang chen
8 篇 feng wang
8 篇 li wang
7 篇 jun wang
7 篇 jun zhang
7 篇 li yuan
7 篇 zhuan zhou
7 篇 hui li
7 篇 xiong-li yang
7 篇 jin-shun qi

语言

1,025 篇 英文
78 篇 中文
1 篇 法文

检索条件"任意字段=第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议"

共 1104 条记录，以下是861-870 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Chronic stress induced cognitive impairment in APP/PS-1 double transgenic mice

Chronic stress induced cognitive impairment in APP/PS-1 doub...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Mingwei Wang Bing Han Li Shen Meiyu Sun Qian Wang Yuan Geng Department of Neurology the First Hospital of Hebei Medical University Brain aging and cognitive neuroscience key laboratory of Hebei province Clinical laboratory the First Hospital of Hebei Medical University

Objective To observe the effect of chronic unpredictable mild stress(CUMS) on the behavior and brain morphological changes in APP/PS1 mice,one of the genetic mouse models of Alzheimer's disease(AD), and to investigate the possible role of environmental factors in genetic mouse model of AD. Methods 22 –week-old wild-type male mice(control group,n=15),transgenic male mice[n=27,AD group(n=13),AD+CUMS group(n=14)]. Morris water maze(MWM) was used to evaluate spatial learning and memory in the mice. The amyloid deposition in the hippocampus were determined by Congo red staining. The neurons ultrastructure of hippocampal CA1 region were observed by transmission electron microscope(TEM). Results The mean escape latency in MWM was significantly longer in AD+CUMS group(P=0.004,compared with control group. P=0.036,compared with AD group),the time spent in the platform quadrant was shortened(P=0.014,compared with control group),and no significant difference was shown among three groups on the frequency that mice crossed over the platform quadrant at the sixth day. The amyloid deposition were increased in AD+CUMS group(P=0.000,compared with control group.P=0.039,compared with AD group). The ultrastructure of hippocampal neurons were damaged in AD+CUMS group compared with control group or AD group,including hazy cell membrane,low density granules and high density granules reduced in cytoplasm, the number of the organelles were reduced, the lipofuscin and autophagosome deposit on neuron, the obvious condensation of chromatin distributing over the fringe of nuclei, the serious fusion of mitochondrial cristaes and membranes, and free ribosome in cytoplasm were decreased. There was no significant difference between AD group and control group in the escape latency(P=0.418)or the time spent in the platform quadrant(P=0.447),however,compared with control group,the amyloid deposition werealso increased in AD group(P=0.000),and the ultrastructure of hippocampal neurons were slightly dama

关键词： stress APP/PS-1 cognition

来源：评论

学校读者我要写书评

暂无评论

Diabetic retinopathy differentially affects distinct subtypes of mouse intrinsically photosensitive retinal ganglion cells

Diabetic retinopathy differentially affects distinct subtype...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Wei-Yi Chen Wen-Long Sheng Xiong-Li Yang Yong-Mei Zhong Shi-Jun Weng Institute of Neurobiology Institutes of Brain ScienceState Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan University

Objective Several lines of evidence suggest that the melanopsin-expressing, intrinsically photosensitive retinal ganglion cells(ip RGCs) are more injury-resistant than conventional ganglion cells. Recent studies have revealed multiple subtypes of ip RGCs with distinct molecular, anatomical and physiological features. We sought to determine whether ip RGCs possess resistant ability against diabetic retinopathy, and whether this ability is uniform among all ip RGC subtypes. Methods Diabetes was induced in male C57BL/6 mice aged 6-8 weeks by an intraperitoneal injection of streptozocin(STZ, 85 mg/kg), and the retinas were collected 3, 6, 12 months after STZ injection. Detailed soma-dendritic profiles of M1, M2 and M3 ip RGCs were revealed byavidin-biotin-peroxidase reaction enhanced immunohistochemistry and computer-assisted reconstruction. Morphometric analysis was carried out with Image J software. Whole retina melanopsin level was assessed by Western blotting analysis. Results In 3-month diabetic mice, the M1 ip RGCs, which ramify in the OFF sublamina of the inner plexiform layer(IPL), exhibited a slightly but significantly smaller soma size than age-matched controls. However, except for this modest remodeling, none of the other major morphometric parameters were significantly changed, suggesting an apparent resistance against diabetic retinopathy. In contrast, for the ON sublamina-stratifying M2 ip RGCs, 3 months of diabetes resulted in significant abnormalities in most of the morphometric parameters measured, including a large soma/dendritic field size, a longer total dendritic length and a more complex dendritic arborization pattern evaluated by Sholl analysis. For the M3 ip RGCs which stratify their dendrites in both ON and OFF sublamina, only the morphological profiles of ON dendritic arbors were significantly altered in 3-month-diabetic mice. Consistent with the morphometric results, the density of M1 cells was unaltered at this stage, whereas a significant ce

关键词： diabetic retinopathy intrinsically photosensitive retinal ganglion cell melanopsin injury resistance soma-dendritic profile

来源：评论

学校读者我要写书评

暂无评论

Decreased glial cell-derived neurotrophic factor and increased pro-inflammatory cytokines in the colonic mucosa with submucosa of 6-hydroxydopamine induced Parkinson's disease rats

Decreased glial cell-derived neurotrophic factor and increas...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Xiao-Li Zhang Chen-Zhe Liu Yue Zhang Jin-Xia Zhu Department of Physiology and Pathophysiology School of Basic Medical ScienceCapital Medical University

Enteric glial cells are one of the most crucial components of enteric nervous system(ENS). They play an important role in gastrointestinal function including intestinal epithelial barrier, supporting enteric neurons, and gut neuro–immune-endocrine network. Several recent studies have indicated that the dysfunctions of enteric glial cells participate in gut inflammation in PD. We therefore undertook the present study to investigate whether the colonic glial dysfunctions and inflammation occurs in 6-OHDA-PD model,rats microinjected with 6-hydroxydopamine(6-OHDA) into bilateral substantianigra(SN). The enzyme-linked immunosorbent assay, western blot and the short-circuit current(Isc) were used in this study. The results showed that the expression level of glial fibrillary acidic protein(GFAP, a glial marker) in colonic mucosa/submucosa of 6-OHDA rats was decreased from 0.99±0.1 to 0.74±0.1(n=9, P<0.01), and the glial cell-derived neurotrophic factor(GDNF) level was decreased from 21.4±1.6 to 14.2±1.5 pg/mg(n=5, P<0.05). However, the pro-inflammatory cytokines tumor necrosis factor alpha(TNF-a) and interleukin-6(IL-6) in colonic mucosa/submucosa of 6-OHDA rats were increased from 269.1±18.0 to 340.4±21.5 pg/mg(n=5, P<0.05) and from 156.3±9.4 to 200.2±20.63 pg/mg(n=5, P<0.05), respectively. No difference in the expression of interleukin-1 beta(IL-1β) was observed in the colonic mucosal/submucosal preparations between control and 6-OHDA rats(n=6). The transepithelial resistance(Rte) of the colonic mucosal/submucosal preparations in 6-OHDA rats was significantly lower than that of the control(control: 78.2±5.3 Ω cm2;6-OHDA: 58.6±7.7Ω cm2)(n=10, P<0.05), indicating that the colonic epithelial permeability and epithelial barrier function might be impaired in 6-OHDA rats. These results suggest that decreased GFAP, GDNF and increased pro-inflammatory cytokines in colonic mucosa/submucosa of 6-OHDA rats might be contributed to the impaired colonic epithelial barrier. But, this

关键词： Parkinson's disease 6-OHDA rats enteric glial cells pro-inflammatory cytokines

来源：评论

学校读者我要写书评

暂无评论

Alteration of dopamine related oxidase in stomach and duodenum of 6-hydroxydopamine–induced Parkinson's disease rats

Alteration of dopamine related oxidase in stomach and duoden...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Chen-zhe Liu Xiao-li Zhang Li-sheng Li Jin-xia Zhu Department of Physiology and Pathophysiology School of Basic Medical ScienceCapital Medical University

Parkinson's disease(PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra. Besides, the changes of dopaminergic neurons have been reported in enteric nervous system of PD patients with gastrointestinal(GI) symptoms. In our previous study, PD rat model manifested increased dopamine(DA) in GI tract with delayed gastric emptying and constipation. However, whether the synthetic and metabolic enzymes of DA are involved in PD remains unknown. Tyrosine hydroxylase(TH) is a rate-limiting enzyme of DA synthesis;Catechol-O-methyltransferase(COMT) and monoamine oxidase(MAO) are important metabolic enzymes of DA. The present study is to explore whether the expressions of TH, COMT or MAO are changed, and the correlation with the change of DA in stomach and duodenum of PD rat model. Rats microinjected with 6-hydroxydopamine into the bilateral substantia nigra(SN)(6-OHDA rats) were used as PD rat model. HPLC, Western Blot and immunofluorescence were used in this study. The result showed that the DA content in duodenum of 6-OHDA rats were significantly increased from 12.9±1.91 to 17.63±1.53 ng/g(n=7, P<0.05). The TH protein levels in the stomach and duodenum of 6-OHDA rats were increase from 0.33±0.02 to 2.53±0.17(n=3, P<0.01) and from 0.36±0.12 to 4.25±1.06(n=5, P<0.05), respectively. The immunofluorescence showed that COMT and MAO were abundantly expressed in the epithelium and the myenteric plexus in stomachand duodenum in both control and 6-OHDA rats. The expression of COMT protein in stomach and duodenum of control and 6-OHDA rats was 0.67±0.11 and 0.60±0.06(n=3), and 0.86±0.08 and 0.57±0.12(n=3), respectively. In addition, no difference in the MAO protein level was observed in stomach(control: 0.2±0.02, 6-OHDA: 0.15±0.02) and duodenum(control: 0.99±0.06, 6-OHDA: 0.94±0.06)(n=3). The increased TH may be involved in the alteration of DA in stomach and duodenum, thus may be responsible to the GI dysfunction in 6-OHDA PD model. However, whether the

关键词： Parkinson's disease Gastrointestinal Tyrosine hydroxylase(TH) Catechol-O-methyltransferase(COMT) Monoamine oxidase(MAO)

来源：评论

学校读者我要写书评

暂无评论

Aplysia locomotion:network and behavioral actions of GdFFD,a D-amino acid-containing neuropeptide

Aplysia locomotion:network and behavioral actions of GdFFD,a...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Chao-Yu Yang Ke Yu Ye Wang Song-An Chen Dan-Dan Liu Zheng-Yang Wang Yan-Nan Su Shao-Zhong Yang Ting-Ting Chen Itarmar Livnat Ferdinand S Vilim Elizabeth C Cropper Klaudiusz R Weiss Jonathan V Sweedler Jian Jing State Key Laboratory of Pharmaceutical Biotechnology Nanjing Advanced Institute for Life SciencesNanjing University School of Life Sciences Beckman Institute for Advanced Science and Technology and Department of Chemistry University of Illinois at Urbana-Champaign Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai

Neuromodulators, such as neuropeptides, are critical regulators of behavior. One emerging principle is that they act on multiple behaviors, particularly motivated behaviors, e.g., feeding and locomotion. However, how neuromodulators may act on multiple neural networks to effect their actions remains poorly understood. These actions depend on the exact chemical form of the peptide, e.g., an alternation of L- to d- form of an amino acid can endow the peptide with bioactivity, as is the case for the Aplysia endogenous peptide Gd FFD(where d F indicates d-phenylalanine). Gd FFD has been shown previously to act as an extrinsic neuromodulator in the feeding network, while the all L-amino acid form, GFFD,was not bioactive(Bai et al 2013, JBC). Given that Gd FFD was also found to be present in neurons of the pedal ganglia that mediate locomotion, we sought to determine whether it and the related peptide GFFD have an impact on locomotion. We first examined the effects of both peptides on isolated cerebral and pleural-pedal ganglia, and monitored fictive locomotor programs using the parapedal commissural nerve(PPCN). Like in the feeding network, we found that Gd FFD was bioactive and GFFD was not. Gd FFD application increased the frequency with which neural activity was observed in the PPCN. In part, there was an increase in bursting activity that resembled fictive locomotor programs. Additionally, there was significant activity between bursts. To determine how the peptide-induced activity in the isolated CNS is translated into behavior, we developed a computer program that performs an automatic video analysis of movements. The program detects and tracks an animal that is placed in a behavior recording setup, and then automatically calculates the path and velocity of locomotion. Using this technique, we found that Gd FFD significantly inhibited locomotion in Aplysia, and induced a foot curl. These data suggest that the overall increase in PPCN activity observed in the isolate

关键词： GdFFD Aplysia locomotion neuromodulation

来源：评论

学校读者我要写书评

暂无评论

Negative regulation of autophagy induced adipogenesis by impaired LKB1/AMPK cascade in DIO hypothalamus

Negative regulation of autophagy induced adipogenesis by imp...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Jie Han Jian-Ying Du Hui-Min Liang Peng-Jiao Xi De-Run Tian Department of human anatomy and histology Tianjin medical university

Objective LKB1 has recently been identified as important regulator of metabolic and adipogenesis and LKB1 repress mT OR in an AMPK dependent manner. Studies have showed that inhibition of autophagy increases lipid storage and mT OR is an inhibitor of autophagy. Whether autophagy participates in the processes of LKB1 regulating adipogenesis was remained to be explored. Methods We established high fat diet induced obesity(DIO) rat models. The m RNA levels of metabolic related factors include LKB1, AMPKα and mT OR and autophagy related factors include LC3 and P62 in hypothalamus of DIO and control rats were identified by qP CR. We then overexpressed LKB1 within 3T3-L1 preadipocytes and identified m RNA levels of LKB1, AMPKα, mT OR, LC3, P62 andadipogenesis related factors PPARγ and Pref-1 after adipogenic treatment by qP CR. Adipocyte differentiation levels of both cells were also evaluated by Oil-Red O staining. Results The m RNA levels of LKB1/AMPK cascade was downregulated and mT OR was upregulated in hypothalamus of DIO rats when compared with control rats, autophagy was inhibited in DIO rats, as LC3 was downregulated and P62 was upregulated. When overexpressed LKB1 within 3T3-L1 preadipocytes, the m RNA levels of AMPKα were increased and m TOR was decreased in overpressed LKB1 cells when compared with control cells, and the autophagy was upregulated, as increased of LC3 and decreased of P62,meanwhile adipogenesis was retarded, as PPARγ were decreased and Pref-1 were increased. And the results of Oil-Red O staining was consistent with qP CR, when applied with compond C, the inhibitor of AMPK, adipogenesis was restore. Conclusion The present work provides evidence that LKB1 can retard adipogenesis and autophagy may participate in it and this function may depend on AMPK/m TOR cascade.

关键词： LKB1 autophagy adipogenesis AMPK mTOR

来源：评论

学校读者我要写书评

暂无评论

The promotion role of orexin-A in emergence of etomidate anesthesia

The promotion role of orexin-A in emergence of etomidate ane...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Li-Na Zhang Xiao-Nan Du Hai-Long Dong Department of Anesthesiology Xijing HospitalFourth Military Medical University

Objective To evaluate the role of orexin-A neurons in the etomidate anesthesia. Methods Thirty male SD rats weighing 230～250 g used in this study. A polyethylene tube was inserted into the jugular vein and rats were rest a week before experiment. PartⅠ:fifteen SD rats were randomly divided into 3 groups(n=5 each):the control group not accept anesthesia(groupsⅠ),the group received etomidate(30 mg·kg-1·h-1) 30 min(groupⅡ) and the group received etomidate(50 mg·kg-1·h-1) 30 min(group Ⅲ) via jugular vein. GroupsⅠeuthanized by CO2 inhalation and groupⅡⅢ euthanized at 30 min of etomidate. The hypothalamus was immediately removed for immunofluorescent staining. The double label of c-fos and orexin-A elucidate activities of orexin-A neurons. PartⅡ:The other fifteen SD rats were randomly divided into A, B C groups(n=5 each): The animals were anesthetized with intraperitoneal 2% pentobarbital 40-60 mg/kg and placed in a stereotactic apparatus to locate two electrode on one side and one electrode on the other side of brain. Groups received Ringer's solution and orexin-A 50 or 100μg/kg respectively via jugular vein,EEG was recorded and 10 min later received iv infusion of etomidate(30 mg·kg-1·h-1),the loss of righting reflex time was recorded as the induction time. Next day, thee groups received infusion of etomidate(30 mg·kg-1·h-1) and record EEG. After 15 min of etomidate infusion, rats were received Ringer's solution and orexin-A 50 or 100μg/kg respectively, then etomidate terminated at 30 min. The return of righting reflex was recorded as emergence time. Results compare to groupⅠ, the double labeled neurons were decreased significantly in group Ⅱand Ⅲ(P<0.05). The result of EEG showed that awakening wave increased at group B and C compare to group A(P<0.05). For induction time, there was no significant difference among A, B and C groups(P>0.05). The emergence time was significantly shorten in group C compare to group A(P<0.05),while no significant change was found in group

关键词： orexin-A,etomidate,anesthesia

来源：评论

学校读者我要写书评

暂无评论

TNF-alpha regulates functional synaptogenesis and anxiety-like behaviors in a dose specific manner

TNF-alpha regulates functional synaptogenesis and anxiety-li...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Pengzhan Ran Yun Wang Rushaniya Khairova Peixiong Yuan Feng Yang Maximilian Li Cristina Wheeler-Castillo Ming Zhu Bai Li Hongkun Bao Yangyang Hou Jun Nie Lijuan Sun Xavier Guitart Navarro Rodrigo Machado-Vieira Chunjie Xiao Wayne C.Drevets Carlos A.Zarate Jr. Husseini K.Manji Jing Du Yunnan University School of Medicine

Objective: The pro-inflammatory cytokine tumor necrosis factor-alpha(TNFα) regulates synaptic scaling, which may be involved in the pathophysiology of depression and anxiety disorder. However, the dose-specific mechanism whereby TNFα regulates formation of functional synapses and its association with these behaviors remains *** present study is to investigate the effects of physiological and pathologically-relevant doses of TNF? on synaptogenesis and anxiety-like behaviors. Methods: Hippocampal neuronal culture was prepared from embryo(E18) of Sprague Dawley rats. Cultured hippocampal neurons were treated with various concentrations of TNF? for one or three days, and the number of postsynaptic marker PSD95-positive synaptic puncta and pre-synaptic marker Synapsin 1-positive puncta were analyzed by double immune-fluorescent staining. The synapsin 1 levels were determined by Western blot analyses. Next, we sought to determine the long-term effects of TNF? treatment on synaptic AMPA receptor signaling by double immunofluorescent staining and measuring miniature excitatory post-synaptic current(mE PSC). After C57BL/6 mice received either low-dose or high-dose TNFα or vehicle infused into the third ventricle by mini-pump for seven days, the effect of TNFα on anxiety-like behaviors were determined. Results: We found that:1) TNFα affects hippocampal synaptogenesis in a dose-specific manner;2) TNFα induces the formation of AMPA-receptor containing and physiologically active synapses;3) TNFα effect on synaptogenesis is mediated via activation of Protein Kinase C;4) TNF? regulates anxiety-like behaviors in a dose-specific manner. Conclusion: The results suggest that TNFα induced synaptogenesis and changed the functional activity of synapses in hippocampal neurons in a dose-specific manner, which might correlate with the behavioral outcomes in animal models of anxiety-like behaviors. Our findings provide novel evidence that TNFα regulates synaptogenesis and behavior in

关键词： TNFα synaptogenesis depression dose-specific AMPA-receptor

来源：评论

学校读者我要写书评

暂无评论

Collateral projections to VPM and lateral parabrachial nuclei from VGLUTs positive neurons in Vp and Vsp

Collateral projections to VPM and lateral parabrachial nucle...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： Chunkui Zhang Zhihong Li Ting Zhang Yacheng Lu Yulin Dong Jinlian Li Department of Human Anatomy and K.K.Leung Brain Research Center The Fourth Military Medical University

The structure and function of trigeminal sensory nuclei is complex, which plays an important role in the delivery and integration of the input information from orofacial area. The different distribution pattern of the two kinds of vesicular glutamate transporters(VGLUTs) in the central nervous system suggests that they may play different roles in function. In previous studies, scholars also observed different distribution patterns of VGLUT1 and VGLUT2 in trigeminal sensory complex, especially in principal sensory trigeminal nucleus(Vp) and spinal trigeminal nucleus(Vsp), as well as their different projection areas to the upper nervous center. On the other hand, lateral parabrachil nucleus(LPB) plays a vital role in pain related emotion behaviors, and previous studies have shown that both Vp and Vsp have projections to LPB. To verify the expression of two types of VGLUTs in Vp and Vsp projection neurons to LPB, and whether the VGLUTs m RNA positive neurons in Vp and Vsp that project to LPB have collateral projections to VPM, retrograde track method combined with in situ hybridization technology were used in the program. We observed that after the injection of FG to the LPB hypothalamic nucleus(VPM) the FG labeled neurons in Vp and Vsp mainly show VGLUT2 m RNA positive, and only a small mount of FG labeled neurons in Vp shown VGLUT1 m RNA positive. After that, FG were injected into left LPB and TMR were injected to right ventromedial hypothalamic nucleus(VPM) at the same time. The results show that in Vp and Vsp, about 51%(Vp)、25%(oral subnucleus of spinal trigeminal nucleus, Vo)、62%(interpolar subnucleus, Vi) and 12%(caudal subnucleus, Vc) FG/VGLUT2 m RNA dual labeled neurons were simultaneously labeled with TMR respectively. What's more, after injection 4% formalin to the left upper lip of rat, the collateral projection neurons in the superficial layer of Vc could be labeled with c-fos. With the help of electron microscope, it could also be observed that parts of th

关键词： Trigeminal sensory nuclei VGLUT thalamus PB collateral projection rat

来源：评论

学校读者我要写书评

暂无评论

Agonists of sigma1-receptor,donepezil and PRE-084,rescue hippocampal long-term potentiation impaired by beta-amyloid peptide

Agonists of sigma1-receptor,donepezil and PRE-084,rescue hip...

引用

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

作者： E.I.Solntseva N.A.Kapai O.V.Popova P.D.Rogozin Research Center of Neurology Russian Academy of Sciences

Donepezil is a potent acetylcholinesterase inhibitor used for the treatment of Alzheimer's disease(AD). Additional therapeutically relevant target for donepezil is sigma1 receptor(Sig1-R). Beta-amyloid peptide(Aβ) is believed to contribute to the pathogenesis of AD. In our previous work(Kapai et al., 2012) we have shown that donepezil antagonizes the suppressive action of Aβ(1-42) on long-term potentiation(LTP) in rat hippocampal slices. The purpose of the present study was to determine whether Sig1-R is involved into the mechanisms of donepezil action. For this purpose, we have tested whether agonist of Sig1-R PRE-084 mimics, and antagonist of Sig1-R haloperidol abolishes the effect of donepezil. Population spikes(PS) were recorded from the pyramidal layer of the CA1 region of rat hippocampal slices. LTP of PS was induced using a train of high frequency stimulation(100 Hz, 1 s). Drugs were applied by addition to the perfusate starting15 min before and ending 5 min after the tetanus. In the control group, the amplitude of PS 30 min post-tetanus reached 153±10%. Aβ(200 n M) markedly suppressed the LTP magnitude or even caused the suppression of baseline PS(82±8%, P<0.001). This suppression of LTP could be markedly prevented when 1 μM donepezil was co-administered with Aβ(136±11%, P<0.05). Further, we co-administered three substances: Aβ, donepezil and 0.5 μM haloperidol, and have found that haloperidol antagonized the stimulating effect of donepezil on LTP(92±6%, P<0.05). Agonist of Sig1-R PRE-084 was found to reverse LTP impairment evoked by Aβ in a dose-dependent manner. The LTP amplitude 30 min post-tetanus restored to 172.4 ± 5.5% with 1 μM PRE-084(P < 0.01). In conclusion, our observations show for the first time that selective agonist of Sig1-R PRE-084 can facilitate both control and Aβ impaired LTP, and this effect mimics the effect of donepezil. In addition to that, antagonist of Sig1-R haloperidol was found to abolish the stimulating effect of donepezil on L

关键词： LTP hippocampus beta-amyloid peptide donepezil PRE-084 haloperidol

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共111页 << < 83 84 85 86 87 88 89 90 91 92 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：