Background: Alternative splicing is a molecular mechanism that produces multiple proteins from a single gene, and is thought to produce in diversity of proteins translated from a limited number of ***, it is still unc...
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Background: Alternative splicing is a molecular mechanism that produces multiple proteins from a single gene, and is thought to produce in diversity of proteins translated from a limited number of ***, it is still unclear that what physicochemical factors in alternative splicing lead to difference of structure.
Background: Nucleosome, as the basic unit of chromatin in eukaryotes cells, canregulate the gene expression, such as DNA replication, transcription and so *** along genome might be determined mainly by preference of D...
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Background: Nucleosome, as the basic unit of chromatin in eukaryotes cells, canregulate the gene expression, such as DNA replication, transcription and so *** along genome might be determined mainly by preference of DNA sequences andexternal factors, such as chromatin remodeler, DNA methylation, histone variation,post-translational modification, and polymerase Ⅱ *** DNA sequence is one of mainfactors to influent the nucleosome positioning.
Background: Complex diseases are supposed to be caused by multiple single nucleotide polymorphisms (SNPs), their interactive effects, and/or their interactions with environmental *** interactive effects of multiple SN...
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Background: Complex diseases are supposed to be caused by multiple single nucleotide polymorphisms (SNPs), their interactive effects, and/or their interactions with environmental *** interactive effects of multiple SNPs that underlie complex diseases are often referred to as epistatic interactions, which are believed to be causative patterns of complex ***, the detection and visualization of epistatic interactions, especially high-order epistatic interactions, are compelling next steps in genome-wide association studies (GWAS) where the order refers to the number of SNPs in an epistatic *** many GWAS to detect epistatic interactions have been performed, most were constrained to pairwise epistatic interactions and algorithms are still being developed.
Background: The combination of high-density transposon-mediated mutagenesis and high-throughput DNA sequencing has contributed to significant advancements in the research on essential *** of essential genes is becomin...
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Background: The combination of high-density transposon-mediated mutagenesis and high-throughput DNA sequencing has contributed to significant advancements in the research on essential *** of essential genes is becoming an increasingly appealing issue not only because it will shed new light on the understanding of life at its simplest level, but also because it has much significance in pharmaceutics and synthetic biology.
Background: High throughput sequencing technologies enable us to sequence uncultured microbes sampled directly from their habitats, which are expanding and transforming our view of the microbial ***, extracting meanin...
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Background: High throughput sequencing technologies enable us to sequence uncultured microbes sampled directly from their habitats, which are expanding and transforming our view of the microbial ***, extracting meaningful information from tens of millions of very short sequences brings a serious challenge to computational *** available computational methods for metagenomics are developed based on either low throughput data or a few well-studied microbiomes, which encounter extensive difficulties when applied to novel environmental *** of the major challenges is how to assemble and functionally annotate metagenomic sequences without closely related reference genomes.
Background: High-throughput sequencing has become a basic source of bioinformatics data *** high-throughput sequencing methods continue to emerge and the data generated in a single sequencing is still *** data managem...
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Background: High-throughput sequencing has become a basic source of bioinformatics data *** high-throughput sequencing methods continue to emerge and the data generated in a single sequencing is still *** data management methods or software are basically designed for the Sanger sequencing data, which are far behind and unable to fit with large-scale sequencing ***, we need a database management program for large-scale high-throughput sequencing data.
Background: Maltose transporter is an important kind of transmembrane transporters with significant biological functions which bears the transportation of intracellular and extracellular maltose *** transport process ...
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Background: Maltose transporter is an important kind of transmembrane transporters with significant biological functions which bears the transportation of intracellular and extracellular maltose *** transport process of maltose molecule accompanies with large scale cooperative motions between different domains of maltose transporter, which makes the transporter transforms between different functional *** these motions involve some key residues that mediate signal transduction and allosteric effects between different regions of the protein.
Cancer is the term for a collection of various malignant tumor, and has different clinical response based on its ***, they are all caused by the abnormality in cell mechanism for replication and growth, and characteri...
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Cancer is the term for a collection of various malignant tumor, and has different clinical response based on its ***, they are all caused by the abnormality in cell mechanism for replication and growth, and characterized by cell's unregulated *** the growth, it consumes much nutrient and may produce *** may transmit to surrounding and remote tissues through blood or *** to its unknown causes and different between patients, we can hardly cure it and it may *** is always the top cause of human death world-wide, and the target of many researchers, generally we think its cause is the inducer in outer or inner environment, and the inducer must cause abnormality in cell mechanism for replication and growth.
Background: Nicotinic acetylcholine receptors (nAChRs), the ligand-gated ion channels in the plasma of certain neurons that signal for synaptic transmission upon a chemical stimulus like acetylcholine and nicotine, pl...
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Background: Nicotinic acetylcholine receptors (nAChRs), the ligand-gated ion channels in the plasma of certain neurons that signal for synaptic transmission upon a chemical stimulus like acetylcholine and nicotine, play a critical role in nicotine *** has been found that different types of nAChRs show specific properties when binding with *** order to elucidate intrinsic functional diversity, and underlying evolutionary mechanism among nAChR subunits, we performed comprehensive bioinformatics analysis of nAChR protein family.
Background: HIV-1 integrase (IN), which responsible for strand transfer (ST) reaction by inserting the viral DNA into host cell DNA, has become an important target for antiviral drug ***, mutants have emerged, such as...
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Background: HIV-1 integrase (IN), which responsible for strand transfer (ST) reaction by inserting the viral DNA into host cell DNA, has become an important target for antiviral drug ***, mutants have emerged, such as N155H/S, which confer resistance to FDA approved diketo-acid (DKA) drugs (RAL, EVG, DTG) and other DKA inhibitors.
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