Background: As an important epigenetic marker, context-specific DNA methylation plays a critical role in regulating gene transcription, thereby involved in many biological ***, previously in most of the efforts to rev...
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Background: As an important epigenetic marker, context-specific DNA methylation plays a critical role in regulating gene transcription, thereby involved in many biological ***, previously in most of the efforts to reverse engineer cancer-specific transcription regulatory networks, DNA methylation has not been taken into account as a significant factor in controlling gene expression, partly due to lack of large-scale genome-wide data.
Background: Understanding biological functions of proteins is a key challenge in the post-genomic *** to its inherent difficulty and expense, experimental annotation of protein functions cannot scale up to accommodate...
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Background: Understanding biological functions of proteins is a key challenge in the post-genomic *** to its inherent difficulty and expense, experimental annotation of protein functions cannot scale up to accommodate the vast amount of sequence data already ***, computational methods that predict biological functions of a protein have emerged as an urgent problem at the forefront of computational and molecular biology, and machine learning techniques provide an effective approach for the construction of classifiers for this task.
Background: Protein structure prediction remains a challenge in the field of computational *** protein structure prediction approaches include template-based modelling (say, homology modelling, and threading), and ab ...
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Background: Protein structure prediction remains a challenge in the field of computational *** protein structure prediction approaches include template-based modelling (say, homology modelling, and threading), and ab initio.
Background: Endogenous small non-coding RNAs have been found to play pivotal roles in regulating gene expression in *** huge interests are put into the function and molecular mechanism of microRNAs in the development ...
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Background: Endogenous small non-coding RNAs have been found to play pivotal roles in regulating gene expression in *** huge interests are put into the function and molecular mechanism of microRNAs in the development and disease of various organisms via the repression of mRNA of protein coding gene, new discoveries indicate that they may trigger the generation of another type of small RNAs, the trans-acting siRNAs (ta-siRNAs).This implies a new mode of RNA function, the regulation between small RNAs which gives rise to an even more complicate and elaborate pattern of RNA regulation mechanism for gene expression.
Background: Although it has already been well documented that, in contrast to translation and transcription systems, DNA replication systems are not universally conserved among the three domains of life (Bacteria, Arc...
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Background: Although it has already been well documented that, in contrast to translation and transcription systems, DNA replication systems are not universally conserved among the three domains of life (Bacteria, Archaea, and Eukaryotes), it comes as a great surprise that even within bacteria the functional DNA polymerase Ⅲ alpha subunits (DnaE) have four different homologs, i.e., DnaE1, DnaE2, DnaE3, and PolC.
Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human ***, many of these disease-associ...
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Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human ***, many of these disease-associated SNPs are located in non-coding regions and have remained largely *** findings indicate that disease-associated SNPs in human large intergenic non-coding RNA (lincRNA) may lead to susceptibility to diseases through their effects on lincRNA *** is, therefore, a need to specifically record these SNPs and annotate them as potential candidates for disease.
Background: Alternative splicing is pervasive in multi-exon genes of human and other organisms, and is a major contributor to the expansion of the transcriptome diversity and functional *** array data demonstrated tha...
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Background: Alternative splicing is pervasive in multi-exon genes of human and other organisms, and is a major contributor to the expansion of the transcriptome diversity and functional *** array data demonstrated that as much as 90% of human genes generate alternatively spliced products.
Background: Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs).These regulatory loops serve as important m...
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Background: Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs).These regulatory loops serve as important motifs in gene regulatory networks and play critical roles in multiple biological processes and different *** of the TF-miRNA mediated regulatory modules have been ***, there are no TF-miRNA analysis in T-cell acute lymphoblastic leukemia (T-ALL) and no comprehensive review of the TF-miRNA network.
Background: Euphorbia factor L713283 is a new lathyrane diterpene isolated from Euphorbia lathyris and shows strong anticancer activity.β-tubulin is identified as the possible drug target of L713283 through molecular...
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Background: Euphorbia factor L713283 is a new lathyrane diterpene isolated from Euphorbia lathyris and shows strong anticancer activity.β-tubulin is identified as the possible drug target of L713283 through molecular similarity analysis.
Background: Microbial nanowires are conductive protein appendages which facilitate long-range extracellular electron transfer (EET).Different species of Geobacter and Shewanella have been found transfer electrons alon...
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Background: Microbial nanowires are conductive protein appendages which facilitate long-range extracellular electron transfer (EET).Different species of Geobacter and Shewanella have been found transfer electrons along their nanowires, which might be used for bioremediation of toxic metals or generation of electricity in microbial fuel ***, studies have suggested that these different species have different mechanisms for EET along their conductive *** sulfurreducens nanowires, which are comprised of pili, have been reported for its metal-like conductivity attributed to overlapping pi-pi orbitals of aromatic amino *** of the subunit structure which is determined with solution state NMR spectroscopy and a stepping stone model proposed before, the pilus structure of *** and the details of mechanism of electron transfer along the pili still remain unknown.
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