Background: Intrinsically disordered proteins (IDPs) are a kind of widespread protein that lack of stable three-dimensional structure, although they carry important biological *** of the flexible structure, it is diff...
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Background: Intrinsically disordered proteins (IDPs) are a kind of widespread protein that lack of stable three-dimensional structure, although they carry important biological *** of the flexible structure, it is difficult to experimentally study *** computational prediction of IDPs have been one of the most important topics of bioinformatics.
Background: Citrus is typical non-climacteric fruits and demonstrate world-wide economic ***, molecular mechanisms underlying citrus fruit ripening and senescence have been poorly *** increase our knowledge in this ar...
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Background: Citrus is typical non-climacteric fruits and demonstrate world-wide economic ***, molecular mechanisms underlying citrus fruit ripening and senescence have been poorly *** increase our knowledge in this area, the main cultivars in Citrus family, including tangerine, mandarin, orange and pummelo were adopted and investigated by microarray and metabolic analysis.
Background: Gene duplication is a general phenomenon in organism, which is related to the genome evolution as an important driving force of genome and genetic differentiation *** present, much fewer researches have be...
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Background: Gene duplication is a general phenomenon in organism, which is related to the genome evolution as an important driving force of genome and genetic differentiation *** present, much fewer researches have been performed on the duplicated genes in prokaryotic *** this paper, sequences analysis is conducted on the multi-copied protein coding genes in prokaryotic genomes for the first time, which can provide the helpful data support for the later research.
Background: Transcription factors (TFs) play key roles in gene expression regulation, so do the transcription cofactors and chromatin remodeling *** them are primary and crucial steps for illustrating their functions ...
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Background: Transcription factors (TFs) play key roles in gene expression regulation, so do the transcription cofactors and chromatin remodeling *** them are primary and crucial steps for illustrating their functions and understanding the transcriptional ***, until now, there is no a comprehensive animal TF family list and a database characterizing all the TFs based on families for the sequenced animal *** existing databases only focus on single or a few genomes, and the TF family classification and annotation for animals also could be improved to better serve the community.
Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse regulation types a...
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Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse regulation types and fewer side *** rational design of allosteric ligands, however, remains challenging, especially for the step of allosteric site *** allosteric ligand binding may work by inducing changes in the pattern of residue-residue interactions, we calculated the residue-residue interaction energies within the allosteric site based on the molecular mechanics generalized Born surface area (MM/GBSA) energy decomposition scheme.
Background: The abnormally methylated DNA can lead to carcinogenesis and some *** methylation, which mostly occurs at CpG sites, is one of epigenetic changes and plays a key role in regulatory gene expression.
Background: The abnormally methylated DNA can lead to carcinogenesis and some *** methylation, which mostly occurs at CpG sites, is one of epigenetic changes and plays a key role in regulatory gene expression.
Background: Extracellular electron transfer (EET) is the key feature of some bacteria, such as Geobacter sulfurreducens and Shewanella *** EET processes, these bacteria can grow on electrode surfaces and make current ...
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Background: Extracellular electron transfer (EET) is the key feature of some bacteria, such as Geobacter sulfurreducens and Shewanella *** EET processes, these bacteria can grow on electrode surfaces and make current output of microbial fuel cells.C-type cytochromes can be used as carriers to transfer electrons, which play an important role in EET ***, from inner membrane through periplasm to outer membrane, they could form EET pathways.
Methods: Interspecies somatic cell nuclear transfer (iSCNT) has been regarded as a potential alternative in rescuing highly endangered species and can be used as a model for studying nuclear-cytoplasmic ***, iSCNT emb...
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Methods: Interspecies somatic cell nuclear transfer (iSCNT) has been regarded as a potential alternative in rescuing highly endangered species and can be used as a model for studying nuclear-cytoplasmic ***, iSCNT embryos often fail to produce viable *** alterations of normal molecular mechanisms contributing to extremely poor development is for the most part unknown.
Background: DNA methylation and various types of histone modifications are widely studied epigenetic modifications that play important roles in regulation of cell development and differentiation *** fulfillment of the...
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Background: DNA methylation and various types of histone modifications are widely studied epigenetic modifications that play important roles in regulation of cell development and differentiation *** fulfillment of these functions depends on designated genome *** islands (CGIs) are specific regions in mammalian genomes with a high frequency of CpG dinucleotides and GC *** genome-wide variation of multiple epigenetic modifications in CpG islands (CGIs) and the interactions between them are of great interest.
Background: The fundamental step of leaming transcriptional regulation mechanism is to identify the target genes regulated by transcription factors (TFs).Despite numerous target genes identified by Chromatin immunopre...
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Background: The fundamental step of leaming transcriptional regulation mechanism is to identify the target genes regulated by transcription factors (TFs).Despite numerous target genes identified by Chromatin immunoprecipitation followed by high-throughput sequencing technology (ChIP-seq) assays, it is not possible to infer function from binding alone in *** is equally true in one of the best model systems, the nematode Caenorhabditiselegans (***), where regulation often occurs through diverse TFs binding features of transcriptional networks identified in modENCODE.
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