Background: Various aberrations such as amplification, deletion and translocation of segmental regions are common features of cancer genomes and play an important role in tumourigenesis and ***-genome sequencing of tu...
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Background: Various aberrations such as amplification, deletion and translocation of segmental regions are common features of cancer genomes and play an important role in tumourigenesis and ***-genome sequencing of tumor samples has been demonstrated as an efficient approach for comprehensive analysis of genomic aberrations in cancer *** issues such as tumor impurity and aneuploidy, GC-content and mappability bias have been reported to complicate identification of copy number alteration and loss of heterozygosity in complex tumor *** efficient computational methods are required to address these issues.
Background: Protein coding gene annotation errors in prokaryotic genomes are accumulating continually, which decrease the quality of bioinformatics *** most cases, the update rate of genome annotation can not keep up ...
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Background: Protein coding gene annotation errors in prokaryotic genomes are accumulating continually, which decrease the quality of bioinformatics *** most cases, the update rate of genome annotation can not keep up with the explosive increasing number of completed genome *** it is essential to manually rectify the genome annotation ***, the diverse re-annotation results obtained by different methods indicate that many existing re-annotation strategies are not credible enough for providing anticipative genome annotation *** differences also indicate potential increases of predicting false positive or false negative instead, which further accelerating the accumulation of genome annotation ***, it is urgent to put forward more rigorous re-annotation strategy for genome annotations.
Background: The typical symptom of Parkinson's disease is the presence of α-synuclein aggregates in the form of β-structure that can be soluble or *** N-terminal region (residues 1-60) of α-synuclein plays a ke...
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Background: The typical symptom of Parkinson's disease is the presence of α-synuclein aggregates in the form of β-structure that can be soluble or *** N-terminal region (residues 1-60) of α-synuclein plays a key role in the formation of α-synuclein ***, the dimerization is important for α-synuclein conformational transition and ***, it is difficult to simulate 120 residues in explicit water *** this study, we selected N-terminal 12 residues peptide of α-synuclein (α-syn12).
Background: Influenza A(H3N2) virus causes continuing epidemics in the human society since its emergence in 1968, due to its ability to change its antigenicity frequently through rapid mutations and thus escape the ho...
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Background: Influenza A(H3N2) virus causes continuing epidemics in the human society since its emergence in 1968, due to its ability to change its antigenicity frequently through rapid mutations and thus escape the host *** is reported to influence the antigenicity of the influenza *** is prevalent in the evolution of influenza A virus, especially for its surface proteins Hemagglutinin (HA) and Neuraminidase (NA).However, it is still unknown to what extent the epistasis contribute to the antigenic evolution of influenza A virus.
It has long been recognized that the "universal" 16S rRNA gene primers commonly used in microbial community surveys are inherently biased toward some *** our previous work, we found that genera have their ow...
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It has long been recognized that the "universal" 16S rRNA gene primers commonly used in microbial community surveys are inherently biased toward some *** our previous work, we found that genera have their own best genus-specific amplicons for genus assignment, which sometimes is not located in hyper variable regions (HVRs).
Background: Alternative splicing is a molecular mechanism that produces multiple proteins from a single gene, and is thought to produce in diversity of proteins translated from a limited number of ***, it is still unc...
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Background: Alternative splicing is a molecular mechanism that produces multiple proteins from a single gene, and is thought to produce in diversity of proteins translated from a limited number of ***, it is still unclear that what physicochemical factors in alternative splicing lead to difference of structure and to what extent alternative splicing influence protein stability.
Background: The homologous FlgM proteins have varieties of disordered degree and temperature adaptability, and the disordered degree is related with high temperature *** is one of the strategies naturally for adaptati...
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Background: The homologous FlgM proteins have varieties of disordered degree and temperature adaptability, and the disordered degree is related with high temperature *** is one of the strategies naturally for adaptation to high temperature that the disordered degree is converted from a fully disordered state to a semidisordered *** thermophile aquifex aeolicus FlgM protein (AAFlgM) is intrinsically disordered proteins, and also semidisordered *** remains unknown how the conformation transitions along with temperature at atomic-level.
Background: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular *** evidence has shown that translational selection is weakly operative in hi...
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Background: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular *** evidence has shown that translational selection is weakly operative in highly expressed genes in human and other ***, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.
Background: It is imperative to develop new simulation sampling method to characterize *** et al divided the long sequence IDPs into eight residues long fragments (for α-synuclein, the first two fragments are residue...
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Background: It is imperative to develop new simulation sampling method to characterize *** et al divided the long sequence IDPs into eight residues long fragments (for α-synuclein, the first two fragments are residues 1-8 and 6-13), then used temperature replica-exchange molecular dynamics (T-REMD) simulation (using implicit solvent model) to construct the structural library of short segments, and then used bayesian statistics to determine a probability distribution for each conformation in the ensemble based on both theoretical and experimental information.
Background: The rapid development of sequencing technologies have been accumulated amounts of genomic data, which provide a powerful opportunity for revealing the origin of *** the accomplishments of different genome ...
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Background: The rapid development of sequencing technologies have been accumulated amounts of genomic data, which provide a powerful opportunity for revealing the origin of *** the accomplishments of different genome projects, more than one chromosome is found in some prokaryotic genomes, while much fewer researches on the evolution of the diverse chromosomes haven been ***, the evolutionary relationships of chromosomes in prokaryotic genome are studied based on codon bias analysis, which provide theoretical support for the related research in the future.
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