Background: Leukocyte β2 integrins of LFA-1, Mac-1, and αxβ2 are constituted with the same β2 subunit and highly homologous α subunits *** mediate leukocyte-endothelial cell adhesion in inflammation by binding of...
详细信息
Background: Leukocyte β2 integrins of LFA-1, Mac-1, and αxβ2 are constituted with the same β2 subunit and highly homologous α subunits *** mediate leukocyte-endothelial cell adhesion in inflammation by binding of their Ⅰ domains presenting on the top of each α subunit to the common ligand of *** three members involve in distinct stages of inflammation cascade even they have similar structures and the same *** distinct functions implicate structural difference, while the corresponding structural profile remains unclear.
Background: The geometry features of a protein surface plays key role in protein-protein *** descriptors or methods have been developed to identify convex and concave regions in proteins, such as protrusion index, sur...
详细信息
Background: The geometry features of a protein surface plays key role in protein-protein *** descriptors or methods have been developed to identify convex and concave regions in proteins, such as protrusion index, surface roughness, FADE, CX and ***, these methods are either coarse descriptors or involve intensive *** by the CX and VisGrid algorithm, an improved surface structural parameter called the convex-and-concave index(CCI) was developed to identify convex and concave regions on protein surfaces.
Background: Salvia miltiorrhiza is one of the most widely used medicinal *** the gene expression regulation in its chloroplast is critical for the use of chloroplast-based genetic engineering efforts to over-produce a...
详细信息
Background: Salvia miltiorrhiza is one of the most widely used medicinal *** the gene expression regulation in its chloroplast is critical for the use of chloroplast-based genetic engineering efforts to over-produce active chemical *** and third generation sequencing technologies such as Single Molecule Real Time sequencing (SMRT) have provided us powerful tools to elucidate the genome, transcriptome, and DNA modification of the *** chloroplast.
Background: Accurate identification of DNA regulatory elements has become an urgent need in the post-genomic ***, a number of machine learning-based approaches have been developed to predict DNA elements based on chro...
详细信息
Background: Accurate identification of DNA regulatory elements has become an urgent need in the post-genomic ***, a number of machine learning-based approaches have been developed to predict DNA elements based on chromatin *** major constraints to the development of this area include (1) incomplete feature extraction of chromatin signatures and (2) lack of multicell models for element prediction across cell types.
Background: Persistent organic pollutants (POPs) cause various diseases in both human and wildlife and have become a new global environmental *** toxic effects of POPs can be induced through their binding to specific ...
详细信息
Background: Persistent organic pollutants (POPs) cause various diseases in both human and wildlife and have become a new global environmental *** toxic effects of POPs can be induced through their binding to specific proteins in the *** instance, recent studies revealed that widespread POPs, dichlorodiphenyldichloroethylene (4,4'-DDE) and polychlorinated biphenyls (PCBs), are antagonists of androgen receptor (AR);2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces rapidly the activity of CK2 (casein kinase Ⅱ) both in vivo and in ***, the inhibition mechanisms remain elusive.
Background: The ribose-binding protein (RBP) from Escherichia coli is one of the representative structures of the periplastic binding *** responses are typically mediated by ligand-induecd conformational changes in wh...
详细信息
Background: The ribose-binding protein (RBP) from Escherichia coli is one of the representative structures of the periplastic binding *** responses are typically mediated by ligand-induecd conformational changes in which the ribose binding event is coupled to a hinge-bending motion that brings together two domains in a closed *** RBP has been crystallized in the open (PDB ID: 1URP) and the closed conformation (PDB ID: 2DRI) and the structures differ by a 41.3° rotation of the N-terminal domain relative to the C-terminal domain.
Transcripts with stage-specific alternative first exon (SAFE) usage involve in the regulation of many biological processes, yet their presence and functions in embryonic stem cells (ESCs) are still largely *** this wo...
Transcripts with stage-specific alternative first exon (SAFE) usage involve in the regulation of many biological processes, yet their presence and functions in embryonic stem cells (ESCs) are still largely *** this work, we identify 137 mESC SAFE isoforms of 128 genes expressed in both ESCs and somatic cells.
Background: Against a declining trend of global HIV epidemic, HIV infection among men who have sex with men (MSM) was reported to be continuously *** assess HIV burden representative by measuring prevalence using a a ...
详细信息
Background: Against a declining trend of global HIV epidemic, HIV infection among men who have sex with men (MSM) was reported to be continuously *** assess HIV burden representative by measuring prevalence using a a spatial-temporal systematic analysis in China.
Background: Protein phosphorylationis one of the most important and essential post-translational modifications (PTMs).It plays a crucial role in a wide range of cellular processes such as metabolism and signal *** nea...
详细信息
Background: Protein phosphorylationis one of the most important and essential post-translational modifications (PTMs).It plays a crucial role in a wide range of cellular processes such as metabolism and signal *** nearly 5 phosphorylation predictors for plants have been developed, they all lack the exact protein kinase (PK) information for the given phosphorylation sites (p-sites).So currently, our understanding of site-specific kinase-substrate phosphorylation networks (KSPNs) remains still very limited.
Background: Cigarette smoking is a main cause of preventable diseases and premature death *** is the major psychoactive component of tobacco and has broad physiological effects within the central nervous *** our under...
详细信息
Background: Cigarette smoking is a main cause of preventable diseases and premature death *** is the major psychoactive component of tobacco and has broad physiological effects within the central nervous *** our understanding of the mechanism of nicotine addiction is still *** recent years, the application of high-throughput technologies to nicotine addiction study has created massive and complex datasets;and a big challenge is how to obtain the relevan tbiological information from such heterogeneous data ***-basedand protein-protein interaction network analyses may provide us an effective way to explore the molecular mechanisms of nicotine addiction.
暂无评论