Background: The role of miRNA in gene regulatory networks has been becoming more *** determine the TF-miRNA regulation, precisely identifying transcriptional start site (TSS) of miRNA and, thus, the location of the pr...
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Background: The role of miRNA in gene regulatory networks has been becoming more *** determine the TF-miRNA regulation, precisely identifying transcriptional start site (TSS) of miRNA and, thus, the location of the promoter is the first and crucial step.
Background: The DNA replication initiate at chromosome special region called ORI, which plays an important role in cell cycle *** the properties of ORIs is the key step for correctly identifying ORIs and understanding...
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Background: The DNA replication initiate at chromosome special region called ORI, which plays an important role in cell cycle *** the properties of ORIs is the key step for correctly identifying ORIs and understanding the regulatory ***, the mining and analysis of DNA sequence in ORIs has become particularly important.
Background: Long ncRNAs (lncRNAs) are long non-coding transcripts (>200nt), but play important roles in various biological processes, such as genomic imprinting, X dosage compensation and chromatin regulation.
Background: Long ncRNAs (lncRNAs) are long non-coding transcripts (>200nt), but play important roles in various biological processes, such as genomic imprinting, X dosage compensation and chromatin regulation.
Background: Transposable elements (TE), the most abundant DNA components in all characterized genomes of higher eukaryotes, have been recognized to play important roles in altering gene structures, regulation of gene ...
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Background: Transposable elements (TE), the most abundant DNA components in all characterized genomes of higher eukaryotes, have been recognized to play important roles in altering gene structures, regulation of gene expression, affecting genome evolution and creating new genes.
Background: Adverse drug reactions (ADRs) is one of the main causes of new drug discovery ***, it is desired to evaluate drug (or candidate) safety in early laboratory stage before they reach further pre-clinical or c...
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Background: Adverse drug reactions (ADRs) is one of the main causes of new drug discovery ***, it is desired to evaluate drug (or candidate) safety in early laboratory stage before they reach further pre-clinical or clinical stages of drug discovery.
Background: Mutation is the ultimate source of genetic variation and *** accumulation (MA) experiments offer an alternative approach to study de novo mutation events *** mutation events are detected using high-through...
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Background: Mutation is the ultimate source of genetic variation and *** accumulation (MA) experiments offer an alternative approach to study de novo mutation events *** mutation events are detected using high-throughput sequencing platforms.
Background: LTR-retrotransposons (LTR-RTs) are the major DNA components of flowering *** are generally enriched in pericentromeric heterochromatin regions of their host genomes, which could be caused by preferential i...
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Background: LTR-retrotransposons (LTR-RTs) are the major DNA components of flowering *** are generally enriched in pericentromeric heterochromatin regions of their host genomes, which could be caused by preferential insertion of LTR-RTs and low effectiveness of purifying selection in these regions.
Background: Most of complex diseases, such as cancer, heart disease, and diabetes, are believed to be mainly caused by epistatic interactions of two single nucleotide polymorphisms (SNPs).Though many works have been d...
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Background: Most of complex diseases, such as cancer, heart disease, and diabetes, are believed to be mainly caused by epistatic interactions of two single nucleotide polymorphisms (SNPs).Though many works have been done for the detection of SNP-SNP interactions, the algorithmic development is still ongoing due to their mathematical and computational complexities.
Background: MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of *** understand microRNAs'...
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Background: MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of *** understand microRNAs' function, it is vital to identify microRNA2target interactions.
Background: The stealth shielding effect of PEGylated nanocarriers is of great importance for their properties including biological targeting and drug *** its inhibitory action on the opsonization of serum proteins, t...
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Background: The stealth shielding effect of PEGylated nanocarriers is of great importance for their properties including biological targeting and drug *** its inhibitory action on the opsonization of serum proteins, the shielding effect of PEGylation nanoparticles (NPs) lies in the ability of suppressing the bending of *** current understanding of the stealth shielding effect of PEGylated nanocarriers is still *** this study, we analyzed the influences of chain length of polyethylene glycol (PEG) on the shielding effect of PEGylated nanoparticles.
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