Background: In the big data era, it is of interests to mine large volume of genome-wide expression profiles to identify biologically meaningful ***: Therefore, in this study, a gene correlation network was constructed...
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Background: In the big data era, it is of interests to mine large volume of genome-wide expression profiles to identify biologically meaningful ***: Therefore, in this study, a gene correlation network was constructed upon 61 samples from three human liver expression datasets by calculating gene-gene expression correlation *** correlation network analysis (WGCNA) algorithm was then applied to the gene network to detect modules (or sub-networks) of highly correlated *** functionally characterize these network modules, a series of statistical analyses were demonstrated.
Adverse drug reaction (ADR) is a common clinical problem, sometimes accompanying with high risk of mortality and *** is also one of the major factors that lead to failure in new drug ***, most of current experimental ...
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Adverse drug reaction (ADR) is a common clinical problem, sometimes accompanying with high risk of mortality and *** is also one of the major factors that lead to failure in new drug ***, most of current experimental and computational methods are unable to evaluate clinical safety of drug candidates in early drug discovery stage due to the very limited knowledge of molecular mechanisms underlying ADRs.
Background: Understanding the folding mechanism of the β-sheet structure is crucial for a general and comprehensive understanding of the protein folding *** WW domain families are named by the two conserved tryptopha...
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Background: Understanding the folding mechanism of the β-sheet structure is crucial for a general and comprehensive understanding of the protein folding *** WW domain families are named by the two conserved tryptophan residues, and are the smallest natural β-sheet *** artificial protein CC45 is designed by the coupled conservation model and is capable of folding into the same structure as WW *** WW domain proteins are usually regarded as one of the simplest models for understanding the folding mechanism of β-sheet.
Background: Mycobacterial tuberculosis can cause one of the most prevalent infectious *** the distribution of mycobacterial proteins in subcellular localization can be provided vital clues for protein function predict...
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Background: Mycobacterial tuberculosis can cause one of the most prevalent infectious *** the distribution of mycobacterial proteins in subcellular localization can be provided vital clues for protein function prediction and drug *** study is to develop a novel computational method to predict the subcellular localization of mycobacterial proteins.
Background: As one of the fastest growing diseases in the world, T2D has developed a main public health problem with more than 280 million people affected by this disease, and is the major type of diabetes with about ...
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Background: As one of the fastest growing diseases in the world, T2D has developed a main public health problem with more than 280 million people affected by this disease, and is the major type of diabetes with about 90% patients of all the diabetes *** 2 diabetes (T2D) is characterized by insulin resistance and the decrease of insulin secretion.
Background: Genetic recombination is an important factor to change and shape genome and its relevant *** transfer or reassortment and recombination in the nature happen quite frequent between different species or indi...
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Background: Genetic recombination is an important factor to change and shape genome and its relevant *** transfer or reassortment and recombination in the nature happen quite frequent between different species or individuals, which lays the foundation for evolution of species.
Background: Non-coding RNAs (ncRNAs) including microRNAs and lncRNAs have been recognized as important players involved in a broad range of biological *** of ncRNAs has been demonstrated to contribute to various human...
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Background: Non-coding RNAs (ncRNAs) including microRNAs and lncRNAs have been recognized as important players involved in a broad range of biological *** of ncRNAs has been demonstrated to contribute to various human diseases through posttranscriptionally regulating target expression (miRNAs) or influencing chromatin modification of target sites (lncRNAs).However, identification of many disease-associated ncRNAs is still an enigma and the mechanism underpinning deregulation of ncRNAs in complex disease is poorly understood.
Background: Intrinsically disordered proteins (IDPs) play important role and lack of stable 3D *** of the flexible structure, it is difficult to study IDPs using wet experiments based ***, To discover the potential in...
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Background: Intrinsically disordered proteins (IDPs) play important role and lack of stable 3D *** of the flexible structure, it is difficult to study IDPs using wet experiments based ***, To discover the potential information behind the IDPs, it is important to develop novel methods to display the intrinsic features.
Background: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-edged sword role in human *** 14-3-3 proteins can bind several hundred diverse target *** reports have indicated that ...
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Background: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-edged sword role in human *** 14-3-3 proteins can bind several hundred diverse target *** reports have indicated that the 14-3-3 protein may be in an open or closed state.
Background: Breast cancer, a leading cause of cancer-related mortality in women worldwide, is considered to be a genetically heterogeneous group of *** genetic and acquired epigenetic abnormalities participate in the ...
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Background: Breast cancer, a leading cause of cancer-related mortality in women worldwide, is considered to be a genetically heterogeneous group of *** genetic and acquired epigenetic abnormalities participate in the development of breast cancer, accurate understanding of subtype-specific epigenetic regulatory programs that depend on DNA methylation and chromatin (histone) modification, holds important implications for cancer diagnosis, and identification of subtype-specific new targets for therapy.
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