Background: Overshoot is a crucial biological function observed in a wide range of biological *** benefits of overshoot are well documented, but the physics behind overshoot remains poorly *** traditional study of ove...
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Background: Overshoot is a crucial biological function observed in a wide range of biological *** benefits of overshoot are well documented, but the physics behind overshoot remains poorly *** traditional study of overshoot under the framework of deterministic systems is not suitable for the study of overshoot in biological systems which are inherently stochastic.
Background: Gene expression is modulated by multiple mechanisms, including genetic and/or epigenetic regulation, and associated with the processes of cellular differentiation and *** nucleotide polymorphisms (SNPs) an...
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Background: Gene expression is modulated by multiple mechanisms, including genetic and/or epigenetic regulation, and associated with the processes of cellular differentiation and *** nucleotide polymorphisms (SNPs) and DNA methylation play important roles in regulating gene *** of the effect on gene expression may mutually restrict each *** focused on revealing the actual relationship between SNPs, DNA methylation and gene expression.
Background: Gram-negative pathogenic bacteria inject type-Ⅲ effectors into host cells to sabotage their immune signaling *** the rapid development of high-throughput sequencing technologies, more and more pathogenic ...
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Background: Gram-negative pathogenic bacteria inject type-Ⅲ effectors into host cells to sabotage their immune signaling *** the rapid development of high-throughput sequencing technologies, more and more pathogenic bacteria genomes have been fully *** is an unprecedented requirement for bioinformatics tools that can accurately identify and conveniently analyze type-Ⅲ effectors from these genome data.
Background: With the increasing prevalence of bacteria antibiotic resistance, phage therapy has become a hotspot in biomedical *** bacterial viruses, bacteriophages widely exist in various natural *** types and quanti...
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Background: With the increasing prevalence of bacteria antibiotic resistance, phage therapy has become a hotspot in biomedical *** bacterial viruses, bacteriophages widely exist in various natural *** types and quantities of phages are far greater than these of *** acting as alternatives of antibiotics, their rich genetic resources can be widely used in various fields, including molecular biology, drug delivery systems, surface displaying technology, third generation sequencing technology, electrochemistry, material science and so on.
The basic unit of chromatin structure is the nucleosome, consisting of histone octamers wrapped in 147 base pairs of *** genomic DNA is assembled into nucleosomes and is further packaged into chromatin to achieve high...
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The basic unit of chromatin structure is the nucleosome, consisting of histone octamers wrapped in 147 base pairs of *** genomic DNA is assembled into nucleosomes and is further packaged into chromatin to achieve high *** positioning plays an important role in gene regulation, such as the initiation of transcription, alternative splicing and the termination of *** mechanism behind these regulations is that nucleosomes can compete with protein factors and directly affect the accessibility of transcription factor and other processing factors to the DNA sequences.
Background: Analyzed the special inherent law of 8-mer usage in human intergenic sequences, available nucleosome binding motif set were predicted by theoretical analysis and a popular and simple parameter to character...
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Background: Analyzed the special inherent law of 8-mer usage in human intergenic sequences, available nucleosome binding motif set were predicted by theoretical analysis and a popular and simple parameter to characterize nucleosome positioning was *** with the experimental nucleosome occupancy rate, the average linear correlation coefficient reached *** results verify our predicting theory.
Background: The existence and function of most proteins in the human proteome are regulated by the ubiquitination *** date, tens of thousands human ubiquitination sites have been identified from high-throughput proteo...
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Background: The existence and function of most proteins in the human proteome are regulated by the ubiquitination *** date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic ***, the mechanism of ubiquitination site selection remains elusive because of the complicated sequence pattern flanking the ubiquitination *** recently developed human ubiquitination site predictor hCKSAAP_UbSite has achieved acceptable performance but still needs further *** this study, we aim to analyze the preferences of ubiquitination sites at an alternative structural perspective.
Background: Transcription factor (TF) binding at specific DNA sequences is the fundamental step in transcriptional regulation, and is highly dependent on the local chromatin structure context in *** basic unit of chro...
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Background: Transcription factor (TF) binding at specific DNA sequences is the fundamental step in transcriptional regulation, and is highly dependent on the local chromatin structure context in *** basic unit of chromatin structure is the *** are specific patterns of nueleosome occupancy around transcription factor binding sites (TFBSs).However, previous studies have focused mainly on nucleosome occupancy around TFBSs of a few specific *** therefore need to collect more TFBSs to systematically investigate the common features of nucleosome occupancy around TFBSs.
Background: Human immunodeficiency virus type 1 (HIV-1), which is the pathogen of acquired immunodeficiency syndrome (AIDS), causes about 2 millions death every *** on the carboxy-terminal heptad repeat (CHR) region o...
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Background: Human immunodeficiency virus type 1 (HIV-1), which is the pathogen of acquired immunodeficiency syndrome (AIDS), causes about 2 millions death every *** on the carboxy-terminal heptad repeat (CHR) region of the transmembrane subunit of envelope protein (gp41) of HIV, several fusion inhibitors have been discovered.
Background: Gene knockout has been used to improve the conversion ratio of strains for some chemical *** on mixed integer bilevel linear programming (MIBLP) and cell network models, there have been several algorithms ...
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Background: Gene knockout has been used to improve the conversion ratio of strains for some chemical *** on mixed integer bilevel linear programming (MIBLP) and cell network models, there have been several algorithms to predict the target for deletion to improve the productivity of chemicals.
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