Background: Recently, lysine was discovered as a hot spot amino acid for the protein post-translation *** relatively well-studied protein lysine modifications (PLMs) such as methylation, acetylation and ubiquitination...
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Background: Recently, lysine was discovered as a hot spot amino acid for the protein post-translation *** relatively well-studied protein lysine modifications (PLMs) such as methylation, acetylation and ubiquitination, a number of new PLMs were discovered to modify lysine residue, for example, butyrylation, crotonylation and *** the detailed regulatory mechanisms are far from understanding, it is anticipated that these PLMs play critical roles in various biological *** curation of the experimental progresses of PLMs will be helpful for further studies.
Background: MFC(Microbial Fuel Cell) is the equipment to convert chemical energy to electricity by the Electricigens like Geobacter sulfurreducens and Shewanella oneidensis *** improve its efficiency of electricity pr...
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Background: MFC(Microbial Fuel Cell) is the equipment to convert chemical energy to electricity by the Electricigens like Geobacter sulfurreducens and Shewanella oneidensis *** improve its efficiency of electricity production,we need to understand the principles of EET(extracellular electron transfer),for example,the EET pathways under specific conditions.
Background: Epigenetic modification plays crucial roles in directing spatial-and temporal-specific gene expression during cellular differentiation and diseases *** data of histone modifications have grown exponentiall...
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Background: Epigenetic modification plays crucial roles in directing spatial-and temporal-specific gene expression during cellular differentiation and diseases *** data of histone modifications have grown exponentially by the next-generation sequencing *** on these data, many theoretical works for epigenetics researches could be *** this study the human embryonic stem (ES) cell and breast cancer cell lines were chosen to study the relationship between histone modifications and gene expression levels.
Background: With the development of genome-scale models of metabolism and phenotype simulation methods, a number of strain optimization methods for predicting genetic manipulation targets that lead to overproduction o...
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Background: With the development of genome-scale models of metabolism and phenotype simulation methods, a number of strain optimization methods for predicting genetic manipulation targets that lead to overproduction of compounds of interest have been *** of them attempt to identify gene deletion strategies by coupling biomass formation with chemical ***, the production of most metabolites can't be coupled with cellular growth.
Background: Thousands of newly discovered long non-coding RNAs (lncRNAs) have been bringing novel insight into biological ***, it is still not trivial to accurately distinguish the novel lncRNA transcripts from the pr...
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Background: Thousands of newly discovered long non-coding RNAs (lncRNAs) have been bringing novel insight into biological ***, it is still not trivial to accurately distinguish the novel lncRNA transcripts from the protein coding ones.
Background: Histone modification is one of the key epigenetic regulation mechanisms which plays a critical role in various biological *** Saccharomyces cerevisiae, the histones H3 and H4 gene are encoded by two copy, ...
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Background: Histone modification is one of the key epigenetic regulation mechanisms which plays a critical role in various biological *** Saccharomyces cerevisiae, the histones H3 and H4 gene are encoded by two copy, named HHT1-HHF1 and *** sites of histone acetylation, methylation and other modifications have a important biological significance to eukaryotic DNA replication.
Background: Extensive studies reveal that cancer genomes are frequently altered in their chromosomal structure by insertion, deletion, translocation and inversion of DNA *** alterations (termed as structural variation...
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Background: Extensive studies reveal that cancer genomes are frequently altered in their chromosomal structure by insertion, deletion, translocation and inversion of DNA *** alterations (termed as structural variation, SV) may produce various phenotypic effects in tumorigenesis and various human genetic ***, current SV detection algorithms are far from being perfect and have limits in terms of the type and size of SVs that they are able to *** still lacks a one-stop solution for full range of structural variant detection, especially for both small INDELs and complex forms of SVs.
Background: Protein-RNA interactions play crucial roles in numerous biological *** detecting the interactions and binding sites between protein and RNA by traditional experiments are still time consuming and *** is va...
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Background: Protein-RNA interactions play crucial roles in numerous biological *** detecting the interactions and binding sites between protein and RNA by traditional experiments are still time consuming and *** is valuable to propose feature-based computational methods to predict the protein-RNA interactions and binding *** prediction of protein-RNA interaction will highly benefit the wet experimental design and decipher the interaction mechanisms between protein and RNA.
Background: MicroRNAs (miRNAs) are a class of~22nt long short non-coding ***-mediated post-transcriptional regulation could be triggered even by only 6-nt complementarity of the miRNA 5'-end "seed region"...
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Background: MicroRNAs (miRNAs) are a class of~22nt long short non-coding ***-mediated post-transcriptional regulation could be triggered even by only 6-nt complementarity of the miRNA 5'-end "seed region" to the target RNA, which confers each miRNA species the capacity to interact with multiple RNA species.
Background: Biocuration involves the integration of the scientific literature as well as large-scale omics data into a database and enables biomedical data standardized, interoperable, and ***, biocuration is of criti...
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Background: Biocuration involves the integration of the scientific literature as well as large-scale omics data into a database and enables biomedical data standardized, interoperable, and ***, biocuration is of critical signifiance in translating big data into big *** than a dozen biological wikis (bio-wiki) have been constructed to call on community intelligence in big data ***, one of the major limitations in bio-wikis is insufficient participation from the scientific community, intrinsically due to no credit for community-curated contributions.
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