Background: Expression quantitative trait locus (eQTL) analysis has been widely used to understand how genetic variations in the genome perturb biological *** association between unique gene and a loci has been widely...
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Background: Expression quantitative trait locus (eQTL) analysis has been widely used to understand how genetic variations in the genome perturb biological *** association between unique gene and a loci has been widely discussed, it is important to explore the effect of genetic variations to a group of *** methods have been proposed such as LA and GFlasso, which focus on the effect on their mean expression ***, the effect on the structure is also need to be discussed.
Background: The recognition of protein functional sites would further enhance our understanding of protein function and some relevant biological ***, due to the problems of insufficient labeled examples and class-imba...
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Background: The recognition of protein functional sites would further enhance our understanding of protein function and some relevant biological ***, due to the problems of insufficient labeled examples and class-imbalance, it can't be well solved just by supervised machine learning methods for many tasks on the recognition of some kinds of functional sites in proteins, such as metal ion-binding sites, non-coding RNA-binding sites, *** this paper, we have stated that the cost-sensitive semi-supervised learning methods is easily extended to many similar tasks and then proposed a general learning framework for predicting multiple types of functional sites in proteins.
Background: Botulinum neurotoxins (BoNTs) are proteins produced by the bacteria Clostridium botulinum and they have been classified into seven serotypes (A-G).Despite their lethal toxicity, BoNTs have emerged as the v...
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Background: Botulinum neurotoxins (BoNTs) are proteins produced by the bacteria Clostridium botulinum and they have been classified into seven serotypes (A-G).Despite their lethal toxicity, BoNTs have emerged as the valuable therapeutic tools for the treatment of a variety of medical conditions, including migraines, spastic muscle disorders and pain *** the previous studies, the synaptic vesicle protein 2 (SV2) has been proposed to be a protein receptor for BoNT/A, but theoretical studies of the interaction between BoNT/A and SV2 are relatively sparse.
Background: Both experimental and computational studies recently suggest that secondary structure of mRNA sequences in specific regions may largely involve in regulating translation and post-translation *** studies de...
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Background: Both experimental and computational studies recently suggest that secondary structure of mRNA sequences in specific regions may largely involve in regulating translation and post-translation *** studies demonstrated that reduced secondary structures near translation initiation sites generally affect synonymous codon choices in prokaryotes and eukaryotes.
Background: Current in-silico methods that are used for genome-wide microRNA (miRNA) prediction are mainly based on BLAST *** often produce a large number of false positives.
Background: Current in-silico methods that are used for genome-wide microRNA (miRNA) prediction are mainly based on BLAST *** often produce a large number of false positives.
Background: Similar to animals, plants highly rely on the immune system as a defense against *** is well established that plants can perceive pathogenic invasions by detecting extracellular pathogen-specific molecules...
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Background: Similar to animals, plants highly rely on the immune system as a defense against *** is well established that plants can perceive pathogenic invasions by detecting extracellular pathogen-specific molecules using transmembrane receptors, which results in pattern-triggered immunity (PTI), or by recognizing intracellular virulence proteins using resistant (R) proteins, which leads to effector-triggered immunity (ETI).However, the downstream immune responses that distinguish PTI and ETI are largely unknown.
Background: Pigs have processed a dramatic artificial selection leading to a different phenotype of domestic pigs compared to wild counterpart, especially in last several ***, a genome-wide scanning the footprints of ...
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Background: Pigs have processed a dramatic artificial selection leading to a different phenotype of domestic pigs compared to wild counterpart, especially in last several ***, a genome-wide scanning the footprints of recent positive selection have been well studied in cattle and ***, few studies focused on porcine selecting footprints, particularly in *** identification of selection footprints across porcine genomes is quite valuable to reveal the genetic mechanisms of phenotypic diversity.
Background: Deep sequencing with new computational approaches for assembling transcriptome has identified tens of thousands of large intergenic transcripts across different tissues and cell *** intergenic transcripts ...
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Background: Deep sequencing with new computational approaches for assembling transcriptome has identified tens of thousands of large intergenic transcripts across different tissues and cell *** intergenic transcripts do not code for proteins and are named long intergenic non-coding RNAs (lincRNAs).Although several lincRNAs have been depicted with relatively explicit molecular mechanisms in several cancers, little is known about the regulatory mechanisms of lincRNAs in tumors or normal tissues, especially on regulation by DNA methylation.
Background: It is critical to study the mechanisms of erythroid and megakaryocytic differentiation for developing therapeutic strategies for blood *** previous studies provided numerous evidences of erythroid or megak...
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Background: It is critical to study the mechanisms of erythroid and megakaryocytic differentiation for developing therapeutic strategies for blood *** previous studies provided numerous evidences of erythroid or megakaryocytic commitment, the mechanism of erythro-megakaryocytic differentiation is still poorly understood.
Background: Finding candidates for cancer-associated genes are of great value for the prevention, diagnosis and treatment of *** classic assays of molecular biology high-throughput technology such as DNA microarray an...
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Background: Finding candidates for cancer-associated genes are of great value for the prevention, diagnosis and treatment of *** classic assays of molecular biology high-throughput technology such as DNA microarray and next-generation sequencing have been widely used in this *** evidence at DNA or RNA level, mass spectrometry-based proteomic profiling has also become a promising approach, which can provide proofs at protein *** the accomplishment of the draft map of the human proteome and NCI-60 proteome, now it becomes possible to systematically identify candidates for cancer-associated genes.
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