Background:Lung cancer is one of the most common cancers in China. Estimation of future cancer trends is important for public health planning. The aim of this study is to examine past trends of lung cancer incidence f...
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Background:Lung cancer is one of the most common cancers in China. Estimation of future cancer trends is important for public health planning. The aim of this study is to examine past trends of lung cancer incidence from 1998 to 2007 and to predict the future lung cancer burden up to 2002 in China. Materials and methods:Lung cancer incidence data were retrieved from the national cancer registration database having continuous data from 1998 to 2007. Annual population projection was obtained from the National Statistics Bureau for the same period. Bayesian Age-Period-Cohort Modeling and Prediction package was applied to describe the trend of overall lung cancer incidence and predict future lung cancer incidence until the year 2020. Results:The crude incidence rates of lung cancer increased from 43.39 per 100,000 in 1998 to 51.25 per 100,000 in 2007. After age standardization, the incidence rates remained relatively stable during the past 10 years. These trends were mainly driven by aging effect, whereas no obvious period effects and cohort effects were seen. Our projection showed that the age-standardized lung cancer incidence would remain steady in the next few years up to 2020. The estimated number of incident cases would increase, with a total of 693,727 new cases in ***:The burden of lung cancer incidence is likely to continue increasing. Effective policies such as smoking cessation and environment protection are imperative for lung cancer control and prevention.
To compare alterations in the proteomes of human epithelial ovarian cancer xenografts between stressed and non-stressed immunodeficient mice. Aslo, to explore the molecular mechanisms linking chronic psychological str...
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To compare alterations in the proteomes of human epithelial ovarian cancer xenografts between stressed and non-stressed immunodeficient mice. Aslo, to explore the molecular mechanisms linking chronic psychological stress to ovarian cancer oncogenesis and progression. Methods: SK-OV-3 cells were injected subcutaneously into nude mice. The stress group was subjected to a chronic physical restraint protocol for 6 h on 35 consecutive days, while the control group was unrestrained. All mice were sacrificed on Day 36 after SK-OV-3 cell injection, and tumors were excised. Tumor tissues were processed for 2D gel electrophoresis, mass spectrometry (nanoUPLC-ESI-MS/MS) and western blotting. Results: The expression of twenty proteins was found to be significantly altered between the stress and control groups, of which fourteen were up-regulated, five were down-regulated, and one protein was found only in the stress group. All proteins were identified by UPLC-ESI-MS/MS, and western blotting results were consistent with those of proteomic methods. Conclusions: The present results provide new evidence relating to the molecular mechanism underlying the relationship between psychological stress and tumor progression.
Background The etiology and high share of proximal gastric cancer (PGC) in China indicates that it is a distinct entity from that in other countries. PGC has a poor outcome compared with distal gastric cancer (DGC), e...
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Background The etiology and high share of proximal gastric cancer (PGC) in China indicates that it is a distinct entity from that in other countries. PGC has a poor outcome compared with distal gastric cancer (DGC), even after curative resection. Prognostic analysis may be of help in the design of clinical trials on adjuvant treatments of proximal gastric cancer. Patients and method Patient data including clinical and pathological information derived from a database established in Beijing Cancer Hospital were analyzed. Comparison between PGC and DGC was performed. Univariate and multivariate prognostic analysis on PGC following curative resection were carried *** Ninety hundred and thirty-eight eligible patients were enrolled in this study. Disease-specific survival of 372 PGC was superior to that of DGC, even stratified by stage. PGC had more male, larger body mass index (BMI), more advanced lesion, and more aggressive. The median number of lymph nodes harvested in PGC was 11 (1-46), less than DGC (19, 1-71). Multivariate analysis demonstrated that lymph node metastasis ratio (LMR), Lauren’s classification, and lympha vascular invasion(LVI)were independent prognostic factors. Proximal gastric cancer with different LMR had significant different prognosis, even in those total lymph nodes less than 15. Conclusion LMR, LVI, and Lauren’s classification were independent prognostic factors for Chinese patients with proximal gastric cancer following curative resection. Clinical trials on adjuvant treatment of proximal gastric cancer should be based on prognostic stratification.
作者:
Paolo BOFFETTAThe Tish Cancer Institute
Mount Sinai School of MedicineNew YorkNYUSA and International Prevention Research Institute95 cours Lafayette69006 LyonFrance
Objective to estimate the contribution of known risk factors of lung cancer in China and to provide evidence to support the National Cancer Prevention and Control Program in China. Methods We calculated the proportion...
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Objective to estimate the contribution of known risk factors of lung cancer in China and to provide evidence to support the National Cancer Prevention and Control Program in China. Methods We calculated the proportion of lung cancer attributable to specific risk factors. Exposed data were from meta-analyses and large-scale national surveys of representative samples of Chinese population. Data on relative risks were from meta-analyses and large-scale prospective studies. Lung cancer mortality and incidence were originated from the 3rd national death cause survey and population-based cancer registries in China. Results We estimated that 285,304 lung cancer deaths (men: 229,990;women: 55,314) and 327,465 cases (men: 263,576, women: 63,889) were attributable to smoking, involuntary smoking (women only), occupational agents, indoor radon, low fruit intake in China in 2005. About 75.04% of lung cancer deaths among men and 18.35% among women were attributable to tobacco smoking. About 10.63% of lung cancer deaths in men and 7.04% in women were caused by occupational agents, and 0.15% for both genders caused by indoor radon. Low fruit intake was responsible for 12.24% lung cancer deaths among men and that of 12.60% among women. The fraction of lung cancer deaths attributable to involuntary smoking from the spouse or at the workplace among non-smoking women was 11.10%. Conclusions Smoking, occupational agents, indoor radon, and low fruit intake are responsible for 80% of lung cancer mortality and incidence among men and 41% among women (including involuntary smoking). However, more than half of lung cancer deaths and cases among women are caused by other risk factors. It is necessary to conduct large-scale, case series studies to demonstrate genetic factors and other important risk factors of lung cancer in women.
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